Full publications

Peer-Reviewed Journal Articles (71) (*: Luo KQ as first, corresponding & co-corresponding authors)

  1. Ma S, Fu A, Lim S, Chiew GGY, Luo KQ* (2018) MnSOD mediates shear stress-promoted tumor cell migration and adhesion. Free Radical Biology and Medicine, DOI: 10.1016/j.freeradbiomed.2018.09.004, Published online: 5 September 2018.
  2. Regmi S, Fung TS, Lim S, Luo KQ* (2018) Fluidic shear stress increases the anti-cancer effects of ros-generating drugs in circulating tumor cells. Breast Cancer Research and Treatment. DOI: 10.1007/s10549-018-4922-8. Published online: 16 August 2018.
  3. Fu A, Peh YM, Ngan W, Wei N, Luo KQ* (2018) Rapid identification of anti-micrometastases drugs using integrated model systems with 2D monolayer, 3D spheroids and zebrafish xenotransplantation tumors. Biotechnology and Bioengineering, DOI: 10.1002/bit.26816, Published online: 13 August 2018.
  4. Dalan R, Liu X, Goh LL, Bing S, Luo KQ* (2017) Endothelial cell apoptosis correlates with low haptoglobin concentrations in diabetes. Diabetes and Vascular Disease Research, 14(6) 534-539, DOI: 10.1177/1479164117719827, published 23 August 2017.
  5. Chiew GGY, Wei N, Sultania S, Lim S, Luo KQ* (2017) Bioengineered three-dimensional co-culture of cancer cells and endothelial cells: a model system for dual analysis of tumor growth and angiogenesis. Biotechnology and Bioengineering, 114(8):1865–1877, DOI:10.1002/bit.26297, published: 28 March 2017.
  6. Ma S, Fu A, Chiew GGY, Luo KQ* (2017) Hemodynamic shear stress stimulates migration and extravasation of tumor cells by elevating cellular oxidative level. Cancer Letters, 388:239-248. DOI:10.1016/j.canlet.2016.12.001, published: 1 March 2017.
  7. Regmi S, Fu A, Luo KQ* (2017) High shear stresses under exercise condition destroy circulating tumor cells in a microfluidic system. Scientific Reports, 7:39975. DOI:10.1038/srep39975, published on 5 January 2017.
  8. Wang Q, Wei N, Liu X, Luo KQ* (2017) Enhancement of the bioavailability of a novel anticancer compound (acetyltanshinone IIA) by encapsulation within mPEG-PLGA nanoparticles: a study of formulation optimization, toxicity, and pharmacokinetics. Oncotarget, 8(7):12013-12030, DOI:10.18632/oncotarget.14481, published: 4 January 2017.
  9. Qiu Y, Taichi M, Wei N, Yang H, Luo KQ, Tam J (2016) An orally active bradykinin B1 receptor antagonist engineered as a bifunctional chimera of sunflower trypsin inhibitor. Journal of Medicinal Chemistry, 60(1):504-510, DOI:10.1021/acs.jmedchem.6b01011, published: 5 December 2016.
  10. Fu A, Ma S, Wei N, Tan BXX, Tan EY, Luo KQ* (2016) High expression of MnSOD promotes survival of circulating breast cancer cells and increases their resistance to doxorubicin. Oncotarget, 7(31):50239-50257, DOI:10.18632/oncotarget.10360, published: 1 July 2016.
  11. Zhu H, Fang Y, Zhen X, Wei N, Gao Y, Luo KQ, Xu CJ, Duan H, Ding D, Chen P, Pu K (2016) Multilayered semiconducting polymer nanoparticles with enhanced NIR fluorescence for molecular imaging in cells, zebrafish and mice. Chemical Science, 7(8):5118-5125. DOI:10.1039/C6SC01251E, published: 14 April 2016.
  12. Sin SH, Xu J, Fung KY, Ng, KM, Luo KQ (2016) Evaluation of bacterial consortium construction approaches for anaerobic decolorization. Journal of Environmental Chemical Engineering, 4(1):1191-1198, DOI:org/10.1016/j.jece.2016.01.029, published: 23 January 2016.
  13. Bhave MS, Hassanbhai AM, Anand P, Luo KQ, Teoh SH (2015) Effect of heat-inactivated clostridium sporogenes and its conditioned media on 3-dimensional colorectal cancer cell models. Scientific Reports 5:15681, published: 28 October 2015.
