Full publications
  1. Li, E., Zhang, Z., Jiang, B., Yan, L., Park, J.W., and Xu, R.-H. Generation of mesenchymal stem cells from human embryonic stem cells in a complete serum-free condition. Int’ J. Biol. Sci. In press.
  2. Yang, J., Park, J.W., Zheng, D., and Xu, R.-H. Universal corneal epithelial-like cells derived from human embryonic stem cells for cellularization of a corneal scaffold. Vision Sci. & Technol. In press.
  3. Yan, L., Jiang, B., Niu, Y., Wang, H., Li, E., Yan, Y., Sun, H., Duan, Y., Chang, S., Chen, G., Ji, W., Xu, R.-H.*, and Si, W.* Intrathecal delivery of human ESC-derived mesenchymal stem cell spheres promotes recovery of a primate multiple sclerosis model. Cell Death & Disc. 5(28):1-14, 2018. *Co-corresponding author
  4. Yan, L., Zheng, D., and Xu, R.-H. Critical role of tumor necrosis factor signaling in mesenchymal stem cell-based therapy for autoimmune and inflammatory diseases. Frontiers Immunol. 9:1-13, 2018.
  5. Wang, H., Pardeshi, L.A., Rong, X., Li, E., Wong, K.H., Peng, Y., and Xu, R.-H. Novel variants identified in multiple sclerosis patients from southern China. Frontiers Neurol. 9:1-6, 2018.
  6. Yan, L., Jiang, B., Li, E., Wang, X., Ling, Q., Zheng, D., Park, J.W., Chen, X., Cheung, E., Du, X., Li, Y., Cheng, G., He, E., and Xu, R.-H. Scalable generation of mesenchymal stem cells from human embryonic stem cells in 3D. Int’ J. Biol. Sci. 14(10):1196-1210, 2018.
  7. Park, J.W., Yang, J., and Xu, R.-H. PAX6 alternative splicing and corneal development. Stem Cells & 27(6):367-377, 2018.
  8. Kurtz, A., Seltmann, S., Bairoch, A., … and Xu, R.-H. A standard nomenclature for referencing and authentication of pluripotent stem Cells. Stem Cell Reports. 10(1):1-6, 2018.
  9. Fu, X., Jiang, B., Zheng, B., Yan, Y., Wang, J., Duan, Y., Li, S., Yan, L., Wang, H., Chen, B., Sang, X., Ji, W., Xu, R.-H., Si, W. Heterogenic transplantation of bone marrow-derived rhesus macaque mesenchymal stem cells ameliorates liver fibrosis induced by carbon tetrachloride in mouse. PeerJ 6:e4336:1-23, 2018.
  10. Liao, H., Wang, H., Rong, X., Li, E., Xu, R.-H., and Peng, Y. Mesenchymal stem cells attenuate radiation-induced brain injury by inhibiting microglia pyroptosis. BioMed Res. Int’l, 2017:1948985:1-9, 2017.
  11. Jiang, B., Yan, L., Miao, Z., Li, E., Wong, K.H., and Xu, R.-H.. Spheroidal formation preserves human stem cells for prolonged time under ambient conditions for facile storage and transportation. Biomaterials 133:275-86, 2017.
  12. Park, J.W., Yan, L., Stoddard, C.E., Wang, X., Yue, Z., Crandall, L., Robinson, T., Chang, Y.-X., Denton, K., Li, E.-Q., Jiang, B., Zhang, Z., Martins-Taylor, K., Yee, S.-P., Nie, H., Gu, F., Si, W., Xie, T., Yue, L., and Xu, R.-H. Recapitulating and correcting Marfan syndrome in a cellular model. Int’l J. Biol. Sci. 13(5):588-603, 2017.
  13. Fu, W.-J., Lei, T., Yin, Z., Pan, J.H., Chai, Y.S., Xu, X.-Y., Yan, Y.-X., Wang, Z.-H., Ke, J., Wu, G., Xu, R.-H., Paranjpe, M., Qu, L., Nie, H. Anti-atherosclerosis and Cardio-protective Effects of the Angong Niuhuang Pill on a High Fat and Vitamin D3 Induced Rodent Model of Atherosclerosis. Ethnopharmacol. 195:118-126, 2017.
