Dr. Chon Lok LEI

1. Lei, C.L., Fabbri, A., Whittaker, D.G., et al. (2020). “A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer.” Wellcome Open Research, 5:152. https://doi.org/10.12688/wellcomeopenres.15968.1
2. Foster, T., Lei, C.L., Robinson, M., et al. (2020). “Model Evidence with Fast Tree Based Quadrature.” arXiv. http://arxiv.org/abs/2005.11300
3. Lei, I.M., Jiang, C., Lei, C.L., et al. (2020). “A neural network trained by 3D printed biomimetic cochleae provides clinical informatics for cochlear implant patients.” medRxiv. https://doi.org/10.1101/2020.11.28.20240176
4. Creswell, R., Lambert, B., Lei, C.L., et al. (2020). “Using flexible noise models to avoid noise model misspecification in inference of differential equation time series models.” arXiv. https://arxiv.org/abs/2011.04854

Peer-reviewed journal articles

1. Lei, C. L., and Mirams, G. R. (2021). “Neural Network Differential Equations For Ion Channel Modelling.” Frontiers in Physiology, 12:708944. https://doi.org/10.3389/fphys.2021.708944
2. Lei, C.L., Ghosh, S., Whittaker, D.G., et al. (2020). “Considering discrepancy when calibrating a mechanistic electrophysiology model.” Trans. R. Soc. A. 378: 20190349. https://doi.org/10.1098/rsta.2019.0349
3. Lei, C.L., Clerx, M., Whittaker, D.G., et al. (2020). “Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments.” Trans. R. Soc. A. 378: 20190348. https://doi.org/10.1098/rsta.2019.0348
4. Clayton, R.H., Aboelkassem, T., Cantwell, C.D., Corrado, C., Delhaas, T., Huberts, W., Lei, C.L., et al. (2020). “An audit of uncertainty in multi-scale cardiac electrophysiology models.” Trans. R. Soc. A. 378: 20190335. https://doi.org/10.1098/rsta.2019.0335
5. Whittaker, D.G., Clerx, M., Lei, C.L., et al. (2020). “Calibration of ionic and cellular cardiac electrophysiology” WIREs Syst. Biol. Med., e1482. https://doi.org/10.1002/wsbm.1482
6. Lei, C.L., Clerx, M., Beattie, K.A., et al. (2019). “Rapid Characterization of hERG Channel Kinetics II: Temperature Dependence.” Biophysical Journal, 117, 12, p.2455-2470. https://doi.org/10.1016/j.bpj.2019.07.030
7. Lei, C.L., Clerx, M., Gavaghan, D.J., et al. (2019). “Rapid Characterization of hERG Channel Kinetics I: Using an Automated High-Throughput System.” Biophysical Journal, 117, 12, p.2438-2454. https://doi.org/10.1016/j.bpj.2019.07.029
8. Clerx, M., Robinson, M., Lambert, B., Lei, C.L., et al. (2019). “Probabilistic Inference on Noisy Time Series (PINTS).” Journal of Open Research Software, 7(1), p.23. https://doi.org/10.5334/jors.252
9. Lei, C.L., Kellard, J., Hara, M., Johnson, J., Rodriguez, B. and Briant, L. (2018). “Beta-cell hubs maintain Ca²⁺ oscillations in human and mouse islet simulations.” Islets, 10(4): 151-167. https://doi.org/10.1080/19382014.2018.1493316
10. Lei, C.L., Wang, K., Clerx, M., Johnstone, R.H., et al. (2017). “Tailoring Mathematical Models to Stem-Cell Derived Cardiomyocyte Lines Can Improve Predictions of Drug-Induced Changes to Their Electrophysiology.” Frontiers in Physiology, 8, 986. https://doi.org/10.3389/fphys.2017.00986

Conference proceedings

1. Camporesi, M., Bartolucci, C., Lei, C.L., et al. (2020). “Development, Implementation and Testing of a Multicellular Dynamic Action Potential Clamp Simulator for Drug Cardiac Safety Assessment.” Computing in Cardiology 2020, Vol. 47. https://doi.org/10.22489/CinC.2020.416″>https://doi.org/10.22489/CinC.2020.416

Professional membership
Biophysical Society
Society for Mathematical Biology
Safety Pharmacology Society