2026-01-28T17:28:53+08:002021-01-27|Publish|
  1. Heng Sun, Jianming Zeng, Zengqiang Miao, Kuan Cheok Lei, Chen Huang, Lingling Hu, Sek Man Su, Un In Chan, Kai Miao, Xu Zhang, Aiping Zhang, Sen Guo, Si Chen, Ya Meng, Min Deng, Wenhui Hao, Haipeng Lei, Ying Lin, Zhonglin Yang, Dongjiang Tang, Koon Ho Wong, Xiaohua Douglas Zhang, Xiaoling Xu, Chu-Xia Deng. Dissecting the heterogeneity and tumorigenesis of BRCA1 deficient mammary tumors via single cell RNA sequencing. Theranostics, 2021, 11(20): 9967-9987.
  2. Xinyu Guo#, Heng Sun#, Feng Yu, Yangyang Feng, Sen Guo, Josh Haipeng Lei, Kai Miao, Ka-U Ip, Ling L, Hanghang Li, Xiaohong Liao, Xiaoling Xu, Rong Zhou, Chu-Xia Deng. Dasatinib Inhibits Basal B Breast Cancer Through ETS1-Mediated Extracellular Matrix Remodeling. Biomedicines. 2025 Nov 26;13(12):2888 (Co-first author).
  3. Ya Meng, Heng Sun*, Chu-Xia Deng*. Cancer can be a purely epigenetic disorder. Int J Biol Sci. 2025 Jan 6;21(3):955-957 (*, Co-corresponding author).
  4. Wang Y, Deng M, Lei H, Miao K, Shu X, Li J, Tang D, Feng Y, Su SM, Li L, Wang Y, Sun H, Shao F, An T, Li X, Zhou F, Xiang T, Xu X, Deng C. Lars2-signaling mediates platinum resistance by accumulating cancer stem cell population and suppressing anti-tumor immunity. Drug Resist Updat. 2025 Nov 28;85:101330.
  5. Lin S, Tang D, Lei JH, Chu X, Wang L, Miao K, Chen P, Zhou J, Zhang A, Li L, Sun H, Xu X, Deng C. RAD51B-EZH2 axis as a potential therapeutic target for TNBC through cell fate conversion. Cell Death Dis. 2025 Nov 30;17(1):64.
  6. Li L, Feng Y, Zhou J, Shao F, Peng Y, Zang S, Lei JH, Sun H, Tang D, Lin S, Chen J, Li H, Chu X, Qiao Y, Guo X, Wu K, Xu X, Deng CX. Proteasomes suppress anticancer drug-induced cytotoxicity by inhibiting mitochondrial protein import and promoting ROS-BNIP3-mediated mitophagy. Drug Resist Updat. 2025 Nov;83:101294.
  7. Tang D, Lin S, Zhou J, Lei JH, Shao F, Sun H, Chu X, Li L, He L, Qiao Y, Xu X, Deng CX. Augment proteasome inhibitor efficacy activates CD8+ T cell-mediated antitumor immunity in breast cancer. Cell Rep Med. 2025 Jul 15;6(7):102211.
  8. Miao K, Zhang A, Yang X, Zhang Y, Lin A, Wang L, Zhang X, Sun H, Xu J, Zhang J, Feng Y, Shao F, Guo S, Weng Z, Luo P, Wang D, Gao S, Zhao XY, Xu X, Deng CX. Lymphatic system is the mainstream for breast cancer dissemination and metastasis revealed by single-cell lineage tracing. Mol Cancer. 2025 Mar 12;24(1):75.
  9. Zehao Wu#, Heng Sun#, Zichen Xu, Kai Feng, Josh Haipeng Lei, Chu-Xia Deng, Qingsong Xu. Magnetically powered cancer cell microrobots for surgery-free generation of targeted tumor mouse models. Cell Reports Physical Science. 2024 (5) 9, 102182 (Co-first author).
  10. Zichen Xu#, Heng Sun#, Yuanhe Chen, Hon Ho Yu, Chu-Xia Deng, and Qingsong Xu. Bubble-Inspired Multifunctional Magnetic Microrobots for Integrated Multidimensional Targeted Biosensing. Nano Letters. 2024 24 (44), 13945-13954(Co-first author).
