何歡歡 - Faculty of Health Sciences (FHS)

haydenlam Lam Su Hang2026-03-05T16:17:10+08:002026-03-05|

聯絡信息

職稱

副教授

辦公室

(地址) E12-2024 / (電話) +853 8822 9301

實驗室

(地址) E12-2073

電郵

huanhuanhe@um.edu.mo

諮詢時間

星期一、星期三 14:00-15:00

教學

Education
PhD	University of California, Los Angeles, USA 2013
BSc	Central South University, China 2006

Position
2026 – Present	Associate Professor, Faculty of Health Sciences, University of Macau
2017 – 2026	Professor, The Fifth Affiliated Hospital, Sun Yat-sen University
2018 – 2025	Director of Molecular Imaging Center, The Fifth Affiliated Hospital, Sun Yat-sen University
2023 – 2026	Director of Molecular Medicine Teaching and Research Office, The Fifth Affiliated Hospital, Sun Yat-sen University
2023 – 2026	Executive Director of Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University

Research Interests
My research focuses on the crosstalk between perivascular cells and the endothelium, the developmental implications and the related pathological conditions. I have a broad background in vascular biology and cancer biology, with particular expertise in vascular permeability and cancer immunology. My current interests include: (1) unraveling vascular development and diseases using cutting-edge techniques; (2) deciphering macrophage heterogeneity within the tumor microenvironment; (3) investigating the biology and pathology of RNA helicases; (4) AI-powered drug discovery for vascular diseases and oncology. Our research involves the use of a variety of animal models and cutting-edge techniques in molecular and cell biology, physiology and genetics.

Research Interests

My research focuses on the crosstalk between perivascular cells and the endothelium, the developmental implications and the related pathological conditions. I have a broad background in vascular biology and cancer biology, with particular expertise in vascular permeability and cancer immunology. My current interests include: (1) unraveling vascular development and diseases using cutting-edge techniques; (2) deciphering macrophage heterogeneity within the tumor microenvironment; (3) investigating the biology and pathology of RNA helicases; (4) AI-powered drug discovery for vascular diseases and oncology. Our research involves the use of a variety of animal models and cutting-edge techniques in molecular and cell biology, physiology and genetics.

