Full publications

Neuroscience and Neuroimaging

  1. Zhishan Hu; Juan Zhang; Lingyan Zhang; Yu-Tao Xiang; Zhen Yuan*. Linking brain activation to topological organization in the frontal lobe as a synergistic indicator to characterize the difference between various cognitive processes of executive functions. Neurophotonics, 6(2), 025008 (2019).
  2. H Ren, MY Wang, Y He, Z Du, J Zhang, J Zhang, D Li, Z Yuan. A novel phase analysis method for examining fNIRS neuroimaging data associated with Chinese/English sight translation. Behavioural brain research 361, 151-158, 2019.
  3. Z Hu, KF Lam, YT Xiang, Z Yuan*. Causal Cortical Network for Arithmetic Problem-Solving Represents Brain’s Planning Rather than Reasoning. International Journal of Biological Sciences 15 (6), 1148-1160, 2019..
  4. Juan Zhang, Yaxuan Meng, Chenggang Wu, Yu-Tao Xiang, Zhen Yuan* (2019). Non-speech and Speech Pitch Perception among Cantonese-speaking Children with Autism Spectrum Disorder: an ERP Study. Neuroscience letters, 703, 205-212.
  5. Z Hu, J Zhang, TA Couto, S Xu, P Luan, Yuan, Zhen* (2018). Optical Mapping of Brain Activation and Connectivity in Occipitotemporal Cortex during Chinese Character Recognition. Brain Topography, 1-15.
  6. X Lin, L Sai, Yuan, Zhen* (2018). Detecting concealed information with fused electroencephalography and functional near-infrared spectroscopy. Neuroscience (06): 049-058.
  7. Liu, CH, Ma, X, Yuan, Z.*(01/02/2017). Decreased resting-state activity in the precuneus is associated with depressive episodes in recurrent depression. The Journal of Clinical Psychiatry, 13(1). pp. 7-13.
  8. HF Ieong, Z Yuan*. Desynchronized Lower Alpha Rhythms Were Associated With Functional Ischemia in the Prefrontal Cortex in Heroin Patients After Protracted Abstinence: A Concurrent EEG-fNIRS Study. Biological Psychiatry 85 (10), S295-S296.
  9. HF Ieong, Yuan, Zhen*. Emotion recognition and its relation to prefrontal function and network in heroin plus nicotine dependence: a pilot study (2018). Neurophotonics 5 (2): 025011.
  10. X Lin, VLC Lei, D Li, Yuan, Zhen* (2018). Which is more costly in Chinese to English simultaneous interpreting, “pairing” or “transphrasing”? Evidence from an fNIRS neuroimaging study. Neurophotonics 5 (2): 025010.
  11. MY Wang, FM Lu, Z Hu, J Zhang, Yuan, Zhen* (2018). Optical mapping of prefrontal brain connectivity and activation during emotion anticipation.  Behavioural Brain Research (350): 122-128.
  12. HF Ieong, Yuan, Zhen* (2018). Emotion Recognition and its Relation to Prefrontal Function and Network in Heroin Plus Nicotine Dependence: A Pilot and Translational Study. Biological Psychiatry 83 (9): S449-S450.
  13. Fu-Chun Zhou, Yuan-Yuan Wang, Wei Zheng, Gabor S.Ungvari,  Chee H.Ng,  Zhen Yuan, Yu-Tao Xiang. Prospective memory in bipolar disorder: A meta-analysis (2018). Psychiatry Research (259): 184-190.
  14. Juan Zhang, Yaxuan Meng, Jinbo He, Yutao Xiang, Chenggang Wu, Shibin Wang, Zhen Yuan (2018). McGurk Effect by Individuals with Autism Spectrum Disorder and Typically Developing Controls: A Systematic Review and Meta-analysis. Journal of Autism and Developmental Disorders:  doi.org/10.1007/s10803-018-3680-0.
  15. ZW Zhao, Z Yuan, DQ Zhao, ZW Wang, FQ Zhu, P Luan (2018). The effect of V-ATP ase function defects in pathogenesis of Alzheimer’s disease. CNS neuroscience & therapeutics 24 (9), 837-840.
  16. Hui Huang, Min Dong, Ling Zhang, Bao-Liang Zhong, Chee H Ng, Gabor S Ungvari, Zhen Yuan, Xiangfei Meng, Yu-Tao Xiang. Psychopathology and extrapyramidal side effects in smoking and non-smoking patients with schizophrenia: Systematic review and meta-analysis of comparative studies (2019). Progress in Neuro-Psychopharmacology and Biological Psychiatry, 92, 476-482.
  17. MY Wang, J Zhang, FM Lu, YT Xiang, Yuan, Zhen*. (8/2018). Neuroticism and conscientiousness respectively positively and negatively correlated with the network characteristic path length in dorsal lateral prefrontal cortex: A resting-state fNIRS study. Brain and Behavior. https://doi.org/10.1002/brb3.1074,
  18. X Lin, VLC Lei, D Li, Z Hu, Y Xiang, Yuan, Zhen* (2018). Mapping the small-world properties of brain networks in Chinese to English simultaneous interpreting by using functional near-infrared spectroscopy. Journal of Innovative Optical Health Sciences 11(3): 1840001.
  19. J Zhang, Y Meng, X Tong, Z Yuan, C Wu (2018). Exploring the neural correlates of lexical stress perception in english among Chinese-English bilingual children with autism spectrum disorder: An ERP study. Neuroscience letters 66: 158-164.
