Full publications

1981-present: A total of >360 publications

H-index: 103, a total citation of over 38,000 times based on SCI Web of Knowledge;

H-index: 125, a total citation of over 54,000 times based on Google Search (https://scholar.google.com/citations?user=1wiz_OEAAAAJ&hl=en). (by May, 2018: Ranked #9 among 18 scholars, whose H-index is over 100, and #1 in Cancer/Biological Sciences in the Great China areas (Mainland China, Taiwan, Hong Kong and Macau).

From Undergraduate Period (1978.3-1981.12):

1). Tang, Z-S, Chuxia Deng and Sun, L. (1981). Chromosomal variations in barley mutants induced by 60Co irradiation. Acta Nanchong Teachers College.

From Master Degree Student and Postgradulate Period (1982.1-1986.8):

2). Yang, Xingqi, Chuxia Deng, and Hongqi Chen (1984). Studies on the lactate dehydrogenase and malate dehydregenase isozymes in tissue of three species in genus tilapia. Acta Genetics Sinica 11, 132-140.

3). Chuxia Deng, Xingqi Yang, and Hongqi, Chen (1985). Cloning techniques in fish cells. Acta Hydrobiological Sinica 9, 2.

4). Chuxia Deng, Xingqi Yang, and Hongqi Chen (1985). Susceptibility to grass carp reovirus of grass carp kidney cells and their clones. Acta Hydrobiological Sinica 9, 325-335.

5).  Chuxia Deng (1987). Inborn error and induced mutations that affect DNA repair in mammalian cells. Progress in Science 5, 1-10.

From Ph.D Student Period (1986.9-1992.5):

6). Mansour, L. Suzi, Kirk, R. Thomas, Chuxia Deng, and Mario R. Capecchi (1990). Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination. Proc. Natl. Acad. Sci. USA 87, 7688-7692.

7). Thomas, R. Kirk, Chuxia Deng, and Mario R. Capecchi (1992). High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors. Mol. and Cell. Biol. 12, 2919-2923.

8). Chuxia Deng, and Mario, R. Capecchi (1992). Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus. Mol. and Cell. Biol. 12, 3365-3371.

9). Chuxia Deng, Kirk, R. Thomas, and Mario, R. Capecchi (1993). Location of crossovers during gene targeting with insertion and replacement vectors. Mol. and Cell. Biol. 13, 2134-2140.

10). Chuxia Deng (1994). Gene targeting in murine embryonic stem cells: a new method to manipulate the mouse genome. Progress in Natural Science 4, 21-31.

From Postdoctoral Period (1992.7-1995.5):

11). Oettgen, C. Hans, Thomas R. Martin, Anthony Wynshaw-Boris, Chuxia Deng, Jeffrey M. drazen and Philip Leder (1994). Active Anaphylaxis in IgE-deficient mice. Nature 370, 367-370.

12). Chuxia Deng, Tony Wynshaw-Boris, Michael Shen, David Ornitz, Cathie Daugherty and Philip Leder (1994). FGFR-1 is required for the early embryonic growth and axial organization. Gene&Deve 8, 3045-3057.

13). Elson, Ari, Chuxia Deng, Juanita Campos-Torres, Lawrence A. Donehower and Philip Leder (1995). The MMTV/c-myc transgene and p53 null alleles collaborate to induce T-cell lymphomas, but not mammary carcinomas in transgenic mice. Oncogene 11, 181-190.

14). Chuxia Deng, Pumin Zhang, J. Wade Harper, Stephen J. Elledge, and Philip Leder (1995). Mice lacking p21cip1/waf1 undergo normal development, but are defective in G1 checkpoint control. Cell 82, 675-684.

(Featured as a HOT PAPER by Scientist on July 1997 due to its high citation. Cited 2263 times until now)

15). Lane, Timothy F., Chuxia Deng, Ari Elson, Myung S. Lyu, Christine A. Kozak and Philip Leder (1995). Expression of murine Brca-1 is associated with terminal differentiation of epithelial tissues in mice. Genes&Deve 9, 2712-2722.

I became a tenure track investigator in NIDDK, NIH on June 25 of 1995. NIDDK has site visit (Board of Scientific Counselor review) every four years, so I organize my publications based on the cycle of every 4 years.

Since 1995.5 after joining NIH

16). Chuxia Deng, Tony Wynshaw-Boris, Fen Chou, Ann Kuo and Philip Leder (1996). FGFR-3 is a negative regulator in bone growth. Cell 84, 911-921.

17). Mantel, Charlie.R., Luo, Zaiming., Canfield, Jeff., Chuxia Deng, and Broxmeyer, Hal. E. (1996). Involvement of p21cip-1 and p27kip-1 in the molecular mechanisms of steel factor-induced proliferative synergy in vitro and of p21cip-1 in the maintenance of stem/progenitor cells in vivo.  Blood 88, 3710-3719.

18). Wu-Chou S. Su, Motoo Kitagawa, Ninrong Xue, Bing Xie, Silvio Garofalo, Jae Cho, Chuxia Deng, William A., Horton and Xin-Yuan Fu (1997). Stat1 activation by mutant fibroblast growth factor receptor 3 responsible for type II thanatophoric dysplasia. Nature 386, 288-292.

19). Chuxia Deng (Corresponding author), Mark Bedford, Cuiling Li, Xiaoling Xu, Xiao Yang, Judy Dunmore & Philip Leder. (1997). Fibroblast Growth Factor Receptor-1 (FGFR-1) is Essential for Normal Neural Tube and Limb Development. Developmental Biology 185, 42-54.

20). Barlow C, Schroeder M, Lekstrom-Himes J, Kylefjord H, Chuxia Deng, Wynshaw-Boris A, Spiegelman BM and Xanthopoulos KG. (1997). Targeted expression of Cre recombinase to adipose tissue of transgenic mice directs adipose-specific excision of loxP-flanked gene segments. Nucleic Acids Res 25, 2543-2545.

21). W.C. Weinberg, N.E. Montano and Chuxia Deng (1997). Loss of p21cip1/waf1 does not recapitulate accelerated malignant conversion caused by p53 loss in experimental skin carcinogenesis. Oncogene 15, 685-690.

22). Tony Wynshaw-Boris, Gabriella Ryan, Chuxia Deng, David C. Chan, Laurie Jackson-Grusby, Denise larson, Judy H. Dunmore, and Philip Leder. (1997). The role of a single formin isoform in the limb and renal phenotypes of limb deformity. Molecular Medicine 3, 372-84.

23). Lijam N, Paylor R, McDonald MP, Crawley JN, Chuxia Deng, Herrup K, Stevens KE, Maccaferri G, McBain CJ, Sussman DJ, Wynshaw-Boris A (1997). Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1. Cell 90:895-905.

24). Barlow C, Brown KD, Tagle DA, Chuxia Deng, Ried T and Wynshaw-Boris A. (1997). Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways.  Nature Genetics 17, 453-456.

25). Barlow C, Liyanage M, Moens PB, Chuxia Deng, Ried T and Wynshaw-Boris A. (1997). Partial rescue of the prophase I defects of Atm-deficient mice by p53 and p21 null alleles. Nature Genetics 17, 462-466.

26) Yuen, D., Mittal, L., Chuxia Deng, and Choi, K (1998). Generation of a primitive erythroid cell line and promotion of its growth by basic fibroblast growth factor. Blood 91:3202-3209.

27). Albrecht, JH, Poon RYC, Ahonen, CL, Rieland BM, Chuxia Deng, and Crary GS. (1998). Involvement of p21 and p27 in the regulation of CDK activity and cell cycle. Oncogene 16, 2124-2150.

28). Xiaoling Xu, Michael Weinstein, Cuiling Li, Michael Naski, Rick I. Cohen, David M. Ornitz, Philip Leder and Chuxia Deng (1998). Fibroblast growth factor receptor 2 (FGFR2) mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development 125, 753-765.

29) Xiao Yang, Cuiling Li, Xiaoling Xu  and Chuxia Deng (1998). The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc. Nati. Acad. Sci. USA 95, 3667-3672.

30). David C. Olson, Chuxia Deng and Douglas Hanahan (1998). Functional Evaluation of the role of FGFR4 in neoplastic conversion. Molecular Cancer Research 9, 557-64.

31). Shanxiang Shen, Zoë Weaver, Xiaoling Xu, Cuiling Li, Michael Weinstein, Xin-Yuan Guan, Thomas Ried and Chuxia Deng (1998). A targeted disruption of murine Brca1 gene (Brca111) causes g-radiation hypersensitivity and genetic instability. Oncogene 17, 3115-24.

32) Michael Weinstein, Xiao Yang, Cuiling Li, Xiaoling Xu and Chuxia Deng (1998). Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor Smad2. PNAS 95, 9378-9383.

33) Michael Weinstein, Xiaoling Xu, Kyoji Ohyama and Chuxia Deng (1998). FGFR-3 and FGFR-4 Function Cooperatively to Direct Secondary Septation in the Murine Lung. Development 125, 3615-3623.

Since 1999

34) Cuiling Li, Lin Chen, Tomoko Iwata, Motoo Kitagawa, Xin-Yuan Fu and Chuxia Deng (1999). A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors. Human Molecular Genetics 8, 35-44.

35). Yujing Liu, Ryuichi Wada, Hiromichi Kawai, Kazunori Sango, Chuxia Deng, Tadashi Tai, Michael P. McDonald, Kristlyn Araujo, Jacqueline N. Crawley, Uwe Bierfreund, Konrad Sandhoff, Kinuko Suzuki and Richard L. Proia (1999). A genetic model of substrate deprivation therapy for a glycosphingolipid storage disorder. J Clin Invest 103, 497-505.

36). Yuxin Yin, Gregary Solomon, Chuxia Deng, and J. Carl Barrett (1999). Differential regulation of p21 by p53 and Rb in cellular response to oxidative stress. Molecular Carcinogenesis 24, 15-24.

37) Xiao Yang, John Letterio, Lin Chen, Ruth Hayman, Hue Gu, Anita Roberts and Chuxia Deng (1999).  Targeted disruption of SMAD3 results in immune dysregulation. EMBO J. 18, 1280-1291.

38). Xiaoling Xu, Zoë Weaver, Steven P. Linke, Cuiling Li, Jessica Gotay, Xin-Wei Wang, Curtis C. Harris, Thomas Ried and Chuxia Deng (1999). Centrosome Amplification and a Defective G2-M Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform-Deficient Cells. Molecular Cell 3, 389-396.

(Featured as a HOT PAPER by Scientist on May 12, 2001 because of its high citation. Cited 744 times until now)

39). Xiao Yang, Lucio Castilla, Xiaoling Xu, Cuiling Li, Jessica Gotay, Pu Paul Liu and Chuxia Deng (1999). Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5. Development 126, 1571-1580.

40). Xiaoling Xu, Cuiling Li, Katsu Takahashi, Harold C. Slavkin, Lillian Shum and Chuxia Deng (1999). Murine Fibroblast Growth Factor Receptor 1 Alpha (FGFR1a) Isoforms Mediate Node Regression and Are Essential for Posterior Mesoderm Development. Developmental Biology 208, 293-306.

41). W. C.Weinberg, E. Fernandez-Salas, D. L. Morgan, A. Shalizi, E. Mirosh, E. Stanulis, Chuxia Deng, H. Hennings, and S. H. Yuspa (1999). Genetic deletion of p21WAF1 enhances papilloma formation but not malignant conversion in experimental mouse skin carcinogenesis. Cancer Research 59, 2050-4.

42).  Xiaoling Xu, Kay-Uwe Wagner, Cuiling Li, Anthony Wynshaw-Boris, Lothar Hennighausen and Chuxia Deng (1999). Conditional mutation of BRCA1 in mammary glands results in abnormal ductal morphogenesis and tumor formation. Nature Genetics 22, 37-43.

(Commentary and news on Science 284, 723-5, Wall Street Journal on April 30, and Nature Genetic 22, 10)

43).  Yamashita, T., Wada, R., Sasaki, T., Chuxia Deng, Bierfreund, U., Sandhoff, K, and Proia, R.L. (1999) A Vital Role for Glycosphingolipid Synthesis During Development and Differentiation. PNAS  96, 9142-9147.

44).  Gomeza J, Zhang L, Kostenis E, Felder C, Bymaster F, Brodkin J, Shannon H, Xia B, Chuxia Deng, Wess J (1999). Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M4 muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A 96, 10483-8.

45).  Gillian S. Ashcroft, Xiao Yang, Adam Glick, Michael Weinstein, John J. Letterio, Diane E. Mizel, Mario Anzano, Teresa Greenwell-Wild, Sharon M. Wahl, Chuxia Deng and Anita B. Roberts. (1999). Mice lacking SMAD3 show accelerated in vivo would healing and an impaired local inflammatory response.  Nature Cell Biology 1, 260-266.

46).  Hollander MC, Sheikh MS, Bulavin DV, Lundgren K, Augeri-Henmueller L, Shehee R, Molinaro TA, Kim KE, Tolosa E, Ashwell JD, Rosenberg MP, Zhan Q, Fernandez-Salguero PM, Morgan WF, Chuxia Deng, Fornace AJ Jr (1999). Genomic instability in Gadd45a-deficient mice. Nat Genet 23, 176-84.

47).  Lin Chen, Efrat O. Monsonego, Xiao Yang, Rivka Adar, Cuiling Li, Avner Yayon, and Chuxia Deng (1999). Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis. J. of Clinic Investigation 104, 1517-1525.

48). Xiaoling Xu, Michael Weinstein, Cuiling Li and Chuxia Deng (1999). Fibroblast growth factor receptors (FGFRs) and their roles in limb development. Cell &Tissue Research 296, 33-43.

[The first site visit (med-term review) was held on May 5, 1999. The Board of Scientific Counselor recommended early tenure based on my outstanding performance].   

49).  Xiaoling Xu, Steven G. Brodie, Xiao Yang, Young-Hyuck Im, W. Tony Parks, Lin Chen, Yong-Xing Zhou, Jian-Wu Xie, Seong-Jin Kim and Chuxia Deng. (2000). Haploinsufficiency of the tumor suppressor Smad4/Dpc4 initiates gastrointestinal polyposis and cancer in mouse. Oncogene 19, 1868-74.