  14. Anand P, Fu A, Teoh SH, Luo KQ* (2015) Application of a fluorescence resonance energy transfer (FRET)-based biosensor for detection of drug-induced apoptosis in a 3D breast tumor model. Biotechnology and Bioengineering, 112(8):1673-1682, published: 15 June 2015. Selected as the spotlight of the journal.
  15. Chiew GGY, Fu A, Luo KQ* (2015) Physical supports from liver cancer cells are essential for differentiation and remodeling of endothelial cells in a HepG2-HUVEC co-culture model. Scientific Reports, 5:10801, published: 8 June 2015.
  16. Zheng XT, Ananthanarayanan A, Luo KQ, Chen P (2015) Glowing graphene quantum dots and carbon dots: properties, syntheses, and biological applications. Small, 11(14):1620-1636, published: 8 April 2015.
  17. Kannadorai RK, Chiew GGY, Luo KQ, Liu Q. (2015) Dual functions of gold nanorods as photothermal agent and autofluorescence enhancer to track cell death during plasmonic photothermal therapy. Cancer Letters, 357(1):152-159, published: 1 February 2015.
  18. Gao Y, Wang Y, Fu A, Shi W, Yeo D, Kolachina M, Luo KQ, Ow H, Xu CJ (2014) Tracking mesenchymal stem cell tumor-homing using fluorescent silica nanoparticles. Journal of Materials Chemistry B, 3(7):1245-1253, published: 11 December 2014.
  19. Xu JJ and Luo KQ* (2014) Enhancing the solubility and bioavailability of isoflavone by particle size reduction using a supercritical carbon dioxide-based precipitation process. Chemical Engineering Research and Design, 92(11):2542-2549. Published: November 2014.
  20. Liu XF, Yu JQ, Dalan R, Liu AQ, Luo KQ* (2014) Biological factors in plasma from diabetes mellitus patients enhance hyperglycaemia and pulsatile shear stress-induced endothelial cell apoptosis. Integrative Biology, 6(5):511-522. Selected as the cover image of the journal. Published: May 2014.
  21. Yu T, Zhou Z, Mu Y, Lopes G, Luo KQ* (2014) A novel anti-cancer agent, acetyltanshinone IIA, inhibits oestrogen receptor positive breast cancer cell growth by down-regulating the oestrogen receptor. Cancer Letters, 346(1):94-103, published: 28 April 2014.
  22. Feng C, Huang SX, Gao XM, Xu HX*, Luo KQ* (2014) Characterization of proapoptotic compounds from the bark of Garcinia oblongifolia. Journal of Natural Products, 77(5):1111-1116, published: 22 April 2014.
  23. Yu T, Li Y, Yang T, Gong Y, Sudibya HG, Chen P, Luo KQ, Liao K (2013) Fabrication of all-in-one multifunctional phage liquid crystalline fibers, RSC Advances, 3(43):20437-20445, published: 27 August 2013.
  24. Yu JQ, Liu XF, Chin LK, Liu AQ, Luo KQ* (2013) Study of endothelial cell apoptosis using fluorescence resonance energy transfer (FRET) biosensor cell line with hemodynamic microfluidic chip system. Lab on a Chip, 13(14):2693-2700, published: 21 July 2013.
  25. Yu Y, Li Jie, Chen S, Hong Y, Ng KM, Luo KQ*, Tang BZ* (2013) Thiol reactive molecule with dual-emission-enhancement property for specific prestaining of cysteine containing proteins in SDS-PAGE. ACS Applied Materials & Interfaces, 5(11):4613-4616, published: 30 May 2013.
  26. Gao XM*, Cui, MZ, Yu T, Hu QF, Pu JX, Du X, Liu TC, Luo KQ* (2013) A novel xanthone from Garcinia oligantha. Helvetica Chimica Acta, 96(3):494-498, published: 13 March 2013.
  27. Lin CS, Xu JJ, Ng KM, Wibowo C, Luo KQ (2012) Encapsulation of a low aqueous solubility substance in a biodegradable polymer using supercritical fluid extraction of emulsion. Industrial & Engineering Chemistry Research, 52(1):134-141, published: 1 June 2012.
