Contact Information
Address (Office) E12-4024
Phone (Office) 8822 4498
Fax 8822 2314
Email liwang@umac.mo
Education
Ph.D Peking Union Medical College, Beijing, China
Positions 
2013-present Senior instructor; Director of Metabolomics core, Faculty of Health Sciences, University of Macau
2008-2013 Research Fellow, National Institutes of Health, U.S.A
Research Interests
  • Adipocyte and muscle Metabolism
  • Obesity; Diabetes
  • Metabolism syndrome
Representative Publications
  1. Wang L*, Wang YZhang CLi JMeng YDou MNoguchi CTDi L. Inhibiting Glycogen Synthase Kinase 3 Reverses Obesity-Induced White Adipose Tissue Inflammation by Regulating Apoptosis Inhibitor of Macrophage/CD5L-Mediated Macrophage Migration. Arterioscler Thromb Vasc Biol.2018 Jul 19. pii: ATVBAHA.118.311363. [Epub ahead of print]
  2. Wang L*, Wang Y, Meng Y, Zhang C, Di L. Gsk3-activated stat5 regulates expression of sfrps to modulate adipogenesis. FASEB J. 2018:fj201701314R
  1. Wang Li; Li JJ; Guo Liyu; Li Peipei; Zhao Zhiqiang; Zhou Haisheng; Di Lijun. Molecular link between glucose and glutamine consumption in cancer cells mediated by CtBP and SIRT4. Oncogenesis. 2018 Mar 13;7(3):26.
  2. Hao DP, Liu J, Chen M, Li JJ, Wang L, Li XB, Zhao Q, Li-jun Di,* Immunogenomic analyses of advanced serous ovarian cancer reveal immune score is a strong prognostic factor and an indicator of chemo-sensitivity. Clin Cancer Res.2018 Aug 1;24(15):3560-3571. doi: 10.1158/1078-0432.CCR-17-3862. Epub 2018 Apr 16.
  3. Hao D, Li J, Jia S, Meng Y, Zhang C, Wang L, Di LJ. Integrated Analysis Reveals Tubal- and Ovarian-Originated Serous Ovarian Cancer and Predicts Differential Therapeutic Responses. Clin Cancer Res. 2017 Dec 1;23(23):7400-7411. doi: 10.1158/1078-0432.CCR-17-0638. Epub 2017 Sep 22
  4. Li JHao DWang LWang HWang YZhao ZLi PDeng CDi LJ. Epigenetic targeting drugs potentiate chemotherapeutic effects in solid tumor therapy. Sci Rep.2017 Jun 22;7(1):4035
  5. Wang YHao DPLi JJWang LDi LJ. Genome-wide methylome and chromatin interactome identify abnormal enhancer to be risk factor of breast cancer Oncotarget. 2017 Jun 2. doi: 10.18632/oncotarget.18348. [Epub ahead of print]
  1. Li PLi JWang LDi LJ. Proximity labeling of interacting proteins: Application of BioID as a discovery tool. 2017 Mar 8. doi: 10.1002/pmic.201700002. [Epub ahead of print]
  2. Liang Wang, Judy Y. Chan, Xinhua Zhou, Guozhen Cui, Zhixiang Yan, Li Wang, Ru Yan, Lijun Di, Yuqiang Wang, Maggie P. Hoi1, Luchen Shan and Simon M. Lee. A Novel Agent Enhances the Chemotherapeutic Efficacy of Doxorubicin in MCF-7 Breast Cancer Cells. Front. Pharmacol., 10 August 2016, August 2016 | Volume 7 | Article 249
  3. Zhao ZQ, Wang L & Di LJ. Compartmentation of metabolites in regulating epigenome of cancer. Molecular Medicine, 2016 (accepted for publication)
  4. Dapeng Hao, LiWang & Li-jun Di. Distinct mutation accumulation rates among tissues determine the variation in cancer risk. Scientific Reports, 2016, | 6:19458 | DOI: 10.1038/srep19458
  5. Wang LZhang XCui GChan JYWang LLi CShan LXu CZhang QWang YDi LJ, Lee SM. A novel agent exerts antitumor activity in breast cancer cells by targeting mitochondrial complex II. Oncotarget, 2016 Mar 27. doi: 10.18632/oncotarget.8410. [Epub ahead of print]
  6. Wang L, Di LJ. Wnt/β-catenin mediates AICAR effect in increasing GATA3 expression and inhibiting adipogenesis. J Biol Chem. 2015 VOL. 290, NO. 32, pp. 19458–19468
  7. 14.   Wang L, Zhou H, Wang Y, Cui, G, Di LJ. CtBP maintains cancer cell growth and metabolic homeostasis via regulating SIRT4. Cell Death Dis. 2015 Jan 29;6:e1620.