50).  Faloon, P., Arentson, E., Kazarov, A., Chuxia Deng, Porcher, C., Orkin, S., and Choi, K. (2000).  Basic fibroblast growth factor positively regulates hematopoietic development. Development 127, 1931-1941.

51).  Chundong Yu, Fen Wang, Mikio Kan, Chengliu Jin, Richard B. Jones, Michael Weinstein, Chuxia Deng, and Wallace L. McKeehan. (2000). Elevated Cholesterol Metabolism and Bile Acid Synthesis in Mice Lacking Membrane Tyrosine Kinase Receptor FGFR4. J Biol Chem 275, 15482-9.

52).  Gong DW, Monemdjou S, Gavrilova O, Leon LR, Marcus-Samuels B, Chou CJ, Everett C, Kozak LP, Li, Chuxia Deng, Harper ME, Reitman ML (2000).  Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3. J Biol Chem 275, 16251-7.

53).  Smith ML, Ford JM, Hollander MC, Bortnick RA, Amundson SA, Seo YR, Chuxia Deng, Hanawalt PC, Fornace AJ Jr. (2000). p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes. Mol Cell Biol 10, 3705-14.

54).  Tomoko Iwata, Lin Chen, Cui-ling Li, Clair A. Francomano, and Chuxia Deng (2000). A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos. Hum Mol Genet 9, 1603-1613.

55).  Yong-Xing Zhou, Xiaoling Xu, Lin Chen, Cuiling Li, Steven G. Brodie, and Chuxia Deng (2000).  A proline to arginine substitution at codon 250 (Pro250Arg) in fibroblast growth factor receptor 1 (Fgfr1) activates Cbfa1 and causes Pfeiffer syndrome in mice. Hum Mol Genet 9, 2001-8.

56).  Xu J, Liao L, Ning G, Yoshida-Komiya H, Chuxia Deng, O’Malley BW. (2000). The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development. Proc Natl Acad Sci U S A 97, 6379-84.

57).  Franklin DS, Godfrey VL, O’Brien DA, Chuxia Deng, Xiong Y. (2000). Functional Collaboration between Different Cyclin-Dependent Kinase Inhibitors Suppresses Tumor Growth with Distinct Tissue Specificity. Mol Cell Biol, 20, 6147-6158.

58).  Liu Y, Wada R, Yamashita T, Mi Y, Chuxia Deng, Hobson JP, Rosenfeldt HM, Nava VE, Chae SS, Lee MJ, Liu CH, Hla T, Spiegel S, Proia RL (2000). Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest 106, 951-61.

59).  Yun J, Schoneberg T, Liu J, Schulz A, Ecelbarger CA, Promeneur D, Nielsen S, Sheng H, Grinberg A, Chuxia Deng, Wess J. (2000). Generation and phenotype of mice harboring a nonsense mutation in the V2 vasopressin receptor gene. J Clin Invest 106, 1361-1371.

60).  Chuxia Deng and Frank Scott (2000). Role of the tumor suppressor gene Brca1 in genetic stability and mammary gland tumor formation. Oncogene 19, 1059-64.

61).  Michael Weinstein, Xiao Yang, and Chuxia Deng (2000). Functions of mammalian Smad genes as revealed by targeted gene disruption in mice.  Cytokine & Growth Factor Rev 11, 49-58.

62).  Chuxia Deng and Steven Brodie (2000). Roles of BRCA1 and its interacting proteins. BioEssay 22, 728-737.

63).  Steven G. Brodie, Xiaoling Xu, Cuiling Li, Philip Leder and Chuxia Deng. (2001). Inactivation of p53 tumor suppressor gene acts synergistically with c-neu oncogene in salivary gland tumorigenesis. Oncogene 20, 1445-1454.

64).  Masahisa Yamada, Tsuyoshi Miyakawa, Alokesh Duttaroy, Akihiro Yamanaka, Toru Moriguchi, Ryosuke Makita, Masaharu Ogawa, Chieh J. Chou, Bing Xia, Jacqueline N. Crawley, Christian C. Felder, Chuxia Deng & Jürgen Wess. (2001).  Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean. Nature 410, 207-12.

65).  Lin Chen, Cuiling Li, Wenhui Qiao, Xiaoling Xu, and Chuxia Deng. (2001). A Ser365 ® Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia.  Human Molecular Genetics 10, 457-465.

66).  Xiao Yang, Lin Chen, Xiaoling Xu, Cuiling Li, Cuifen Huang and Chuxia Deng. (2001). TGF-beta/Smad3 signals repress chondrocyte differentiation and are required for maintaining articular cartilage and bone density. J. of Cell Biology 153, 35-46.

67). Xiaoling Xu, Cuiling Li, Lisa Garrett-Beal, Denise Larson, Anthony Wynshaw-Boris, and Chuxia Deng. (2001). Direct removal in the mouse of a floxed neo gene from a three-loxP conditional knockout allele by two novel approaches.  Genesis 30, 1-6.

68).  Piek E, Ju W, Heyer J, Escalante-Alcalde D, Stewart CL, Weinstein M, Chuxia Deng, Kucherlapati R, Boettinger EP, Roberts AB. (2001).  Functional Characterization of TGF-b Signaling in Smad2- and Smad3-Deficient Fibroblasts. J Biol Chem 276, 19945-19953.

69).  Huber LJ, Sarkisian CJ, Master SR, Chuxia Deng and Chodosh LA (2001). Impaired DNA Damage Response in Cells Expressing an Exon 11-Deleted Murine Brca1 Variant That Localizes to Nuclear Foci.  Molecular & Cellular Biology 21, 4005-15.

70).  Tansey JT, Sztalryd C, Gruia-Gray J, Roush DL, Zee JV, Gavrilova O, Reitman ML, Chuxia Deng, Li C, Kimmel AR, Londos C. (2001). Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc Natl Acad Sci U S A 98, 6494-9.

71).  Zhou YX, Qiao WH, Gu WH, Xie H, Tang BS, Zhou LS, Yang BX, Takiyama Y, Tsuji S, He HY, Chuxia Deng, Goldfarb LG, Wang GX. (2001). Spinocerebellar Ataxia Type 1 in China: Molecular Analysis and Genotype-Phenotype Correlation in 5 Families. Arch Neurol 58, 789-794.

72).  Tomoko Iwata, Cuiling Li, Chuxia Deng, and Clair A. Francomano. (2001).  Highly activated Fgfr3 with the K644M mutation causes prolonged survival in the severe dwarf mice.  Human Molecular Genetic 10, 1255-1264.

73).  Xiaoling Xu, Wenhui Qiao, Steven P. Linke, Liu Cao, Wen-Mei Li, Cuiling Li, Curtis C. Harris, and Chuxia Deng (2001). Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle, genomic stability and tumorigenesis. Nature Genetics 28, 266-271.

74).  Michael Weinstein, Satdarshan PS Monga, Yi Tang, Lopa Mishra, and Chuxia Deng (2001). Smad proteins and HGF control parallel regulatory pathways that converge on the b1-integrin to promote normal liver development. Molecular & Cellular Biology 21, 5122-31.

75).  Gomeza J, Zhang L, Kostenis E, Felder CC, Bymaster FP, Brodkin J, Shannon H, Xia B, Duttaroy A, Chuxia Deng, and Wess J. (2001). Generation and pharmacological analysis of M2 and M4 muscarinic receptor knockout mice. Life Sci 68, 2457-66.

76).  Cuiling Li, Huimin Guo, Xiaoling Xu, Wendy Weinberg, and Chuxia Deng. (2001). Fibroblast growth factor receptor 2 (Fgfr2) plays an important role in eyelid and skin induction and patterning. Developmental Dynamics 222, 471-483.

77).  SG. Brodie, Xiaoling Xu, Wenhui Qiao, Wen-Mei Li, Liu Cao and Chuxia Deng. (2001). Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice. Oncogene 20, 7514-7523.

78).  Ito Y, Zhao J, Mogharei A, Shuler CF, Weinstein M, Chuxia Deng, Chai Y. (2001). Antagonistic effects of Smad2 versus Smad7 are sensitive to their expression level during tooth development. J Biol Chem 276, 44163-72.

79).  Ito Y, Sarkar P, Mi Q, Wu N, Bringas P Jr, Liu Y, Reddy S, Maxson R, C Deng, and Chai Y. (2001). Overexpression of Smad2 reveals its concerted action with Smad4 in regulating TGF-beta-mediated epidermal homeostasis. Dev Biol 236, 181-94.

80). Yamada M, Lamping KG, Duttaroy A, Zhang W, Cui Y, Bymaster FP, McKinzie DL, Felder CC, Chuxia Deng, Faraci FM, Wess J. (2001). Cholinergic dilation of cerebral blood vessels is abolished in M5 muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A 98, 14096-101.

81). Lechleider RJ, Ryan JL, Garrett L, Eng C, Chuxia Deng, Wynshaw-Boris A, Roberts AB. (2001). Targeted mutagenesis of Smad1 reveals an essential role in chorioallantoic fusion. Dev Biol 240, 157-67.

82). McDonald MP, Miller KM, Li C, Chuxia Deng, Crawley JN. (2001). Motor deficits in fibroblast growth factor receptor-3 null mutant mice. Behav Pharmacol 12, 477-86.

83). Yang X, Sun YX, Zhou J, Huang PT, Huang CF, Xu XL, Li CL, Gotay J, Chen L, Chuxia Deng (2001). Establishment of murine Smad5 double knockout ES cells and the studies on their properties. Sci China C Life Sci 44, 121-129.

84).  Chuxia Deng (2001). Tumorigenesis as a consequence of genetic instability in Brca1 mutant mice. Mutation Research 477, 183-189.

85). Chuxia Deng and Steven G. Brodie (2001). Knockout mouse models and mammary tumorigenesis. Seminar in Cancer Biology 11, 387-394.

86).  Steven G. Brodie and Chuxia Deng (2001). BRCA1, what have we learned from knockout mice. Trends in Genet 17, S18-22.

87). Kawai H, Allende ML, Wada R, Kono M, Sango K, Deng C, Miyakawa T, Crawley JN, Werth N, Bierfreund U, Sandhoff K, Proia RL. (2001). Mice expressing only monosialoganglioside GM3 exhibit lethal audiogenic seizures. J Biol Chem. 276(10):6885-8.

88). Fisahn A, Yamada M, Duttaroy A, Gan JW, Chuxia Deng, McBain CJ, Wess J. (2002). Muscarinic Induction of Hippocampal Gamma Oscillations Requires Coupling of the M1 Receptor to Two Mixed Cation Currents. Neuron 33, 615-624.

89). Huang S, Tang B, Usoskin D, Lechleider RJ, Jamin SP, Li C, Anzano MA, Ebendal T, Chuxia Deng, Roberts AB. (2002).  Conditional knockout of the Smad1 gene. Genesis 32, 76-9.

90). Xaioling Xu, Wenhui Qiao, Cuiling Li, and Chuxia Deng (2002). Generation of Fgfr1 conditional knockout mice. Genesis 32, 85-6.

91). Xiao Yang, Cuiling Li, Pedro-Luis Herrera and Chuxia Deng (2002). Generation of Smad4/Dpc4 conditional knockout mice. Genesis 32, 80-1.

92). Tomic D, Brodie SG, Chuxia Deng, Hickey RJ, Babus JK, Malkas LH, Flaws JA. (2002). Smad 3 may regulate follicular growth in the mouse ovary. Biol Reprod 66, 917-23.

93). Flanders KC, Sullivan CD, Fujii M, Sowers A, Anzano MA, Arabshahi A, Major C, Chuxia Deng, Russo A, Mitchell JB, Roberts AB. (2002) Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation. Am J Pathol. 160, 1057-68.

94). Yang YA, Tang B, Robinson G, Hennighausen L, Brodie SG, Chuxia Deng, Wakefield LM. (2002). Smad3 in the mammary epithelium has a nonredundant role in the induction of apoptosis, but not in the regulation of proliferation or differentiation by transforming growth factor-beta. Molecular Cancer Research 13, 123-30.

95). Ito Y, Bringas P Jr, Mogharei A, Zhao J, Chuxia Deng, Chai Y. (2002) Receptor-regulated and inhibitory Smads are critical in regulating transforming growth factorbeta-mediated Meckel’s cartilage development. Dev Dyn 224, 69-78.

96). Weaver Z, Montagna C, Xu X, Howard T, Gadina M, Brodie SG, Chuxia Deng, Ried T. (2002). Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer. Oncogene 21, 5097-107.

97). Ganesan S, Silver DP, Greenberg RA, Avni D, Drapkin R, Miron A, Mok SC, Randrianarison V, Brodie S, Salstrom J, Rasmussen TP, Klimke A, Marrese C, Marahrens Y, Chuxia Deng, Feunteun J, Livingston DM. (2002). BRCA1 Supports XIST RNA Concentration on the Inactive X Chromosome. Cell 111, 393-405.

98). Chuxia Deng (2002). Tumor formation in Brca1 conditional mutant mice. Environ Mol Mutagen 39, 171-7.

99). Chuxia Deng (2002). Roles of BRCA1 in centrosome duplication. Oncogene 21, 6222-7.

Since 2003 (Second site visit in May 2003)

100). Agarwal P, Wylie JN, Galceran J, Arkhitko O, Li C, Chuxia Deng, Grosschedl R, Bruneau BG. (2003). Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo. Development 130, 623-633.

101). Richard Bachelier, Xiaoling Xu, Xaoyan Wang, Wenmei Li, Mayumi Naramura, Hua Gu, and Chuxia Deng, (2003). Normal lymphocyte development and thymic lymphoma formation in Brca1 exon 11-deficient mice. Oncogene 22, 528-537.

102). Liu Cao, Wenmei Li, Sangsoo Kim, Steven G. Brodie, and Chuxia Deng (2003). Senescence, ageing and malignant transformation mediated by p53 in mice lacking Brca1 exon 11 isoform. Genes and Development 17, 201-213.

103). Yi Tang, M. Katuri, A. Dillner, B. Mishra*, Chuxia Deng*, and L. Mishra*. (*Corresponding authors) (2003). Disruption of TGF-beta signaling in ELF-beta-spectrin deficient mice. Science 299, 574-7.