  28. Feng C, Zhou LY, Yu T, Xu G, Tian HL, Xu JJ, Xu HX*, Luo KQ* (2012) A new anticancer compound, Oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through Bax activation. International Journal of Cancer, 131(6):1445-1454.
  29. Wu ZM, Ling L, Zhou LY, Guo XD, Jiang W, Qian Y, Luo KQ, Zhang LJ (2012) Novel preparation of PLGA/HP55 nanoparticles for oral insulin delivery, Nanoscale Research Letters, Volume: 7, Article: 299.
  30. Wu ZM, Zhou LY, Guo XD, Jiang W, Ling L, Qian Y, Luo KQ, Zhang LJ (2012) HP55-coated capsule containing PLGA/RS nanoparticles for oral delivery of insulin. International Journal of Pharmaceutics, 425(1-2):1-8.
  31. Gao XM, Yu T, Pu Cui MZ, Pu JX, Du X, Han QB, Hu QF, Liu TC, Luo KQ*, Xu HX* (2012) Identification and evaluation of apoptotic compounds from Garcinia oligantha. Bioorganic & Medicinal Chemistry Letters, 22(6):2350-2353.
  32. Zhu XM, Fu AF, Luo KQ* (2012) A high-throughput fluorescence resonance energy transfer (FRET)-based endothelial cell apoptosis assay and its application for screening vascular disrupting agents. Biochemical and Biophysical Research Communications, 418(4):641-646.
  33. Yu Y, Qin A, Feng C, Lu P, Ng KM, Luo KQ*, Tang BZ* (2012) An amine-reactive tetraphenylethylene derivative for protein detection in SDS-PAGE. Analyst, 137(23): 5592-5596.
  34. Yu Y, Liu J, Zhao Z, Ng KM, Luo KQ*, Tang BZ* (2012) Facile preparation of non-self-quenching fluorescent DNA strands with the degree of labeling up to the theoretic limit. Chemical Communications, 48(51):6360-6362.
  35. Yu Y, Feng C, Hong Y, Liu J, Chen S, Ng KM, Luo KQ*, Tang BZ* (2011). Cytophilic fluorescent bioprobes for long-term cell tracking. Advanced Materials, 23(29):3298-3302.
  36. Chin LK, Yu JQ, Fu Y, Yu T, Liu AQ, Luo KQ* (2011) Production of reactive oxygen species in endothelial cells under different pulsatile shear stresses and glucose concentrations. Lab on a Chip, 11(11):1856-1863.
  37. Lam KW, Xu JJ, Ng KM, Wibowo C, Lin G, Luo KQ (2010) Pharmaceutical salt formation guided by phase diagrams. Industrial & Engineering Chemistry Research, 49:12503-12512.
  38. Tian HL, Yu T, Xu NN, Feng C, Zhou LY, Luo HW, Chang DC, Le XF, Luo KQ* (2010) A novel compound modified from tanshinone inhibits tumor growth in vivo via activation of the intrinsic apoptotic pathway. Cancer Letters, 297(1):18-30.
  39. Han QB, Yu T, Lai F, Zhou Y, Feng C, Wang WN, Fu XH, Lau CB, Luo KQ, Xu HX, Sun HD, Fung KP, Leung PC (2010) Quick identification of apoptosis inducer from Isodon eriocalyx by a drug discovery platform composed of analytical high-speed counter-current chromatography and the fluorescence-based caspase-3 biosensor detection. Talanta, 82(4):1521-1527.
  40. Hong Y, Feng C, Yu Y, Liu J, Lam JW, Luo KQ, Tang BZ (2010) Quantitation, visualization, and monitoring of conformational transitions of human serum albumin by a tetraphenylethylene derivative with aggregation-induced emission characteristics. Analytical Chemistry, 82(16):7035-7043.
  41. Liu X, Yu T, Gao XM, Zhou Y, Qiao CF, Peng Y, Chen SL, Luo KQ*, Xu HX* (2010) Apoptotic effects of polyprenylated benzoylphloroglucinol derivatives from the twigs of Garcinia multiflora. Journal of Natural Products, 73(8):1355-1359.
