Talk titleĀ Ovarian Cancer in an Era of Precision Medicine:
From Mechanisms to Opportunities for New Diagnosis and Therapy
Prof. Benjamin K. TSANG
Professor
Director, Reproductive Biology Unit
Professor of Obstetrics & Gynecology and
Cellular & Molecular Medicine, University of Ottawa
Senior Scientist, Chronic Disease Program
Ottawa Hospital Research Institute
Date & Time12 Nov 2019 (Tue)
15:00-16:00
VenueRoom G002, N22 Building (University of Macau)
AbstractOvarian cancer (OVCA) is the most lethal gynecological cancer, due mainly to late diagnosis, recurrence and chemoresistance. Although combined cytoreductive surgery and chemotherapy is a successful treatment modality initially, chemoresistance remains a major hurdle for long term therapeutic success. OVCA is considered a cold tumor and has poor immune cell infiltration, rendering immunotherapy ineffective to date. In this lecture, Professor Ben TSANG will elaborate on the role of plasma gelsolin (pGSN), a calcium-dependent actin-binding protein, in the molecular and cellular basis of chemoresistance in OVCA. Specifically, pGSN secretion is involved in exosome-mediated signaling in the ovarian tumor microenvironment, resulting in subtype-specific T cell anergy, apoptosis and chemoresistance. The clinical significance of his studies is pGSN could serve as a new biomarker for diagnosis of stage 1 cancer, in the prognostication in residual disease and a possible target for immunomodulation in chemoresistant OVCA patients