  20. Luo, CW, Lin, XH, Burns, E, Yuan, Z., & Xu, H (20/09/2016). Amodal completion in facial expression aftereffect: an EEG study. Journal of Vision, 16(12). pp. 156-156.
  21. Hada Ieong, Zhen Yuan* (7/2017). Resting-state neuroimaging and neuropsychological findings in opiate use disorder during abstinence: a review. Front. Hum. Neurosci., 11, 169.
  22. Zhang, ZM, Wang, MY, Miao, XC, Li, YJ, Hitchman, G, & Yuan, Z.* (14/10/2016). Individuals with high obsessive-compulsive tendencies or undermined confidence rely more on external proxies to access their internal states. Journal of Behavior Therapy and Experimental Psychiatry, 54. pp. 263-269.
  23. Zhang, J, Li, YY, Chen, HF, Ding, JR, & Yuan, Z.* (21/10/2016). An Investigation of the Differences and Similarities between Generated Small-World Networks for Right and Left-Hand Motor Imageries. Scientific Reports, 6(36562). pp. 1-10.
  24. Yuan-Yuan Wang, Yuan Feng, Dan-Dan Xu, Wei Huang, Ines HI Chow, Chee H Ng, Gabor S Ungvari, Zhen Yuan, Gang Wang, Yu-Tao Xiang. The development and validation of a short version of the 33-item Hypomania Checklist (HCL-33) (2018). Journal of affective disorders (235), 206-210.
  25. Fei Wang, Qing-E Zhang, Ling Zhang, Chee H Ng, Gabor S Ungvari, Zhen Yuan, June Zhang, Yu-Tao Xiang (2018). Prevalence of major depressive disorder in older adults in China: A systematic review and meta-analysis. Journal of affective disorders, 241, 297-304.
  26. X Lin, L Sai, G Fu, Z Yuan*, (17/12/2016).  Neural correlated of Spontaneous deception with Spatiotemporal analysis: A functional near infrared spectroscopy (fnirs) study. International Journal of Psychology 51, 884.
  27. Y He, MY Wang, D Li, Yuan, Zhen*(2017). Optical mapping of brain activation during the English to Chinese and Chinese to English sight translation. Biomedical Optics Express 8 (12), 5399-5411
  28. Zhong-Ming Zhang, Meng-Yun Wang, Xiaowei Guo, Xiaocui Miao, Ting Zhang, Dong Gao, Yuan, Zhen* (8/2017). Attentional avoidance of threats in obsessive compulsive disorder: An event related potential study. Behaviour Research and Therapy, 97, pp. 96-104.
  29. FM Lu, YF Wang, J Zhang, HF Chen, Yuan, Zhen* (2017). Optical mapping of the dominant frequency of brain signal oscillations in motor systems. Scientific Reports 7 (1), 14703.
  30. Zhang, Juan, C Wu, Y Meng, Yuan, Zhen*(2017). Different Neural Correlates of Emotion-Label Words and Emotion-Laden Words: An ERP Study, Frontiers in Human Neuroscience 11, 455.
  31. Jiang Zhang, Jiansong Zhou, Fengmei Lu, Liangyin Chen, Yunzhi Huang, Huafu Chen, Yutao Xiang, Gang Yang, Yuan, Zhen* (9/2017). Investigation of the Changes in the Power Distribution in Resting-State Brain Networks Associated with Pure Conduct Disorder. Scientific Reports, 7(1), pp.5528-5530.
  32. Feng-Mei Lu, Jian-Song Zhou, Jiang Zhang, Xiao-Ping Wang, Yuan, Zhen* (7/2017). Disrupted small-world brain network topology in pure conduct disorder. Oncotarget, 8, pp.65506-65524.
  33. Ieong, H, & Yuan, Z.*, Abnormal regional resting-state functionality connectivity in the orbitofrontal cortex of chronic heroin users and its relationship with anxiety: a pilot functional near infrared spectroscopy study. Scientific Reports, 7, 46522(2017)
  34. Liu, CH, Liu, CZ, Zhang, JH, Yuan, Z.*, Tang, LR, Tie, CL, Fan, J, & Liu, QQ (16/07/2016). Reduced spontaneous neuronal activity in the insular cortex and thalamus in healthy adults with insomnia symptoms. Brain Research, 8993 (6). pp. doi: 10.1016/j.brainres.2016.07.024.-doi: 10.1016/j.brainres.2016.07.024.
  35. Zhang, J, Lin, XH, FU, GY, Sai, LA, Chen, HF, Yang, JB, Wang, MW, Liu, Q, Yang, G, Zhang, JR, & Yuan, Z. *(10/05/2016). Mapping the small-world properties of brain networks in deception with functional near-infrared spectroscopy. Scientific Reports, 6:25297. pp. 1-11.
  36. Yuan Feng, Yuan‐Yuan Wang, Wei Huang, Gabor S Ungvari, Chee H Ng, Gang Wang, Zhen Yuan, Yu‐Tao Xiang. (01/03/2017). Comparison of the 32‐item Hypomania Checklist, the 33‐item Hypomania Checklist, and the Mood Disorders Questionnaire for bipolar disorder, Psychiatry and Clinical Neurosciences, DOI: 10.1111/pcn.12506:1-7.
  37. Feng-Mei Lu, Jian-Song Zhou, Xiao-Ping Wang, Yu-Tao Xiang, Zhen Yuan*. Short- and long-range functional connectivity density alterations in adolescents with pure conduct disorder at resting-state. Neuroscience, 351, 96-107 (2017).
