Contact Information    
Address(Office)E12-4009Lijun DI
(Lab)N22-4011
Phone(Office)8822 4497
(Lab)8822 4291
Fax8822 2314
Emaillijundi@um.edu.mo

Di lab 2015 NovDr. Lijun Di’s group is actively looking for both PhD students and research staff. For any enquiry, please address to lijundi@um.edu.mo

Education
PhD.Biochemistry and molecular biology, Peking Union Medical College, Tsinghua University, Beijing, China (2006)
MasterGenetics, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China (2003)
BachelorBiology, School of life sciences, University of Inner Mongolia, Huhehaote, China (2000)
Positions
2018-presentAssociate Professor, Faculty of Health Sciences, University of Macau
2013-2018Assistant Professor, Faculty of Health Sciences, University of Macau
2007-2012Visiting Fellow and Research Fellow, National Cancer Institute, National Institutes of Health, USA
2006-2007Postdoc Fellow, Biochemistry Department, University of Texas, Health Science Center at San Antonio, USA
Research Interests
My research interest mainly focus on the mechanisms of transcriptional regulation of gene expression and gene expression regulatory network. I am also interested in understanding the mechanisms of human diseases such as cancer by exploring the aberrant gene expression associated with these diseases. For instance, the current on-going projects focus on transcriptional factors such as BRCA1 and CtBP by illustrating their important role in alteration cell metabolism which may associates with cancer development. The research strategy relies on both high throughput screening technologies such as NGS, gene expression microarray etc and individual gene study. The conclusion from cell based studies will be validated in other relevant model system such engineered mouse models.
Representative Publications
 