104). Xiaoling Xu (Corresponding author), Olga Aprelikova, Peter Moens, Chuxia Deng, and Priscilla A. Furth (2003). Impaired meiotic DNA-damage repair and lack of crossing-over during spermatogenesis in BRCA1 full-length isoform deficient mice. Development 130, 2001-2012.

105). Yokozeki M, Afanador E, Nishi M, Kaneko K, Shimokawa H, Yokote K, Chuxia Deng, Tsuchida K, Sugino H, Moriyama K. (2003). Smad3 is required for enamel biomineralization. Biochem Biophys Res Commun. 305, 684-690.

106). Pat P. Ongusaha, Toru Ouchi, Kyung-tae Kim, Emily Nytko, Jennifer C. Kwak, Chuxia Deng and Sam W. Lee (2003). BRCA1 shifts p53-mediated cellular outcomes toward irreversible growth arrest . Oncogene 22(24):3749-58.

107). Wess J, Duttaroy A, Zhang W, Gomeza J, Cui Y,  Miyakawa T, Bymaster FP, McKinzie L, Felder CC, Lamping KG, Faraci FM, Chuxia Deng, Yamada M (2003). M(1)-m(5) muscarinic receptor knockout mice as novel tools to study the physiological roles of the muscarinic cholinergic system. Receptors Channels 9(4):279-90.

108). Yamada M, Basile AS, Fedorova I, Zhang W, Duttaroy A, Cui Y, Lamping KG, Faraci FM, Deng CX, Wess J. (2003). Novel insights into M5 muscarinic acetylcholine receptor function by the use of gene targeting technology. Life Sci. 5;74(2-3):345-53.

109). Li SH, Yu ZX, Li CL, Nguyen HP, Zhou YX, Deng C, Li XJ (2003). Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington’s disease. J Neurosci. 23(17):6956-64.

110). Yong-Xing Zhou, Kazuhiro Shimazu, Kazuko Sakata, Dan Li, Chuxia Deng* (*Corresponding authors) and Bai Lu* (*Corresponding authors) (2003). Cerebellar Deficits and Hyperactivity in Mice Lacking Smad4. J Biol Chem. 278(43):42313-20.

111). Berton TR, Matsumoto T, Page A, Conti CJ, Chuxia Deng, Jorcano JL, Johnson DG (2003). Tumor formation in mice with conditional inactivation of Brca1 in epithelial tissues. Oncogene 22(35):5415-26.

112). Chen L, Li D, Li C, Engel A, Chuxia Deng (2003). A Ser250Trp substitution in mouse fibroblast growth factor receptor 2 (Fgfr2) results in craniosynostosis. Bone 33(2):169-78.

113). Wenmei Li, Wenhui Qiao, Lin Chen, Xiaoling Xu, Xiao Yang, Dan Li, Cuiling Li, Steven G. Brodie, Lothar Hennighausen, and Chuxia Deng (2003), Squamous cell carcinoma and mammary abscess formation through squamous metaplasia in Smad4/Dpc4 conditional knockout mice. Development 130, 6143-53.

114). Aglipay JA, Lee SW, Okada S, Fujiuchi N, Ohtsuka T, Kwak JC, Wang Y, Johnstone RW, Chuxia Deng, Qin J, Ouchi T.  (2003). A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. Oncogene 22(55): 8931-8.

115). SG. Brodie and C Deng (2003). Mouse Models Orthologous to FGFR3 Related Skeletal Dysplasias. Pediatric Pathology & Molecular Medicine 22, 87-103.

116). C Deng and R Wang (2003). Roles of BRCA1 in DNA damage repair: a link between development and cancer. Human Molecular Genetics 12, R113-23.

117). Coumoul X and Chuxia Deng. (2003). Roles of FGF receptors in mammalian development and congenital diseases. Birth Defects Res Part C Embryo Today 69(4): 286-304.

118). Cho JY, Guo C, Torello M, Lunstrum GP, Iwata T, Chuxia Deng, Horton WA. (2004). Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia. Proc Natl Acad Sci U S A 101(2): 609-14.

119). Ouchi M, Fujiuchi N, Sasai K, Katayama H, Minamimori YA, Ongusaha PP, Chuxia Deng, Sen S, Lee SW, Ouchi T. (2004). BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition. J Biol Chem. 279(19):19643-8.

120). Wang Y, Cui F, Lv Y, Li C, Xu X, Chuxia Deng, Wang D, Sun Y, Hu G, Lang Z, Huang C, Yang X. (2004). HBsAg and HBx knocked into the p21 locus causes hepatocellular carcinoma in mice. Hepatology 39 (2):318-24.

121). Coumoul X, Li W, Wang RH, Chuxia Deng. (2004). Inducible suppression of Fgfr2 and Survivin in ES cells using a combination of the RNA interference (RNAi) and the Cre-LoxP system. Nucleic Acids Res. 32(10):e85.

122). Wang X, Wang RH, Li W, Xu X, Hollander C, Fornace A, Chuxia Deng. (2004).   Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability and neural tube closure. J Biol Chem. 9;279(28):29606-14.

123). Li AG, Lu SL, Zhang MX, Chuxia Deng, Wang XJ. (2004). Smad3 knockout mice exhibit a resistance to skin chemical carcinogenesis. Cancer Res. 64(21):7836-45.

124). Kim SS, Cao L, Li C, Xu X, Huber LJ, Chodosh LA, Chuxia Deng. (2004). Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1. Mol Cell Biol. 24(21):9498-507.

125). Castrop H, Huang Y, Hashimoto S, Mizel D, Hansen P, Theilig F, Bachmann S, Chuxia Deng, Briggs J, Schnermann J. (2004).  Impairment of tubuloglomerular feedback regulation of GFR in ecto-5′-nucleotidase/CD73-deficient mice. J Clin Invest. 114(5):634-42.

126). Cui Y, Riedlinger G, Miyoshi K, Tang W, Li C, Chuxia Deng, Robinson GW, Hennighausen L. (2004). Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol. 24(18):8037-47.

127). Rui-Hong Wang, Hongtao Yu, and Chuxia Deng. (2004). A requirement for the breast cancer associated gene 1 (BRCA1) in the spindle checkpoint. PNAS 101:17108-13.

128). James MA Turner*, Olga Aprelikova*, Xiaoling Xu* (*equal contribution), Ruihong Wang, Sangsoo Kim, GVR Chandramouli, JC Barrett, Paul S Burgoyne, and Chuxia Deng (2004). BRCA1 interacts with ATR and gH2AX and plays an essential role in meiotic sex chromosome inactivation during spermatogenesis. Current Biology 14(23):2135-42.

129). Wang JM, Du XL, Li CL, Yin LJ, Chen B, Sun J, Su N, Zhao L, Song RH, Song WW, Chen L, Chuxia Deng. (2004). Gly374Arg mutation in Fgfr3 causes achondroplasia in mice. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 21(6):537-41.

130). Xiaoling Xu and Chuxia Deng. (2004). Generation and analysis of Brca1 conditional knockout mice. Methods Mol Biol. 280:185-200.

131). James MA Turner, Shantha K Mahadevaiah, Chuxia Deng and Paul S Burgoyne (2005). Silencing of unsynapsed meiotic chromosomes in the mouse. Nature Genetics 37(1):41-7.

132). Simeone AM, Chuxia Deng, Kelloff GJ, Steele VE, Johnson MM, Tari AM. (2005). N-(4-hydroxyphenyl)retinamide is more potent than other phenylretinamides in inhibiting the growth of BRCA1-mutated breast cancer cells. Carcinogenesis. 26, 1000-7.

133). Jones LP, Li M, Halama ED, Ma Y, Lubet R, Grubbs CJ, Chuxia Deng, Rosen EM, Furth PA.            (2005). Promotion of mammary cancer development by tamoxifen in a mouse model of Brca1-mutation-related breast cancer. Oncogene 24(22):3554-62.

134). Yamashita M, Ying SX, Zhang GM, Li C, Cheng SY, Chuxia Deng, Zhang YE. (2005). Ubiquitin Ligase Smurf1 Controls Osteoblast Activity and Bone Homeostasis by Targeting MEKK2 for Degradation. Cell 121(1):101-13.

135). Chodankar R, Kwang S, Sangiorgi F, Hong H, Yen HY, Chuxia Deng, Pike MC, Shuler CF, Maxson R, Dubeau L. (2005). Cell-nonautonomous induction of ovarian and uterine serous cystadenomas in mice lacking a functional Brca1 in ovarian granulosa cells. Curr Biol. 15(6):561-5.

136). Liu J, Chen M, Chuxia Deng, Bourc’his D, Nealon JG, Erlichman B, Bestor TH, Weinstein LS. (2005). Identification of the control region for tissue-specific imprinting of the stimulatory G protein alpha-subunit. PNAS 102(15):5513-8.

137). Chen M, Gavrilova O, Liu J, Xie T, Chuxia Deng, Nguyen AT, Nackers LM, Lorenzo J, Shen L, Weinstein LS. (2005). Alternative Gnas gene products have opposite effects on glucose and lipid metabolism. Proc Natl Acad Sci U S A 102(20):7386-91.

138). Sun Y, Zhou J, Liao X, Lu Y, Chuxia Deng, Huang P, Chen Q, Yang X. (2005).     Disruption of Smad5 gene induces mitochondria-dependent apoptosis in cardiomyocytes. Exp Cell Res. 306(1):85-93.

139). Coss D, Thackray VG, Chuxia Deng, Mellon PL (2005). Activin Regulates Luteinizing Hormone ß-Subunit Gene Expression through Smad-Binding and Homeobox Elements. Exp Cell Res 19:2610-23.

140). Xavier Coumoul, Vivek Shukla, Cuiling Li, Rui-Hong Wang, and Chuxia Deng, (2005). Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference.  Nucleic Acid Research 33(11):e102.

141). Richard Bachelier, Cuiling Li, Wenhui Qiao, Priscilla A. Furth, Ronald A. Lubet, and Chuxia Deng. (2005). Effects of Bilateral Oophorectomy on Mammary Tumor Formation in Brca1 Mutant Mice. Oncol Rep 14(5):1117-20.

142). Verheyden JM, Lewandoski M, Chuxia Deng, Harfe BD, Sun X. (2005). Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning.  Development 132(19):4235-45.

143). Cuiling Li, Xiaoling Xu, Danielle K. Nelson, Trevor Williams, Michael R. Kuehn and Chuxia Deng. (2005). FGFR1 plays an indispensable role in the earliest stages of limb development that may be critical for autopod morphogenesis at later stages of the mouse limb. Development 132(21):4755-64.

144). Shen KC, Heng H, Wang Y, Lu S, Liu G, Chuxia Deng, Brooks SC, Wang YA. (2005). ATM and p21 Cooperate to Suppress Aneuploidy and Subsequent Tumor Development.  Cancer Res. 65:8747-53.

145). Tian JH, Wu ZX, Unzicker M, Lu L, Cai Q, Li C, Schirra C, Matti U, Stevens D, Chuxia Deng, Rettig J, Sheng ZH. (2005). The role of Snapin in neurosecretion: snapin knock-out mice exhibit impaired calcium-dependent exocytosis of large dense-core vesicles in chromaffin cells. J Neurosci. 25(45):10546-55.

146). Ruihong Wang, Cuiling Li, Xiaoling Xu, Yin Zheng, Cuiying Xiao, Patricia Zerfas, Sharon Cooperman, Michael Eckhaus, Tracey Rouault, Lope Mishra, and Chuxia Deng. (2005). A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metabolism 2(6):399-409.

147). Chen L, Chuxia Deng. (2005). Roles of FGF signaling in skeletal development and human genetic diseases. Front Biosci. 10:1961-76.

148). Jürgen Wess, Dinesh Gautam, Sung-Jun Han, Jongrye Jeon, Cuiling Li, and Chuxia Deng. (2005). Generation and Phenotypical Analysis of Muscarinic Acetylcholine Receptor Knockout Mice. Chapter 5 in “G Protein-Coupled Receptors: Structure, Function, and Ligand Screening“, Editors: Tatsuya Haga and Shigeki Takeda, CRC Press.

149). Wenhui Qiao, Xiaoling Xu, Allen G. Li, Xiao-Jin Wang and Chuxia Deng. (2006). Hair follicle defects and skin tumor formation in Smad4 conditional knockout mice. Oncogene 25(2):207-17.

150). Katuri V, Tang Y, Li C, Jogunoori W, Chuxia Deng, Rashid A, Sidawy AN, Evans S, Reddy EP, Mishra B, Mishra L. (2006). Critical interactions between TGF-beta signaling/ELF, and E-cadherin/beta-catenin mediated tumor suppression. Oncogene 25(13):1871-86.

151). Smolen GA, Muir B, Mohapatra G, Barmettler A, Kim WJ, Rivera MN, Haserlat SM, Okimoto RA, Kwak E, Dahiya S, Garber JE, Bell DW, Sgroi DC, Chin L, Chuxia Deng, Haber DA. (2006). Frequent met oncogene amplification in a Brca1/Trp53 mouse model of mammary tumorigenesis. Cancer Res. 66(7):3452-5.

152). Israelsson C, Lewen A, Kylberg A, Usoskin D, Althini S, Lindeberg J, Chuxia Deng, Fukuda T, Wang Y, Kaartinen V, Mishina Y, Hillered L, Ebendal T. (2006). Genetically modified bone morphogenetic protein signalling alters traumatic brain injury-induced gene expression responses in the adult mouse. J Neurosci Res. 84(1):47-57.

153). Wang W, Huang XR, Canlas E, Oka K, Truong LD, Chuxia Deng, Bhowmick NA, Ju W, Bottinger EP, Lan HY. (2006). Essential Role of Smad3 in Angiotensin II-Induced Vascular Fibrosis. Circ Res. 98(8):988-9.

154). Liu Cao, Sangsoo Kim, Cuiying Xiao, Rui-Hong Wang, Xavier Coumoul, Xiaoyan Wang, Wen-Mei Li, Xiao-Ling Xu, Joseph A. De Soto, Hiroyuki Takai, Sabine Mai, Stephen J Elledge, Noboru Motoyama and Chuxia Deng (2006). ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency. EMBO J. 25(10):2167-77.