  38. Feng-Mei Lu, Chun-Hong Liu, Shun-Li Lu, Li-Rong Tang, Chang-Le Tie, Juan Zhan, Zhen Yuan*. Disrupted topology of frontostriatal circuits is linked to the severity of insomnia. Frontiers in Neuroscience, 11,214(2017)
  39. Xiaohong Lin, Shiyang Xu, Hada Fong-Ha Ieong, and Zhen Yuan* (9/2017). Optical mapping of prefrontal activity in pathological gamblers. Applied Optics, 56(21), pp.5948-5953.
  40. Lu, FM, & Yuan, Z.* (20/05/2015). PET/SPECT Molecular Imaging in Clinical Neuroscience: Recent Advances in the Investigation of CNS Diseases. Quantitative Imaging in Medicine and Surgery, 5(3). pp. 433-447.
  41. Zhang, J, Liu, Q, Chen, HF, Yuan, Z., Huang, J, Deng, LH, Lu, FM, Zhang, JP, Wang, YQ, Wang, MW, & Chen, LY (25/08/2015). Combining self-organizing mapping and supervised affinity propagation clustering approach to investigate functional brain networks involved in motor imagery and execution with fMRI measurements. Front. Hum. Neurosci, 9. pp. 400-406.
  42. Zhang, ZJ, Yuan, Z.*, Huang, J, Yang, Q, & Chen, HF (25/08/2014). Quantitative Analysis of the Power Changes in BOLD Signals of Cortical Activity during Different Single-hand Motor Imageries Using Welch Spectrum Method. Magnetic Resonance Imaging, 32. pp. 1307-1313.
  43. Yuan, Z.* (31/08/2013). Fusion of fNIRS and fMRI data: identifying when and where hemodynamic signals are changing in human brains. Front Hum Neurosci, 7. pp. 676(1)-676(9).
  44. Yuan, Z.* (01/10/2013). Spatiotemporal and time-frequency analysis of functional near infrared spectroscopy brain signals using independent component analysis. Journal of Biomedical Optics, 18(10). pp. 106011(1)-106011(10).
  45. Yuan, Z.* (01/11/2013). Combining independent component analysis and Granger causality to investigate brain network dynamics with fNIRS measurements. Biomedical Optics Express, 4(11). pp. 2629-2643.
  46. Tian, Y., Huang, SS, Yuan, Z.*, Chen, SF, Xu, P, & Chen, HF (30/07/2014). White matter structure in loneliness: Preliminary findings from diffusion tensor imaging. Neuroreport, 25(11). pp. 843-847.
  47. Lu, FM, Zhou, JS, Zhang, J, Xiang, Y., Zhang, J, Liu, Q, Wang, XP, & Yuan, Z.* (31/12/2015). Functional Connectivity Estimated from Resting-State fMRI Reveals Selective Alterations in Male Adolescents with Pure Conduct Disorder. PLOS ONE, DOI: 10.137. pp. 1-14.
  48. Qing-E Zhang, Fei Wang, Geng Qin, Wei Zheng, Chee H Ng, Gabor S Ungvari, Zhen Yuan, Songli Mei, Gang Wang, Yu-Tao Xiang. (9/2018). Depressive symptoms in patients with irritable bowel syndrome: a meta-analysis of comparative studies. International journal of biological sciences 14(11), 1504-1509.
  49. J Zhang, C Wu, Z Yuan, Y Meng (10/2018).. Different early and late processing of emotion-label words and emotion-laden words in second language: An ERP study. Second Language Research, 0267658318804850.
  50. MY Wang, P Luan, J Zhang, YT Xiang, H Niu, Yuan, Zhen*(10/2018). Concurrent mapping of brain activation from multiple subjects during social interaction by hyperscanning: a mini-review. Quant Imaging Med Surg. 2018 Sep; 8(8): 819–837.

Molecular Imaging and Cancer Nanomedicine

  1. Hao Xu, Tymish Y Ohulchanskyy, Artem Yakovliev, Roman Zinyuk, Jun Song, Liwei Liu, Junle Qu, Yuan, Zhen*. Nanoliposomes Co-Encapsulating CT Imaging Contrast Agent and Photosensitizer for Enhanced, Imaging Guided Photodynamic Therapy of Cancer. THERANOSTICS, 2019, 9(5), 1323-1335.
  2. K Chang, D Gao, Y Liu, Q Qi, Yuan, Zhen*. Engineering biocompatible benzodithiophene-based polymer dots with tunable absorptions as high-efficiency theranostic agents for multiscale photoacoustic imaging-guided photothermal therapy. Biomater. Sci., 2019, 7, 1486-1492.
  3. Kaiwen Chang, Yubin Liu, Dehong Hu, Qiaofang Qi, Duyang Gao, Yating Wang, Dongliang Li, Xuanjun Zhang, Hairong Zheng, Zonghai Sheng, Zhen Yuan* (2018). Highly Stable Conjugated Polymer Dots as Multifunctional Agents for Photoacoustic Imaging-Guided Photothermal Therapy. ACS Appl. Mater. Interfaces, 10 (8), pp 7012–7021.
