2021-03-05T10:25:18+08:002019-12-03|
Contact Information
Title
Assistant Professor (Primary Affiliation to Faculty of Science and Technology)
Office
(Office) N21-3001ca / (Lab) N21-3001
Phone
(Office) +853 8822-4451
Email
yanweijia@um.edu.mo
Teaching

Course Outlines

Education
PhD Department of Physics, National University of Singapore, 2006
MSc Department of Physics, Hunan University, Changsha, China, 2002
BSc Department of Physics, Hunan University, Changsha, China, 1996
Positions
2016 – present Assistant Professor, State Key Laboratory of Analog and Mixed Signal VLSI, University of Macau
2013 – 2015 Postdoctoral Fellow, State Key Laboratory of Analog and Mixed Signal VLSI, University of Macau
2007 – 2011 Research Scientist, Department of Biology, Brandeis Unviersity
2006 – 2007 Postdoctoral Fellow, Department of Physics, Brandeis University
2006 Research Fellow, Department of Physics, National University of Singapore
Research Interests
  • Microfluidics for biological and chemical applications
  • PCR technology for disease diagnostics
  • Automated point-of-care device for disease diagnostics
Representative Publications
* Corresponding author

  1. J. Zhai, H. R. Li, A. H. H. Wong, C. Dong, S. H. Yi, Y. W. Jia*, P. I. Mak, C. X. Deng and R. P. Martins, A digital microfluidic system with 3D microstructures for single-cell culture, Microsystems and Nanoengineering, in press.
  2. Y. J. Zhu, Q. M. Chen, L. Y. Shao, Y. W. Jia, and X. M. Zhang, Microfluiidc immobilized enzyme reactors for continuous biocatalysis, Reaction Chemistry and Engineering, in press.
  3. Y. J. Zhu, Z. Huang, Q. Chen, Q. Wu, X. Huang, P. So, L. Shao, Z. Yao, Y. W. Jia, Z. Li, W. Yu, Y. Yang, A. Jian, S. Sang, W. Zhang, X. M. Zhang, Continuous artificial synthesis of glucose precursor using enzyme-immobilized microfluidic reactors, Nature Communications, 10, 4049, 2019.
  4. J. Zhai, S. H. Yi, Y. W. Jia*, P. I. Mak, R. P. Martins, Cell-based drug screening on microfluidics, Trends in Analytical Chemistry, 117, 231-241, 2019.
  5. M. Z. Li, C. Dong, M. K. Law*, Y. W. Jia*, P. I. Mak and R. P. Martins, Hydrodynamic-flow-enhanced rapid mixer for isothermal DNA hybridization kinetics analysis on digital microfluidics platform, Sensors and Actuators B, 287, 390-397, 2019.
  6. L. Wan, J. Gao, T. L. chen, C. Dong, H. R. Li, Y. Z. Wen, Z. R. Lun, Y. W. Jia*, P. I. Mak, R. P. Martins, LampPort: a handheld digital microfluidic device for loop-mediated isothermal amplification (LAMP), Biomedical Microdevices, 21:9, 2019.
  7. R. Shen, L. Wan, and Y. W. Jia*, Applications of microfluidic technology in clinical diagnosis, Journal of Molecular Diagnostics and Therapy, 10(5), 289, 2018.
  8. J. Zhai, Y. W. Jia, L. N. Zhao, Q. Yuan, F. P. Gao, X. C. Zhang, P. J. Cai, L. Gao, J. J. Guo, S. H. Yi, Z. F. Chai, Y. L. Zhao and X. Y. Gao, Turning on/off the anti-tumor effect of the Au cluster via atomically controlling its molecular size, ACS Nano, 12(5), 4378-4386, 2018.