155). Xiaoling Xu, S. Kobayashi, W. Qiao, C. Li, C. Xiao, S. Radaeva, B. Stiles, R.H. Wang, N. Ohara, T. Yoshino, D. LeRoith, M.S. Torbenson, G.J. Gores, H. Wu, B. Gao and Chuxia Deng (2006). Induction of intrahepatic cholangiocellular carcinoma by liver specific disruption of Smad4 and Pten in mice. Journal of Clinic Investigation 116(7):1843-1852.

156). Byung Kim, Cuiling Li, Wenhui Qiao, Mizuko Mamura, Barbara kasperczak, Miriam Anver Lawrence Wolfraim, Suntaek Hong, Elizabeth Mushinski, Michael Potter, Seong-Jin Kim, Xin-Yuan Fu, Chuxia Deng, and John Letterio (2006). Smad4 signaling in T cells is required for suppression of gastrointestinal Cancer. Nature 441(7096):1015-9.

157). Dinesh Gautam, Sung-Jun Han, Fadi F. Hamdan, Jongrye Jeon, Bo Li, Jian Hua Li, Yinghong Cui, David Mears, H Lu, Chuxia Deng, T Heard, and Jürgen Wess (2006). A critical role for beta-cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell Metablism. 3:449-61.

158). Xiaoyan Wang, Yong-Xing Zhou, Wenhui Qiao, Yohei Tominaga, Mutsuko Ouchi, Toru Ouchi, and Chuxia Deng (2006).  Over expression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation. Oncogene 25(54):7148-58.

159). Vivek Shukla, Xavier Coumoul, Liu Cao, Rui-Hong Wang, Cuiying Xiao, Xiaoling Xu, Sebastiano Ando, Shoshana Yakar, Derek LeRoith, and Chuxia Deng (2006). Absence of the full-length BRCA1 leads to increased expression of IGF signaling axis members. Cancer Research 66(14):7151-7.

160). Yohei Tominaga, Cuiling Li, Rui-Hong Wang and Chuxia Deng (2006). Murine Wee1 Plays a Critical Role in Cell Cycle Regulation and Pre-Implantation Stages of Embryonic Development. International Journal of Biological Sciences 2(4):161-70.

161). Joseph A. De Soto, Xianyan Wang, Yohei Tominaga, Rui-Hong Wang, Liu Cao, Amanda P. Skoumbourdis, Craig Thomas, Chuxia Deng. (2006). The Inhibition of Breast Cancer with Poly (ADP-ribose) Polymerase (PARP-1) Inhibitors. International Journal of Biological Sciences 2(4):179-85.

162). Sang Soo Kim, Liu Cao, Sung-Chul Lim, Cuiling Li, Rui-Hong Wang, Xiaoling Xu, Richard Bachelier, and Chu-Xia Deng. (2006) Hyperplasia and spontaneous tumor development in the gynecologic system in mice lacking the BRCA1-Delta 11 isoform. MCB 26(18):6983-92.

163). Oppermann M, Mizel D, Huang G, Li C, Chu-Xia Deng, Theilig F, Bachmann S, Briggs J, Schnermann J, Castrop H. (2006). Macula Densa Control of Renin Secretion and Preglomerular Resistance in Mice with Selective Deletion of the B Isoform of the Na,K,2Cl Co-Transporter. J Am Soc Nephrol. 17(8):2143-52.

164). Overholtzer M, Zhang J, Smolen GA, Muir B, Li W, Sgroi DC, Deng CX, Brugge JS, Haber DA. (2006), Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. PNAS 103(33):12405-10.

165). Park C, Lavine K, Mishina Y, Deng CX, Ornitz DM, Choi K. (2006), Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation. Development 133(17):3473-84.

166). Xavier Coumoul and Chuxia Deng. (2006). RNAi in mice: a promising approach to decipher gene functions in vivo. Biochimie. 88(6):637-43.

167). Chuxia Deng. (2006). BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution. Nucleic Acids Res. 34(5):1416-26.

168). Joseph A. De Soto and Chu-Xia Deng. (2006). PARP-1 inhibitors, are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers? International Journal of Medical Sciences 3(4):117-23.

169). Michael Weinstein, and Chuxia Deng. (2006). Genetic disruptions within the murine genome reveal the numerous roles of the Smad gene family in development, disease, and cancer. In “Smad signal Transduction: Smads in proliferation, differentiation and disease”. Editors: Ten Dijke, P. and Heldin, Carl-Henrik. Vol 5, Chapter 8, 151-176, Springer.

170). Gautam D, Duttaroy A, Cui Y, Han SJ, Deng C, Seeger T, Alzheimer C, Wess J. (2006). M1-M3 muscarinic acetylcholine receptor-deficient mice: novel phenotypes. J Mol Neurosci. 30(1-2):157-60.

Since 2007 (Third site visit in May 2007)

171). Yohei Tominaga, Anran Wang, Xiaoyan Wang, Rui-Hong Wang, Liu Cao and Chuxia Deng (2007). Genistein inhibits Brca1 mutant tumor growth through activation of DNA damage checkpoints, cell cycle arrest and mitotic catastrophe. Cell Death and Differentiation 14(3):472-9.

172). Niwa Y, Masamizu Y, Liu T, Nakayama R, Deng CX, Kageyama R. (2007). The initiation and propagation of hes7 oscillation are cooperatively regulated by fgf and notch signaling in the somite segmentation clock. Dev Cell 13(2):298-304.

173). Song L, Yan W, Chen X, Deng CX, Wang Q, Jiao K. (2007). Myocardial smad4 is essential for cardiogenesis in mouse embryos. Circ Res. 101(3):277-85.

174). Li W, Xiao C, Vonderhaar BK, Deng CX. (2007). A role of estrogen/ERalpha signaling in BRCA1-associated tissue-specific tumor formation. Oncogene 26(51):7204-12.

175). Li W, Chen Y, Cameron DJ, Wang C, Karan G, Yang Z, Zhao Y, Pearson E, Chen H, Deng C, Howes K, Zhang K (2007). Elovl4 haploinsufficiency does not induce early onset retinal degeneration in mice. Vision Res. (47): 714-22.

176). Li H, Watford W, Li C, Parmelee A, Bryant MA, Deng C, O”Shea J, Lee SB (2007). Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development. J Clin Invest. (117): 1314-23.

177). Pan D, Schomber T, Kalberer CP, Terracciano LM, Hafen K, Krenger W, Hao-Shen H, Deng C, Skoda RC (2007). Normal erythropoiesis but severe polyposis and bleeding anemia in Smad4 deficient mice. Blood 110(8):3049-55.

178). Oppermann M, Mizel D, Kim SM, Chen L, Faulhaber-Walter R, Huang Y, Li C, Deng C, Briggs J, Schnermann J, Castrop H (2007). Renal function in mice with targeted disruption of the A isoform of the Na-K-2Cl co-transporter. J Am Soc Nephrol. (18): 440-8.

179). Shukla V, Coumoul X, Deng CX (2007). RNAi-based conditional gene knockdown in mice using a U6 promoter driven vector. Int J Biol Sci. (3): 91-9.

180). Anthoni M, Wang G, Deng C, Wolff HJ, Lauerma AI, Alenius HT (2007). Smad3 signal transducer regulates skin inflammation and specific IgE response in murine model of atopic dermatitis. J Invest Dermatol. (127): 1923-9.

181). Mizugishi K, Li C, Olivera A, Bielawski J, Bielawska A, Deng CX, Proia RL. (2007). Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice. J Clin Invest. 117(10):2993-3006.

182). Deeb KK, Michalowska AM, Yoon CY, Krummey SM, Hoenerhoff MJ, Kavanaugh C, Li MC, Demayo FJ, Linnoila I, Deng CX, Lee EY, Medina D, Shih JH, Green JE. (2007). Identification of an integrated SV40 T/t-antigen cancer signature in aggressive human breast, prostate, and lung carcinomas with poor prognosis. Cancer Res. 67(17):8065-80.

183). Varticovski L, Hollingshead MG, Robles AI, Wu X, Cherry J, Munroe DJ, Lukes L, Anver MR, Carter JP, Borgel SD, Stotler H, Bonomi CA, Nunez NP, Hursting SD, Qiao W, Deng CX, Green JE, Hunter KW, Merlino G, Steeg PS, Wakefield LM, Barrett JC. (2007). Accelerated preclinical testing using transplanted tumors from genetically engineered mouse breast cancer models. Clin Cancer Res. 13(7):2168-77.

184). Cao L, Xu X, Cao LL, Wang RH, Coumoul X, Kim SS, Deng CX. (2007). Absence of full-length Brca1 sensitizes mice to oxidative stress and carcinogen-induced tumorigenesis in the esophagus and forestomach. Carcinogenesis 28(7):1401-7.

185). Karlsson G, Blank U, Moody JL, Ehinger M, Singbrant S, Deng CX, Karlsson S. (2007). Smad4 is critical for self-renewal of hematopoietic stem cells. J Exp Med. 204(3):467-74.

186). Izeradjene K, Combs C, Best M, Gopinathan A, Wagner A, Grady WM, Deng CX, Hruban RH, Adsay NV, Tuveson DA, Hingorani SR. (2007). Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas. Cancer Cell 11(3):229-43.

187). Wang L, Balas B, Christ-Roberts CY, Kim RY, Ramos FJ, Kikani CK, Li C, Deng CX, Reyna S, Musi N, Dong LQ, DeFronzo RA, Liu F. (2007). Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo. Mol Cell Biol. 27(18):6497-505.

188). Wang X, Liu L, Montagna C, Ried T, Deng CX. (2007). Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality. Cell Death Differ. 14(5):924-31.

189). Li W, Sandhoff R, Kono M, Zerfas P, Hoffmann V, Ding BC, Proia RL, Deng CX. (2007). Depletion of ceramides with very long chain fatty acids causes defective skin permeability barrier function, and neonatal lethality in ELOVL4 deficient mice. Int J Biol Sci. 3(2):120-8.

190). Zhao M, Li D, Shimazu K, Zhou YX, Lu B, Deng CX. (2007). Fibroblast Growth Factor Receptor-1 Is Required for Long-Term Potentiation, Memory Consolidation, and Neurogenesis. Biol Psychiatry 62(5):381-90.

191). Xiao C#, Sharp JA# (#equal contribution), Kawahara M, Davalos AR, Difilippantonio MJ, Hu Y, Li W, Cao L, Buetow K, Ried T, Chadwick BP, Deng CX* (*Corresponding authors), Panning B*(*Corresponding authors). (2007). The XIST noncoding RNA functions independently of BRCA1 in X inactivation. Cell 128(5):977-89.

(The authorship list is arranged to reflect the equal contribution of both laboratories with my lab took the first and the second to last author positions, and the other lab took the second and the last author positions)

192). Shukla V, Coumoul X, Wang RH, Kim HS, Deng CX. (2007). RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis. Nat Genet. 39(9):1145-50. Commentes by Andrew O M Wilkie, Nature Genetics 39 (9), 1057-1059, and by Juan Carlos Lopez, Research Highlights, Nature Medicine 13 (10), 1149.

193). Jia Q, McDill BW, Li SZ, Deng CX, Chang CP, Chen F. (2007). Smad signaling in the neural crest regulates cardiac outflow tract remodeling through cell autonomous and non-cell autonomous effects. Dev Biol. 311(1):172-84.

194). Chuxia Deng (2007). Editorial: In Celebration of Dr. Mario R. Capecchi’s Nobel Prize. Int. J. Biol. Sci. 3: 417-419.

195). Ko SO, Chung IH, Xu X, Oka S, Zhao H, Cho ES, Chu-Xia Deng, Chai Y. (2007). Smad4 is required to regulate the fate of cranial neural crest cells. Dev Biol. 312(1):435-47.

196). Wahl MB, Chu-Xia Deng, Lewandoski M, Pourquié O. (2007). FGF signaling acts upstream of the NOTCH and WNT signaling pathways to control segmentation clock oscillations in mouse somitogenesis. Development 134(22):4033-41.

197). Jian-Sheng Kang, Jin-Hua Tian1, Ping-Yue Pan, Philip Zald, Cuiling Li, Chuxia Deng, and Zu-Hang Sheng. (2008). Docking of Axonal Mitochondria by Syntaphilin Controls their Mobility and Affects Short-term Facilitation. Cell 132(1):137-48.

198). Colak D, Mori T, Brill MS, Pfeifer A, Falk S, Chu-Xia Deng, Monteiro R, Mummery C, Sommer L, Götz M. (2008). Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells. J Neurosci. 28(2):434-46.

199). Yi Tang, Krit Kitisin, Wilma Jogunoori, Cuiling Li, Chu-Xia Deng, Susette Mueller, Habtom Ressom, Asif Rashid, Aiwu Ruth He, Jonathan S. Mendelson, Kirti Shetty, Michael Zasloff, Bibhuti Mishra, E. P. Reddy, Lynt Johnson, Lopa Mishra. (2008), Progenitor/Stem Cells Give Rise to Liver Cancer Due to Aberrant TGF-beta and IL-6 Signaling. Proc Natl Acad Sci U S A 105(7):2445-50.

200). Yin L, Du X, Li C, Xu X, Chen Z, Su N, Zhao L, Qi H, Li F, Xue J, Yang J, Jin M, Chu-Xia Deng*, Chen L* (*Corresponding authors). (2008). A Pro253Arg mutation in fibroblast growth factor receptor 2 (Fgfr2) causes skeleton malformation mimicking human Apert syndrome by affecting both chondrogenesis and osteogenesis. Bone 42: 631-643.

201). Alexander Aulehla, Winfried Wiegraebe, Valerie Baubet, Matthias B. Wahl, Chuxia Deng, Makoto Taketo, Mark Lewandoski & Olivier Pourquié. (2008). A bold beta-catenin gradient links the clock and wavefront systems in mouse embryo segmentation. Nature Cell Biology 10(2):186-93.

202). Nie X, Chuxia Deng, Wang Q, Jiao K. (2008). Disruption of Smad4 in neural crest cells leads to mid-gestation death with pharyngeal arch, craniofacial and cardiac defects. Dev Biol. 316, 417-430.

203). Athanasios Vasilopoulos, Rui-Hong Wang, Constantinos Petrovas, David Ambrozac, Richard Koup and Chu-Xia Deng (2008). Identification and characterization of cancer initiating cells from BRCA1-associated mammary tumors using markers for normal mammary stem cells. Int. J. Biol. Sci. 4: 133-142.

