Contact Information
Address(Office)E12-4015Renhe Xu
(Lab)N22-2003
Phone(Office)8822 4993
(Lab)8822 2908
Fax 8822 2314
Email RenheXu@umac.mo
Education
Ph.D.University of Tokyo, Tokyo, Japan
M.S.Central South University (formerly Xiangya Medical University), Changsha, China
B.M.South China University (formerly Hengyang Medical College), Hengyang, China
Positions
2018-presentAssociate Dean (Research), Faculty of Health Sciences, University of Macau, Macau
2014-presentProfessor, Faculty of Health Sciences, University of Macau, Macau
2006-2014Associate Professor, Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT, USA
1999-2006Senior Scientist, WiCell Research Institute, Madison, WI, USA
1994-1996Research Fellow, NCI-FCRDC, NIH, Frederick, MD, USA
Research Interests
We are interested in stem cell biology and application. We first discovered the key factors to sustain self-renewal and prolonged culture of human embryonic stem cells (hESCs) without the need for animal feedercells (Nat. Biotechnol. 2002; Nat. Methods 2005; Cell Stem Cell 2008) and revealed recurrent copy number variations in human induced pluripotent stem cells (Nat. Biotechnol. 2011). Recently, we treated animal models of multiple sclerosis and colitis with hESC-differentiated mesenchymal stem cells (EMSC) with superior efficacy (Stem Cell Reports 2014; Stem Cells 2016) and reported a novel method for stem cell transportation under ambient conditions without need for the costly and inconvenient cryopreservation methods (Biomaterials 2017). Our current research interests include