  4. Duyang Gao, Xia Ji, Jiuling Wang, Yating Wang, Dongliang Li, Yubin Liu, Kaiwen Chang, Junle Qu, Zheng Jun, Zhen Yuan* (2018). Engineering Protein-Based Nanoplatform as Antibacterial Agents for Light Activated Dual-Modal Photothermal and Photodynamic Therapy of Infection in Both the NIR I and II Windows. J. Mater. Chem. B, 6, 732-739.
  5. Gao, DY, Sheng, ZH, Liu, YB, Hu, DR, Zhang, J, Zhang, X., Zheng, HR, & Yuan, Z.* (01/01/2017).  Protein-Modified CuS Nanotriangle: A Potential Multimodal Nanoplatform for in vivo Tumor Photoacoustic/Magnetic Resonance Dual-Modal Imaging. Advanced Healthcare Materials, 6(1),1601094 adhm.201601094.
  6. D Gao, P Zhang, Y Liu, Z Sheng, H Chen, Yuan, Zhen* (2018). Protein-modified conjugated polymer nanoparticles with strong near-infrared absorption: a novel nanoplatform to design multifunctional nanoprobes for dual-modal photoacoustic and fluorescence imaging. Nanoscale, 10, 19742-19748.
  7. Zhang, J, Chen, HB, ZHou, T, Wang, LM, Gao, DY, Zhang, X., Liu, YB, Wu, CF, & Yuan, Z.* (15/09/2016). A PIID-DTBT based semiconducting polymer dot with broad and strong optical absorption in the visible-light region as a highly-effective contrast agent for multiscale and multi-spectral photoacoustic imaging. Nano Research, 12274. pp. 1-14.
  8. H Xu, Y Liu, J Qu, Z Yuan. PEGylated Liposomal Photosensitizers as Theranostic Agents for Dual-modal Photoacoustic and Fluorescence Imaging-guided Photodynamic Therapy. Journal of Innovative Optical Health Sciences, 2019, https://doi.org/10.1142/S1793545819410037.
  9. Lipeng Zhu, Ping Li, Duyang Gao, Jie Liu, Yubin Liu, Chen Sun, Mengze Xu, Zonghai Sheng, Ruibing Wang, Zhen Yuan, Lintao Cai, Yifan Ma, Qi Zhao. pH-sensitive loaded retinal/indocyanine green micelles as a “all-in-one” theranostic agent for multi-modal imaging in vivo guided cellular senescence-photothermal synergistic therapy. Chem. Commun., 2019, DOI: 10.1039/C9CC02567G.
  10. B Zhang, F Wang, H Zhou, D Gao, Z Yuan, C Wu, X Zhang. Polymer Dots Compartmentalized in Liposomes as a Photocatalyst for In Situ Hydrogen Therapy. Angewandte Chemie International Edition 58 (9), 2744-2748, 2019.
  11. S Wang, Z Li, Y Liu, G Feng, Zheng, Jun*, Yuan, Zhen*, Zhang, Xuanjun* (2018). Activatable Photoacoustic and Fluorescent Probe of Nitric Oxide for Cellular and in Vivo Imaging. Sensors and Actuators B: Chemical 267: 403-411.
  12. Libo Zhou, Ying Jing, Yubin Liu, Zhihe Liu, Duyang Gao, Haobin Chen, Weiye Song, Tao Wang, Xiaofeng Fang, Weiping Qin, Zhen Yuan, Sheng Dai, Zhen-An Qiao, Changfeng Wu. Mesoporous Carbon Nanospheres as a Multifunctional Carrier for Cancer. Theranostics. 2018; 8(3): 663–675.
  13. X Men, Yuan, Zhen*. Multifunctional conjugated polymer nanoparticles for photoacoustic-based multimodal imaging and cancer photothermal therapy. Journal of Innovative Optical Health Sciences. https://doi.org/10.1142/S1793545819300015.
  14. Kai Sun, Yingkun Yang, Hua Zhou, Shengyan Yin, Weiping Qin, Jiangbo Yu, Daniel T Chiu, Zhen Yuan, Xuanjun Zhang, Changfeng Wu (2018). Ultrabright Polymer-Dot Transducer Enabled Wireless Glucose Monitoring via a Smartphone. ACS Nano 12 (6): 5176–5184.
  15. Kaiwen Chang, Zhihe Liu, Xiaofeng Fang, Haobin Chen, Xiaoju Men, Ye Yuan, Kai Sun, Xuanjun Zhang, Zhen Yuan, Changfeng Wu (8/2017). Enhanced Phototherapy by Nanoparticle-Enzyme via Generation and Photolysis of Hydrogen Peroxide. Nano Letters, 17 (7), pp 4323–4329.
  16. Zhaoyang Ding, Jingyun Tan, Gang Feng, Zhen Yuan, Changfeng Wu, Xuanjun Zhang (4/2017). Nanoscale metal-organic frameworks coated with poly (vinyl alcohol) for ratiometric peroxynitrite sensing through FRET. Chemical Science, 8, pp. 5101-5106.
  17. Duyang Gao, Yubin Liu, Yating Wang, Zhen Yuan* (2018).Protein-modified ultra-small gold clusters for dual-modal in vivo fluorescence/photoacoustic imaging. Quantitative Imaging in Medicine and Surgery, 8(3): 326–332.
  18. J Wang, Z Yuan, Y Zhang (2018). Alternative translation initiation from two in-frame start codons in DHX33 gene. Biochemical and biophysical research 502: 501-507
  19. Gao, DY, Yuan, Zhen,*(01/03/2017). Photoacoustic-Based Multimodal Nanoprobes: from Constructing to Biological Applications. International Journal of Biological Sciences, 13(4), 401-412.