204). Gautam D, Jeon J, Li JH, Han SJ, Hamdan FF, Cui Y, Lu H, Chu-Xia Deng, Gavrilova O, Wess J. (2008). Metabolic roles of the m(3) muscarinic acetylcholine receptor studied with m(3) receptor mutant mice: a review. J Recept Signal Transduct Res. 28(1):93-108.

205). Kautz L, Meynard D, Monnier A, Darnaud V, Bouvet R, Wang RH, Chuxia Deng, Vaulont S, Mosser J, Coppin H, Roth MP. (2008). Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood 112(4):1503-9.

206). Xun Xu, Jun Han, Yoshihiro Ito, Pablo Bringas, Jr., Chuxia Deng, and Yang Chai. (2008). Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-β/BMP signaling during tooth and palate development. Developmental Cell 15(2):322-9.

207). Ahn BH*, Kim HS*(*Equal contribution), Song SW, Lee IH, Liu J, Chuxia Deng* (*Corresponding authors), and Finkel T. (2008). The mitochondrial deacetylase SIRT3 regulates energy homeostasis. PNAS 105(38):14447-52.

208). Jacobs KM, Pennington JD, Bisht KS, Aykin-Burns N, Kim HS, Mishra M, Nguyen P, Ahn BH, Chuxia Deng, Spitz DR, and Gius D. SIRT3 interacts with the daf-16 homolog FOXO3a in the Mithochondria, as well as increases FOXO3a Dependent Gene Expression. Int. J. Biol. Sci. 2008, 4: 291-299.

209). Charlie R. Mantel, Rui-Hong Wang, Chuxia Deng, and Hal E. Broxmeyer (2008). Sirt1, Notch, and stem cell “age asymmetry”. Cell Cycle 7(18):2821-5.

210). Ramya Rajagopal, Lisa K. Dattilo, Vesa Kaartinen, Chuxia Deng, Lieve Umans, An Zwijsen, Anita B. Roberts, Erwin P. Bottinger, and David C. Beebe. (2008). The Functions of the type I BMP receptor, Acvr1 (Alk2), in Lens Development: Cell Proliferation, Terminal Differentiation and Survival. Investigative Ophthalmology and Visual Science 49(11):4953-60.

211). Jeker LT, Barthlott T, Keller MP, Zuklys S, Hauri-Hohl M, Chuxia Deng, Hollander GA (2008). Maintenance of a normal thymic microenvironment and T cell homeostasis require Smad4-mediated signaling in thymic epithelial cells. Blood 112(9):3688-95.

212). Wang RH, Sengupta K, Li C, Kim HS, Cao L, Xiao C, Kim SS, Xu X, Zheng Y, Chilton B, Jia R, Zheng ZM, Appella E, Wang XW, Ried T, and Chuxia Deng (2008). Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell 14, 312–323.

Comment by S.A. Danovi: Nature Reviews, Cancer 9, 5.

213). Wang RH, Zheng Y, Kim HS, Xu X, Cao L, Luhasen T, Lee MY, Xiao C, Vassilopoulos A, Chen W, Man YG, Hung MC, Finkel T, and Chuxia Deng (2008). Interplay among BRCA1, SIRT1, and SURVIVIN during BRCA1-associated Tumorigenesis. Mol. Cell 32, 11–20.

Comment by J. Luo and DC Altieri: Mol. Cell 32, 159-160.

ScienceDaily: http://www.sciencedaily.com/releases/2008/10/081009143655.htm

Comment by S.A. Danovi: Nature Reviews, Cancer 9, 5.

214). Yu YM, Pace SM, Allen SR, Chuxia Deng, Hsu LC. (2008). A PP1-binding motif present in BRCA1 plays a role in its DNA repair function. Int J Biol Sci. 4(6):352-61.

215). Vivek Shukla, Xavier Coumoul, Athanassios Vassilopoulos, Chuxia Deng (2008). IGF signaling pathway as a selective target of familial breast cancer therapy. Current Molecular Medicine 8(8):727-40.

216). H. Thomas Lee, Sean W. C. Chen, Thomas C. Doetschman, Chuxia Deng, Vivette D. D’Agati, and Mihwa Kim (2008). Sevoflurane protects against renal ischemia and reperfusion injury in mice via the transforming growth factor-β1 pathway. Am J Physiol Renal Physiol. 295(1):F128-36.

217). Xu Z, Wang W, Chuxia Deng, Man YG. (2009). Aberrant p63 and WT-1 expression in myoepithelial cells of pregnancy-associated breast cancer: implications for tumor aggressiveness and invasiveness. Int J Biol Sci. 5: 82-96.

218). Chuxia Deng (2009). SIRT1, Is It a Tumor Promoter or Tumor Suppressor? Int. J. Biol. Sci. 5: 147-152.

219). Greg Holmes, Gerson Rothschild, Upal Basu Roy, Chuxia Deng, Alka Mansukhani, Claudio Basilico (2009). Early onset of craniosynostosis in an Apert mouse model reveals critical features of this pathology. Developmental Biology 328, 273-284.

220). Stine Büchmann-Møller, Jaya Krishnan, Nessy John, Chuxia Deng, and Lukas Sommer (2009). Multiple lineage-specific roles of Smad4 during neural crest development. Developmental Biology, 328(2):273-84.

221). Matina Economopoulou, Harald F. Langer, Arkady Celeste, Valeria V. Orlova, Eun Young Choi, Mingchao Ma, Athanassios Vassilopoulos, Elsa Callen, Chuxia Deng, Craig H. Bassing, Giovanna Tosato, Manfred Boehm, Andre Nussenzweig, and Triantafyllos Chavakis (2009). Histone H2AX is integral to hypoxia-driven neovascularisation.  Nature Medicine, 15(5):553-8.

222). Ji J, Yamashita T, Budhu A, Forgues M, Jia HL, Li C, Chuxia Deng, Wauthier E, Reid LM, Ye QH, Qin LX, Yang W, Wang HY, Tang ZY, Croce CM, Wang XW. (2009). Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology, 50(2):472-80.

223). Liu A, Wei L, Gardner WA, Chuxia Deng, Man YG (2009). Correlated alterations in prostate basal cell layer and basement membrane. Int J Biol Sci. 5:276-85.

224). Huang J, Dattilo LK, Rajagopal R, Liu Y, Kaartinen V, Mishina Y, Chuxia Deng, Umans L, Zwijsen A, Roberts AB, Beebe DC (2009). FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate. Development 136(10):1741-50.

225). Jie Liu*, Liu Cao* (*Equal contribution), Jichun Chen, Shiwei Song, In Hye Lee, Bong-Hyun Ahn, Neil G. Kumar, Long-Yue Cao, Hongjun Liu, Ilsa I. Rovira, Keyvan Keyvanfar, Xiao-Ling Xu, Maarten van Lohuizen, Noboru Motoyama, Chu-Xia Deng and Toren Finkel (2009). Deletion of Bmi1 activates a redox-sensitive DNA damage response pathway. Nature, 459(7245):387-92.

226). Toren Finkel, Chu-Xia Deng *(*Corresponding author), Raul Mostoslavsky (2009). Recent progress in the biology and physiology of sirtuins. Nature, 460(7255):587-91.

227). Liu Cao, Xioaling Xu, Samuel F. Bunting, Rui-Hong Wang, Jie Liu, Longyue L. Cao, Junjie Chen, Andre Nussenzweig, Chu-Xia Deng* (*Corresponding author) and Toren Finkel* (*Corresponding author) (2009). A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Molecular Cell, 35(4):534-41.

228). Jian Hua Li, Dinesh Gautam, Sung-Jun Han, Jean-Marc Guettier, Yinghong Cui, Huiyan Lu, Chu-Xia Deng, William Jou, Oksana Gavrilova, Christoph Buettner, and Jugen Wess. (2009). Hepatic Muscarinic Acetylcholine Receptors are not Critically Involved in Maintaining Glucose Homeostasis in Mice. Diabetes, 58(12):2776-87.

229). Bornstein S., White R., Malkoski SP, Oka M, Han G, Cleaver T, Reh D, Anderson P, Gross N, Olson S, Chu-Xia Deng, Lu S, Wang XJ. (2009). Smad4 Loss in Mice Causes Spontaneous Head and Neck Cancer with Increased Genomic Instability and Inflammation. J Clin Invest, 119(11):3408-19.

230). Rajagopal R, Huang J, Dattilo LK, Kaartinen V, Mishina Y, Chu-Xia Deng Umans L, Zwijsen A, Roberts AB, Beebe DC (2009). The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation. Dev Biol. 335(2):305-16.

231). Sang Soo Kim, Liu Cao, Hye Jung Baek, Sung-Chul Lim, Cuiling Li, Rui-Hong Wang, Xiaoling Xu, Kwan Ho Cho, and Chu-Xia Deng. (2009). Impaired skin and mammary gland development and increased g-irradiation-induced tumorigenesis in mice carrying a targeted mutation of the S1152-ATM phosphorylation site in Brca1. Cancer Research, 69(24):9291-300.

232). Morikawa Y, Zehir A, Maska E, Chu-Xia Deng, Schneider MD, Mishina Y, Cserjesi P. (2009). BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways. Development.136(21):3575-84.

233). Jian Hua Li, Chung-Lin Chou, Bo Li, Oksana Gavrilova, Christoph Eisner, Jugen Schnermann, Stasia A. Anderson, Chu-Xia Deng, Mark A. Knepper and Jugen Wess. (2009). A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus. J Clin Invest. 119(10):3115-26.

234). Xiaoling Xu, Beeta Ehdaie, Nobuya Ohara, Tadashi Yoshino, and Chu-Xia Deng (2010). Synergistic action of Smad4 and Pten in suppressing pancreatic ductal adenocarcinoma formation in mice. Oncogene, 4;29(5):674-86.

235). Athanassios Vassilopoulos, Chu-Xia Deng* (Corresponding author), Triantafyllos Chavakis* (Corresponding author). (2010). Crosstalk between the DNA damage response, histone modifications and neovascularisation. The International Journal of Biochemistry & Cell Biology, 42(2):193-7.

236). Hyun-Seok Kim#, Krish Patel# (#equal contribution), Kristi Muldoon-Jacobs, Kheem S. Bisht, Nukhet Aykin-Burns, J. Daniel Pennington, Riet van der Meer, Phuongmai Nguyen, Jason Savage, Kjerstin M. Owens, Athanassios Vassilopoulos, Ozkan Ozden, Keshav K. Singh, Sarki A. Abdulkadir, Douglas R. Spitz, Chu-Xia Deng* (Corresponding authors), and David Gius* (Corresponding authors). (2010).  SIRT3 is a Mitochondrially Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress. Cancer Cell, 17, 41-52.

Comment on: Cancer Cell 2010 Jan 19;17(1):41-52 by Schumacker PT

237). Jongrye Jeon, Ditte Dencker, Gitta Wörtwein, David Woldbye, Yinghong Cui, Albert A. Davis, Allan I. Levey, Günther Schütz, Thomas Sager, Arne Mørk, Cuiling Li, Chu-Xia Deng, Anders Fink-Jensen, and Jürgen Wess. (2010). A Subpopulation of Neuronal M4 Muscarinic Acetylcholine Receptors Plays a Critical Role in Modulating Dopamine-Dependent Behaviors. The Journal of Neuroscience. 30(6):2396-405.

238). Xiao R. Huang, Arthur CK Chung, Fuye Yang, Wensheng Yue, Chuxia Deng, Chu Pak Lau, Hung Fat Tse,  Hui Y. Lan. (2010). Smad3 mediates cardiac inflammation and fibrosis in angiotensin II-induced hypertensive cardiac remodeling. Hypertension, 55(5):1165-71.

239). T Maruyama, A Mirando, Chuxia Deng and Wei Hsu. (2010). The balance of WNT and FGF signaling influences mesenchymal stem cell fate during skeletal development. Science Signaling, 3(123):ra40.

240). Samuel Bunting, Nancy Wong, Hua-Tang Chen, Federica Polato, Oscar Fernandez-Capetillo, Jeremy M. Stark, Liu Cao, Xiaoling Xu, Chu-Xia Deng, Toren Finkel, Elsa Callén1, André Nussenzweig (2010). Loss of 53BP1 rescues homologous recombination in Brca1-deficient cells. Cell, 141(2):243-54.

241). Thomas Fishler, Yu-Ying Li, Rui-Hong Wang, Hyun-Seok Kim, Kundan Sengupta, Athanassios Vassilopoulos, Tyler Lahusen, Xiaoling Xu, Mi-Hye Lee, Qinghua Liu, Steve Elledge, Thomas Ried, and Chu-Xia Deng (2010). Genetic instability and mammary tumor formation in mice carrying mammary specific disruption of Chk1 and p53. Oncogene, 29(28):4007-17.

242). Chu-Xia Deng, Liu H. (2010). An unknown piece of early work of nuclear reprogramming in fish eggs. Int J Biol Sci. 6(2):190-1.

243). Liu W, Yan M, Liu Y, Wang R, Li C, Chu-Xia Deng, Singh A, Coleman WG Jr, Rodgers GP. (2010). Olfactomedin 4 down-regulates innate immunity against Helicobacter pylori infection. PNAS, 107(24):11056-61.

244). Su N, Xu X, Li C, He Q, Zhao L, Li C, Chen S, Luo F, Yi L, Du X, Huang H, Chu-Xia Deng* (Corresponding author), Chen L* (Corresponding author). (2010). Generation of Fgfr3 conditional knockout mice, Int J Biol Sci. 6(4):327-32.

245). Joseph A. Baur, Danica Chen, Eduardo N. Chini, Katrin Chua, Rafael deCabo, Chu-Xia Deng, Leonard, P. Guarente, David Gius, Stephen L. Helfand, Shin-Ichiro Imai, Hiroshi Itoh, Daisuke Koya, Philipp Oberdoerffer, Blanka Rogina, Manuel Serrano, David A. Sinclair, Marc Tatar, and Eric Verdin. (2010). Dietary Restriction: Standing Up for Sirtuins. Science. 329(5995):1012-3.