  1. Wang L*, Di LJ, Noguchi CT. AMPK is involved in mediation of erythropoietin influence on metabolic activity and reactive oxygen species production in white adipocytes. Int J Biochem Cell Biol. 2014 Sep;54:1-9
  2. Wang L*, Li-Jun Di. BRCA1 And Estrogen/Estrogen Receptor In Breast Cancer: Where They Interact? International Journal of biological Sciences. 2014; 10(5):566-575
  3. Yuanyuan Zhang, Li Wang, Soumyadeep Dey, Mawadda Alnaeeli, Sukanya Suresh,Heather Rogers, Ruifeng Teng and Constance Tom Noguchi. Erythropoietin action in stress response, tissue maintenance and metabolism. J. Mol. Sci.2014, 15(6), 10296-10333
  4. Li Wang, Lijun Di, Constance Tom Noguchi. Erythropoietin, a novel versatile player regulating energy metabolism beyond the erythroid system. International Journal of Biological Sciences. 2014 Aug 23;10(8):921-39
  5. Li Wang, Ruifeng Teng, Lijun Di, Heather Rogers, Hong Wu, Jeffrey B. Kopp and Constance Tom Noguchi1. PPARα and Sirt1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders. Diabetes, 2013, Dec;62(12):4122-31
  1. Li Wang, Yi Jia, Heather Rogers, Norio Suzuki, Max Gassmann, Qian Wang, Alex McPheron, Jeffery Kopp, Masayuki Yamamoto, Constance Tom Noguchi. Erythropoietin contributes to slow oxidative muscle fiber specification via PGC-1a and AMPK. The International Journal of Biochemistry & Cell Biology 45 (2013) 1155– 1164
  2. Li Wang, Yi Jia, Heather Rogers, Suming Huang, Constance Tom Noguchi. GATA-4 and TAL1 regulate myogenic differentiation and erythropoietin response via cross talk with Sirt1. J Biol Chem. 2012 Aug 31;287(36):30157-69
  3. Heather Rogers #, Li Wang# (#co-first author), Xiaobing Yu, Mawadda Al-naeeli, Kairong Cui, Keji Zhao, James J Bieker, Josef Prchal, Suming Huang, Babette Weksler and Constance Tom Noguchi. T-cell Acute Leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis. J Biol Chem, 2012 Oct 26;287(44):36720-31
  4. Mawadda Alnaeeli, LiWang, Barbora Piknova, Heather Rogers, Xiaoxia Li, and Constance Tom Noguchi. Erythropoietin in Brain Development and Beyond. Anatomy Research International Volume 2012, Article ID 953264, 15 pages doi:10.1155/2012/953264.
  5. Beleslin-Čokić BB, Cokić VP, Wang L, Piknova B, Teng R, Schechter AN, Noguchi CT. Erythropoietin and hypoxia increase erythropoietin receptor and nitric oxide levels in lung microvascular endothelial cells. 2011 2011 May;54(2):129-35
  6. Foskett A, Alnaeeli M, Wang L, Teng, R, Noguchi CT. The effects of Erythropoietin Dose Titration During High Fat Diet-induced Journal of Biomedicine & Biotechnology. 2011;2011:373781. Epub 2011 Apr 20.
  7. Zhi-Yong Chen, Li Wang, Pundit Asavaritkrai, and Constance Tom Noguchi. Up-Regulation of Erythropoietin Receptor by Nitric Oxide Mediates Hypoxia Preconditioning. Journal of Neuroscience Research. 2010 Nov 1;88(14):3180-8.
  8. Wang L, Di LJ, Lv X, Zheng W, Xue Z, Guo ZC, Liu DP, Liang CC., Inter-MAR Association Contributes to Transcriptionally Active Looping Events in Human b-globin Gene Cluster.  PLoS ONE. 2009;4(2):e4629. Epub 2009 Feb 27.
  9. Gong H, Wang Z, Zhao GW, Lv X, Wei GH, Wang L, Liu DP, Liang CC, SATB1 regulates beta-like globin genes through matrix related nuclear relocation of the cluster. Biochem Biophys Res Commun. 2009 May 22;383(1):11-5. Epub 2009 Mar 28.
  10. Di LJ*, Wang L*(Co-first author), Zhou GL, Wu XS, Guo ZC, Ke XS, Liu DP, Liang CC, Identification of Long Range Regulatory Elements of Mouse a-Globin Gene Cluster by Quantitative Associated Chromatin Trap (QACT). J Cell Biochem. 2008 Sep 1;105(1):301-12.
  11. CT Noguchi, Li Wang, HM Rogers, R Teng, and Y Jia, Survival and proliferative roles of erythropoietin beyond the erythroid lineage. Expert Rev Mol Med, Jan 2008; 10: e36.