  14. Ge, X., Xi, H., Yang, F., Zhi, X., Fu, Y., Chen, D., Xu, R.-H., Lin, G., Qu, J., Zhao, J., and Gu, F. CRISPR/Cas9-AAV mediated knock-in at NRL locus in human embryonic stem cells. Therapy Nucleic Acids, Nov. 29, 2016.
  15. Zheng, D., Wang, X., and Xu, R.-H. One stone for multiple birds: generating universally compatible human embryonic stem cells. Stem Cells. 34(9):2269-75, Sept. 2016.
  16. Wang, X., Lazorchak, A.S., Song, L., Li, E., Jiang, B., Zhang, Z., and Xu, R.-H. Immune modulatory mesenchymal stem cells derived from human embryonic stem cells through a trophoblast-like stage. Stem Cells 34(2):380-91, 2016.
  17. Drissi, H., Gibson, J.D., Guzzo, R.M., Xu, R.-H. Derivation and Chondrogenic Commitment of Human Embryonic Stem Cell-Derived Mesenchymal Progenitors. Methods Mol. Biol. 1340:65-78, 2015. Published by Springer.
  18. Jha, R., Xu, R.-H., and C. Xu. Efficient differentiation of cardiomyocytes from human pluripotent stem cells with growth factors. Methods Mol. Biol. 1299:115-31, 2015. Published by Springer.
  19. Wang, X., Kimbrel, E.A., Ijichi, K. Paul, D., Lazorchak, A.S., Chu, J., Kouris, N.A., Yavanian, G., Lu, S.-J., Pachter, J.S., Crocker, S.J., Lanza, R., and Xu, R.-H. Human ES cell-derived MSC outperform bone marrow MSC in the treatment of an EAE model of multiple sclerosis. Stem Cell Reports 3(1):115-30, 2014.
  20. Guzzo, R.M., Scanlon, V., Sanjay, A., Xu, R.-H., Drissi H. Establishment of human cell type-specific iPS cells with enhanced chondrogenic potential. Stem Cell Rev. & Rep. 10:820-9, 2014.
  21. Wang, J., Park, J.W., Drissi, H., Wang, X., and Xu, R.-H. Epigenetic regulation of miR-302 by JMJD1C inhibits neural differentiation of human embryonic stem cells. Biol. Chem. 289(4):2384-95, 2014.
  22. Guzzo, R.M., Gibson, J., Xu, R.-H., Lee, F.Y., and Drissi, H. Efficient differentiation of human iPSC-derived mesenchymal stem cells to chondroprogenitor cells. Cell. Biochem. 114(2):480-90, 2013.
  23. Martins-Taylor, K., Wang, X. Li, X.-J., and Xu, R.-H. Stem cells and tissue regeneration in Regenerative Engineering Ed: Laurencin, C. and Khan, Y. Published by CRC Press/Taylor & Francis Group, LLC.
  24. Kim, C., Park, J., Amano, T., Xu, R.-H., Lin, G., Carter, M.G., and Tian, X.-C. Established preblastocyst- and blastocyst-derived ES cell lines have highly similar gene expression profiles, despite their differing requirements for derivation culture conditions. Cell Reprogram. 14(1):1-7, 2012.
  25. Martins-Taylor, K. Schroeder, D.I., LaSalle, J.M., Lalande, M., and Xu, R.-H. Role of DNMT3B in the regulation of early neural and neural crest specifiers. Epigenetics 7(1):71-82, 2012.
  26. Fei, Y., Xu, R.-H., Hurley, M.M. Stem cell-based bone repair (review). J. Stem Cells.  1(2):106-113, 2012.
  27. Martins-Taylor, K. and Xu, R.-H. Genomic stability of human induced pluripotent stem cells (invited review). Stem Cells 30(1):22-7, 2012.
  28. Luong, M.X., Auerbach, J., Crook, J.M., Daheron, , Hei, D., Lomax, J., Loring, J.F., Ludwig, T., Rooke, H.M., Schlaeger, T.M., Smith, K.P., Stacey, G., Xu, R.-H., and Zeng, F. A call for standardized naming and reporting of human ES and iPS cell lines. Cell Stem Cell 8(4):357-9, 2011.
