聯絡信息
職稱
教授
辦公室
(辦公室) E12-4014
/(實驗室) N22-4002a
電話
(辦公室) +853 8822 4992
/ (實驗室) +853 8822 2941
傳真
+853 8822 2933
諮詢時間
星期一、四 10:00 – 11:00
教學
研究團隊
Education | |
Postdoctoral Research Fellow | Department of Molecular Biology and Genetics, Cornell University (1999-2004) |
PhD | Molecular Biology, School of Biological Sciences, Faculty of Science and Engineering, University of Manchester (1995-2000) |
BA | Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California, Berkeley (1988-1992) |
Position | |
2013 – Present | Professor, Faculty of Health Sciences, University of Macau |
2011 – 2013 | Adjunct Associate Professor, Department of Biochemistry, National University of Singapore |
2006 – 2011 | Adjunct Assistant Professor, Department of Biochemistry, National University of Singapore |
2006 – 2013 | Faculty, NUS Graduate School for Integrative Sciences & Engineering, National University of Singapore |
2006 – 2013 | Adjunct Assistant Professor, School of Biological Sciences, Nanyang Technological University |
2004 – 2013 | Senior Investigator, Cancer Biology and Pharmacology, Genome Institute of Singapore |
1996 – 1998 | Graduate Research/Teaching Assistant, School of Biological Sciences, the University of Manchester |
Research Interests |
My lab is interested in understanding the molecular details of nuclear hormone signaling and how these pathways relate to disease conditions, including cancers. Currently, we are investigating how lipophilic hormones such as estrogens and androgens regulate the transcriptional activities of nuclear hormone receptors in the context of a chromatin environment. We employ a combination of powerful biological tools, including modern genetic and cell-based techniques (RNAi, ChIP, and FISH) and next-generation sequencing approaches (ChIP-Seq, RNA-Seq, and ChIA-PET), to define the molecular mechanisms of transcriptional regulation by estrogen and androgen receptors. The findings from our work will have direct impact towards the development of therapeutic targets for the wide range of diseases and disorders in which these and other nuclear receptors play a role. |
Representative Publications |
*Co-corresponding authors |
Research Grants | |
2018 – 2021 | University of Macau MYRG (MOP1,500,000: PI) |
2016 – 2019 | FDCT Research Grant (MOP1,616,900: PI) |
2015 – 2018 | University of Macau MYRG (MOP2,400,000: PI) |
2015 – 2018 | FDCT Research Grant (MOP2,600,000: PI) |
2015 – 2016 | FDCT Special Equipment Fund (MOP6,750,000: PI) |
2014 – 2015 | University of Macau SRG (MOP150,000: PI) |
2012 – 2015 | A*STAR Joint Council Office Grant, Integrative Analysis of the Oncogenic Transcription Factor, AP-2gamma, in Breast Cancer Using Nanobiotechnology and Genome Biology, (SGD$1,000,000, Project Director/PI) |
2011 – 2014 | NMRC IRG, Novel Anti-Androgens of Botanical Origin as Multiple-Site Modulators of Androgen Receptor Signalling to Inhibit Prostate Cancer Development and Growth, (SGD$849,622, Co-PI) |
2011 – 2013 | A*STAR-NZ HRC JGC Grant, Oestrogen-Dependent Regulation of Gene Expression by Cohesion in Breast Cancer, (SGD$250,000, Co-PI) |
2008 – 2011 | A*STAR BMRC Grant, Molecular Mechanisms of Action and Human Bioaccumulation of a Novel Estrogenic Compound Secreted by a Singapore Phytoplankton Isolate, Chattonella marina, (S$604,132, Co-PI) |
Patents | |
2013 | 201303835-1: A method to screen small ligands and determine protein-ligand interactions (filed) |
2013 | 201303638-9: A hybrid sensor using metal nanoparticles and conjugated polymers (filed) |
2012 | 13/651,141: Method of modulating a prostate cancer cell (filed) |
Awards | |
2003 – 2004 | NIH NRSA Postdoctoral Fellowship |
2000 – 2003 | Susan G. Komen Breast Cancer Foundation Postdoctoral Fellowship |
1996 – 1998 | Overseas Research Studentship Award |
1995 – 1998 | Frederick Craven Moore Research Studentship Award |
Professional Activities | |
2013 – Present | Editorial Board, Molecular Cancer Research |
Others |
Conference Presentations
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