Representative Publications
First/Corresponding Authorship Shuai Li#, Yuxuan Liu#, Yingying Dong#, Yujiao Gong#, Simeng He, Jianyu Yuan, Shengfeng Deng, Qianqian Zhang, Lijie Wang, Fei Liu, Qiuyun Tu, Hong Shan, Huanhuan He, DEAD-box helicase DDX24 is essential for endothelial mitochondrial function to maintain the blood-brain barrier, Cell Reports*, 2025, 44(10):116428. Fangbin Chen#, Zhaohua Deng#, Xiaoming Wang#,Yuxuan Liu#, Kaichen Zhao, Yue Zhang, Simeng He, Rensen Ran, Yingying Dong, Shuang Guo, Yitong Zhou, Bin Zhou, Pengfei Pang, Wei Ge, Chang Liu, Hong Shan, Huanhuan He, DDX24 spatiotemporally orchestrates VEGF and Wnt signaling during developmental angiogenesis, Proceedings of the National Academy of Sciences of the United States of America, 2025, 122(19):e2417445122. Hui Luo#, Xiaolu She#, Yubo Zhang#, Bingfan Xie#, Shibo Zhang, Qianqian Li, Yangyang Zhou, Shuang Guo, Shushan Zhang, Yanhui Jiang, Yingying Dong, Jianzhong He, Lijie Wang, Qianqian Zhang, Yuan Zhuang, Panxia Deng, Feng Wang, Jihong Liu, Xin Chen, Huilong Nie, Huanhuan He, PLIN2 promotes lipid accumulation in ascites-associated macrophages and ovarian cancer progression by HIF1α/SPP1 signaling, Advanced Science, 2025, 12(12):e2411314. Baibin Wang#, Yuan Zhuang#, Chongrong Weng#, Yanhui Jiang#, Bingfan Xie, Lijie Wang, Yingying Dong, Xiangpei Fang, Jianzhong He, Xiaojin Wang, Huanhuan He, Yong Chen, Huilong Nie, DDX24 promotes lymphangiogenesis and lymph node metastasis via AGRN production in cervical squamous cell carcinoma, Chinese Medical Journal, 2025, 138(3):361-363. YuJiao Gong^#, Yan Liang^#, Jie Liu^#, Jiaxing Wei^#, Shushan Zhang, Fangbin Chen, Qianqian Zhang, Lijie Wang, Huimin Lan, Wei Ge, Shuai Li, Li Wang, Hong Shan, Huanhuan He, DDX24 is essential for cell cycle regulation in vascular smooth muscle cells during vascular development via binding to FANCA mRNA, Arteriosclerosis Thrombosis and Vascular Biology, 2023, 43(9):1653-1667. Haopei Zhang^#, Qiuyue Chen^#, Qianqian Zhang, Hairun Gan, Hanjie Li, Shoudeng Chen, Hong Shan, Pengfei Pang, Huanhuan He, DDX24 mutation alters NPM1 phase behavior and disrupts nucleolar homeostasis in vascular malformations, International Journal of Biological Sciences, 2023, 19(13): 4123-4138. Tianze Liu^#, Hairun Gan^#, Simeng He^#, Jia Deng^#, Xinyan Hu^#, Luting Li, Cai Li, Jianzhong He, Haoyu Long, Jianxun Cai, Hanjie Li, Qianqian Zhang, Lijie Wang, Fangbin Chen, Yuming Chen, Haopei Zhang, Jian Li, Lukun Yang, Ye Liu, Jianhua Yang, Dongming Kuang, Pengfei Pang, Huanhuan He, Hong Shan, RNA helicase DDX24 stabilizes LAMB1 to promote hepatocellular carcinoma progression, Cancer Research, 2022, 82(17): 3074-3087. Famin Zeng^#, Yingwen Li^#, Zhaohua Deng^#, Jianzhong He^#, Wei Li, Lijie Wang, Ting Lyu, Zhanyu Li, Chaoming Mei, Meilin Yang, Yingying Dong, Guanmin Jiang, Xiaofeng Li, Xi Huang, Fei Xiao, Ye Liu, Hong Shan, Huanhuan He, SARS-CoV-2 spike spurs intestinal inflammation via VEGF production in enterocytes, EMBO Molecular Medicine, 2022, 14(5):e14844. Cuizan Cai, Xuxu Zhuang, Qi Zhu, Mingyue Wu, Huanxing Su, Xiaojin Wang, Iyaswamy Ashok, Zhenyu Yue, Qian Wang, Bin Zhang, Yu Xue, Jieqiong Tan, Min Li, Huanhuan He, Jiahong Lu, Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models, Theranostics, 2022, 12(4): 1738–1755. Yuan Wei, Chunxiang Huang, Xiao Xiao, Dongping Chen, Hong Shan^, Huanhuan He, Dongming Kuang, B cell heterogeneity, plasticity, and functional diversity in cancer microenvironments, *Oncogene, 2021, 40(29):4737-4745. (review article) Shibo Zhang^#, Bingfan Xie^#, Lijie Wang^#, Hua Yang^#, Haopei Zhang, Yuming Chen, Feng Wang, Changqing Liu, Huanhuan He, Macrophage-mediated vascular permeability via VLA4/VCAM1 pathway dictates ascites development in ovarian cancer, Journal of Clinical Investigation, 2021, 131(3):e140315. Pengfei Pang^#, Xiaojun Hu^#, Bin Zhou^#, Junjie Mao^#, Yu Liang, Zaibo Jiang, Mingsheng Huang, Ruihong Liu, Youyong Zhang, Jiesheng Qian, Jinsong Liu, Jinxin Xu, Yaqin Zhang, Maoheng Zu, Yiming Wang, Huanhuan He, Hong Shan, DDX24 mutations associated with malformations of major vessels to the viscera, Hepatology, 2019, 69(2):803-816. Huanhuan He, Julia J Mack, Esra Guc, Carmen M Warren, Mario Leonardo Squadrito, Witold W Kilarski, Caroline Baer, Ryan D Freshman, Austin I McDonald, Safiyyah Ziyad, Melody A Swartz, Michele De Palma, M Luisa Iruela-Arispe, Perivascular macrophages limit permeability, *Arteriosclerosis Thrombosis and Vascular Biology, 2016, 36(11): 2203-2212. Huanhuan He, Jingying Xu, Carmen M Warren, Dan Duan, Xinmin Li, Lily Wu, M Luisa Iruela-Arispe. Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages. *Blood. 2012;120(15):3152-3162. Collaborative authorship* Kun Wu, Yiming Yue, Lingling Zhou, Zhiwei Zhang, Hong Shan, Huanhuan He, Wei GE, Disrupting Amh and androgen signaling reveals their distinct roles in zebrafish gonadal differentiation and gametogenesis, Communications Biology, 2025, 8(1):371. Rensen Ran, Lanxin Li, Tingting Xu, Jixuan Huang, Huanhuan He, Yonglong Chen, Revealing mitf functions and visualizing allografted tumor metastasis in colorless and immunodeficient Xenopus tropicalis, *Communications Biology, 2024, 7(1):275. Lauren Goddard, Thomas Murphy, Tonis Org, Josephine M Enciso, Minako K Hashimoto-Partyka, Carmen Warren, Courtney Domigan, Austin McDonald, Huanhuan He, Lauren Sanchez, Nancy Allen, Fabrizio Orsenigo, Lily Chao, Elisabetta Dejana, Peter Tontonoz, Hanna Mikkola, Luisa Iruela-Arispe, Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation, *Cell. 2014, 156(3):549-62. Jeanine Roodhart, Huanhuan He, Laura Daenen, Arnaud Monvoisin, Chad Barber, Miranda van Amersfoort, Jennifer Hofmann, Freddy Radtke, Timothy Lane, Emile Voest, Luisa Iruela-Arispe, Notch1 regulates angio-supportive bone marrow-derived cells in mice: relevance to chemoresistance, *Blood*. 2013, 122(1):143-53.
Full publications list