  29. Martins-Taylor, K., Nisler, B.S., Taapken, S.M., Compton, T., Crandall, L., Montgomery, K.D., Lalande, M., and Xu, R.-H. Recurrent copy number variations in human induced pluripotent stem cells. Biotechnol. 29(6):488-91, 2011.
  30. Zeng, H., Guo, M., Martins-Taylor K., Wang, X., Zhang, Z., Park, J.W., Zhan, S., Kronenberg, M.S., Lichtler, A., Liu, H.-X., Chen, F.-P., Yue, L., Li, X.-J., and Xu, R.-H. Specification of region-specific neurons including forebrain glutamatergic neurons from human induced pluripotent stem cells. PLoS ONE 5(7):e11853, 2010.
  31. Lin, G. and Xu, R.-H. Progresses and challenges in optimization of human pluripotent stem cell culture (invited review). Current Stem Cell Res. & Therapy 5(3):207-14, 2010.
  32. Martins-Taylor, K. and Xu, R.-H. Determinants of pluripotency: from avian, rodents to primates (invited review). Cell. Biochem. 109(1):16-25, 2010.
  33. Lin, G., Martins-Taylor, K. and Xu, R.-H. Human embryonic stem cell derivation, maintenance, and differentiation to trophoblast (book chapter). Methods Mol. Biol. 636:1-24, 2010. Published by Springer.
  34. 徐仁和, 王瑊玏: 奇妙无穷的全能干细胞。海外学人 2:9-13, 2010.
  35. Wang, X., Lin, G., Martins-Taylor, K., Zeng, H., and Xu, R.-H. Inhibition of caspase-mediated anoikis is critical for bFGF-sustained culture of human pluripotent stem cells. Biol. Chem. 284(49):34054-64, 2009.
  36. Li, Y., Zeng, H., Xu, R.-H., Liu, B., and Li, Z. Vaccination with human pluripotent stem cells generates a broad spectrum of immunological and clinical response against colon cancer. Stem Cells 27(12):3103-11, 2009.
  37. Zeng, H., Park, J.W., Guo, M., Lin, G., Crandall, L., Compton, T., Wang, X., Li, X.-J., Chen, F.-P., and Xu, R.-H. Lack of ABCG2 expression and side population properties in human pluripotent stem cells. Stem Cells 27(10):2435-45, 2009.
  38. Xie, C.-Q., Jeong, Y., Fu, M. Bookout, A.L., Garcia-Barrio, M.T., Sun, T., Kim, B.-h., Xie, Y., Root, S., Zhang, J., Xu, R.-H., Chen, Y.E., and Mangelsdorf, D.J. Expression profiling of nuclear receptors in human and mouse embryonic stem cell Mol. Endocrinol. 23(5):724-33, 2009.
  39. Zhou, J., Xu, R.-H., and Wang Y. Nanoporous membrane-encapsulated feeder cells for culture of human embryonic stem cells. Int’l J. Functional Informatics & Personalized Med. 2(1):77-88, 2009.
  40. Wang, S., Shen, Y., Yuan, X., Chen, K., Guo, X., Chen, Y., Niu, Y., Li, J., Xu, R.-H., Yan X., and Ji, W. Dissecting signaling pathways that govern self-renewal of rabbit embryonic stem cells. Biol. Chem. 283(51):35929-40, 2008.
  41. Xu, -H., Sampsell-Barron, T.L., Gu, F., Root, S., Peck, R.M., Pan, G., Yu, J., Antosiewicz-Bourget, J., Tian, S., Stewart, and Thomson, J.A. NANOG is a direct target of TGF-beta/Activin mediated SMAD signaling in human ES cells. Cell Stem Cell 3(2):196-206, 2008.
  42. Shen, Y., Matsuno, Y., Fouse, S.D., Rao, N., Root, S., Xu, R.-H., Pellegrini, M., Riggs, A.D., and Fan, G. X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alternations. Natl. Acad. Sci. U.S.A. 105(12):4709-14, 2008.
  43. Peng, Y., Yang, P.-H., Tanner, J.A., Huang, J.-D., Li, M., Lee, H.F., Xu, R.-H., Kung, H.-F., and Lin, M.C. Cold-Inducible RNA Binding Protein is Required for the Expression of Adhesion Molecules and Embryonic Cell Movement in Xenopus Biochem. Biophys. Res. Commun. 344(1):416-24, 2006.