  20. Chen D, Li Q, Meng Z, Guo L, Tang Y, Liu Z, Yin S, Qin W, Yuan Z, Zhang X, Wu C (6/2017). Bright Polymer Dots Tracking Stem Cell Engraftment and Migration to Injured Mouse Liver. Theranostics, 7(7), pp.1820–1834.
  21. Haobin Chen, Jian Zhang, Kaiwen Chang, Xiaoju Men, Xiaofeng Fang, Libo Zhou, Dongliang Li, Duyang Gao, Shengyan Yin, Xuanjun Zhang, Zhen Yuan, Changfeng Wu. (2017). Highly absorbing multispectral near-infrared polymer nanoparticles from one conjugated backbone for photoacoustic imaging and photothermal therapy. Biomaterials 144, 42-52.
  22. Zhang, J, Liu, J, Wang, LM, Li, Zy, & Yuan, Z.* (23/05/2016). Retroreflective-type Janus microspheres as a novel contrast agent for enhanced optical coherence tomography. Journal of Biophotonics, jbio.20160. pp. 1-9.
  23. Sun, K., Tang, Y., Li, Q., Yin, S., Qin, W., Yu, J., Chiu, D., Liu, Y., Yuan, Z., Zhang, X., & Wu, C. (16/06/2016). In vivo dynamic monitoring of small molecules with implantable polymer-dot transducer. ACS Nano, 10(1). pp. 1-16.
  24. Liu, ZH, Sun, ZZ, Di, WH, Qin, WP, Yuan, Z., & Wu, CF (15/02/2015). Brightness calibrates particle size in single particle fluorescence imaging. Optics Letters, 2015(2). pp. 231829(1)-2318299(3).
  25. Zhang, YL, Liu, XH, Lang, YB, Yuan, Z., Zhao, D, Qin, GS, & Qin, WP (01/03/2015). Synthesis of ultra-small BaLuF 5: Yb 3+, Er 3+@ BaLuF 5: Yb 3+ active-core–active-shell.  Journal of Materials Chemistry, 2015(3). pp. 2045-2053.
  26. Zhang, KZ, Song, WY, He, GH, Yuan, Z., & Qin, WP (16/03/2015). Five-photon UV upconversion emissions of Er3+. Optics Express, 23(6). pp. 7653-7658.
  27. Li, SY, Chen, J, Chen, G, Li, Q, Sun, K, Yuan, Z., Qin, WP, Xu, H, & Wu, CF (12/12/2015). Semiconductor Polymer Dots Induce Proliferation in Human Gastric Mucosal and Adenocarcinoma Cells. Macromolecular Bioscience, 15(3). pp. 318-327.
  28. Zhang, W, Sun, H, Yin, SY, Chang, JJ, Li, YH, Guo, XY, & Yuan, Z. (27/05/2015). Bright red-emitting polymer dots for specific cellular imaging. Journal of Materials Science, 50(16). pp. 5571-5577.
  29. Chang, KW, Men, XJ, Chen, HB, Liu, ZH, Yin, SY, Qin, WP, Yuan, Z., & Wu, CF (16/06/2015). Silica-encapsulated semiconductor polymer dots as stable phosphors for white light-emitting diodes. Journal of Materials Chemistry C, 3. pp. 7281-7285.
  30. Da Zhang, Hao Xu, Xiaolong Zhang, Yubin Liu, Ming Wu, Juan Li, Huanghao Yang, Gang Liu, Xiaolong Liu, Jingfeng Liu, Zhen Yuan( 5/2018). Self-Quenched Metal–Organic Particles as Dual-Mode Therapeutic Agents for Photoacoustic Imaging-Guided Second Near-Infrared Window Photochemotherapy. ACS applied materials & interfaces 10(30), 25203-25212.
  31. Duyang Gao, Yuan, Zhen* 99/2018).Controllable synthesis of biocompatible triangular quantum dots with near-infrared emitting and their application for in vivo lymph node imaging. Nanomedicine: Nanotechnology, Biology and Medicine. 14(5):1881.
  32. Shigao Huang, Chi Ian Fong, Mengze Xu, Bing-nan Han, Zhen Yuan*, Qi Zhao. Nano-loaded natural killer cells as carriers of ICG for synergetic cancer immunotherapy and phototherapy. Journal of Innovative Optical Health Sciences, 2019, https://doi.org/10.1142/S1793545819410025.


Biomedical Optics and Optical Imaging


  1. Xiong Kedi,, Wei Wang, Ting, Guo, Zhen Yuan, Sihua Yang. Shape-adapting panoramic photoacoustic endomicroscopy, Optics Letters, 2019, https://www.osapublishing.org/DirectPDFAccess/7D6253E9-B64C-569A-9E6518977695128E_ads363592.pdf?da=1&adsid=363592&journal=3&seq=0&mobile=no.
  2. Yubin Liu  Duyang Gao  Mengze Xu  Zhen Yuan*. Multispectral photoacoustic imaging of cancer with broadband CuS nanoparticles covering both near‐infrared I and II biological windows. Journal of Biophotonics, 2019, https://doi.org/10.1002/jbio.201800237.
  3. Y Liu, L Fu, M Xu, J Zheng, Yuan, Zhen*. Dual-Modal In Vivo Fluorescence/Photoacoustic Microscopy Imaging of Inflammation Induced by GFP-Expressing Bacteria(2019). Sensors 19 (2), 238-243.
