| Talk title | Development of Red/NIR emissive optical nanoprobes for bioimaging and disease theranostics |
| Speaker | Dr. Pengfei Zhang Postdoctoral fellow The Hong Kong University of Science and Technology |
| Date & Time | 24 October 2018 (Wed) 10:00am-11:00am |
| Venue | Room G004, E12 Building (University of Macau) |
| Abstract | Chemotherapy is currently the principal method for treating many malignancies. Thus, the development of improved antitumor drugs with enhanced efficacy and selectivity remains a high priority. Anthracycline antibiotics (AAs), for example, doxorubicin, daunomycin, and mitomycin C, belong to an important family of antitumor agents widely used in chemotherapy. These compounds are all quinones. They are, thus, capable of being reduced by appropriate chemicals or reductases. One of their important properties is that under aerobic conditions their reduced forms undergo oxidation, with concomitant generation of reactive oxygen species (ROS), namely, superoxide anion radicals, hydrogen peroxide, and hydroxyl radicals. The presence of metal ions is essential for the generation of ROS by AAs in biological systems. Critical Issues: A fundamental shortcoming of the AAs is their high cardiotoxicity. We have proposed, and experimentally realized, a new type of quinones that is capable of coordinating metal ions. We have demonstrated in vitro that they can be reduced by electron transfer chains and glutathione with concomitant generation of ROS. They can also produce ROS under photo-excitation. The mechanisms of these reactions have been characterized by using nuclear magnetic resonance and electron paramagnetic resonance, including spin trapping technique.Optical imaging is unequivocally the most versatile and widely used visualization modality in clinical practice and research. Fluorescence imaging has received particular attention due to the increasing availability of fluorescent probes that enable the noninvasive study of gene expression, protein function, protein-protein interactions, and a large number of biological processes in real time. The importance of long wavelength and near infra-red (NIR) imaging has dramatically increased due to the desire to perform whole animal and deep tissue imaging. Fluorescence imaging relies on high performance fluorescent materials. In this report, I will introduce our research on Red/NIR emissive probes based on inorganic nanomaterials and organic optical materials for biomedical application, such as cancer targeting, virus labeling, etc.
Dr. Pengfei Zhang received his PhD degree in Bioengineering from HKUST in 2018. He has published more than 70 publications in peer-reviewed journals. |
