Doctor of Philosophy in Biomedical Sciences
Programme Description
Biomedical scientists bridge the gap between the basic sciences and medicine, conduct research in order to comprehend human disease and find ways to improve human health. Graduates interested in conducting independent research and gaining laboratory experience might benefit from our PhD programme. Students in the programme are supervised individually by an academic staff at a professoriate rank to carry out a research project for a research dissertation. Our PhD programme is designed to educate learners who aspire to pursue careers as research scientists, scholars, or academic careers in biological and biomedical science.
Research Directions
Curriculum
Normative Study Period
4 Years
Admission
| Supervisor | Research Topic |
|---|---|
| Prof. Chuxia DENG | Oncogenes and tumor suppressor genes |
| Stem cells, Cancer metastasis and Drug development | |
| Prof. Wei GE | Genetic analysis of growth and reproduction in the zebrafish model |
| Impacts of environmental endocrine-disrupting chemicals (EDCs) on reproduction and public health | |
| Zebrafish as a model for aging, human diseases and drug discovery | |
| Prof. Han-Ming SHEN | Autophagy: Regulatory mechanisms and biological functions in cancer |
| Mitophagy: Novel regulatory mechanisms | |
| Cancer metabolism: Targeting glucose metabolism in lung cancer | |
| Prof. Ren-He XU | Mesenchymal stem cells: the development, heterogeneity, functions, and therapeutic application |
| Prof. Guokai CHEN | Metabolic regulation in stem cell maintenance and differentiation |
| Novel mechanisms involved in cardiomyocyte differentiation and maturation | |
| Skin cell differentiation for regenerative medicine | |
| Endoderm differentiation for disease model | |
| Prof. Edwin CHEUNG | Mechanism of gene regulation in cancer |
| Single cell analysis | |
| Prof. Kathy Qian LUO | Circulating tumor cells and cancer metastasis |
| Drug resistant and anti-cancer drug discovery | |
| Prof. Garry WONG | Bioinformatics and Computational Biology of Aging related neurodegenerative diseases |
| Prof. Yutao XIANG | Psychiatric epidemiology |
| Health services research in psychiatry | |
| Evidence-based medicine in psychiatry | |
| COVID-19 related studies in psychiatry | |
| Cognition and psychiatric disorders | |
| Prof. Xiaohua Douglas ZHANG | High throughput sequencing studies and data analysis |
| Data mining for biomedical research | |
| Development of analytic software for high-throughput biomedical data | |
| Prof. Wenhua ZHENG | Foxo and neuronal differentiation or new drugs development like artemisinin and metformin |
| Drug development | |
| Neurodegenerative diseases | |
| The effect of Chinese medicine on tumor growth/metastasis and their underlying mechanisms | |
| Prof. William Chong Hang CHAO | Structure and Function of Epigenetic Regulators |
| Prof. Lijun DI | Remodeling of transcriptional program in cancer development by both endogenous and exogenous factors via regulating CtBP status |
| Molecular mechanism of cancer metastasis | |
| Investigating the molecular mechanisms and identifying the potential therapeutic targets of obesity and related disease | |
| Prof. Hang Fai (Henry) KWOK | Antibody / Venom-based peptide targeted therapy for anti-cancer prototype drug discovery & development (Novel multi-specific antibody platforms for immunotherapy; Novel protein expression system for large scale production of hard-to-express venom-based protein drugs |
| Biomarkers identification and validation based on the hallmarks of cancer | |
| Tackling cancer metastasis and drug resistance: from mechanism to therapy (Glyco-engineering to improve antibody quality attibutes for cancer therapy) |
|
| Prof. Gang LI | Cancer epigenetics: from mechanism to therapy |
| Signal transduction pathways in Epigenetics | |
| Prof. Tzu-Ming LIU | In vivo microscopy and spectroscopy of tumor microenvironment |
| Develop serum fluoroscope for the diagnosis of organ function | |
| Prof. Terence C.W. POON | Proteomics/Protein/Biomarker-based research in precision medicine |
| Bioinformatics-based research in precision medicine | |
| Prof. Joong Sup SHIM | Exploiting synthetic lethality for cancer target discovery |
| Prof. Kin Yip TAM | Development of small molecule inhibitors targeting cancer metabolism or Alzheimer’s disease |
| Combined use of metabolic inhibitors in lung cancer models | |
| Prof. Chris Koon Ho WONG | Transcription regulation of fungal metabolism and infection. |
| Identification of novel fungal secondary metabolites with anti-cancer and antibiotic properties. | |
| Understanding the regulation of fungal spore dormancy and germination. | |
| Prof. Ruiyu XIE | Develop transplantable platform for stem-cell based diabetic therapy |
| Molecular switches in endodermal lineage specification | |
| Epigentic regulation shapping tumor immune microenvironment in pancreas | |
| Prof. Xiaoling XU | BRCA1 associated breast cancer and cancer metastasis |
| Prof. Zhen YUAN | Neuroscience and neuroimaging |
| Biomedical Optics | |
| Optical Molecular Imaging and Cancer Nanomedicine | |
| Prof. Xuanjun ZHANG | Molecular probes for imaging/sensing and diagnosis |
| Design of nanoreactors for biomedical applications | |
| Prof. Wa Kam CHANG | How cells polarize during cell migration, with a focus on the cytoskeleton and nuclear envelope proteins |
| How aging affects cell polarization and how cell polarization contributes to aging defects | |
| Deciphering the acting mechanism of aging factors on the cellular and whole genome levels | |
| Prof. Yunlu DAI | Cancer nanomedicine |
| Molecular imaging | |
| Drug delivery | |
| Prof. Leo Tsz On LEE | Explore the role of GPCR biased signalling in cancers |
| Proteomic and metabolic analyses of EPAC signaling in cancer cells | |
| Prof. Ningyi SHAO | Study of lncRNA regulation in gender-biased diseases |
| Integrated multi-omics analysis of tumor microevolution at the single cell level | |
| Prof. Vivien Ya-Fan WANG | Mechanism of gene regulation by NFkappaB and co-factors |
| Prof. Hongjie ZHANG | Deciphering the mRNP code in epithelial morphogenesis |
| Post-translational modification in tubular organ formation | |
| Sphingosine 1-phosphate signaling in lumenal membrane integrity | |
| Prof. Qi ZHAO | Nanomedicine and target drug delivery |
| Antibody-based therapeutics against tumors | |
| Prof. Jun ZHENG | Type VI Secretion System in Pathogenic bacteria |
| Development next generation antibiotics | |
| Bacterial persistence | |
| Prof. Qiang CHEN | Molecular mechanisms of cancer development |
| Regulation of metabolic homeostasis | |
| Mechanisms of drug resistance in cancer |
Contact
| Academic advisors: |
Prof. Chuxia DENG, Chair of Graduate Studies Committee Email: cxdeng@um.edu.mo Prof. Guokai CHEN, Associate Dean (Teaching) Email: guokaichen@um.edu.mo |
|
Administrative support (Admission) |
Mr. David REN Email: davidren@um.edu.mo |
|
Administrative support (Programme Operation) |
Ms. Stephanie NG Email: stephaniepwng@um.edu.mo |