  4. A Dolet, F Varray, S Mure, T Grenier, Y Liu, Z Yuan, P Tortoli, D Vray (2018). Spatial and spectral regularization to discriminate tissues using multispectral photoacoustic imaging. EURASIP Journal on Advances in Signal Processing (1), 39-48.
  5. Y Liu, D Li, & Yuan, Z.*, (30/11/2016). Photoacoustic tomography imaging of the adult zebrafish by using unfocused and focused high-frequency ultrasound transducer. Applied Sciences, 6(12), 392-394.
  6. Liu, YB, & Yuan, Z.* (01/07/2016). Two schemes for quantitative photoacoustic tomography based on Monte Carlo simulation. Medical Physics, 43(7). pp. 3987-3997.
  7. Liu, YB, & Yuan, Z.* (01/07/2016). Multi-spectral photoacoustic elasticity tomography. Biomedical Optics Express, 7(9). pp. 3323-3334.
  8. Y Zhao, S Yang, Y Wang, Z Yuan, J Qu, L Liu (2018). In vivo blood viscosity characterization based on frequency-resolved photoacoustic measurement. Applied Physics Letters 113 (14), 143703.
  9. Y Huang, L Han, H Dou, H Luo, Z Yuan, Q Liu, J Zhang, G Yin. Two-stage CNNs for computerized BI-RADS categorization in breast ultrasound images. Biomedical engineering online 18 (1), 8, 2019.
  10. Yao Sun, Zhen Yuan, Huaibei Jiang (2018). Enhancing Mesh-based Photoacoustic Tomography with Parallel Computing on Multiprocessor Scheme. Communications in Computational Physics 24 (3), 764-773.
  11. Danying Lin, Teng Luo, Liwei Liu, Yuan Lu, Shaoxiong Liu, Zhen Yuan, Junle Qu (9/2017). Implementation of FLIM and SIFT for improved intraoperative delineation of glioblastoma margin. Chinese Optics Letters, 15(9), pp. 090006.
  12. Zhang, J, Zhang, Z, Ge, W., & Yuan, Z.* (14/06/2016). Long-term in vivo monitoring of injury induced brain regeneration of the adult zebrafish by using spectral domain optical coherence tomography. CHINESE OPTICS LETTERS, 14(8). pp. 1-3.
  13. Liu, YB, Wang, YT, & Yuan, Z.* (25/07/2016). Dual-modality imaging of the human finger joint systems by using combined multi-spectral photoacoustic computed tomography and ultrasound computed tomography. Biomedical Research International, 2016. pp. Article ID 1453272 (1)-Article ID 1453272 (7).
  14. Jian Zhang, Sio Hang Pun, Yuanyu Yu, Duyang Gao, Jiujiang Wang, Peng Un Mak, Kin Fong Lei, Ching-Hsiang Cheng, Yuan, Zhen* (5/2017). Development of a multi-band photoacoustic tomography imaging system based on a capacitive micromachined ultrasonic transducer array. Applied Optics, 56 (24), pp. 4012-4018.
  15. Huang, N, Guo, H, Qi, WZ, Huang, ZW, Rong, J, Yuan, Z., Ge, W., Jiang, HB, & Xi, L (31/07/2016). Whole-body multispetral photoacoustic imaging of adult zebrafish. Biomedical Optics Express, 7(9). pp. 3543-3550.
  16. Yubin Liu, Lingyan Zhang, Sushu Li, Xinai Han, Zhen Yuan* (2018). Imaging molecular signatures for clinical detection of scleroderma in the hand by multispectral photoacoustic elastic tomography. Journal of Biophotonics. DOI: 10.1002/jbio.201700267.
  17. Pun, Sio Hang, Yu, Yuanyu*, Zhang, Jian, Wang, et al., Yuan, Zhen*, Mak, Peng Un (2018). Monolithic Multi-band CMUTs for Photoacoustic Computed Tomography (PACT) with in vivo Biological Tissue Imaging. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. Volume: 65, Issue: 3, 465-485.
  18. Zhang, J., Ge, W., & Yuan, Z.* (11/09/2015). In vivo three-dimensional characterization of the adult zebrafish brain at video rate with a 1325 nm long range spectral-domain optical coherence tomography system. Biomedical Optics Express, 6. pp. 3932-3940.
  19. Tian, Y, Li, FL, Xu, P, Yuan, Z.*, Zhao, DC, & Zhang, HY (16/09/2014). Combining canonical correlation analysis and infinite reference for frequency recognition of steady-state visual evoked potential recordings: A comparison with periodogram method. Bio-Medical Materials and Engineering, 24. pp. 2901- 2908.
  20. Liu, YB, Li, ZF, Li, H, & Yuan, Z.* (16/09/2014). Quantification of the chemical composition variations of tumors in photothermal therapy by photoacoustic spectroscopy: An in vitro study. Bio-Medical Materials and Engineering, 24. pp. 2901-2908.
  21. Yuan, Z.*, Ieong, Hada, Jiang, HB, & Sobel, E (16/09/2014). Osteoarthritis and psoriatic arthritis: Findings in three-dimensional biophotonics imaging. Bio-Medical Materials and Engineering, 24. pp. 3063-3071.
  22. Zhang, X., Yu, J, & Yuan, Z. (2016). Fluorescent Probes for Biological Imaging. BioMed Research International, 2016. pp. 1-1.