  44. Levenstein, M.E., Ludwig, T.E., Xu, R.-H., Llanas, R.A., VanDenHeuvel-Kramer, K., Manning, D., and Thomson, J.A. Basic FGF support of human embryonic stem cell self-renewal. Stem Cells 24(3):568-74, 2006.
  45. Xu, R.-H. In vitro induction of trophoblast from human embryonic stem cells. Methods Mol. Med. 121:189-202, 2006. Published by Springer
  46. Xu, -H., Peck, R.M., Li, D.S., Feng, X., Ludwig, T., and Thomson, J.A. Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells. Nat. Methods 2(3):185-190, 2005.
  47. Golos, T. and Xu, R.-H. Trophoblast differentiation from embryonic stem cells. In Ordorico, J., Pedersen, R., and Zhang, S.-C. ed. Human embryonic stem cells. pp101-120, 2005. Published by BIOS Scientific Publishers Ltd., Oxford, U.K.
  48. Xu, R.-H., Chen, X., Li, D.S., Li, R., Addicks, G.C., Glennon, C., Zwaka, T.P., and Thomson, J.A. BMP4 initiates human embryonic stem cell differentiation to trophoblast.  Biotechnol. 20(12):1261-4, 2002.
  49. Peng, Y., Xu, R.-H., Mei, J.M., Li, X.-P., Yan, D.-H., Kung, H.-f., and Phang, J.M. Neural inhibition by c-Jun as a synergizing factor in BMP-4 signaling.  109(4):657-64, 2002.
  50. Kim J., Lee, H.-S., Roh, D.-H., Hwang, Y.-S., Xu, R.-H., Kung, H.-f., Bae, Y.-C., and Mae-Ja Park. Transcriptional regulation of the Xbr-1a/Xvent-2 gene by BMP-4 signaling during Xenopus embryonic development.  Biophys. Res. Commun. 298(5):815-23, 2002.
  51. Peng, Y., Kok, K.H., Xu, R.-H., Kwok, K.H.H., Fung, P.C.W., Kung, H.-f., and Lin, M.C.M. Maternal cold inducible RNA binding protein is required for Xenopus laevis embryonic kidney formation.  FEBS Letter 24130:1-7, 2000.
  52. Xu, R.-H., Peng, Y., Fan, J., Yan, D.-H., Yamagoe, S., Princler, G., Sredni, D., Ozato, K., and Kung, H.-f. Histone acetylation is a checkpoint in FGF-stimulated mesoderm induction.  Dyn. 218:628-635, 2000.
  53. Liu, W., Ren, C., Shi, J., Feng, X., He, Z., Xu, L., Lan, K., Xie, L., Peng, Y., Fan, J., Kung, H.-f., Yao, K.-T., and Xu, R.-H. Characterization of the functionally related sites in the neural inducing gene noggin. Biophys. Res. Commun. 270:293-297, 2000.
  54. Xu, R.-H., Lechleider, R.J., Shih, H.-M., Hao, C.-F., Sredni, D., Roberts, A.B., and Kung, H.-f. Functional analysis of human Smad1: role of the amino-terminal domain. Biophys. Res. Commun. 258:366-373, 1999.
  55. Xu, R.-H., Ault, K.T., Kim, J., Park, M.-J., Hwang, Y.-S., Peng, Y., Sredni, D., and Kung, H.-f. Opposite effects of FGF and BMP-4 on embryonic blood formation: roles of 1 and GATA-2Dev. Biol. 208:352-361, 1999.
  56. Kim, J., Ault, K.T., Chen, H.-D., Xu, R.-H., Roh, D.-H., Lin, M.C., Park, M.-J., and Kung, H.-f. Transcriptional regulation of BMP-4 in the Xenopus embryo; analysis of genomic BMP-4 and its promoter.  Biophys. Res. Commun. 250:516-530, 1998.