Book Chapter

Li Wang. The author of the fifth chapter: The Molecular Mechanism of Magnesium Absorption in Plants, Nutrition Molecular Mechanism and Signal Transduction in Plants(book) 2nd edition(in Chinese), Science Press- Scientific Pubishing Center, Beijing,P.R. China.ISBN:7030166957.2006

Li PP, Meng Y, Wang L, and Di LJ, BioID: A Proximity-Dependent Labeling Approach 2 in Proteomics Study Functional Proteomics : Functions and methods, Springer, ISBN 9781588299710, 2018

 

Invited Conference Oral Presentation

Li Wang. GSK3 inhibitors reverse fat inflammation during diet-induced obesity. 2017, Inflammation – Basic Mechanisms & Related Diseases conference, 2017

Li Wang. GSK3β activity that can be regulated by AICAR via stimulated AKT in preadipocytes is involved in the regulation of adipogenesis, glucose metabolism and insulin action in adipocytes, Chinese Society of Biochemistry and Molecular Biology meeting, 2016.

Li Wang. AICAR increases GATA3 expression and regulates Wnt/ß-catenin pathway to inhibit adipogenesis. Lipid Metabolism and Human Metabolic Disorders, 2015.

Research Grant
Project Code: MYRG2016-00251-FHS

Funding Body/Scheme: UM-RDAO

Role in the Project: Principal Investigator

Funding Period: 01/01/2015-01/01/2018 – 31/12/2019

Senior instructor; Director of Metabolomics core, Faculty of Health Sciences, University of Macau

Professional Activities
Lead Judge of the NIH 2012 Postbac Poster day
Judge of National institutes of Health Fellows Award for Research Excellence (FARE) awards, 2011
Judge of 8th Annual Graduate Student Symposium of National Institutes of Health
Peer reviewer for international scientific journal – Cell Biology International
Peer reviewer for Cytokine
Peer reviewer for Clinical Science
Peer reviewer for Journal of Neurochemistry
Peer review for International Journal of Biological Sciences
Membership of Chinese Association of Molecular Biology & Biochemistry
Membership of American Society of Hematology Membership
Membership of American Diabetes Association Membership