Representative Publications

First/Corresponding Authorship

Shuai Li#, Yuxuan Liu#, Yingying Dong#, Yujiao Gong#, Simeng He, Jianyu Yuan, Shengfeng Deng, Qianqian Zhang, Lijie Wang, Fei Liu*, Qiuyun Tu*, Hong Shan*, Huanhuan He*, DEAD-box helicase DDX24 is essential for endothelial mitochondrial function to maintain the blood-brain barrier, Cell Reports, 2025, 44(10):116428.
Fangbin Chen#, Zhaohua Deng#, Xiaoming Wang#,Yuxuan Liu#, Kaichen Zhao, Yue Zhang, Simeng He, Rensen Ran, Yingying Dong, Shuang Guo, Yitong Zhou, Bin Zhou, Pengfei Pang, Wei Ge*, Chang Liu*, Hong Shan*, Huanhuan He*, DDX24 spatiotemporally orchestrates VEGF and Wnt signaling during developmental angiogenesis, Proceedings of the National Academy of Sciences of the United States of America, 2025, 122(19):e2417445122.
Hui Luo#, Xiaolu She#, Yubo Zhang#, Bingfan Xie#, Shibo Zhang, Qianqian Li, Yangyang Zhou, Shuang Guo, Shushan Zhang, Yanhui Jiang, Yingying Dong, Jianzhong He, Lijie Wang, Qianqian Zhang, Yuan Zhuang, Panxia Deng, Feng Wang, Jihong Liu*, Xin Chen*, Huilong Nie*, Huanhuan He*, PLIN2 promotes lipid accumulation in ascites-associated macrophages and ovarian cancer progression by HIF1α/SPP1 signaling, Advanced Science, 2025, 12(12):e2411314.
Baibin Wang#, Yuan Zhuang#, Chongrong Weng#, Yanhui Jiang#, Bingfan Xie, Lijie Wang, Yingying Dong, Xiangpei Fang, Jianzhong He, Xiaojin Wang*, Huanhuan He*, Yong Chen*, Huilong Nie*, DDX24 promotes lymphangiogenesis and lymph node metastasis via AGRN production in cervical squamous cell carcinoma, Chinese Medical Journal, 2025, 138(3):361-363.
YuJiao Gong^#, Yan Liang^#, Jie Liu^#, Jiaxing Wei^#, Shushan Zhang, Fangbin Chen, Qianqian Zhang, Lijie Wang, Huimin Lan, Wei Ge, Shuai Li*, Li Wang*, Hong Shan*, Huanhuan He*, DDX24 is essential for cell cycle regulation in vascular smooth muscle cells during vascular development via binding to FANCA mRNA, Arteriosclerosis Thrombosis and Vascular Biology, 2023, 43(9):1653-1667.
Haopei Zhang^#, Qiuyue Chen^#, Qianqian Zhang, Hairun Gan, Hanjie Li, Shoudeng Chen*, Hong Shan*, Pengfei Pang*, Huanhuan He*, DDX24 mutation alters NPM1 phase behavior and disrupts nucleolar homeostasis in vascular malformations, International Journal of Biological Sciences, 2023, 19(13): 4123-4138.
Tianze Liu^#, Hairun Gan^#, Simeng He^#, Jia Deng^#, Xinyan Hu^#, Luting Li, Cai Li, Jianzhong He, Haoyu Long, Jianxun Cai, Hanjie Li, Qianqian Zhang, Lijie Wang, Fangbin Chen, Yuming Chen, Haopei Zhang, Jian Li, Lukun Yang, Ye Liu, Jianhua Yang, Dongming Kuang*, Pengfei Pang*, Huanhuan He*, Hong Shan*, RNA helicase DDX24 stabilizes LAMB1 to promote hepatocellular carcinoma progression, Cancer Research, 2022, 82(17): 3074-3087.
Famin Zeng^#, Yingwen Li^#, Zhaohua Deng^#, Jianzhong He^#, Wei Li, Lijie Wang, Ting Lyu, Zhanyu Li, Chaoming Mei, Meilin Yang, Yingying Dong, Guanmin Jiang, Xiaofeng Li, Xi Huang, Fei Xiao*, Ye Liu*, Hong Shan*, Huanhuan He*, SARS-CoV-2 spike spurs intestinal inflammation via VEGF production in enterocytes, EMBO Molecular Medicine, 2022, 14(5):e14844.
Cuizan Cai, Xuxu Zhuang, Qi Zhu, Mingyue Wu, Huanxing Su, Xiaojin Wang, Iyaswamy Ashok, Zhenyu Yue, Qian Wang, Bin Zhang, Yu Xue, Jieqiong Tan, Min Li, Huanhuan He*, Jiahong Lu*, Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models, Theranostics, 2022, 12(4): 1738–1755.
Yuan Wei, Chunxiang Huang, Xiao Xiao, Dongping Chen, Hong Shan^*, Huanhuan He*, Dongming Kuang*, B cell heterogeneity, plasticity, and functional diversity in cancer microenvironments, Oncogene, 2021, 40(29):4737-4745. (review article)
Shibo Zhang^#, Bingfan Xie^#, Lijie Wang^#, Hua Yang^#, Haopei Zhang, Yuming Chen, Feng Wang, Changqing Liu*, Huanhuan He*, Macrophage-mediated vascular permeability via VLA4/VCAM1 pathway dictates ascites development in ovarian cancer, Journal of Clinical Investigation, 2021, 131(3):e140315.
Pengfei Pang^#, Xiaojun Hu^#, Bin Zhou^#, Junjie Mao^#, Yu Liang, Zaibo Jiang, Mingsheng Huang, Ruihong Liu, Youyong Zhang, Jiesheng Qian, Jinsong Liu, Jinxin Xu, Yaqin Zhang, Maoheng Zu*, Yiming Wang*, Huanhuan He*, Hong Shan*, DDX24 mutations associated with malformations of major vessels to the viscera, Hepatology, 2019, 69(2):803-816.
Huanhuan He, Julia J Mack, Esra Guc, Carmen M Warren, Mario Leonardo Squadrito, Witold W Kilarski, Caroline Baer, Ryan D Freshman, Austin I McDonald, Safiyyah Ziyad, Melody A Swartz, Michele De Palma, M Luisa Iruela-Arispe*, Perivascular macrophages limit permeability, Arteriosclerosis Thrombosis and Vascular Biology, 2016, 36(11): 2203-2212.
Huanhuan He, Jingying Xu, Carmen M Warren, Dan Duan, Xinmin Li, Lily Wu, M Luisa Iruela-Arispe*. Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages. Blood. 2012;120(15):3152-3162.

