| Talk title | The Role of Anesthetics in Cancer Growth and Metastasis |
| Speaker | Professor of Anesthesiology, Attending Physician
State University of New York at Stony Brook |
| Date & Time | 28 Oct 2019 (Mon) 16:00-17:00 |
| Venue | Room G004, E12 Building (University of Macau) |
| Abstract | Dr. Jun LIN, M.D., Ph.D., is Professor of Anesthesiology and Attending Physician at State University of New York at Stony Brook, New York. Dr. LIN received his medical training at Sun Yat-sen University where he also conducted his postgraduate studies in pharmacology. He was awarded a Ph.D. in Biomedical science from Mount Sinai School of Medicine of NYU, and M.D. from State University of New York. Dr. LIN completed his residency in Anesthesiology at Albert Einstein College of Medicine and is a Diplomat of American Board of Anesthesiology. He was elected a full membership of Association of University Anesthesiologists. Dr. LIN was a tenured professor and attending physician of State University of New York Downstate Medical Center, where he served as Director of Obstetric Anesthesiology, Vice Chair of medical affairs QC Committee, research mentor of Anesthesiology. Dr. LIN is a Faculty Senate and Admission Committee member of SUNY at Stony Brook School of Medicine. He is the Section Editor of General Pharmacology and Pharmacokinetics of BMC Anesthesiology, and Editor-in-Chief of International Journal of Physiology, Pathophysiology and Pharmacology. His research focuses on drug receptors, ion channels, and cancer metastasis post-surgery.
Surgery is crucial for treating solid organ tumors and offers hope of cure. However, metastatic recurrence does occur and is the main cause of breast cancer death. It has been suggested that the perioperative period presents many risks to cancer patients. One of the factors is the choice of general anesthetics used during surgery. However, the role of anesthetics in cancer growth and metastasis remains undefined. The potential mechanisms are largely unknown. We will present and discuss our data showing the distinct effects and underlying mechanisms of two most commonly used general anesthetics volatile anesthetic sevoflurane and intravenous anesthetic propofol on metastasis in mouse models of breast cancers that incorporate clinically relevant surgery. |