  11. Yilan Li#, Jingru Yan#, Heng Sun#, Yating Liang, Qianqian Zha, Shan Yu, Yao Zhang. Ferroptosis inhibitor alleviates sorafenib-induced cardiotoxicity by attenuating KLF11-mediated FSP1-dependent ferroptosis. Int J Biol Sci. 2024 Apr 22;20(7):2622-2639. doi: 10.7150/ijbs.86479 (#, Co-first author).
  12. Dongliang Leng#, Ziyi Yang#, Heng Sun#, Chengcheng Song, Chen Huang, Ka U Ip, Guokai Chen, Chu-Xia Deng, Xiaohua Douglas Zhang, Qi Zhao.Comprehensive analysis of tumor microenvironment reveals prognostic ceRNA network related to immune infiltration in sarcoma. Clin Cancer Res. 2023 Aug 1:CCR-22-3396. doi: 10.1158/1078-0432.CCR-22-3396. (Co-first author).
  13. Ya Meng*, Haitao Wang*, Xuebing Li*, Xinwei Wu*, Heng Sun*. Editorial: Immunity in the development of anti-cancer drug resistance. Front Pharmacol. 2022;13:1120037 (*, Co-corresponding author).
  14. Hailuan Zeng*, Xiaofan Lu*, Heng Sun*, Haitao Wang*. Editorial: Epigenetics of metabolism, immunology and aging. Front Genet. 2023;14:1135889 (*, Co-corresponding author).
  15. Lv T, Hong X, Liu Y, Miao K, Sun H, Li L, Deng C, Jiang C, Pan X. AI-powered interpretable imaging phenotypes noninvasively characterize tumor microenvironment associated with diverse molecular signatures and survival in breast cancer. Comput Methods Programs Biomed. 2024 Jan;243:107857. doi: 10.1016/ j.cmpb. 2023.107857. Epub 2023 Oct 12.
  16. Jing-Bo Zhou, Dongyang Tang, Lin He, Shiqi Lin, Josh Haipeng Lei, Heng Sun, Xiaoling Xu, Chu-Xia Deng. Machine learning model for anti-cancer drug combinations: Analysis, prediction, and validation. Pharmacol Res. 2023;194:106830.
  17. Xiaodong Shu, Jianjie Li, Un In Chan, Sek Man Su, Changxiang Shi, Xin Zhang, Tingting An, Jun Xu, Lihua Mo, Jianlin Liu, Yuqing Wang, Xiaoling Li, Min Deng, Josh Haipeng Lei, Chunfei Wang, Hao Tian, Sun Heng, Joong Sup Shim, Xuanjun Zhang, Yunlu Dai, Zhicheng Yao, Xiaying Kuang, Ying Lin, Chu-Xia Deng, Xiaoling Xu. BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance. Cancer Res. 2023;83(15):2614-2633.
  18. Si Chen, Fangyuan Shao, Jianming Zeng, Sen Guo, Lijian Wang, Heng Sun, Josh Haipeng Lei, Xueying Lyu, Shuai Gao, Qiang Chen, Kai Miao, Xiaoling Xu, Chu-Xia Deng. Cullin-5 deficiency orchestrates the tumor microenvironment to promote mammary tumor development through CREB1-CCL2 signaling. Sci Adv. 2023;9(3):eabq1395.
  19. Jiansong Fan, Lei Zhang, Tianxu Lv, Yuan Liu, Heng Sun, Kai Miao, Chunjuan Jiang, Lihua Li, Xiang Pan. MEAI: an artificial intelligence platform for predicting distant and lymph node metastases directly from primary breast cancer. J Cancer Res Clin Oncol. 2023;149(11):9229-9241.
  20. Aiping Zhang, Kai Miao, Heng Sun, Chu-Xia Deng. Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistance. Int J Biol Sci. 2022;18(7):3019-3033.
  21. Jianjie Li, Xiaodong Shu, Jun Xu, Sek Man Su, Un In Chan, Lihua Mo, Jianlin Liu, Xin Zhang, Ragini Adhav, Qiang Chen, Yuqing Wang, Tingting An, Xu Zhang, Xueying Lyu, Xiaoling Li, Josh Haipeng Lei, Kai Miao, Heng Sun, Fuqiang Xing, Aiping Zhang, Chuxia Deng, Xiaoling Xu. S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy. Nat Commun. 2022;13(1):1481.