Collaborative authorship

Kun Wu, Yiming Yue, Lingling Zhou, Zhiwei Zhang, Hong Shan, Huanhuan He, Wei GE*, Disrupting Amh and androgen signaling reveals their distinct roles in zebrafish gonadal differentiation and gametogenesis, Communications Biology, 2025, 8(1):371.
Rensen Ran, Lanxin Li, Tingting Xu, Jixuan Huang, Huanhuan He, Yonglong Chen*, Revealing mitf functions and visualizing allografted tumor metastasis in colorless and immunodeficient Xenopus tropicalis, Communications Biology, 2024, 7(1):275.
Lauren Goddard, Thomas Murphy, Tonis Org, Josephine M Enciso, Minako K Hashimoto-Partyka, Carmen Warren, Courtney Domigan, Austin McDonald, Huanhuan He, Lauren Sanchez, Nancy Allen, Fabrizio Orsenigo, Lily Chao, Elisabetta Dejana, Peter Tontonoz, Hanna Mikkola, Luisa Iruela-Arispe*, Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation, Cell. 2014, 156(3):549-62.
Jeanine Roodhart, Huanhuan He, Laura Daenen, Arnaud Monvoisin, Chad Barber, Miranda van Amersfoort, Jennifer Hofmann, Freddy Radtke, Timothy Lane, Emile Voest, Luisa Iruela-Arispe*, Notch1 regulates angio-supportive bone marrow-derived cells in mice: relevance to chemoresistance, Blood. 2013, 122(1):143-53.

