| Talk title | Potential Roles of β-amyloid in an Animal Model of Temporal Lobe Epilepsy |
| Speaker | Prof. Satyabrata KAR Professor |
| Date & Time | 10 June 2019 (Mon) 15:00-16:00 |
| Venue | Room G004, E12 Building (University of Macau) |
| Abstract | Establishing and maintaining polarity is critical for many cellular processes and for development and physiological functions of multicellular tissues. Some of these polarity-dependent functions are altered during aging, but little is known about the underlying mechanisms. Prof. Kar found that cell polarization in migratory fibroblasts is impaired by both pathological and normal aging due to upregulation of nuclear envelope proteins SUN1. Elevated SUN1 leads to excessive association of the nucleus to microtubules, thus preventing actin-dependent cell polarization. This cell polarity defect is further aggravated by a protein factor secreted by cells from aged people. Such a factor is also present in serum from aged people, suggesting its role in physiologically aging. Prof. Kar have identified several candidate proteins for the factor and will study how its level is regulated during aging. Prof. Kar will examine its effects on aging-related phenotypes using cellular and animal models and elucidate molecular mechanisms through which cell polarity interacts with aging. |