  9. L. Wan, T. L. Chen, J. Gao, C. Dong, A. H. H. Wong, Y. W. Jia*, P. I. Mak, C. X. Deng and R. Martins, A digital microfluidic system for loop-mediated isothermal amplification and sequence specific pathogen detection, Scientific Reports, 7, 14586, 2017.
  10. A. H. H. Wong, H. R. Li, Y. W. Jia, P. I. Mak, R. P. Martins, Y. Liu, C. M. Vong, H. C. Won, P. K. Wong, H. T. Wang, H. Sun, C. X. Deng, Drug screening of cancer cell lines and human primary tumors using droplet microfluidics,Scientific Reports,7, 9109, 2017.
  11. C. Xu, Y. L. Wang, C. Y. Zhang, Y. W. Jia, Y. J. Luo and X. Y. Gao, AuGd integrated nanoprobes for optical/MRI/CT triple-modal in vivo tumor imaging, Nanoscale, 9, 4620-4628, 2017.
  12. C. Dong, Y. W. Jia*, J. Gao, T. L. Chen, P. I. Mak, M. I. Vai and R. P. Martins, A 3D microblade structure for precise and parallel droplet splitting on digital microfluidic chips, Lab on a Chip, 17, 896-904, 2017.
  13. T. L. Chen, Y. W. Jia, C. Dong, J. Gao, P. I. Mak, and R. P. Martins, Sub-7-second genotyping of single-nucleotide polymorphism by high-resolution melting curve analysis on a thermal digital microfluidic device, Lab on a Chip, 16, 743-752, 2016.
  14. J. Gao, T. L. Chen, C. Dong, Y. W. Jia, P. I. Mak, M. I. Vai and R. P. Martins, Adhesion Promoter for Multi-dielectric-layer on digital microfluidic chip, RSC Advances, 5, 48626-48630, 2015.
  15. C. Dong, T. L. Chen, J. Gao. Y. W. Jia. P. I. Mak, M. I. Vai and R. P. Martins, On the droplet velocity and electrode lifetime of digital microfluidics: voltage actuation techniques and comparison, Microfluidics and Nanofluidics, 18, 673-683, 2015.
  16. T. L. Chen, C. Dong, J. Gao, Y. W. Jia, P. I. Mak, M. I., Vai and R. P. Martins, Natural discharge after pulse and cooperative electrodes to enhance droplet velocity in digital microfluidics, AIP Advances, 4, 047129, 2014.
  17. Y. W. Jia, J. A. Sanchez, L. J. Wangh, Kinetic Hairpin Oligonucleotide Blockers for Selective Amplification of Rare Mutations, Scientific Reports, 4, 5921, 2014.
  18. Y. W. Jia, P. I. Mak, C. Massey, R. P. Martins and L. J. Wangh, Construction of a Microfluidic Chip for LATE-PCR Amplification and Detection of Single-Stranded DNA using Dried-Down Reagents, Lab on a Chip, 13, 4635-4641, 2013
  19. Y. W. Jia, A. Osborne, J. E. Rice and L. J. Wangh, Dilute-‘N’-Go Dideoxy Sequencing of All DNA Strands Generated in Multiplexed LATE-PCR Assays, Nucleic Acids Research, 38 (11), e119, 2010.
  20. Y. W. Jia, C. Hartshorn, O. Hartung and L. J. Wangh, Heat Shock Memory in Preimplantation Mouse Embryos, Fertility and Sterility, 93 (8), 2760-2763, 2010.
  21. H. Boukellal, S. Selimovic, Y. W. Jia, G. Cristobal and S. Fraden, Simple, Robust Storage of Drops and Fluids in a Microfluidic Device, Lab on a Chip, 9, 331-338, 2009.
  22. S. Selimovic, Y. W. Jia and S. Fraden, Measuring the Nucleation Rate of Lysozyme Using Microfluidics, Crystal Growth & Design, 9, 1808-1810, 2009.
  23. J.-uk Shim, G. Cristobal, D. Link, T. Thorsen, Y. W. Jia, K. Piatelli and S. Fraden, Control and Measurement of the Phase Behavior of Aqueous Solutions Using Microfluidics, Journal of the American Chemical Society, 129, 8825-8835, 2007. (Highlighted byLab on a Chip7, 1091-1093, 2007; SCIENCE317, 18, 2007)
