Contact Information
Address(Office)N22-4034
(Lab)N22-4031
Phone(Office)8822 4254
(Lab)N22-4031
Fax8822 4254
Emailzhihuiweng@um.edu.mo
Education
Ph.D.2014-2018The Chinese University of Hong Kong
B.S.2003-2008Peking University
Position
2019-PresentResearch Assistant Professor, the University of Macau
2018-2019Postdoctoral Fellow, The Chinese University of Hong Kong
Research Interests
Dr. WENG graduated from Peking University with a degree in Bachelor of Medicine. He received further training in the field of stem cells (human embryonic stem cells and induced pluripotent stem cells) in the Chinese Academy of Sciences in Shanghai and Guangzhou. He was later recruited as a Technical Officer in the Stem cell and Regenerative Medicine Consortium in the University of Hong Kong. He then earned his Ph.D. degree in the School of Biomedical Sciences, Chinese University of Hong Kong and worked there as a postdoctoral fellow. His main researches focus on the discovery of novel driver/core genes related to cancer stem cells and how they contribute to cancer initiation, development and progression. Dr. WENG has published many research papers on stem cell and cancer areas.

  1. Discover Cancer Stem Cell related genes and how they regulate stemness of tumor cells.
  2. Drug screen of Patients Derived Organoid in human Hepatocellular Carcinoma.
  3. Molecular mechanisms of tumor initiation in human Hepatocellular Carcinoma.
Representative Publications
  1. He J#, Weng Z#, Wu SCM, Boheler KR. Generation of Induced Pluripotent Stem Cells from Patients with COL3A1 Mutations and Differentiation to Smooth Muscle Cells for ECM-Surfaceome Analyses. Methods Mol Biol. 2018;1722:261-302. (co-first author)
  2. Zhang JT#, Weng Z#, Tsang KS, Tsang LL, Chan HC, Jiang XH. MycN Is Critical for the Maintenance of Human Embryonic Stem Cell-Derived Neural Crest Stem Cells. PLoS One. 2016 Apr 14;11(4):e0154068. (co-first author)
  3. Zhihui Weng, Chi-Wing Kong, etc. (2014) A simple, cost-effective but highly efficient system for deriving ventricular cardiomyocytes from human pluripotent stem cells. Stem Cells and Development. (cited 62 times since published, first author)
  4. Zhihui Weng, Jiaozi He, Jiacheng Lin, Lin Gao, JT Zhang, Gang Li, JX Jiang. Human Embryonic Stem Cells derived Neuroblastoma model reveals novel Twist1-dependent genes cluster with distinct function in MYCN-amplified Neuroblastoma. (first author) In preparation.
  5. He J#, Weng Z#, Victor HF Lee. Oncofetal gene I***, an unreported bona fide driver and novel subtype of biomarkers in aggressive hepatocellular carcinoma In preparation to Gastroenterology. (co-First author)
  6. Liu Z, Guo J, Wang Y, Weng Z, Huang B, etc. CFTR-β-catenin interaction regulates mouse embryonic stem cell differentiation and embryonic development. Cell Death Differ. 2017 Jan;24(1):98-110.
  7. Miguel Angel Esteban, Tao Wang, Baoming Qin, Jiayin Yang, Dajiang Qin, Jinglei Cai, Wen Li, Zhihui Weng, etc., Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells, Cell Stem Cell 6, 2010 1–9
  8. Poon E, Keung W, Liang Y, Ramalingam R, Lieu DK, Wong HS, Weng Z, etc. Proteomic Analysis of Human Pluripotent Stem Cell-Derived, Fetal, and Adult Ventricular Cardiomyocytes Reveals Pathways Crucial for Cardiac Metabolism and Maturation. CircCardiovasc Genet. 2015;8(3):427-36.
  9. YAN Lai-lai, LIU Li-ping, NIU Gang, WENG Zhihui, WANG Jing-yu. Correlation Research between Lead and Other Elements in the Blood of Lead-Exposed Rats. Journal of Chinese Mass Spectrometry Society. 2009 Vol.30 No.5P.295-299
  10. Yang Chen, Zhihui Weng, Erjun Ling. Functional characterization of PGRP-LC1 of Anopheles gambiae through deletion and RNA interference Insect Science (2009)

11. Yang Chen, ZhiHui Weng and Liangbiao Zheng. Innate immunity against malaria parasites in Anopheles gambiae. Insect Science (2008) 15, 45-52.