Full publications
  1. Chen S, Li F, Ding M, Wang D, Zhao Q, Wang Y, Zhou G, Wang Y, Andrographolide Derivative as STAT3 Inhibitor that Protects Acute Liver Damage in Mice. Bioorganic & Medicinal Chemistry. 2018. org/10.1016/j.bmc.2018.09.002
  2. Wu Y, Chen Z, Zhang P, Zhou L,  Jiang T,  Chen H,  Gong P,  Dimitrov DS,  CaiL, Zhao Q, Recombinant-fully-human-antibody decorated highly-stable far-red AIEdots for in vivo HER-2 receptor-targeted imaging. Chemical Communications. 2018. 54(53):7314-7317
  3. Li D, Yao G, Han B, Liu J, Su W, Wang P, Zhu Z, Dimitrov DS, Zhao Q, N-terminal α-amino group modification of antibodies using a site-selective click chemistry method. mAbs. 2018 10(5):712-719
  4. Liang T, Zhao Q, He S, Mu F, Deng W, Han B. Modeling Analysis of Potential Target of Dolastatin 16 by Computational Virtual Screening. Chemical and Pharmaceutical Bulletin. 2018. 6: 602-607.
  5. Hao D, Liu J, Chen M, Li J, Wang L, Wang G, Zhao Q, Di LJ,. Immunogenomic analyses of advanced serous ovarian cancer reveal immune score is a strong prognostic factor and an indicator of chemo-sensitivity. Clin Cancer Res. 2018 Apr 16. pii: clincanres.3862.2017. doi: 10.1158/1078-0432.CCR-17-3862. [Epub ahead of print]
  6. Chen Z, Liu J, Chu D, Ma G, Zhang H, Shan Y, Chen Q, Deng C, Chen W, Dimitrov DS, Zhao Q, A dual-specific IGF-I/II human engineered antibody domain inhibits IGF signaling in breast cancer cells. Int J Biol Sci 14(7):799-806
  7. Xie R, Zhang X, Zhao Q, Peng B, Zheng J. Analysis of global prevalence of antibiotic resistance in Acinetobacter baumannii infections disclosed a faster increase in OECD countries. Emerging Microbes & Infections 7:31 DOI 10.1038/s41426-018-0038-9.
  8. Li F, Li X, Sheng D, Chen S, Nie X, Liu Z, Wang D, Zhao Q, Wang Y, Wang Y, Zhou G. Discovery and preliminary SAR of 14-aryloxyandrographolide derivatives as antibacterial agents with immunosuppressant activity. RSC Adv. 2018, 8, 9440
  9. XuY,Li P, Nie J, Zhao Q, Guan S, Kuai , Qiao Y, Jiang X,  Li Y, Li W, Shi Y, Kong W, Shan Y, Humanization and directed evolution of the selenium-containing scFv phage abzyme. RSC Adv., 2018,8, 17218-17223
  10. Kuai Z, Xu Y, Zhao Q, Liu J, Guan S, Qiao Y, Gong X, Nie J, Li P, Liu D, Xing Y, Li H, Sun Z, Wang W, Ning C, Shi Y, Kong W, Shan Y. Effects of insulin on transcriptional response and permeability in an in vitro model of human blood-brain barrier. J Cell Biochem. 2018 Jan 31. doi: 10.1002/jcb.26744. [Epub ahead of print]
  11. Han B, Liang T, Keen LJ, Fan T, Zhang X, Xu L, Zhao Q, Wang S, Lin H, Two Marine Cyanobacterial Aplysiatoxin Polyketides, Neo-debromoaplysiatoxin A and B, with K+ Channel Inhibition Activity. Organic Letters. 2018 Feb 2;20(3):578-581.
  12. Xu T, Ying T, Wang L, Zhang X, Wang Y, Kang L, Huang T, Cheng L, Wang L, Zhao Q. A native-like bispecific antibody suppresses the inflammatory cytokine response by simultaneously neutralizing tumor necrosis factor-alpha and interleukin-17A. Oncotarget. 2017.8 (47), 81860-81872
  13. Chen C, Jin Y, Lo I, Zhao H, Sun B, Zhao Q, Zhang XDComplexity Change in Cardiovascular Diseases. International Journal of Biological Sciences. 2017.13: 1320-1328
  14. Chu D, Dong X, Zhao Q, Gu J, Wang ZPhotosensitization priming of tumor microenvironments improves delivery of nanotherapeutics via neutrophil infiltration. Advanced Materials. 2017. May 15. doi: 10.1002/adma.201701021. [Epub ahead of print]
  15. Li D, Gong R, Zheng J, Chen X, Dimitrov D, Zhao Q, Engineered antibody CH2 domains binding to nucleolin: Isolation, characterization and improvement of aggregation. Biochemical and Biophysical Research Communications. 2017 (17): 30328-5.
  16. Chen Z, Wang L, Xu T, Wang Q, Kang L, Zhao Q. Generation of bispecific antibodies by Fc heterodimerization and their application. Current Pharmaceutical Biotechnology. 2016.17:1324-1332.
  17. Chu D, Zhao Q, Yu J, Zhang F, Zhang H, Wang J. Nanoparticle Targeting of Neutrophils for Improved Cancer Immunotherapy. Advanced Healthcare Materials, 2016.5(9):1088-93.
  18. Li D, Liu J, Zhang L, Xu T, Chen J, Wang L, Zhao Q. N terminal residues of an HIV-1 gp41 membrane-proximal external region antigen might hinder to direct neutralizing 2F5-like antibodies. Virologica Sinica, 2015.30: 449-456
  19. Ahmed M, Cheng M, Zhao Q, Guo H, Cheal S, Larson S, Cheung N. Humanized affinity-matured monoclonal antibody 8H9 has potent anti-tumor activity and binds to FG loop of B7-H3. Journal of Biological Chemistry, 2015.290 (50):30018-29.