  1. Exploring novel therapeutical applications of EMSC
  2. Elucidating the fate of EMSC in host under various pathological conditions
  3. Addressing the immunogenicity and biosafety concerns of hESC-derived allografts
Representative Publications(from more than 70)
  1. Jiang, B., Yan, L., Wang, X., Li, E., Murphy, K., Vaccaro, K., Li, Y., and Xu, R.-H. Mesenchymal stem cells derived from human pluripotent stem cells, an unlimited and quality-controllable source, for therapeutic applications. Stem Cells Dec. 8, 2018.
  2. Yan, L., Zheng, D., and Xu, R.-H. Critical role of tumor necrosis factor signaling in mesenchymal stem cell-based therapy for autoimmune and inflammatory diseases. Frontiers Immunol. 9:1-13, 2018.
  3. Kurtz, A., Seltmann, S., Bairoch, A., … and Xu, R.-H. A standard nomenclature for referencing and authentication of pluripotent stem Cells. Stem Cell Reports. 10(1):1-6, 2018.
  4. Jiang, B., Yan, L., Miao, Z., Li, E., Wong, K.H., and Xu, R.-H. Spheroidal formation preserves human stem cells for prolonged time under ambient conditions for facile storage and transportation. Biomaterials 133:275-86, 2017.
  5. Zheng, D., Wang, X., and Xu, R.-H. One stone for multiple birds: generating universally compatible human embryonic stem cells. Stem Cells. 34(9):2269-75, Sept. 2016.
  6. Wang, X., Lazorchak, A.S., Song, L., Li, E., Jiang, B., Zhang, Z., and Xu, R.-H. Immune modulatory mesenchymal stem cells derived from human embryonic stem cells through a trophoblast-like stage. Stem Cells 34(2):380-91, 2016.
  7. Wang, X., Kimbrel, E.A., Ijichi, K. Paul, D., Lazorchak, A.S., Chu, J., Kouris, N.A., Yavanian, G., Lu, S.-J., Pachter, J.S., Crocker, S.J., Lanza, R., and Xu, R.-H. Human ES cell-derived MSC outperform bone marrow MSC in the treatment of an EAE model of multiple sclerosis. Stem Cell Reports 3(1):115-30, 2014.
  8. Wang, J., Park, J.W., Drissi, H., Wang, X., and Xu, R.-H. Epigenetic regulation of miR-302 by JMJD1C inhibits neural differentiation of human embryonic stem cells. J. Biol. Chem. 289(4):2384-95, 2014.
  9. Martins-Taylor, K. Schroeder, D.I., LaSalle, J.M., Lalande, M., and Xu, R.-H. Role of DNMT3B in the regulation of early neural and neural crest specifiers. Epigenetics 7(1):71-82, 2012.
  10. Martins-Taylor, K. and Xu, R.-H. Genomic stability of human induced pluripotent stem cells (invited review). Stem Cells 30(1):22-7, 2012.
  11. Luong, M.X., Auerbach, J., Crook, J.M., Daheron, , Hei, D., Lomax, J., Loring, J.F., Ludwig, T., Rooke, H.M., Schlaeger, T.M., Smith, K.P., Stacey, G., Xu, R.-H., and Zeng, F. A call for standardized naming and reporting of human ES and iPS cell lines. Cell Stem Cell 8(4):357-9, 2011.
  12. Martins-Taylor, K., Nisler, B.S., Taapken, S.M., Compton, T., Crandall, L., Montgomery, K.D., Lalande, M., and Xu, R.-H. Recurrent copy number variations in human induced pluripotent stem cells. Nat. Biotechnol. 29(6):488-91, 2011.
  13. Wang, X., Lin, G., Martins-Taylor, K., Zeng, H., and Xu, R.-H. Inhibition of caspase-mediated anoikis is critical for bFGF-sustained culture of human pluripotent stem cells. J. Biol. Chem. 284(49):34054-64, 2009.
  14. Li, Y., Zeng, H., Xu, R.-H., Liu, B., and Li, Z. Vaccination with human pluripotent stem cells generates a broad spectrum of immunological and clinical response against colon cancer. Stem Cells 27(12):3103-11, 2009.
  15. Zeng, H., Park, J.W., Guo, M., Lin, G., Crandall, L., Compton, T., Wang, X., Li, X.-J., Chen, F.-P., and Xu, R.-H. Lack of ABCG2 expression and side population properties in human pluripotent stem cells. Stem Cells 27(10):2435-45, 2009.
  16. Xu, R.-H., Sampsell-Barron, T.L., Gu, F., Root, S., Peck, R.M., Pan, G., Yu, J., Antosiewicz-Bourget, J., Tian, S., Stewart, and Thomson, J.A. NANOG is a direct target of TGF-beta/Activin mediated SMAD signaling in human ES cells. Cell Stem Cell 3(2):196-206, 2008.
  17. Shen, Y., Matsuno, Y., Fouse, S.D., Rao, N., Root, S., Xu, R.-H., Pellegrini, M., Riggs, A.D., and Fan, G. X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alternations.  Proc. Natl. Acad. Sci. U.S.A. 105(12):4709-14, 2008.
  18. Xu, R.-H., Peck, R.M., Li, D.S., Feng, X., Ludwig, T., and Thomson, J.A. Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells. Nat. Methods 2(3):185-190, 2005.
  19. Xu, R.-H., Chen, X., Li, D.S., Li, R., Addicks, G.C., Glennon, C., Zwaka, T.P., and Thomson, J.A. BMP4 initiates human embryonic stem cell differentiation to trophoblast.  Nat. Biotechnol. 20(12):1261-4, 2002.
  20. Xu, R.-H., Dong, Z., Maeno, M., Kim, J., Suzuki, A., Ueno, N., Sredni, B., Colburn, N.H., and Kung, H.-f.: Involvement of Ras/Raf/AP-1 in BMP-4 signaling during Xenopus embryonic development. Proc. Natl. Acad. Sci. U.S.A. 93:834-838, 1996.
Full Publications List
Current Research Grants

Current Research Grants

  • Macau Science and Technology Development Fund (FDCT) #095-2017-A2 (2018-2021)
  • Macau FDCT #0112-2018-A3 (2019-2022)
  • University of Macau Multiyear Research Grant (MYRG) #2016-00070-FHS (2017-2019)
  • University of Macau MYRG #2017-00124-FHS (2018-2020)
  • University of Macau Faculty of Health Sciences (FHS) Internal Grant 2017-02 (2017-2020)
  • University of Macau FHS Internal Grant 2018-03 (2018-2021)
Patents
  • Jiang, B., Yan, L., Li, E.-Q., and Xu, R.-H. A method and medium for storing and transporting stem cells under ambient conditions. Patent application #201710230​345.X
  • Wang, X. and Xu, R.-H. Using mesenchymal-like stem cells derived from human embryonic stem cell-differentiated hemangioblast to treat multiple sclerosis. Patent # WO2014011881A2
  • Wang, X. and Xu, R.-H. Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof. Patent # WO2014011881A2​
  • Xu, R.-H. and Thomson, J.A. Feeder-independent extended culture of embryonic stem cells. Patent # US 7,514,260 B2
  • Xu, R.-H. and Thomson, J.A. Method for generating primate trophoblasts. Patent # US 7,148,062 B2
Awards
  • 2009. International Research Award of Royan Institute, Iran
  • 2007. Connecticut United for Research Excellence (CURE): Award of Merit for UConn Stem Cell Core. New Haven, Connecticut, USA.
  • 2007. Connecticut State Register and Manual (Annual State Bluebook): Honoree of 2007, State Capitol, Hartford, Connecticut, USA.
  • 1997. NIH NCI-FCRDC: Outstanding Science Achievement Award, Frederick, MD, USA
News Coverage