  1. Peipei Li, Yuan Meng, Li Wang, Li-jun Di, BioID: a proximity-dependent labeling approach in proteomics study, Methods Mol Biol. 2019;1871:143-151
  2. Zhiqiang Zhao, Dapeng Hao, Li Wang, Jingjing Li, Yuan Meng, Peipei Li, Yuan Wang, Chao Zhang, Haisheng Zhou, Kevin Gardner, Li-jun Di, CtBP promotes metastasis of breast cancer through repressing cholesterol and activating TGF-b signaling, Oncogene. 2018 Nov 15. doi: 10.1038/s41388-018-0570-z. [Epub ahead of print]
  3. Li Wang, Yuan Wang, Chao Zhang, Jingjing Li, Yuan Meng, Man Dou, Constance T, Noguchi, Li-jun Di, Inhibiting Glycogen Synthase Kinase 3 Reverses Obesity-Induced White Adipose Tissue Inflammation by Regulating Apoptosis Inhibitor of Macrophage/CD5L-Mediated Macrophage Migration. Arteriosclerosis, Thrombosis, and Vascular Biology 2018 Sep;38(9):2103-2116
  4. Dapeng Hao, Jie Liu, Meng Chen, JingJing Li, Li Wang, Xiaobo Li, Qi Zhao, Li-jun Di, Immunogenomic analyses of advanced serous ovarian cancer reveal immunoscore is a strong prognostic factor and a predictor of chemo-sensitivity. Clinical Cancer Research 2018 Aug 1;24(15):3560-3571
  5. Li Wang, Yuan Wang, Yuan Meng, Chao Zhang, Li-jun Di, GSK3 activated STAT5 regulates expression of SFRPs to modulate adipogenesis. FASEB J 2018 Sep;32(9):4714-4726
  6. Li Wang, Jing-jing Li, Li-yu Guo, Peipei Li, Zhiqiang Zhao, Haisheng Zhou, Li-jun Di, Molecular link between glucose and glutamine consumption in cancer cells mediated by CtBP and SIRT4., Oncogenesis 2018 Mar 13;7(3):26
  7. Dapeng Hao, Jingjing Li, Shanshan Jia, Yuan Meng, Chao Zhang, Li Wang, Lijun Di†, Integrated analysis reveals tubal and ovarian originated serous ovarian cancer and predicts differential therapeutic responses, Clinical Cancer Research, 2017 Dec 1;23(23):7400-7411.
  8. Li J, Hao D, Wang L, Wang H, Wang Y, Zhao Z, Li P, Deng C, Di LJ†. Epigenetic targeting drugs potentiate chemotherapeutic effects in solid tumor therapy. Sci Rep. 2017 Jun 22;7(1):4035
  9. Li P, Li J, Wang L, Di, Lijun†, Proximity labeling of interacting proteins: Application of BioID as a discovery tool. Proteomics, 2017 Oct;17(20)
  10. Hao Dapeng, Wang Li, Di Lijun†, Distinct mutation accumulation rates among tissues determine the variation in cancer risk, Scientific Report, 2016, Jan 20;6:19458
  11. Wang L, Di LJ†. Wnt/β-catenin mediates AICAR effect in increasing GATA3 expression and inhibiting adipogenesis. J Biol Chem. 2015 Aug 7;290(32):19458-68.
  12. Wang L., Zhou HS., Wang YT., Cui GZ., Di, L.J. †, CtBP maintains cancer cell growth and metabolic homeostasis via regulating SIRT4. Cell Death Diseases. 2015 Jan 29;6:e1620,
  13. Wang L., Di, L.J.†, BRCA1 And Estrogen/Estrogen Receptor In Breast Cancer: Where They Interact? Int J Biol Sci. 2014 14;10(5):566-75,
  14. Wang L, Di L.J. †, Noguchi CT. Erythropoietin, a novel versatile player regulating energy metabolism beyond the erythroid system. Int J Biol Sci. 2014 Aug 23;10(8):921-39.
  15. Wang L, Di L.j.(Co-first), Noguchi CT. AMPK is involved in mediation of erythropoietin influence on metabolic activity and reactive oxygen species production in white adipocytes. Int J Biochem Cell Biol. 2014 Sep;54:1-9,
  16. Wang L, Teng R, Di L.j., Rogers H, Wu H, Kopp JB, Noguchi CT. PPARα and Sirt1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders. Diabetes. 2013 Dec;62(12):4122-31.
  17. Di, LJ., Byun, J., Wong, M., Wakano, C., Hunter, K., Olopade, OI., Perou, C., Evan, M., Chou, JW., Gardner, K., CtBP integrates genome scale targeting of genome stability, EMT pathways and stem cell fate in breast cancer( Commun, 2013 4:1449).
  18. Wakano, C., Byun, J., Di, LJ., Gardner, K., The Dual Lives of Bidirectional Promoters. BBA-Gene Regulatory Mechanism 2012 Jul;1819(7):688-93,
  19. Di, LJ., Fernandez, A., De Siervi A., Longo DL, Gardner K., Regulation of BRCA1 transcription by a metabolic switch. Struct. Mol. Biol. 2010 Dec;17(12):1406-13,
  20. De Siervi A, De Luca P, Byun JS, Di LJ, Fufa T, Haggerty CM, Vazquez E, Moiola C, Longo DL, Gardner K., Transcriptional autoregulation by BRCA1. Cancer Res. 2009 70:532-42,
  21. Di, LJ., Wang, L., Lv X., Zheng W., Xue Z., Guo Zhi-Chen., Liu, DP & Liang, CC., Inter-MARs’ association mediated by SATB1 contributes to active transcriptional looping events in human -globin gene cluster. (PLoS ONE.4(2):e4629. 2009,
  22. Di, LJ., Wang, L., Zhou, GL., Wu, XS., Guo, ZC., Ke, XS., Liu, DP & Liang, CC., Identification of long range regulatory elements of mouse alpha-globin gene cluster by quantitative associated chromatin trap (QACT). Cell. Biochem. 105:301-312. 2008,
  23. Zhou, GL., Xin, L., Song, W., Di, LJ., Liu, G., Wu, XS., Liu, DP & Liang, CC., Active chromatin hub of the mouse alpha-globin locus forms in a transcription factory of clustered housekeeping genes. Mol Cell Biol  26:5096-5105, 2006.

 

Awards
2010Top10 scientific proceedings in Center of Cancer Research, NCI2010 Fellows Award for Research Excellence (FARE), NIH
Professional Activities
Associated Membership of AACR 2009-Journal Reviewer
(Tumor Biology,Cell Biology International,Chinese Journal of Cancer Research,International Journal of Biological Sciences)