246). Liu Y, Kawai K, Khashabi S, Deng C, Yiu S. (2010). Inactivation of Smad4 leads to impaired ocular development and cataract formation. Biochem Biophys Res Commun. 400(4):476-82.

247). Hyun-Seok Kim, Cuiying Xiao, Rui-Hong Wang, Tyler Lahusen, Xiaoling Xu, Athanassios Vassilopoulos, Guelaguetza Vazquez-Ortiz, Won-Il Jeong, Ogyi Park, Sung Hwan Ki, Bin Gao, and Chu-Xia Deng. (2010). Hepatic specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metabolism, 12(3):224-36.

248). Vivek Shukla, Xavier Coumoul, Tyler Lahusen, Rui-Hong Wang, Xiaoling Xu, Athanassios Vassilopoulos, Cuiying Xiao, Mi-Hye Lee, Yan-Gao Man, Mutsuko Ouchi, Toru Ouchi, and Chu-Xia Deng (2010). BRCA1 Affects Global DNA Methylation through Regulation of DNMT1. Cell Research. 20(11):1201-15.

249) Mohamad Azhar, Pei-Yu Wang, Tony Frugier, Kyoko Koishi, Chu-Xia Deng, Peter G. Noakes and Ian S. McLennan (2010). Myocardial Deletion of Smad4 Causes Misalignment of the Cardiac Outflow Tract. Int J Biol Sci. 6(6):546-55.

250) Brian J. Kluk, Yebo Fu, Trina A. Formolo, Lei Zhang, Anne K. Hindle, Yan-gao Man, Robert S. Siegel, Patricia E. Berg, Chu-Xia Deng, Timothy A. McCaffrey, Sidney W. Fu (2010). BP1, an Isoform of DLX4 Homeoprotein, Negatively Regulates BRCA1 in Sporadic Breast Cancer. Int J Biol Sci. 6(5):513-24.

251) Xiao C, Kim HS, Lahusen T, Wang RH, Xu X, Gavrilova O, Jou W, Gius D, Chu-Xia Deng. (2010). SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice. J Biol Chem. 285, 36776-84.

252) Liu M, Wilk SA, Wang A, Zhou L, Wang RH, Ogawa W, Chu-Xia Deng, Dong LQ, Liu F. (2010). Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR. J Biol Chem. 285:36387-94.

253) Cuiling Li, Yi-Ping Li, Xin-Yuan Fu, and Chu-Xia Deng (2010). Anterior Visceral Endoderm SMAD4 Signaling Specifies Anterior Embryonic Patterning and Head Induction in Mice. Int J Biol Sci. 6(6):569-83.

254) Rui-Hong Wang, Cuiling Li, and Chu-Xia Deng (2010). Liver Steatosis and Increased ChREBP Expression in Mice Carrying a Liver Specific SIRT1 Null Mutation under a Normal Feeding Condition. Int J Biol Sci. 6(7):682-90.

255) Rong Jia, Cuiling Li, J. Philip McCoy, Chu-Xia Deng, Zhi-Ming Zheng. (2010). SRp20 is a proto-oncogene critical for cell proliferation and tumor induction and maintenance. Int. J. Biol. Sci. 6: 806-826.

256) Y Deng, J Liu, G Han, S-L Lu, S-Y Wang, S Malkoski, A C Tan, Chu-Xia Deng, X-J Wang and Q Zhang (2010). Redox-dependent Brca1 transcriptional regulation by an NADH-sensor CtBP1. Oncogene, 29(50):6603-8.

Since 2011 (The fourth site visit on April 8, 2011. Next site visit will be in April of 2015)

257). Chuxia Deng. (2011). The Use of Cre-loxP Technology and Inducible Systems to Generate Mouse Models of Cancer.  In Genetically-engineered Mice for Cancer Research: design, analysis, pathways, validation and pre-clinical testing (Editors: ‪ Green JE, and ‪Thomas Ried T). Chapter 2, pp 17-36, Springer.

258) Xuan Ou, Hee-Don Chae, Rui-Hong Wang, William C. Shelley, Scott Cooper, Tammi Taylor, Young-June Kim, Chu-Xia Deng, Mervin C. Yoder and Hal E. Broxmeyer. (2011). SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse. Blood, 117(2):440-50.

259) Schwer B, Schumacher B, Lombard DB, Xiao C, Kurtev MV, Gao J, Schneider JI, Chai H, Bronson RT, Tsai LH, Chu-Xia Deng, Alt FW. (2011). Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. PNAS, 107(50):21790-4.

260). Kim EH, Chu-Xia Deng, Sporn MB, Liby KT. (2011). CDDO-Imidazolide Induces DNA Damage, G2/M Arrest and Apoptosis in BRCA1-Mutated Breast Cancer Cells. Cancer Prev Res. 4(3):425-34.

261). Deepa Murali, Motoko Kawaguchi-Niida, Chu-Xia Deng, and Yasuhide Furuta. (2011). Smad4 is required predominantly in the developmental processes dependent on the BMP branch of the TGFß signaling system in the embryonic mouse retina. Investigative Ophthalmology & Visual Science, 52(6):2930-7.

262). Hsiao YH, Chu-Xia Deng, Mason JT, Chou MC, Man YG. (2011). Hidden malignant cells within leukocyte aggregates: Seeds for invasive and metastatic cancer? Cancer Epidemiol. 35(5):475-9.

263). Choksi S, Lin Y, Pobezinskaya Y, Chen L, Park C, Morgan M, Li T, Jitkaew S, Cao X, Kim YS, Kim HS, Levitt P, Shih G, Birre M, Chu-Xia Deng, and Liu ZG. (2011). A HIF-1 Target, ATIA, Protects Cells from Apoptosis by Modulating the Mitochondrial Thioredoxin, TRX2. Mol Cell, 42(5):597-609.

264). Min Zhu, Ming Yi, Chang Hee Kim, Chu-Xia Deng, Yi Li, Daniel Medina, Robert Stephen, and Jeffrey E. Green. (2011). Integrated miRNA and mRNA expression profiling of mouse mammary tumor models identifies miRNA signatures associated with mammary tumor lineage. Genome Biology, 12(8):R77.

265). Sato Y, Heimeier RA, Li C, Chu-Xia Deng, Shi YB. (2011). Extracellular domain of CD98hc is required for early murine development. Cell Biosci. Feb 25;1(1):7.

266). Suhwan Chang, Rui-Hong Wang, Keiko Akagi, Kyung-Ae Kim, Betty K. Martin, Luca Cavallone, kConFab, Diana C. Haines, Mark Basik, Phuong Mai, Elizabeth Poggi, Claudine Isaacs, Lai M. Looi, Kein S. Mun, Mark H. Greene, Stephen W. Byers, Soo H. Teo, Chu-Xia Deng and Shyam K. Sharan (2011). Tumor Suppressor BRCA1 epigenetically controls oncogenic miRNA-155. Nature Medicine, 17(10):1275-82.

267). Hyun-Seok Kim, Athanassios Vassilopoulos, Rui-Hong Wang, Tyler Lahusen, Zhen Xiao, Xiaoling Xu, Cuiling Li, Timothy D. Veenstra, Bing Li, Hongtao Yu, Junfang Ji, Xin Wei Wang, Seong-Hoon Park, Yong I. Cha, David Gius, and Chu-Xia Deng. (2011). SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity. Cancer Cell, 20, 487–499.

Comments: http://blog.nextbio.com/2011/10/18/sirt2-finds-a-place-in-the-family/

268). Rui-Hong Wang, Hyun-Seok Kim, Cuiying Xiao, Xiaoling Xu, Oksana Gavrilova, and Chu-Xia Deng. (2011). Hepatic SIRT1 Deficiency Results in Hyperglycemia, Oxidative Damage, and Insulin Resistance Mediated by mTORC2/AKT Signaling. JCI, 121(11):4477-90.

269). Liu-Ya Tang, Motozo Yamashita, Nathan Coussens, Yi Tang, Xiangchun Wang, Cuiling Li, Chu-Xia Deng, Steven Cheng, and Ying Zhang (2011). Ablation of Smurf2 reveals an inhibition in TGF-b2 signaling through multiple mono-ubiquitination of Smad3. EMBO J. 30(23):4777-89.

270) Praphulla C. Shukla, Krishna K. Singh, Adrian Quan, Mohammed Al-Omran, Hwee Teoh, Fina Lovren, Liu Cao, Ilsa I. Rovira, Yi Pan, Christine Brezden-Masley, Bobby Yanagawa, Aanika Gupta, Chu-Xia Deng, John G. Coles, Howard Leong-Poi, William L. Stanford, Thomas G. Parker, Michael D. Schneider, Toren Finke & Subodh Verma (2011). BRCA1 is an essential regulator of heart function and survival following myocardial infarction. Nature Communications, 2:593.

271) Ni Zeng, Xiaoling Xu, Lina He, Vivian Galacia, Chu-Xia Deng, and Bangyan Stiles (2011). Adaptive basal phosphorylation of eIF2a is responsible for resistance to cellular stress induced cell death in Pten null hepatocytes. Molecular Cancer Research, 9(12):1708-17.

272). Mi-Hye Lee, Tyler Lahusen, Rui-Hong Wang, Cuiying Xiao, Xiaoling Xu, Yoo-Seok Hwang, Wei-Wu He, Yang Shi, and Chu-Xia Deng. (2012). Yin Yang 1 positively regulates BRCA1 and inhibits mammary cancer formation. Oncogene, 31(1):116-27.

273). Kim EH, Chu-Xia Deng, Sporn MB, Williams CR, Royce DB, Risingson GR, Liby KT (2012). CDDO-Methyl ester delays breast cancer development in BRCA1-mutated mice. Cancer Prev Res. 5(1):89-9.

274). Chen G, Chu-Xia Deng,* Li YP* (*Corresponding authors) (2012). TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation. Int J Biol Sci. 8(2):272-88.

275). Haigis MC, Chuxia Deng, Finley LW, Kim HS, Gius D. (2012). SIRT3 Is a Mitochondrial Tumor Suppressor: A Scientific Tale That Connects Aberrant Cellular ROS, the Warburg Effect, and Carcinogenesis. Cancer Res. 72(10):2468-72.

276). Zhao M, Ross JT, Itkin T, Perry JM, Venkatraman A, Haug JS, Hembree MJ, Chuxia Deng, Lapidot T, He XC, Li L. (2012) FGF signaling facilitates post-injury recovery of mouse hematopoietic system. Blood. 120(9):1831-42.

277) Weng T, Yi L, Huang J, Luo F, Wen X, Du X, Chen Q, Chuxia Deng, Chen D, Chen L. (2012).  Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice. Arthritis Rheum. 64(12):3982-92.

278) Park SH, Zhu Y, Ozden O, Kim HS, Jiang H, Chuxia Deng, Gius D, Vassilopoulos A. (2012). SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis. Transl Cancer Res. 1(1):15-21.

279) Xie Y, Su N, Jin M, Qi H, Yang J, Li C, Du X, Luo F, Chen B, Shen Y, Huang H, Xian CJ, Chuxia Deng, Chen L. (2012). Intermittent PTH (1-34) injection rescues the retarded skeletal development and postnatal lethality of mice mimicking human achondroplasia and thanatophoric dysplasia. Hum Mol Genet. 15;21(18):3941-55.

280) Sundaresan NR, Vasudevan P, Zhong L, Kim G, Samant S, Parekh V, Pillai VB, Ravindra PV, Gupta M, Jeevanandam V, Cunningham JM, Chuxia Deng, Lombard DB, Mostoslavsky R, Gupta MP. (2012). The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. Nat Med. 18(11):1643-50.

281) Xiao C, Wang RH, Lahusen TJ, Park O, Bertola A, Maruyama T, Reynolds D, Chen Q, Xu X, Young HA, Chen WJ, Gao B, Chuxia Deng. (2012). Progression of Chronic Liver Inflammation and Fibrosis Driven by Activation of c-JUN Signaling in Sirt6 Mutant Mice. J Biol Chem. 287(50):41903-13.

282) Jin M, Yu Y, Qi H, Xie Y, Su N, Wang X, Tan Q, Luo F, Zhu Y, Wang Q, Du X, Xian CJ, Liu P, Huang H, Shen Y, Chuxia Deng, Chen D, Chen L. (2012). A novel FGFR3-binding peptide inhibits FGFR3 signaling and reverses the lethal phenotype of mice mimicking human thanatophoric dysplasia. Hum Mol Genet. 21(26):5443-55.

283). Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Chuxia Deng, Choudhary C. (2012). Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3. PLoS One. 2012;7(12):e50545.

284). Quan Wu, Kohei Kanata, Rie Saba, Chu-Xia Deng, Hiroshi Hamada, and Yumiko Saga. (2013). Nodal/Activin signaling promotes male germ cell fate and suppresses female programming in somatic cells. Development. 140(2):291-300.

285) Dine J, and Chuxia Deng. (2013). Mouse models of BRCA1 and their application to breast cancer research. Cancer Metastasis Rev. 32, (1): 25-37.

286). Chen S, Li H, Zueckert-Gaudenz K, Paulson A, Guo F, Trimble R, Peak A, Seidel C, Chuxia Deng, Furuta Y, Xie T. (2013). Defective FGF signaling causes coloboma formation and disrupts retinal neurogenesis. Cell Res. 23(2):254-73.

287). Su Mi Choi, Yonghak Kim, Joong Sup Shim, Joon Tae Park, Rui-Hong Wang, Steven D. Leach, Jun O. Liu, Chu-Xia Deng, Zhaohui Ye, Yoon-Young Jang (2013). Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells. Hepatology. 57(6):2458-68.

288). Seung Min Jeong* (equal contribution), Cuiying Xiao* (equal contribution), Lydia W.S Finley, Tyler Lahusen, Amanda L. Souza, Kerry Pierce, Ying-Hua Li, Xiaoxu Wang, Gaëlle Laurent, Natalie J. German, Xiaoling Xu, Cuiling Li, Rui-Hong Wang, Jaewon Lee, Alfredo Csibi, Richard Cerione, John Blenis, Clary B. Clish, Alec Kimmelman, Chu-Xia Deng* (Corresponding authors) & Marcia C. Haigis* (Corresponding authors) (2013). SIRT4 is a tumor suppressor that regulates cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell, 23(4):450-63. (Two labs combined data together for this study)

289). Olivier J. Becherel, Abrey J. Yeo, Alissa Stellati, Evelyn Y.H. Heng, John Luff, Amila M. Suraweera, Rick Woods, Jean Fleming, Dianne Carrie, Kristine McKinney, Xiaoling Xu, Chu-Xia Deng and Martin F. Lavin (2013). Senataxin plays an essential role with DNA damage response proteins in meiotic recombination and gene silencing. Plos Genetics, Apr;9(4):e1003435.