  24. C. Hartshorn, A. Anshelevich, Y. W. Jia and L. J. Wangh, Early Onset of Heat-Shock Response in Mouse Embryos Revealed by Quantification of Stress-Inducible hsp70i RNA, Gene Regulation and Systems Biology, 1, 365-373,2007.
  25. Y. W. Jia and X. Y. Liu, From Surface Self-assembly to Crystallization: Prediction of Protein Crystallization Conditions, Journal of Physical Chemistry B,110, 6949-6955, 2006.
  26. Y. W. Jia, J. Narayanan, X. Y. Liu and Y. Liu, Investigation of the Mechanism of Crystallization of Soluble Protein in the Presence of Nonionic Surfactant, Biophysical Journal89, 4245-4251, 2005.
  27. Y. W. Jia and X. Y. Liu, Prediction of Protein Crystallization Based on Interfacial and Diffusion Kinetics,Applied Physics Letters 87(10), 103902, 2005.
  28. Y. W. Jia and X. Y. Liu, Self-assembly of Protein at Aqueous Solution Surface in Correlation to Protein Crystallization, Applied Physics Letters 86(2), 023903, 2005.
  29. Q. H. Liu, Y. W. Jia, W. H. Qi, Z. C. Ou-Yang, Static Bistable Helices in Generalized Helfrich Elastic Theory of a Chiral Filament, Physics Letters A, 317, 401-405, 2003
Research Grants
  1. PI, FDCT 0053/2019/A1, Pico-pipette in Digital Microfluidic System for Precise Sample Delivery with Wide Range, MOP 2,243,000, 2019-2022
  2. Co-PI, FDCT 047/A1/2014, Electronic-automated Digital Microfluidic System for Disease diagnostics, 06/2015 – 06/2018
  3. PI, FDCT 110/A3/2016, Integration of Digital & Channel Microfluidic Systems for High-throughput Drug Screening, 03/2018 – 03/2020
  4. PI, SRG 2016-00072-AMSV, Digital Microfluidics for Disease Diagnostics, 04/16 – 04/19
  5. PI, MYRG 2017-00022-AMSV, Intelligent-controlled Point-of-Care Fast Infectious Disease Diagnostic System, 01/2018 – 12/2020
  6. PI, MYRG 2018-00114-AMSV, 3D Micro-structured Digital Microfluidic System with Closed-Loop Image Analysis for Cell Recognition in Precision Medicine Investigations, 01/2019 – 12/2021
  7. PI, Guangzhou Science and Technology Innovation and Development of Special Funds, EF009/AMSV-JYW/2018/GSTIC, Development and Industrialization of Drug Resistant Tuberculosis Detection Kit and Equipment Based on Digital Microfluidic PCR and HRM Platform, Collaborating with DaAn Gene Ltd., 04/2018 – 04/2021
Patents
  1. S. Fraden, H. Boukellal, Y. W. Jia, S. Selimovic, A. Rowat, J. Agresti, D. A. Weitz, Manipulation of fluids, fluid components and reactions in microfluidic systems, US PATENT, No. 10357772, July 23, 2019
  2. S. Fraden, H. Boukellal, Y. W. Jia, S. Selimovic, A. Rowat, J.y Agresti, D. A. Weitz, Manipulation of fluids, fluid components and reactions in microfluidic systems, US PATENT, No. 10286396, May 14, 2019
  3. C. Dong, T. L. Chen, J. Gao, Y. W. Jia,P. I. Mak, M. I. Vai, R. Martins, Cooperative-electrode Driving Technique for Droplet-velocity Improvement of Digital Microfluidic Systems, US PATENT, No. 10016759 , Jul 10, 2018
