Dr. Zhihui WENG

Education
PhD	2014-2018	The Chinese University of Hong Kong
BS	2003-2008	Peking University

Position
2019-Present	Research Assistant Professor, the University of Macau
2018-2019	Postdoctoral Fellow, The Chinese University of Hong Kong

Research Interests

Dr. WENG graduated from Peking University with a degree in Bachelor of Medicine. He received further training in the field of stem cells (human embryonic stem cells and induced pluripotent stem cells) in the Chinese Academy of Sciences in Shanghai and Guangzhou. He was later recruited as a Technical Officer in the Stem cell and Regenerative Medicine Consortium in the University of Hong Kong. He then earned his PhD degree in the School of Biomedical Sciences, Chinese University of Hong Kong and worked there as a postdoctoral fellow. His main researches focus on the discovery of novel driver/core genes related to cancer stem cells and how they contribute to cancer initiation, development and progression. Dr. WENG has published many research papers on stem cell and cancer areas. Discover Cancer Stem Cell related genes and how they regulate stemness of tumor cells. Drug screen of Patients Derived Organoid in human Hepatocellular Carcinoma. Molecular mechanisms of tumor initiation in human Hepatocellular Carcinoma.

Representative Publications

J He#, Z Weng#, SCM Wu, KR Boheler. Generation of Induced Pluripotent Stem Cells from Patients with COL3A1 Mutations and Differentiation to Smooth Muscle Cells for ECM-Surfaceome Analyses. Methods Mol Biol. 2018;1722:261-302. (co-first author) JT Zhang#, Z Weng#, KS Tsang, LL Tsang, HC Chan, XH Jiang. MycN Is Critical for the Maintenance of Human Embryonic Stem Cell-Derived Neural Crest Stem Cells. PLoS One. 2016 Apr 14;11(4):e0154068. (co-first author) Z Weng, CW Kong, L Ren, L Karakikes, L Geng, J He, MZY Chow, CF Mok, HYS Chan, SE Webb, W Keung, H Chow, AL Miller, AYH Leung, RJ Hajjar, RA Li, CW Chan. A simple, cost-effective but highly efficient system for deriving ventricular cardiomyocytes from human pluripotent stem cells. Stem Cells and Development. 2014 Jul 15;23(14)1704-16. (cited 62 times since published, first author) Z Weng, J He, J Lin, L Gao, JT Zhang, G Li, JX Jiang. Human Embryonic Stem Cells derived Neuroblastoma model reveals novel Twist1-dependent genes cluster with distinct function in MYCN-amplified Neuroblastoma. In preparation. (first author) J He#, Z Weng#, VHF Lee. Oncofetal gene I***, an unreported bona fide driver and novel subtype of biomarkers in aggressive hepatocellular carcinoma In preparation to Gastroenterology. (co-First author) Z Liu, J Guo, Y Wang, Z Weng, B Huang, MK Yu, X Zhang, P Yuan H Zhao, WY Chan, X Jiang, HC Chan. CFTR-β-catenin interaction regulates mouse embryonic stem cell differentiation and embryonic development. Cell Death Differ. 2017 Jan;24(1):98-110. MA Esteban, T Wang, B Qin, J Yang, D Qin, J Cai, W Li, Z Weng, J Chen, S Ni, K Chen, Y Li, X Liu, J Xu, S Zhang, F Li, W He, K Labuda, Y Song, A Peterbauer, S Wolbank, H Redl, M Zhong, D Cai, L Zeng, D Pei. Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells. Cell Stem Cell. 2010 Jan 8;6(1):71-79. E Poon, W Keung, Y Liang, R Ramalingam, B Yan, S Zhang, A Chopra, J Moore, A Herren, DK Lieu, HS Wong, Z Weng, OT Wong, YW Lam, GF Tomaselli, C Chen, KR Boheler, RA Li. Proteomic Analysis of Human Pluripotent Stem Cell-Derived, Fetal, and Adult Ventricular Cardiomyocytes Reveals Pathways Crucial for Cardiac Metabolism and Maturation. Circ Cardiovasc Genet. 2015 Jun;8(3):427-436. L Yan, L Liu , G Niu, Z Weng, J Wang. Correlation Research between Lead and Other Elements in the Blood of Lead-Exposed Rats. Journal of Chinese Mass Spectrometry Society. 2009;30(5):295-299. Y Chen, Z Weng, E Ling. Functional characterization of PGRP-LC1 of Anopheles gambiae through deletion and RNA interference. Insect Science. 2009 Nov 26;16(6)443-453 Y Chen, Z Weng and L Zheng. Innate immunity against malaria parasites in Anopheles gambiae. Insect Science. 2008 Jan 22;15(1):45-52.