| Talk title | Strategies Focused on Overcoming Bacterial Resistance |
| Speaker | Prof. PharmDr. JOSEF JAMPÍLEK Professor Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava |
| Date & Time | 29 Oct 2019 (Tue) 11:00-12:00 |
| Venue | Room G004, E12 Building (University of Macau) |
| Abstract | The development of resistance to used anti-infectives (especially antibacterial and antifungal drugs) and the development of cross-resistant or multidrug-resistant strains are global problems. This lecture provides a comprehensive review of recently reported new anti-microbial agents with a new/innovative mode of action, i.e. agents affecting new targets. Anti-microbially effective nanomaterials are discussed as well. In addition, an attention is also paid to agents decreasing bacterial resistance, i.e. to agents that do not have sufficient intrinsic bacteriostatic or bactericidal activity, but in combination with clinically used antimicrobial drugs are able to restore the effect of these drugs or demonstrate synergistic antimicrobial properties together with the drugs. Special attention is devoted to compounds derived from 8-hydroxyquiniline, cinnamic acid and hydroxynaphthalenes. These scaffolds can be considered as privilege structures due to the wide range of their biological activities. The scaffolds can be easily and rapidly functionalized, which provides a possibility of a great number of targeted modifications as well as the optimization of physicochemical properties. In addition, compounds based on the above-mentioned scaffolds are multi-target drugs, i.e. they fulfil the concept of polypharmacology and multifactorial diseases. |