  22. Yihang Wang, Chunjuan Jiang, Youqing Wu, Tianxu Lv, Heng Sun, Yuan Liu, Lihua Li, Xiang Pan. Semantic-Powered Explainable Model-Free Few-Shot Learning Scheme of Diagnosing COVID-19 on Chest X-Ray. IEEE J Biomed Health Inform. 2022;26(12):5870-5882.
  23. Josh Haipeng Lei, Mi-Hye Lee, Kai Miao, Zebin Huang, Zhicheng Yao, Aiping Zhang, Xu Jun, Ming Zhao, Zenan Huang, Xin Zhang, Si Chen, NG Jiaying, Yuzhao Feng, Fuqiang Xing, Ping Chen, Heng Sun, Qiang Chen, Lin Chen, Xiaoling Xu, and Chu-Xia Deng. Activation of FGFR2 Signaling Suppresses BRCA1 and Drives Triple-Negative Mammary Tumorigenesis that Is Sensitive to Immunotherapy. Advanced Science, 2021, 8(21):e2100974.
  24. Chen P, Zhang X, Ding R, Yang L, Lyu X, Zeng J, Lei JH, Wang L, Bi J, Shao N, Shu D, Wu B, Wu J, Yang Z, Wang H, Wang B, Xiong K, Lu Y, Fu S, Choi TK, Lon NW, Zhang A, Tang D, Quan Y, Meng Y, Kai Miao, Heng Sun, Zhao M, Bao J, Zhang L, Xiaoling Xu, Shi Y*, Lin Y*, Chu-Xia Deng. Patient-derived organoids can guide personalized-therapies for patients with advanced breast cancer. Advanced Science, 2021, 8(22):e2101176.
  25. Fuqiang Xing, Yu-Cheng Liu, Shigao Huang, Xueying Lyu, Sek Man Su, Un In Chan, Pei-Chun Wu, Yinghan Yan, Nana Ai, Jianjie Li, Ming Zhao, Barani Kumar Rajendran, Jianlin Liu, Fangyuan Shao, Heng Sun, Tak Kan Choi, Wenli Zhu, Guanghui Luo, Shuiming Liu, De Li Xu, Kin Long Chan, Qi Zhao, Kai Miao, Kathy Qian Luo, Wei Ge, Xiaoling Xu, Guanyu Wang*, Tzu-Ming Liu*, Chu-Xia Deng. Accelerating precision anti-cancer therapy by time-lapse and label-free 3D tumor slice culture platform. Theranostics, 2021; 11(19): 9415-9430.
  26. Ming Zhao, Yingyao Quan, Jianming Zeng, Xueying Lyu, Haitao Wang, Josh Haipeng Lei, Yangyang Feng, Jun Xu, Qiang Chen, Heng Sun, Xiaoling Xu, Ligong Lu, Chu-Xia Deng. Cullin3 deficiency shapes tumor microenvironment and promotes cholangiocarcinoma in liver-specific Smad4/Pten mutant mice. International Journal of Biological Sciences 2021, 17(15): 4176-4191.
  27. Ren-Bo Ding, Ping Chen, Barani Kumar Rajendran, Xueying Lyu, Haitao Wang, Jiaolin Bao, Jianming Zeng, Wenhui Hao, Heng Sun, Ada Hang-Heng Wong, Monica Valecha, Eun Ju Yang, Sek Man Su, Tak Kan Choi, Shuiming Liu, Kin Iong Chan, Ling-Lin Yang, Jingbo Wu, Kai Miao, Qiang Chen, Joong-Sup Shim, Xiaoling Xu, and Chu-Xia Deng. Molecular Landscape and Subtype-Specific Therapeutic Response of Nasopharyngeal Carcinoma Revealed by Integrative Pharmacogenomics for Precision Oncology. Nature Communications. 2021, 12(1):3046.
  28. Heng Sun, Xin Zhang, Un In Chan, Sek Man Su, Sen Guo, Xiaoling Xu and Chu-Xia Deng. In vivo Mouse Mammary Gland Formation. Bio-protocol. 2020, 10(13): e3667.
  29. Heng Sun, Xiaoling Xu and Chu-Xia Deng. Preparation of Single Epithelial Cells Suspension from Mouse Mammary Glands. Bio-protocol. 2020, 10(04): e3530.
  30. Liu J, Adhav R, Miao K, Su SM, Mo L, Chan UI, Zhang X, Xu J, Li J, Shu X, Zeng J, Zhang X, Lyu X, Pardeshi L, Tan K, Sun H, Wong KH, Deng C, Xu X. Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor. Nature Communications. 2020, 25;11(1):4875.