  4. Y. W. Jia, H. R. Li, R. Shen, C. Dong, T. L. Chen, J. Gao, P. I. Mak, and R. Martins, A method for on-chip precise sample delivery in a microfluidic system, PCT/ UMPT161-2018, July 2018
  5. T. L. Chen, C. Dong, J. Gao, Y. W. Jia, P. I. Mak, M. I. Vai, R. Martins,一种检测和分析DNA的方法, PCT/CN2018/088762, 28 May 2018
  6. Y. W. Jia, L. Wan, et al., Ultrafast PCR on Digital Microfluidic Chip with Sloppy Temperature Control, US Provisional Patent, Application No. 62677071, 28 May 2018
  7. T. L. Chen, C. Dong, J. Gao, Y. W. Jia, P. I. Mak, M. I. Vai, R. Martins, 一种检测和分析DNA的方法, CHN PATENT, application number 201711499798.9, 29 Dec 2017
  8. T. L. Chen, C. Dong, J. Gao, Y. W. Jia, P. I. Mak, M. I. Vai, R. Martins, Electrode-voltage Waveform for Droplet-Velocity and Chip-lifetime Improvements of Digital Microfluidic Systems, US PATENT No. 9808800, Nov. 7, 2017
  9. L. J. Wangh, J. E. Rice, N. Rice, Y. W. Jia, Reagents and Methods for PCR, US PATENTNo. 9758813, Sept 12, 2017
  10. J. Gao, T. L. Chen, C. Dong, Y. W. Jia,P. I. Mak, M. I. Vai, R. Martins, Electronic Module for Real-time Droplet-position Sensing and Driving in Digital Microfluidic System, US PATENT No. 9751083, Sept 5, 2017
  11. S. Fraden, H. Boukellal, Y. W. Jia, S. Selimovic, A. Rowat, J. Agresti, D. A. Weitz, Manipulation of Fluids, Fluid Components and Reactions in Microfluidic Systems, US PATENT No. 9588025, March 7, 2017
  12. Y. W. Jia, L. J. Wangh, J. A. Sanchez and J. Rice, Detecting Nucleic Acid Variations within Populations of Genomes, US PATENT No. 9169514, Oct. 23. 2015
  13. S. Fraden, H. Boukellal, Y. W. Jia, S. Selimovic, A. Rowat, J. Agresti, D. A. Weitz, Manipulation of Fluids, Fluid Components and Reactions in Microfluidic Systems, US PATENT No. 9068699, Issued date: June 30, 2015
  14. L. J. Wangh, J. Rice, N. Rice and Y. W. Jia, Reagents and Methods for PCR, US PATENT No. 9034605, Issued Date: May 19, 2015
  15. S. Fraden, Y. W. Jia, H. Boukellal, S. Selimovic, A. Rowat, J. Agresti, D. A. Weitz, Manipulation of Fluids, Fluid Components and Reactions in Microfluidic Systems, US PATENT No. 8592221, Issued date: Nov. 23, 2013
  16. X. Y. Liu and Y. W. Jia, Method for Prediction de novo Biomacromolecule Crystallization Conditions and for Crystallization of the Same, SINGAPORE PATENT No. 124995 (WO2005/080422); Issued date: Sept. 28, 2007
Awards
  • Innovation Award, The 9th International Multidisciplinary Conference on Optofluidics, 2019
  • Outstanding Mentor Award, Ministry of Education of Singapore, 2004
  • Innovation Prize, International Organization for Biological Crystallization, 2008
Others
Team members:Current Members:

Yanwei Jia, Principle Investigator

Ning Yang, Visiting Fellow

Jiao Zhai, Postdoctoral Fellow

Meiqing Liu, Postdoctoral Fellow

Xiong Zhou, Research Assistant

Liang Wan, PhD candidate

Haoran Li, PhD candidate

Ren Shen, PhD candidate

Sizhe Dong, PhD candidate

Alumni:

Cheng Dong, Tianlan Chen, Jie Gao, Yujiao Zhu, Terry Choi, Yunyi Li

Highly motivated researchers interested in multidisciplinary research are always welcome to join our team. Please directly contact the PI.