  57. Rosenblatt-Bin, H., Kalechman, Y., Vonsover, A., Xu, R.-H., Da, J.-P., Shalit, F., Huberman, M., Klein, A., Strassmann, G., Albeck, M., and Sredni, B. The immunomodulator AS101 restores T(H1) type of response suppressed by Babesia rodhaini in BALB/c mice. Cell Immunol. 184:12-25, 1998.
  58. Kamata, T., Daar, I.O., Subleski, M., Copeland, T., Kung, H.-f., and Xu, R.-H. Xenopus CRMP-2 is an early response gene to neural induction. Brain Res. 57:201-210, 1998.
  59. Jones, T., Chong, L.D., Kim, J., Xu, R.-H., Kung, H.-f., and Daar, I.O. Loss of cell adhesion in Xenopus laevis embryos mediated by the cytoplasmic domain of Xlerk, an erythropoietic producing hepatocellular ligand.   Natl. Acad. Sci. U.S.A. 95:576-581, 1998.
  60. Kim, J., Lin, J-J., Xu, R-H., and Kung, H-F. Mesoderm induction by Heterodimer AP-1 (c-Jun and c-Fos) and its involvement in mesoderm formation through Xbra/eFGF autocatalytic loop during the early development of Xenopus  J. Biol. Chem. 273:1542-1550, 1997.
  61. Ault, K.T., Xu, R.-H., Kung, H.-F., and Jamrich, M. The homeobox gene 1 mediates specification of the prospective neural ectoderm in Xenopus embryos.  Dev. Biol. 192:162-171, 1997.
  62. Xu, R-H., Kim, J., Taira, M., Sredni, M. and Kung, H-f. Studies on the role of fibroblast growth factor signaling in neurogenesis using conjugated/aged animal caps and dorsal ectoderm-grafted embryos.  Neurosci. 17:6892-6898, 1997.
  63. Xu, R.-H., Kim, J., Taira, M., Lin, J.-J., Zhang, C.-h., Sredni, D., Evans, T., and Kung, H.-f.: Differential regulation of neurogenesis by the two Xenopus GATA-1  Mol. Cell. Biol. 17:436-443, 1997.
  64. Maeno, M., Mead, P.E., Kelly, C., Xu, R.-H., Kung, H.-f., Suzuki, A., Ueno, N., and Zon, L.I.: The role of BMP-4 and GATA-2 in the induction and differentiation of hematopoietic mesoderm in Xenopus Blood 88:1965-1972, 1996.
  65. Xu, R.-H., Kalechman, Y., Albeck, M., Kung, H.-f., and Sredni, B.: Inhibition of B16 melanoma metastasis by the immunomodulator AS101. J. Oncol. 9:319-325, 1996.
  66. Dong, Z., Xu, R.-H., Kim, J., Zhan, S., Ma, W., Colburn, N.H., and Kung, H.-f.: AP-l/Jun is required for early Xenopus development and mediates the mesoderm induction by FGF but not by activin. Biol. Chem. 271:9942-9946, 1996.
  67. Sredni, B., Xu, R.-H., Albeck, M., Gafter, U., Gal, R., Shani, A., Tichler, T., Shapira, J., Bruderman, I., Catane, R., Kaufman, B., Whisnanty, J.K., Mettinger, K.L., and Kalechman, Y.: The protective role of the immunomodulator AS101 against chemotherapy-induced alopecia. Studies on human and animal models. J. Cancer 65:97-103, 1996.
  68. Xu, R.-H., Dong, Z., Maeno, M., Kim, J., Suzuki, A., Ueno, N., Sredni, B., Colburn, N.H., and Kung, H.-f.: Involvement of Ras/Raf/AP-1 in BMP-4 signaling during Xenopus embryonic development. Natl. Acad. Sci. U.S.A. 93:834-838, 1996.
  69. Xu, R.-H., Kim, J., Taira, M., Zhan, S., Sredni, D., and Kung, H.-f.: A dominant negative bone morphogenetic protein 4 receptor causes neuralization in Xenopus  Biochem. Biophys. Res. Commun. 212:212-219, 1995.
  70. Xu, R.-H., Kalechman, Y., Albeck, M. and Sredni, B.: The cyto­protective effect of the immunomodulator AS101 against hydrochloride induced gastric lesions. Commun.  Mol. Pathol. Pharmacol. 87:4-20, 1995.