2017. UM researchers develop new technology for stem cell storage (澳大幹細胞研究新突破 無需冷藏可保存7天以上)
澳門每日時報
UM Today
Hojemacau

2014. Reuters: ImStem Biotechnology, Inc. makes progress on multiple sclerosis treatment with embryonic stem cells.
http://www.reuters.com/article/2014/06/05/ct-imstem-biotech-idUSnPn5KtTZ2+96+PRN20140605/
2014. UM academic achieves new breakthrough in stem cell research for multiple sclerosis (科研又一突破 澳大學者幹細胞研究有望治療多發性硬化症)
Macau Governmental Portal
UM Today
2013. UConn Today: Health Center Researchers Awarded State Stem Cell Funds. http://today.uconn.edu/blog/2013/06/uconn-health-center-researchers-awarded-state-stem-cell-funds/
2013. UConn Today: New Stem Cell Company Opens Lab at UConn Health Center. http://today.uconn.edu/blog/2013/02/new-stem-cell-company-opens-lab-at-uconn-health-center/
2011. Health Center Today: Researchers Study Genomic Stability of Human Induced Pluripotent Stem Cells.
http://today.uchc.edu/features/2011/jun11/stemcells.html
2010. UConn Today: Four UConn Stem Cell Lines Approved for Use in Federally Funded Research.
http://today.uconn.edu/blog/2010/06/four-uconn-stem-cell-lines-approved-for-use-in-federally-funded-research/
2007. Connecticut United for Research Excellence (CURE): Award of Merit for UConn Stem Cell Core. New Haven, Connecticut on Dec. 4.
2007. Connecticut State Register and Manual (Annual State Bluebook): Honoree of 2007 an annual ceremony hosted by the Secretary of the State Susan Bysiewicz in the State Capitol, Hartford, Connecticut on Oct. 3.
2005. Science: Getting the Mice out of ES Cell Cultures.
http://www.ncbi.nlm.nih.gov/pubmed/?term=15746400
2005. USA Today: Cell Researchers make gains in removing mouse molecules. http://www.usatoday.com/tech/science/genetics/2005-02-18-broken-stems_x.htm
1997. NIH NCI-FCRDC: Outstanding Science Achievement Award, Frederick, MD, U.S.A.
Professional Activities
Members

  • International Society for Stem Cell Research
  • American Society for Biochemistry and Molecular Biology
  • Chinese Society for Cell Biology
Review Services

  • Strategic Trailblazing Program, Chinese Academy of Sciences
  • Thousands Talents (Youth) Program, China
  • Women’s Health Research, Yale University
  • National Natural Science Foundation, China
  • Kansas City Area Life Sciences Institute
  • New York State Stem Cell Science (NYSTEM) Program
  • Maryland State Stem Cell Research Fund
  • Changjiang Scholar Program, China
Editorial Board Member

  • American Journal of Stem Cells
  • Experimental Biology and Medicine
  • Journal of Biological Chemistry (2011-2017)
  • Journal of Cellular Biochemistry
  • International Journal of Biological Sciences (Executive editor)
Current Staff
Jung Woo Park, Senior Instructor
Angela Enqin Li, Laboratory Manager
Li Yan, Postdoctoral Fellow
Zhengyan Yang, Postdoctoral Fellow

Changkun Yang, Research Assistant
Grace Guihui Qin, Research Assistant
Xiaoyan Wang, PhD student
Dejin Zheng, PhD student
Roma Borkar, PhD student
Borong Huang, PhD student
Siyi Fu, Macau Talent Program PhD student
Haibo Peng, PhD student
Grace Yanying Guo, FYP student