290). Chu-Xia Deng. (2013). “Conditional Knockout Mouse Models of Cancer”. Invited chapter for a textbook to be published by Cold Spring Harbor laboratories entitled “Mouse Models of Cancer” Editors: Cory Abate-Shen, Katerina Politi, Lewis Chodosh, and Kenneth P. Olive.

291). Laronda MM, Unno K, Ishi K, Serna VA, Butler LM, Mills AA, Orvis GD, Behringer RR, Chu-Xia Deng, Sinha S, Kurita T. (2013). Diethylstilbestrol induces vaginal adenosis by disrupting SMAD/RUNX1-mediated cell fate decision in the Müllerian duct epithelium. Dev Biol. 381(1):5-16.

292). Tao R, Xiong X, Depinho RA, Chu-Xia Deng. Dong XC. (2013), Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6. J Lipid Res. 2013, 54(10):2745-53.

293), Li DQ, Pakala SB, Reddy SD, Peng S, Balasenthil S, Chu-Xia Deng, Lee CC, Rea MA, Kumar R. (2013). Metastasis-associated protein 1 is an integral component of the circadian molecular machinery. Nat Commun. 2013 Oct 3;4:2545.

294). Majdazari A, Stubbusch J, Müller CM, Hennchen M, Weber M, Chu-Xia Deng, Mishina Y, Schütz G, Deller T, Rohrer H (2013). Dendrite Complexity of Sympathetic Neurons Is Controlled during Postnatal Development by BMP Signaling. J Neurosci. 33(38):15132-15144.

295). Rui-Hong Wang, Xiaoling Xu, Hyun-Seok Kim, Zhen Xiao, Chu-Xia Deng (2013). SIRT1 Deacetylates FOXA2 and Is Critical for Pdx1 Transcription and β-Cell Formation. Int. J. Biol. Sci. 2013; 9(9): 934-946.

296). Tao R, Xiong X, Depinho RA, Chu-Xia Deng. Dong XC. (2013). FoxO3 transcription factor and Sirt6 deacetylase regulate LDL-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression. J Biol Chem. 2013 288(41):29252-9.

297). Athanassios Vassilopoulos, Cristine Chisholm, Tyler Lahusen, Hongping Zheng, and Chu-Xia Deng. (2014). A critical role of CD29 and CD49f in mediating metastasis for cancer initiating cells isolated from a Brca1-associated mouse model of breast cancer. Oncogene 33(47):5477-82. doi: 10.1038/onc.2013.516.

298). Morita J, Nakamura M, Kobayashi Y, Chu-Xia Deng, Funato N, Moriyama K. (2014). Soluble form of FGFR2 with S252W partially prevents craniosynostosis of the apert mouse model. Dev Dyn. 243(4):560-7. doi: 10.1002/dvdy.24099.

299). Vassilopoulos A, Pennington DJ, Andresson T, Rees D, Fearnley I, Ham A, Yan Y, Flynn CR, Jones K, Kim HS, Chu-Xia Deng (Corresponding author), Walker J, Gius D. (Corresponding author) (2014), SIRT3 Deacetylates ATP Synthase F1 Complex Proteins in Response to Nutrient and Exercise-Induced Stress. Antioxid Redox Signal. 21(4):551-64.

300). Bonzo JA, Brocker C, Wang RH, Chu-Xia Deng, Gonzalez FJ. (2014). Hepatic sirtuin 1 is dispensable for fibrate-induced peroxisome proliferator activated receptor α function in vivo. Am J Physiol Endocrinol Metab. Apr;306(7):E824-37. doi: 10.1152/ajpendo.00175.2013.

301). Fortin J, Boehm U, Chu-Xia Deng, Treier M, Bernard DJ. (2014). Follicle-stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2. FASEB J. 28(8):3396-410.

302). Qi H, Jin M, Duan Y, Du X, Zhang Y, Ren F, Wang Y, Tian Q, Wang X, Wang Q, Zhu Y, Xie Y, Liu C, Cao X, Mishina Y, Chen D, Chu-Xia Deng, Chang Z, Chen L. (2014). FGFR3 induces degradation of BMP type I receptor to regulate skeletal development. Biochim Biophys Acta. 2014 Mar 20;1843(7):1237-1247. doi: 10.1016/j.bbamcr.2014.03.011.

303). Willis NA, Chandramouly G, Huang B, Kwok A, Follonier C, Chu-Xia Deng, Scully R. (2014). BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks. Nature. 510(7506):556-9. doi: 10.1038/nature13295.

304). Ryu J, Galan AK, Xin X, Dong F, Abdul-Ghani MA, Zhou L, Wang C, Li C, Holmes BM, Sloane LB, Austad SN, Guo S, Musi N, DeFronzo RA, Chu-Xia Deng, White MF, Liu F, Dong LQ. APPL1 Potentiates Insulin Sensitivity by Facilitating the Binding of IRS1/2 to the Insulin Receptor. Cell Rep. 7(4):1227-38.

305). Jun Won Park, Seok Hoon Jang, Beom Gyu Choi, Dong Min Park, Dae Yong Kim, Je Kyoung Seong, Byoung S. Kwon, Chu-Xia Deng, Jeffrey E. Green, and Hark K. Kim. (2014). Loss of E-cadherin and Smad4 cooperate to promote the development and metastasis of diffuse-type gastric adenocarcinoma.. MOLECULAR CANCER RESEARCH. 12(8):1088-99.

306). Yanping Xu, Fulong Li, Lei Lv, Tingting Li, Xin Zhou, Chuxia Deng, Kun-Liang Guan, Qun-Ying Lei, and Yue Xiong (2014). Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase. Cancer Research. 74(13):3630-42.

307). Guelaguetza Vazquez-Ortiz, Cristine Chisholm, Xiaoling Xu, Tyler J Lahusen, Cuiling Li, Srilatha Sakamuru, Ruili Huang, Craig J Thomas, Menghang Xia, Chu-Xia Deng (2014). Drug repurposing screen identifies lestaurtinib that amplifies the ability of the PARP1 inhibitor AG14361 to kill BRCA1 mutant and wild type breast cancer cells. Breast Cancer Research, 16(3):R67.

308) Zhang P, Tu B, Wang H, Cao Z, Tang M, Zhang C, Gu B, Li Z, Wang L, Yang Y, Zhao Y, Wang H, Luo J, Chu-Xia Deng, Gao B, Roeder RG, Zhu WG. (2014). Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10684-9, PMID: 25009184

309). Vassilopoulos A, Xiao C, Chisholm C, Chen W, Xu X, Lahusen TG, Bewley C, Chu-Xia Deng. (2014). Synergistic therapeutic effect of cisplatin and PI3K inhibitors in cancer growth and metastasis of Brca1 mutant tumors. J Biol Chem. 289(35):24202-14. PMID: 25006250

310). Masri S, Rigor P, Cervantes M, Ceglia N, Sebastian C, Xiao C, Roqueta-Rivera M, Deng C, Osborne TF, Mostoslavsky R, Baldi P, Sassone-Corsi P. (2014). Partitioning Circadian Transcription by SIRT6 Leads to Segregated Control of Cellular Metabolism. Cell. 2014 Jul 31;158(3):659-72. PMID: 25083875

311). Bert Yu-Hung Chen, Chen-Hsiang Huang, Ying-Hsi Lin, Ching-Chun Huang, Chu-Xia Deng, and Lih-Ching Hsu (2014). The K898E Germline Mutation in the PP1-binding Motif of BRCA1 Causes Defects in DNA Repair. Scientific Report, 4:5812.

312). Mei Ming, Weinong Han, Baozhong Zhao, Nagalingam R. Sundaresan, Chu-Xia Deng, Mahesh Gupta, and Yu-Ying He. (2014). Keratinocyte SIRT6 is an oncogene by promoting cell survival. Cancer Research. 74(20):5925-33.

313). Yuying Li, Andrew Zhang, Weiping Chen, Rui-Hong Wang, Xiao-Ling Xu, and Chu-Xia Deng. (2014).  Enhancing mammary differentiation by overcoming lineage specific epigenetic modification and signature gene expression of fibroblast derived iPSCs. Cell Death Dis. 2014 Dec 4;5:e1550. doi: 10.1038/cddis.2014.499.

314). Rui-Hong Wang, Tyler J. Lahusen, Qiang Chen, Xiaoling Xu, Lisa M. Miller Jenkins, Elisabetta Leo, Haiqing Fu, Mirit Aladjem, Yves Pommier, Ettore Appella, and Chu-Xia Deng. (2014). SIRT1 Deacetylates TopBP1 and Modulates Intra-S-Phase Checkpoint and DNA Replication Origin Firing. IJBS, 10(10):1193-20.

December of 2014: Relocated to Faculty of Health Sciences, University of Macau

315). Tyler J. Lahusen, and Chu-Xia Deng. (2015). SRT1720 induces lysosomal-dependent cell death in breast cancer cells. Molecular Cancer Therapy. 14(1):183-92. doi: 10.1158/1535-7163.

316). Balaji Parameswaran, Huai-Chin Chiang, Yunzhe Lu, Julia Coates, Kevin D Mills, Chu-Xia Deng, Richard Baer, Hui-Kuan Lin, Rong Li, Tanya T Paull, Yanfen Hu. (2015). Damage-Induced BRCA1 Phosphorylation by Chk2 Contributes to the Timing of End Resection. Cell Cycle. 14(3):437-48. doi: 10.4161/15384101.2014.972901.

317). Athanassios Vassilopoulos, Yohei Tominaga, Hyun-Seok Kim, Tyler Lahusen, Bing Li, Hongtao Yu, David Gius and Chu-Xia Deng. (2015). WEE1 Murine Deficiency Induces Hyper-activation of APC/C and Results in Genomic Instability and Carcinogenesis. Oncogene. 34(23):3023-35.

318). Jamie Lane, PhD; Kenji Yumoto, PhD; Mohamad Azhar, PhD; Jun Ninomiya-Tsuji; Maiko Inagaki; Yingling Hu, PhD; Chu-Xia Deng; Jieun Kim; Yuji Mishina, PhD; Dr. Vesa Kaartinen (2015). Tak1, Smad4 and Trim33 redundantly mediate TGF-beta 3 signaling during palate development. Developmental Biology, 398(2):231-41.

319). Zhou ZQ, Ota S, Chu-Xia Deng; Akiyama H, Hurlin PJ. (2015). Mutant activated FGFR3 impairs endochondral bone growth by preventing SOX9 downregulation in differentiating chondrocytes. Hum Mol Genet. 24(6):1764-73.

320). Ajiro M, Jia R, Wang RH, Chu-Xia Deng, Zheng ZM. Adapted Resistance to the Knockdown Effect of shRNA-Derived Srsf3 siRNAs in Mouse Littermates. Int J Biol Sci. 2015 Sep 3;11(11):1248-56.

321). Hongzhen Li, Wenli Liu, Weiping Chen, Jianqiong Zhu, Chu-Xia Deng, Griffin P. Rodgers (2015). Olfactomedin 4 Plays a Critical Tumor Suppressor Role in Prostate Neoplastic Progression Through Regulating Hedgehog Signaling Pathway. Scientific Report. 5:16974. doi: 10.1038/srep16974.

322). Ada Hang-Heng Wong and Chu-Xia Deng (2015). Precision medicine for personalized cancer therapy. Int J Biol Sci. Nov 17;11(12):1410-2. doi: 10.7150/ijbs.14154.

323). Takaaki Masuda, Xiaoling Xu, Emilios K. Dimitriadis, Tyler Lahusen and Chu-Xia Deng (2016). “DNA Binding Region” of BRCA1 Affects Genetic Stability through modulating the Intra-S-Phase Checkpoint. Int J Biol Sci. Int. J. Biol. Sci. 2016; 12(2): 133-143. doi:10.7150/ijbs.14242

324), Wang RH, Zhao T, Cui K, Hu G, Chen Q, Chen W, Wang XW, Soto-Gutierrez A, Zhao K, Chu-Xia Deng (2016). Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging. Sci Rep. 2016 Jun 27;6:28633. doi: 10.1038/srep28633.

325). Petit FG, Chu-Xia Deng, Jamin SP. (2016). Partial Müllerian Duct Retention in Smad4 Conditional Mutant Male Mice. Int J Biol Sci. 2016 Apr 21;12(6):667-76.

326). Son MY, Chu-Xia Deng, Hoeijmarkers JH, Rebel VI, Hasty P. (2016). A mechanism for 1,4-Benzoquinone-induced genotoxicity. Oncotarget. 2016 Jun 20. doi: 10.18632/oncotarget.10184.

327). Tobita T, Guzman-Lepe J, Takeishi K, Nakao T, Wang Y, Meng F, Chu-Xia Deng, Collin de l’Hortet A, Soto-Gutierrez A. (2016). SIRT1 Disruption in Human Fetal Hepatocytes Leads to Increased Accumulation of Glucose and Lipids. PLoS One. Feb 18;11(2):e0149344.

328). Morita M, Yoshida S, Iwasaki R, Yasui T, Sato Y, Kobayashi T, Watanabe R, Oike T, Miyamoto K, Takami M, Ozato K, Chu-Xia Deng, Aburatani H, Tanaka S, Yoshimura A, Toyama Y, Matsumoto M, Nakamura M, Kawana H, Nakagawa T, Miyamoto T. (2016). Smad4 is required to inhibit osteoclastogenesis and maintain bone mass. Sci Rep. 6:35221. doi: 10.1038/srep35221.