  23. Zhang, LY, Li, SH, Hao, S, & Yuan, Z.* (20/03/2016). Quantification of fat deposition in bone marrow in the lumbar vertebra by proton MRS and in-phase and out-of-phase MRI for the diagnosis of osteoporosis. Journal of X-Ray Science and Technology, 24. pp. 257-266.
  24. Li, SF, Montcel, B, Yuan, Z., Liu, W, & Vray, D (01/07/2015). Multigrid-based reconstruction algorithm for quantitative photoacoustic tomography. Biomedical Optics Express, 6(7). pp. 2424-2434.
  25. Chen, HB, Yuan, Z.*, & Wu, CF (11/12/2015). Nanoparticle Probes for Structural and Functional Photoacoustic Molecular Tomography. BioMed Research International, 757101. pp. 757101(1)-757101(12).
  26. Zhu, DW, Zhao, Y, Baikejiang, R, Li, CQ, & Yuan, Z. (29/04/2014). Comparison of Regularization Methods in Fluorescence Molecular Tomography. Photonics, 1. pp. 95-99.
  27. Yuan, Z.*, Li, XQ, & Xi, L. (01/05/2014). Listening to light scattering in turbid media: quantitative optical scattering imaging using photoacoustic measurements with one-wavelength illumination. J. Opt., 16. pp. 065301(1)-065301(8).
  28. Yuan, Z.*, Zhang, J, Wang, XD, & Li, CQ (12/08/2014). A systematic investigation of reflectance diffuse optical tomography using nonlinear reconstruction methods and continuous wave measurements. Biomedical Optics Express, 5(9). pp. 3012-3022.
  29. Yuan, Z., Wang, Q, & Jiang, HB (10/07/2006). Simultaneous reconstruction of acoustic and optical properties of heterogeneous media by quantitative photoacoustic tomography. Optics Express, 14(15). pp. 6749-6754.
  30. Yuan, Z., & Jiang, HB (10/05/2007). Image reconstruction scheme that combines modified Newton method and efficient initial guess estimation for optical tomography of finger joints. Applied Optics, 46(14). pp. 2757-2768.
  31. Yuan, Z., Zhang, QZ, Sobel, E, & Jiang, HB (21/05/2007). Three-dimensional diffuse optical tomography of osteoarthritis: initial results in the finger joints. Journal of Biomedical Optics, 12(3). pp. 034001-1-034001-11.
  32. Yuan, Z., & Jiang, HB (18/12/2007). Reconstruction of optical absorption coefficient maps of heterogeneous media by photoacoustic tomography coupled with diffusion equation based regularized Newton Method . Optics Express, 15(26). pp. 18076-18081.
  33. Zhang, QZ, Yin, L, Tan, YY, Yuan, Z., & Jiang, HB (22/01/2008). Quantitative bioluminescence tomography guided by diffuse optical tomography. OPTICS EXPRESS, 16(3). pp. 1481-1486.
  34. Zhang, QZ, Liu, Z, Carney, PR, Yuan, Z., Chen, HX, Noper, SR, & Jiang, Hb (01/02/2008). Non-invasive imaging of epileptic seizures in vivo using photoacoustic tomography. Physics in Medicine and Biology, 53(7). pp. 1921-1931.
  35.  Yuan, Z., Zhang, QZ, Sobel, ES, & Jiang, HB (01/07/2008). Tomographic x-ray–guided three-dimensional diffuse optical tomography of osteoarthritis in the finger joints. Journal of Biomedical Optics, 13(4). pp. 044006-1-044006-10.
  36. Yuan, Z., Hu, XH, & Jiang, HB (29/10/2008). A higher order diffusion model for three-dimensional photon migration and image reconstruction in optical tomography. Phys. Med. Biol., 54. pp. 67-90.
  37. Yuan, Z., & Jiang, HB (16/11/2008). Three-dimensional finite-element-based photoacoustic tomography: Reconstruction algorithm and simulations. Medical Physics, 34(2). pp. 538-546.
  38. Yuan, Z., & Jiang, HB (01/01/2010). Photoacoustic tomography for imaging nanoparticles. Cancer Nanotechnology: Methods and Protocols, 624. pp. 309-324.
  39. Yuan, Z., & Jiang, HB (01/06/2009). Simultaneous recovery of tissue physiological and acoustic properties and the criteria for wavelength selection in multispectral photoacoustic tomography. Optics Letters, 34(11). pp. 1714-1716.
  40. Yuan, Z., & Jiang, HB (01/08/2009). Quantitative photoacoustic tomography. Phil. Trans. R. Soc. A, 367. pp. 3043-3054.
  41. Yuan, Z., Zhang, QZ, Sobel, E, & Jiang, HB (07/10/2009). Comparison of diffusion approximation and higher order diffusion equations for optical tomography of osteoarthritis. Journal of Biomedical Optics, 14(5). pp. 054013-1-054013-7.
  42. Yuan, Z., Zhang, QZ, Sobel, E, & Jiang, HB (18/06/2010). Image-guided optical spectroscopy in diagnosis of osteoarthritis: a clinical study. Biomedical Optics Express, 1(1). pp. 74-86.
  43.  Yuan, Z., Zhang, QZ, Sobel, E, & Jiang, HB (02/07/2010). High-resolution x-ray guided three-dimensional diffuse optical tomography of joint tissues in hand osteoarthritis: Morphological and functional assessments. Medical Physics, 37(8). pp. 4343-4354.