  31. Miao K, Lei JH, Valecha MV, Zhang A, Xu J, Wang L, Lyu X, Chen S, Miao Z, Zhang X, Su SM, Shao F, Rajendran BK, Bao J, Zeng J, Sun H, Chen P, Tan K, Chen Q, Wong KH, Xu X, Deng CX. NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation. Nature Communications. 2020, 26;11(1):3256.
  32. Heng Sun, Zhengqiang Miao, Xin Zhang, Un In Chan, Sek Man Su, Sen Guo, Chris Koon Ho Wong, Xiaoling Xu, Chuxia Deng. Single-cell RNA-Seq reveals cell heterogeneity and hierarchy within mouse mammary epithelia. Journal of Biological Chemistry, 2018, 1;293(22):8315-8329.
  33. Fangyuan Shao, Heng Sun, Chuxia Deng. Potential therapeutic targets of triple-negative breast cancer based on its intrinsic subtype. Oncotarget, 2017; 8:73329-73344.
  34. Wong AH, Li H, Jia Y, Mak P, Martins RPS, Liu Y, Vong CM, Wong HC, Wong PK, Wang H, Sun H, Deng C. Drug screening of cancer cell lines and human primary tumors using droplet microfluidics. Rep., 2017, 7(1): 9109.
  35. Chen#, Heng Sun#, Kai Miao#, Chu-Xia Deng. CRISPR-Cas9: from Genome Editing to Cancer Research. International Journal of Biological Sciences, 2016, 12(12): 1427-1436 (#, Co-first author).
  36. Heng Sun, Xuebing Li, Li Fan, Guohao Wu, Min Li, Jing Fang. TRAF6 Is Upregulated in Colon Cancer and Promotes Proliferation of Colon Cancer Cells. Int J Biochem Cell Biol, 2014, Apr, 53:195-201.
  37. Heng Sun#, Xuebing Li#, Ya Meng, Li Fan, Min Li, Jing TRAF6 upregulates expression of HIF-1α and promotes tumor angiogenesis. Cancer Research, 2013, May, 73: 4950- 4959 (#, Co-first author).
  38. Heng Sun#, Xuebing Li#, Jing Hypoxia and tumors. Chinese Bulletin of Life Sciences, 2013, Feb, 25(2): 206-217 (#, Co-first author).
  39. Ying Chen, Hai-Sheng Zhang, Guo-Hua Fong, Qiu-Lei Xi, GuoHao Wu, Chen-Guang Bai, Zhi-Qiang Ling, Li Fan, Yi-Ming Xu, Yan-Qing Qin, Tang-Long Yuan, Heng Sun, and Jing Fang. PHD3 Stabilizes the Tight Junction Protein Occludin and Protects Intestinal Epithelial Barrier Function. J Biol Chem, 2015, Aug, 290(33): 20580-9.
  40. Liu Q, Hu T, He L, Huang X, Tian X, Zhang H, He L, Pu W, Zhang L, Sun H, Fang J, Yu Y, Duan S, Hu C, Hui L, Zhang H, Quertermous T,Xu Q, Red-Horse K, Wythe JD, Zhou B. Genetic targeting of sprouting angiogenesis using Apln-CreER. Nature Communications, 2015, Jan, 19; 6: 6020.
  41. Zhou CF, Li XB, Sun H, Zhang B, Han YS, Jiang Y, Zhuang QL, Fang J, Wu GH. Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells. IUBMB Life, 2012, Sep, 64(9): 775-82.
  42. Xue J, Lv DD, Jiao S, Zhao W, Li X, Sun H, Yan B, Fan L, Hu RG, Fang J. pVHL mediates K63-linked ubiquitination of nCLU. PLoS One, 2012, 7(4): e35848.
  43. Li XB, Jiao S, Sun H, Xue J, Zhao WT, Fan L, Wu GH, Fang J. The orphan nuclear receptor EAR2 is overexpressed in colorectal cancer and it regulates survivability of colon cancer cells. Cancer Lett, 2011, Oct, 309(2): 137-44.
  44. Meng D, Lv DD, Zhuang X, Sun H, Fan L, Shi XL, Fang J. Benzo[a]pyrene induces expression of matrix metalloproteinases and cell migration and invasion of vascular smooth muscle cells. Toxicol Lett, 2009, Jan, 184(1): 44-9.