  20. Zhang L, Chen J, Zhao Q. (2015) Regulatory Roles of Alu Transcript on Gene Expression Regulation. Experimental Cell Research.  2015.338(1):113-8.
  21. Zhao Q, Ahmed M, Guo H, Cheung IY, Cheung NK. Alteration of electrostatic surface potential enhances affinity and tumor killing properties of anti-GD2 monoclonal antibody hu3F8. Journal of Biological Chemistry. 2015.290:13017-13027
  22. Zhao Q, Ahmed M, Tassev DV,Hasan A, Kuo T, Guo H, O’Reilly RJ, Cheung NK. Affinity maturation of T-cell receptor-like antibodies for Wilms tumor 1 peptide greatly enhances therapeutic potential. Leukemia. 2015.29(11):2238-2247
  23. Zhao Q, Tran H, Dimitrov DS, Cheung NK. (2015) A dual specific anti-IGF-1/IGF-2 human monoclonal antibody alone and in combination with temsirolimus for therapy of neuroblastoma. International Journal of Cancer. 2015.137:2243-2252
  24. Leung SO, Gao K, Wang GY, Cheung BK, Lee KY, Zhao Q, Cheung WT, Wang JZ. Surrogate target cells expressing surface anti-idiotype antibody for the clinical evaluation of an internalizing CD22-specific antibody. mAbs. 2015.7(1):66-76
  25. Feng Y, Zhao Q, Chen W, Wang Y, Crowder K, Dimitrov DS, A new bispecific antibody targeting non-overlapping epitopes on IGF2: Design, in vitro characterization and pharmacokinetics in macaques. Experimental and Molecular Pathology97: 359-67
  26. Zhao Q, Wong PF, Lee ST, Cheung WT, Leung RO, Wang JZ, Generation of anti-idiotype scFv for pharmacokinetic measurement in lymphoma patients treated with chimera anti-CD22 antibody SM03, PLOS One. 2014.9(5): e96697
  27. Zhang R, Zhang CY, Zhao Q, Li DH, Spectrin: Structure, function and disease, SCIENCE CHINA-Life Sciences12: 1076–1085
  28. Zhao Q., Zhu Z., Dimitrov D. Yeast display of engineered antibody domain. Methods in Molecular Biology, 2012.899: 73-84
  29. Chen W, Feng Y, Zhao Q, Zhu Z, Dimitrov D. Human monoclonal antibodies targeting nonoverlapping epitopes on insulin-like growth factor II as a novel type of candidate cancer therapeutics. Molecular Cancer Therapeutics11 (7): 1400-10
  30. Zhao Q., Feng Y., Zhu Z., Dimitrov D. Human monoclonal antibodies to IGF1/2 with picomolar affinity. Molecular Cancer Therapeutics, 2011.10(9); 1677-85
  31. Cheng M., Chan S., Zhao Q., Chan E., Au S., Lee S., Cheung W.T., Construction and Characterization of Single-chain Variable Fragment Antibody Library Derived from Germline Rearranged Immunoglobulin Variable Genes. PLOS One 6(11): e27406
  32. Chen W., Feng Y., Zhu Z., Zhao Q., Dimitrov D. Engineered single human CD4 domains as potent HIV-1 inhibitors and components of vaccine immunogens. Journal of Virology, 2011.85 (18): 9395-405
  33. Gong R., Wang Y., Feng Y., Zhao Q., Dimitrov D. Shortened Engineered Human Antibody CH2 Domains: Increased Stability and Binding to the Human Neonatal Receptor. Journal of Biological Chemistry, 2011.286(31): 27288-93
  34. Zhu Z., Qin H., Chen W., Zhao Q., et al. Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies. Journal of Virology,85(21)11401-8
  35. Zhao Q., Chan Y.W., Lee S.S., Cheung W.T. One-step expression and purification of single-chain variable antibody fragment using an improved hexahistidine tag phagemid vector. Protein Expression and Purification,68(2):190-5.
  36. Cheng M., Chan C.W., Cheung R.C., Bikkavilli R.K., Zhao Q., Au S.W., Chan P.K., Lee S.S., Cheng G., Ho W.K. and Cheung W.T.. Cross-reactivity of antibody against SARS-coronavirus nucleocapsid protein with IL-11. Biochemical and Biophysical Research Communications338: 1654-60.
  37. Liu J., Zhao Q., Zhao B., Cheng J., Wang X., Song L., Zhang Z., Lin Q. and Huang H. A new format of single chain tri-specific antibody with diminished molecular size efficiently induces ovarian tumor cell killing. Biotechnology Letters 27: 1821-7.
  38. Wang X.B., Zhao B.F., Zhao Q., Piao J.H., Liu J., Lin Q. and Huang H.L. A new recombinant single chain trispecific antibody recruits T lymphocytes to kill CEA (carcinoma embryonic antigen) positive tumor cells in vitro efficiently. Journal of Biochemistry135: 555-65.
  39. Liu J, Wan X, Lv W, Li J, Zhao Q. (2015) Research Progress of microRNA in Revention and Treatment of Non-small Cell Lung Cancer. Progress in Modern Biomedicine. 10: 1966-70, Chinese
  40. Tian Y, Chen F, Liu J, Zou J, Wan X, Zhao Q, (2015) The Progression of Neuroblastoma Treatment with Immunotherapy, Progress in Modern Biomedicine, 10: 1973-04, Chinese
  41. Liu J, Chen J, Xu T, Wang L, Zhao Q. (2014) Construction of a large human Fab phage display antibodies library and screening of phage antibodies against CD276. Chinese Medicinal Biotechnology. 4:273-77, Chinese