  44. Xiao, JY, Yuan, Z., He, SS, & Jiang, HB (18/08/2010). Quantitative multispectral photoacoustic tomography and wavelength optimization. Journal of X-Ray Science and Technology, 18(4). pp. 415-427.
  45.  Zhang, ZJ, Wang, J, Yuan, Z., Sobel, E, & Jiang, HB (08/06/2011). Computer-aided classification of optical images for diagnosis of osteoarthritis in the finger joints. Journal of X-Ray Science and Technology, 19(4). pp. 531-544.
  46. Zhang, J, Tuo, XG, Yuan, Z., Liao, W, & Chen, HF (25/11/2011). Analysis of fMRI data using an integrated principal component analysis and supervised affinity propagation clustering approach. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 58(11). pp. 3184-3196.
  47. Yuan, Z., & Jiang, HB (11/2012). A calibration-free, one-step method for quantitative photoacoustic tomography. Medical Physics, 39(11). pp. 6895-6899.
  48. Yuan, Z., Wu, CF, Zhao, HZ, & Jiang, HB (15/11/2005). Imaging of small nanoparticle-containing objects by finite-element-based photoacoustic tomography. Optics Letters, 30(22). pp. 3054-3056.
  49. Jiang, HB, Yuan, Z., & Gu, XJ (01/04/2006). Spatially varying optical and acoustic property reconstruction using finite-element-based photoacoustic tomography. Journal of the Optical Society of America A, 23(4). pp. 878-888.
  50. Yuan, Z., Zhao, HZ, Wu, CF, Zhang, QZ, & Jiang, HB (01/05/2006). Finite-element-based photoacoustic tomography: phantom and chicken bone experiments. Applied Optics, 45(13). pp. 3177-3183.
  51. Yuan, Z., & Jiang, HB (05/06/2006). Quantitative photoacoustic tomography: Recovery of optical absorption coefficient maps of heterogeneous media. Applied Physics Letters, 88. pp. 231101-1-231101-3.
  52. Yuan, Z., Wu, CC, & Li, H (01/06/2003). Homogenization-based topology design for pure torsion of composite shafts. Acta Mechanica Sinica, 19(3). pp. 241-246.
  53. Li, H, Yuan, Z., Ng, TY, Lee, HP, Lam, KY, Wang, QX, Wu, SN, Fu, J, & Hanes, J (05/07/2003). Constitutive model development and micro-structural topology optimisation for Nafion hydrogel membranes with ionic clustering. J. Biomater. Sci. Polymer Edn, 14(11). pp. 1181-1196.
  54. Li, H, Yuan, Z., Lam, K, Lee, HP, Chen, J, Hanes, J, & Fu, J (14/10/2003). Model development and numerical simulation of electric-stimulus-responsive hydrogels subject to an externally applied electric field. Biosensors and Bioelectronics, 19(9). pp. 1097-1107.
  55. Yin, L, Yuan, Z., & He, LH (01/11/2004). Model development and numerical simulation of temperature-sensitive hydrogels. Computational Materials Science, 31(3-4). pp. 299-308.
  56. Z. Yuan, H. Jiang, “Photoacoustic tomography for imaging nanoparticles,” in Cancer Nanotechnology by Drs. Stephen R. Grobmyer and Brij Moudgil. http://www.springer.com/978-1-60761-608-5.
  57. Z. Yuan, H. Jiang, “Diffuse Optical Tomography of osteoarthritis,” in Handbook of Biophotonics, Volume 2 (35), Photonics for Health Care, Edited by Jurger Popp, Valery V. Tuchin, Arthur Chiou, and Stefan Heinemann. Published by Wiley-VCH (2011).
  58. Z. Yuan, H. Jiang, “Optical Methods and Instrumentation in Brain Imaging and Therapy,” Invited  Book Chapter by Springer. (http://link.springer.com/book/10.1007/978-1-4614-4978-2/page/1).
  59. H. Jiang, Z. YuanPhotoacoustic tomography,” Advances in Optical Imaging for Clinical Medicine by Dr. N.V. Iftimia, Dr. W. Brugge, and Dr. D.X. Hammer (John Wiley and Sons Ltd);(http://www.wisepress.com/index.asp-Q-I-E-9780470619094-advances-in-optical-imaging-for-clinical-medicine,61860).
  60. Fengmei Lu, Xiaohong Lin, Zhen Yuan (corresponding author), “fNIRS and its application in neurosciences,” in the Book “The Computational Optical Biomedical Spectroscopy and Imaging,” CRC Press-Taylor and Francis Group, LLC (2015). http://www.crcpress.com/product/isbn/9781482230819
  61. Zhen Yuan, Book, “Technological advances and prospects in multimodal neuroimaging,” LAP Lambert Academic Publishing (2014).
  62. J Zhang, Z Yuan, “Nano Sensors for in Vivo Biomedical Imaging,” Bookchapter, in Book “ Nanobiosensors for Personalized and Onsite Biomedical Diagnosis.” Published by the Institution of Engineering and Technology, London, United Kingdom (2016). http://www.theiet.org/resources/books/healthcare/nanobio.cfm
  63. H. Jiang, Z Yuan et al., Hybrid Photoacoustic Tomography (PAT) and Diffuse Optical Tomography (DOT): Methods and Algorithms, International Application No. PCT/US2008/055894, patent.
  65.  Feimei Lu, Zhen Yuan*, “Neuroimaging of Interpretation by using fNIRS, Bookchapter, CRC Press-Taylor and Francis Group.