329). Wu Q, Fukuda K, Kato Y, Zhou Z, Chu-Xia Deng, Saga Y. (2016). Sexual Fate Change of XX Germ Cells Caused by the Deletion of SMAD4 and STRA8 Independent of Somatic Sex Reprogramming. PLoS Biol. 14(9):e1002553. doi: 10.1371/journal.pbio.1002553. eCollection 2016 Sep. PMID: 27606421

330). Cristine L. Chisholm, Haitao Wang, Ada Hang-Heng Wong, Guelaguetza Vazquez-Ortiz, Weiping Chen, Xiaoling Xu, Chu-Xia Deng (2016). Ammonium tetrathiomolybdate treatment targets the copper transporter ATP7A and enhances sensitivity of breast cancer to cisplatin. Oncotarget, 7(51):84439-84452. doi: 10.18632/oncotarget.12992.

331). Chen S, Sun H, Miao K, Chu-Xia Deng. (2016). CRISPR-Cas9: from Genome Editing to Cancer Research. Int J Biol Sci. 12(12):1427-1436. PMID: 27994508

332), Li Y, Schang G, Boehm U, Chu-Xia Deng, Graff J, Bernard DJ. (2016). SMAD3 Regulates Follicle-Stimulating Hormone Synthesis by Pituitary Gonadotrope Cells In Vivo. J Biol Chem. 292(6):2301-2314. PMID: 27994055

333). Hongping Zheng, Fangyuan Shao, Scots Martin, Xiaoling Xu, and Chu-Xia Deng. (2017). WEE1 inhibition targets cell cycle checkpoints for triple negative breast cancers to overcome cisplatin resistance. Scientific Reports. Mar 6;7:43517. doi: 10.1038/srep43517.

334). Qiang Chen, Wenhui Hao, Cuiying Xiao, Ruihong Wang, Xiaoling Xu, Huiyan Lu, Weiping Chen, Chu-Xia Deng (2017). SIRT6 is Essential for Adipocyte Differentiation through Regulating Mitotic Clonal Expansion. Cell Reports. Mar 28;18(13):3155-3166. doi: 10.1016/j.celrep.2017.03.006

335). Barani Kumar Rajendran and Chu-Xia Deng (2017). Characterization of Potential Driver Mutations Involved in Human Breast Cancer by Computational Approaches. Oncotarget, Jul 25;8(30):50252-50272. doi: 10.18632/oncotarget.17225.

336). Xu W, Luo F, Wang Q, Tan Q, Huang J, Zhou S, Wang Z, Sun X, Kuang L, Jin M, Su N, Jiang W, Chen L, Qi H, Zhu Y, Chen B, Chen H, Chen S, Gao Y, Xu X, Chu-Xia Deng, Chen L, Xie Y, Du X. Inducible activation of FGFR2 in adult mice promotes bone formation after bone marrow ablation. J Bone Miner Res. 2017 Nov;32(11):2194-2206. doi: 10.1002/jbmr.3204.

337). Li J, Hao D, Wang L, Wang H, Wang Y, Zhao Z, Li P, Chu-Xia Deng, Di LJ. Epigenetic targeting drugs potentiate chemotherapeutic effects in solid tumor therapy. Sci Rep. 2017 Jun 22;7(1):4035. doi: 10.1038/s41598-017-04406-0.

338). Ren-Bo Ding, Jiaolin Bao, Chu-Xia Deng (2017). Emerging roles of SIRT1 in fatty liver diseases. Int J Biol Sci. Jul 6;13(7):852-867. doi: 10.7150/ijbs.19370.

339). Wong AH, Li H, Jia Y, Mak PI, Martins RPDS, Liu Y, Vong CM, Wong HC, Wong PK, Wang H, Sun H, Chu-Xia Deng (2017). Drug screening of cancer cell lines and human primary tumors using droplet microfluidics. Sci Rep. 2017 Aug 22;7(1):9109. doi: 10.1038/s41598-017-08831-z.

340). Shin J, Mishra V, Glasgow E, Zaidi S, Ohshiro K, Chitti B, Kapadia AA, Rana N, Mishra L, Chu-Xia Deng, Rao S, Mishra B. (2017). PRAJA is overexpressed in glioblastoma and contributes to neural precursor development. Genes Cancer. 2017 Jul;8(7-8):640-649. doi: 10.18632/genesandcancer.151.

341). Fangyuan Shao, Heng Sun and Chu-Xia Deng (2017). Potential therapeutic targets of Triple Negative Breast Cancer Based on Its Intrinsic Subtype. Oncotarget. 8:73329-73344. https://doi.org/10.18632/oncotarget.20274

342). Haipeng Lei and Chu-Xia Deng (2017). Fibroblast growth factor receptor 2 signaling in breast cancer. Int J Biol Sci. Sep 5;13(9):1163-1171. doi: 10.7150/ijbs.20792.

343). Cuiying Xiao, Ramón A. Piñol, Jesse Lea Carlin, Cuiling Li, Chu-Xia Deng, Oksana Gavrilova, Marc L. Reitman (2017). Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism. Molecular Metabolism. Nov;6(11):1540-1550. doi: 10.1016/j.molmet.2017.08.013.

344). Wan L, Chen T, Gao J, Dong C, Wong AH, Jia Y, Mak PI, Chu-Xia Deng, Martins RP (2017). A digital microgluid system for loopmediated isothermal amplification and sequence specific pathogen detection. Sci Rep. 2017 Nov 6;7(1):14586. doi: 10.1038/s41598-017-14698-x.

345). Gu S, Nguyen BN, Rao S, Li S, Shetty K, Rashid A, Shukla V, Chu-Xia Deng, Mishra L, Mishra B. (2017). Alcohol, stem cells and cancer. Genes Cancer. Sep;8(9-10):695-700. doi: 10.18632/genesandcancer.156. Review. PMID: 29234487

346). Azoury SC, Reddy S, Shukla V, Chu-Xia Deng (2017). Fibroblast Grouth Factor Receptor (FGFR2) Mutation Related Symdromic Craniosynostosis. Int J Biol Sci. Nov 2;13(12):1479-1488. doi: 10.7150/ijbs.22373. eCollection 2017.

347) Rajendran BK, Chu-Xia Deng (2017). A comprehensive genomic meta-analysis identifies confirmatory role of OBSCN gene in breast tumorigenesis. Oncotarget. Aug 23;8(60):102263-102276. doi: 10.18632/oncotarget.20404.

348). Jian Chen, Sobia Zaidi, Shuyun Rao, Jiun-Sheng Chen, Liem Phan, Patrizia Farci, Xiaoping Su, Kirti Shetty, Jon White, Fausto Zamboni, Xifeng Wu, Asif Rashid, Nagarajan Pattabiraman, Raja Mazumder, Anelia Horvath, Ray-Chang Wu, Shulin Li, Cuiying Xiao, Chu-Xia Deng, David A. Wheeler, Bibhuti Mishra, Rehan Akbani, and Lopa Mishra. (2017). Analysis of Genomes and Transcriptomes of Hepatocellular Carcinomas Identifies Mutations and Gene Expression Changes in the Transforming Growth Factor β Pathway. Gastroenterology. Jan;154(1):195-210. pii: S0016-5085(17)36144-9.

349). ­­­ Tyler J. Lahusen, Seung-Jin Kim, Kai Miao, Zebin Huang, Xiaoling Xu and Chu-Xia Deng. (2018). BRCA1 function in the intra-S checkpoint is activated by acetylation via a pCAF/SIRT1 axis. Oncogene, Apr;37(17):2343-2350. doi: 10.1038/s41388-018-0127-1.

350). Ming Zhao, Lopa Mishra, and Chu-Xia Deng. (2018). The role of TGF-β/SMAD4 signaling in cancer. Int J Biol Sci. Jan 12;14(2):111-123. doi: 10.7150/ijbs.23230.

351). Sun H, Miao Z, Zhang X, Chan UI, Su SM, Guo S, Wong CKH, Xu X, and Chu-Xia Deng. (2018). Single-cell RNA-Seq reveals cell heterogeneity and hierarchy within mouse mammary epithelia. J Biol Chem. Apr 17. pii: jbc.RA118.002297. doi: 10.1074/jbc.RA118.002297.

352). Li Y, Schang G, Wang Y, Zhou X, Levasseur A, Boyer A, Chu-Xia Deng, Treier M, Boehm U, Boerboom D, Bernard DJ. (2018). Conditional deletion of FOXL2 and SMAD4 in gonadotropes of adult mice causes isolated FSH deficiency. Endocrinology.  May 23. doi: 10.1210/en.2018-00100.

353). Tang Y, Tang LY, Xu X, Li C, Chu-Xia Deng, Zhang YE. (2018). Generation of Smerf2 conditional knockout mice. Int J Biol Sci. 14(5):542-548.

354). Chen Z, Liu J, Chu D, Shan Y, Ma G, Zhang H, Zhang XD, Wang P, Chen Q, Chu-Xia Deng, Chen W, Dimitrov DS, Zhao Q. (2018). A dual-specific IGF-I/II human engineered antibody domain inhibits IGF signaling in breast cancer cells. Int J Biol Sci. 2018 May 21;14(7):799-806. doi: 10.7150/ijbs.25928.

355). Zhang B, Lyu J, Liu Y, Wu C, Yang EJ, Pardeshi L, Tan K, Wong KH, Chen Q, Xu X, Chu-Xia Deng, Shim JS. (2018). BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition. Oncogene. 2018 Jul 24. doi: 10.1038/s41388-018-0408-8.

356). Tan Q, Chen B, Wang Q, Xu W, Wang Y, Lin Z, Luo F, Huang S, Zhu Y, Su N, Jin M, Li C, Kuang L, Qi H, Ni Z, Wang Z, Luo X, Jiang W, Chen H, Chen S, Li F, Zhang B, Huang J, Zhang R, Jin K, Xu X, Chu-Xia Deng, Du X, Xie Y, Chen L. (2018). A novel FGFR1-binding peptide attenuates the degeneration of articular cartilage in adult mice. Osteoarthritis Cartilage. 26(12):1733-1743. doi: 10.1016/j.joca.2018.08.012.

357). Tan Q, Wang Z, Wang Q, Wang Y, Huang Z, Su N, Jin M, Kuang L, Qi H, Ni Z, Li C, Zhu Y, Jiang W, Chen H, Chu-Xia Deng, Du X, Xie Y, Chen L. (2018). A novel FGFR1-binding peptide exhibits anti-tumor effect on lung cancer by inhibiting proliferation and angiogenesis. Int J Biol Sci. 2018 Jul 27;14(10):1389-1398. doi: 10.7150/ijbs.24739.

358). Wang Q, Tan Q, Xu W, Kuang L, Zhang B, Wang Z, Ni Z, Su N, Jin M, Li C, Jiang W, Huang J, Li F, Zhu Y, Chen H, Du X, Chen D, Chu-Xia Deng, Qi H, Xie Y, Chen L. (2018). Postnatal deletion of Alk5 gene in meniscal cartilage accelerates age-dependent meniscal degeneration in mice. J Cell Physiol. 2018 234(1):595-605. doi:10.1002/jcp.26802.

359). Baek HJ, Kim SE, Kim JK, Shin DH, Kim TH, Kim KG, Chu-Xia Deng, Kim SS. (2018), Inhibition of AKT suppresses the initiation and progression of BRCA1-associated mammary tumors. Int J Biol Sci.14(13):1769-1781. doi: 10.7150/ijbs.29242.

360). Baek HJ, Kim SE, Choi EK, Kim JK, Shin DH, Park EJ, Kim TH, Kim JY, Kim KG, Chu-Xia Deng, Kim SS. (2018). Inhibition of Estrogen Signaling Reduces the Incidence of BRCA1-associated Mammary Tumor Formation. Int J Biol Sci. 14(12):1755-1768. doi: 10.7150/ijbs.28142.

361). Choi EK, Lim JA, Kim JK, Jang MS, Kim SE, Baek HJ, Park EJ, Kim TH, Chu-Xia Deng, Wang RH, Kim SS. (2018). Cyclin B1 stability is increased by interaction with BRCA1, and its overexpression suppresses the progression of BRCA1-associated mammary tumors. Exp Mol Med.50(10):136. doi:10.1038/s12276-018-0169-z.

362). Luo F, Xie Y, Wang Z, Huang J, Tan Q, Sun X, Li F, Li C, Liu M, Zhang D, Xu M, Su N, Ni Z, Jiang W, Chang J, Chen H, Chen S, Xu X, Chu-Xia Deng, Wang Z, Du X, Chen L. (2018). Adeno-Associated Virus-Mediated RNAi against Mutant Alleles Attenuates Abnormal Calvarial Phenotypes in an Apert Syndrome Mouse Model. Mol Ther Nucleic Acids. 13:291-302. doi: 10.1016/j.omtn.2018.09.012.

363). Korkut A, Zaidi S, Kanchi RS, Rao S, Gough NR, Schultz A, Li X, Lorenzi PL, Berger AC, Robertson G, Kwong LN, Datto M, Roszik J, Ling S, Ravikumar V, Manyam G, Rao A, Shelley S, Liu Y, Ju Z, Hansel D, de Velasco G, Pennathur A, Andersen JB, O’Rourke CJ, Ohshiro K, Jogunoori W, Nguyen BN, Li S, Osmanbeyoglu HU, Ajani JA, Mani SA, Houseman A, Wiznerowicz M, Chen J, Gu S, Ma W, Zhang J, Tong P, Cherniack AD, Chu-Xia Deng, Resar L; Cancer Genome Atlas Research Network, Weinstein JN, Mishra L, Akbani R. (2018). A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily. Cell Syst. 7(4):422-437.e7. doi: 10.1016/j.cels.2018.08.010.

364). Miao K, Zhang X, Su SM, Zeng J, Huang Z, Chan UI, Xu X, Chu-Xia Deng. (2018). Optimizing CRISPR/Cas9 technology for precise correction of the Fgfr3-Gly374Arg mutation in achondroplasia in mice. J Biol Chem.  2018 Nov 28. pii: jbc.RA118.006496. doi: 10.1074/jbc.RA118.006496. [Epub ahead of print]

365). Xu X, Chen E, Mo L, Zhang L, Shao F, Miao K, Liu J, Su SM, Valecha M, In Chan U, Zheng H, Chen M, Chen W, Chen Q, Fu H, Aladjem MI, He Y, Deng CX. (2018). BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1-MCM2 signaling during pregnancy. Hum Mol Genet. 2018 Nov 15. doi: 10.1093/hmg/ddy398. [Epub ahead of print]