  42. Gao XM, Yu T, Lai FS, Zhou Y, Liu X, Qiao CF, Song JZ, Chen SL, Luo KQ*, Xu HX* (2010) Identification and evaluation of apoptotic compounds from Garcinia paucinervis. Bioorganic & Medicinal Chemistry, 18(14):4957-4964.
  43. Dai W, Zheng YZ, Luo KQ, Wu H (2010) A prototypic microfluidic platform generating stepwise concentration gradients for real-time study of cell apoptosis. Biomicrofluidics, Vol:4, Issue:2, Article number:024101.
  44. Gao XM, Yu T, Lai FS, Pu JX, Qiao CF, Zhou Y, Liu X, Song JZ, Luo KQ*, Xu HX* (2010) Novel polyisoprenylated benzophenone derivatives from Garcinia paucinervis. Tetrahedron Letters, 51(18):2442-2446.
  45. Han QB, Zhou Y, Feng C, Xu G, Huang SX, Li SL, Qiao CF, Song JZ, Chang DC, Luo KQ*, Xu HX* (2009) Bioassay guided discovery of apoptosis inducers from gamboge by high-speed counter-current chromatography and high-pressure liquid chromatography/ electrospray ionization quadrupole time-of-flight mass spectrometry. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 877(4):401-40
  46. Huang SX, Feng C, Zhou Y, Xu G, Han QB, Qian CF, Chang DC, Luo KQ*, Xu HX* (2009) Bioassay-guided isolation of xanthones and polycyclic prenylated acylphloro glucinols from Garcinia oblongifolia. Journal of Natural Products, 72(1):130-135.
  47. Yu Y, Hong YN, Feng C, Liu J, Lam JWY, Faisal M, Ng KM, Luo KQ*, Tang BZ* (2009) Synthesis of an AIE-active fluorogen and its application in cell imaging. Science in China Series B: Chemistry, 52(1):15-19.
  48. Xu G, Feng C, Zhou Y, Han QB, Qian CF, Huang SX, Chang DC, Zhao QS, Luo KQ*, Xu HX* (2008) Bioassay and ultraperformance liquid chromatograph/mass spectrometry guided isolation of apoptosis-inducing benzophenones and xanthones from the pericarp of Garcinia yunnanensis Hu. Journal of Agricultural and Food Chemistry, 56(23):11144-11150.
  49. Zhou L, Chan WK, Xu N, Xiao K, Luo H, Luo KQ, Chang DC (2008) Tanshinone IIA, an isolated compound from Salvia miltiorrhiza Bunge, induces apoptosis in HeLa cells through mitotic arrest. Life Sciences, 83(11-12):394-403.
  50. Han QB, Yang NY, Tian HL, Qiao CF, Song JZ, Chang DC, Chen SL, Luo KQ*, Xu HX* (2008) Xanthones with growth inhibition against HeLa cells from Garcinia xipshuanbannaensis. Phytochemistry, 69(11):2187-2192.
  51. Zhang EJ, Ng KM, Luo KQ* (2008) Response to comment on extraction and purification of isoflavones from soybeans and characterization of their estrogenic activities. Journal of Agricultural and Food Chemistry, 56(9):3428-3430.
  52. Wei B, Cheng I, Luo KQ, Mi YL (2008) Capture and release of protein by a reversible DNA-induced sol-gel transition system. Angewandte Chemie-International Edition, 47(2):331-333.
  53. Han QB, Tian HL, Yang NY, Qiao CF, Song JZ, Chang DC, Luo KQ*, Xu HX* (2008) Polyprenylated xanthones from Garcinia lancilimba showing apoptotic effects against HeLa-C3 cells. Chemistry & Biodiversity, 5(12):2710-2717.
  54. Zhang EJ, Ng KM, Luo KQ* (2007) Extraction and purification of isoflavones from soybeans and characterization of their estrogenic activities. Journal of Agricultural and Food Chemistry, 55(17):6940-6950.
  55. Tian H, Ip L, Luo H, Chang DC, Luo KQ* (2007) A high throughput drug screen based on fluorescence resonance energy transfer (FRET) for anticancer activity of compounds from herbal medicine. British Journal of Pharmacology, 150(3):321-334.
  56. Harjo B, Wibowo C, Zhang EJ, Luo KQ, Ng KM (2007) Development of process alternatives for separation and purification of isoflavones. Industrial & Engineering Chemistry Research, 46(1):181-189.
  57. Zhou LL, Zhou LY, Luo KQ, Chang DC (2005) Smac/DIABLO and cytochrome c are released from mitochondria through a similar mechanism during UV-induced apoptosis. Apoptosis, 10(2):289-299.
  58. Luo KQ*, Chang DC (2004) The gene-silencing efficiency of siRNA is strongly dependent on the local structure of mRNA at the targeted region. Biochemical and Biophysical Research Communications, 318(1):303-310.
  59. Chang DC, Xu NH, Luo KQ (2003) Degradation of cyclin B is required for the onset of anaphase in mammalian cells. Journal of Biological Chemistry, 278(39):37865-37873.
  60. Luo KQ*, Elsasser S, Chang DC, Campbell JL (2003) Regulation of the localization and stability of Cdc6 in living yeast cells. Biochemical and Biophysical Research Communications, 306(4):851-859.
  61. Xu NH, Luo KQ, Chang DC (2003) Ca2+ signal blockers can inhibit M/A transition in mammalian cells by interfering with the spindle checkpoint. Biochemical and Biophysical Research Communications, 306(3):737-745.
  62. Luo KQ*, Yu VC, Pu YM, Chang DC (2003) Measuring dynamics of caspase-8 activation in a single living HeLa cell during TNF alpha-induced apoptosis. Biochemical and Biophysical Research Communications, 304(2):217-222.
  63. Pu YM, Luo KQ, Chang DC (2002) A Ca2+ signal is found upstream of cytochrome c release during apoptosis in HeLa cells. Biochemical and Biophysical Research Communications, 299(5):762-769.
  64. Gao WH, Pu YM, Luo KQ, Chang DC (2001) Temporal relationship between cytochrome c release and mitochondrial swelling during UV-induced apoptosis in living HeLa cells. Journal of Cell Science, 114(15):2855-2862.
  65. Luo KQ*, Yu VC, Pu YM, Chang DC (2001) Application of the fluorescence resonance energy transfer method for studying the dynamics of caspase-3 activation during UV-induced apoptosis in living HeLa cells. Biochemical and Biophysical Research Communications, 283(5):1054-1060.
  66. Luo Q*, Michaelis C, Weeks G (1995) Cyclin B and Cdc2 expression and Cdc2 kinase activity during Dictyostelium DNA and Cell Biology, 14(11):901-908.
  67. Michaelis C, Luo Q, Weeks G (1995) A Dictyostelium-discoideum gene, which is highly related to mo15 from Xenopus, is expressed during growth but not during development. Biochemistry and Cell Biology, 73(1-2):51-58.
  68. Luo Q*, Michaelis C, Weeks G (1994) Overexpression of a truncated cyclin B gene arrests Dictyostelium cell-division during mitosis. Journal of Cell Science, 107:3105-3114.
  69. Schlech WF, Luo Q, Faulkner G, Galsworthy S (1994) Interaction of Listeria species with human cell monolayers. Clinical and Investigative Medicine, 17(1):9-17.
  70. Bessesen MT, Luo Q, Rotbart HA, Blaser MJ, Ellison RT (1990) Detection of Listeria-monocytogenes by using the polymerase chain reaction. Applied and Environmental Microbiology, 56(9):2930-2932.
  71. Ellison RT, Luo Q, Reller LB (1990) Enhancement of the activity of cefotaxime by iron-binding proteins. Journal of Antimicrobial Chemotherapy, 25(3):479-481.


Book Chapters (2)

  1. Yu T, Gao XM, Xu HX, Luo KQ* (2011) Identification and evaluation of apoptotic compounds from Garcinia oligantha with caspase-3 FRET biosensor. Book Editors: Chua CK, Lee MY, Guan YL, Chen JP, Luo KQ, Lai CS, Kwoh CK, Lee JD, Chian KS, Wu SL (eds.) Proceedings of First International Symposium on Bioengineering (ISOB 2011). Research Publishing, Singapore. pp 56-63. Selected as the cover image of the book.
  2. Chang DC, Zhou LY, Luo KQ (2005) Using GFP and FRET technologies for studying signaling mechanisms of apoptosis in a single living cell. In: Shen X, VanWijk R (eds.) Biophotonics-Optical Science and Engineering for the 21st Century. Springer, New York. pp 25-38.