Full publications list

Research Grants
2024 – 2026	國家自然科學基金優秀青年科學基金專案
2022 – 2024	國家自然科學基金重大研究計畫培育專案
2020 – 2021	廣東省國際科研合作專案
2019 – 2022	國家自然科學基金面上專案
2018 – 2020	中山大學高校基本科研業務費青年教師重點培育專案
2018	國家自然科學基金應急專案

Patents
何歡歡, 單鴻, 董影影, 秦靜波, S100A8作為血管畸形的治療靶點的應用, ZL 202411008710.9 單鴻, 何歡歡, 董影影, 蔡翠贊, 孟魯斯特酸恩扎妥林鹼類複鹽化合物及其製備方法和應用, ZL 202410016848.7 單鴻, 何歡歡, 陳守登, 張浩培, 陳秋樾, DDX24 在維持內皮細胞的核仁穩態中的應用, ZL 202310622734.2 何歡歡, 聶惠龍, 佘曉露, 張舒珊, 謝冰帆, 基於高表達PLIN2的巨噬細胞亞群對卵巢癌腹水診斷和治療的應用, ZL202210809799.3 何歡歡, 聶惠龍, 王柏彬, 翁崇蓉, 王曉進, 蔣豔輝, DDX24 在促進宮頸鱗癌淋巴管生成和淋巴結轉移中的應用, ZL202210950329.9 何歡歡, 單鴻, 王莉, 宮宇嬌, 韋嘉幸, 劉婕, 血管平滑肌細胞特異性 DDX24 及其下游分子在血管發育中的應用, ZL202210667552.2 單鴻, 何歡歡, 陳芳彬, 鄧昭華, CHIR-99021 或 BML-284 在製備恢復 ddx24 敲低的腦血管發育的產品中的應用, ZL202111516415.0 何歡歡, 陳勇, 劉繼紅, 蔣豔輝, 王柏彬, 黎永良, 基於 DDX19A 促進宮頸鱗狀細胞癌轉移的應用, ZL202110009925.2 何歡歡 , 曾發敏 , 嚴志祥 , 劉長青 , 謝冰帆 , 何建忠 , 莊圓 , 無乳鏈球菌Streptococcus agalactiae 治療子宮內膜異位症的應用, ZL202010833844.X 何歡歡, 張詩博, 王莉傑, 張浩培, 巨噬細胞在保護血管屏障中的應用及卵巢癌腹水的預防、抑制和治療, ZL202010094660.6

Patents

何歡歡, 單鴻, 董影影, 秦靜波, S100A8作為血管畸形的治療靶點的應用, ZL 202411008710.9
單鴻, 何歡歡, 董影影, 蔡翠贊, 孟魯斯特酸恩扎妥林鹼類複鹽化合物及其製備方法和應用, ZL 202410016848.7
單鴻, 何歡歡, 陳守登, 張浩培, 陳秋樾, DDX24 在維持內皮細胞的核仁穩態中的應用, ZL 202310622734.2
何歡歡, 聶惠龍, 佘曉露, 張舒珊, 謝冰帆, 基於高表達PLIN2的巨噬細胞亞群對卵巢癌腹水診斷和治療的應用, ZL202210809799.3
何歡歡, 聶惠龍, 王柏彬, 翁崇蓉, 王曉進, 蔣豔輝, DDX24 在促進宮頸鱗癌淋巴管生成和淋巴結轉移中的應用, ZL202210950329.9
何歡歡, 單鴻, 王莉, 宮宇嬌, 韋嘉幸, 劉婕, 血管平滑肌細胞特異性 DDX24 及其下游分子在血管發育中的應用, ZL202210667552.2
單鴻, 何歡歡, 陳芳彬, 鄧昭華, CHIR-99021 或 BML-284 在製備恢復 ddx24 敲低的腦血管發育的產品中的應用, ZL202111516415.0
何歡歡, 陳勇, 劉繼紅, 蔣豔輝, 王柏彬, 黎永良, 基於 DDX19A 促進宮頸鱗狀細胞癌轉移的應用, ZL202110009925.2
何歡歡 , 曾發敏 , 嚴志祥 , 劉長青 , 謝冰帆 , 何建忠 , 莊圓 , 無乳鏈球菌Streptococcus agalactiae 治療子宮內膜異位症的應用, ZL202010833844.X
何歡歡, 張詩博, 王莉傑, 張浩培, 巨噬細胞在保護血管屏障中的應用及卵巢癌腹水的預防、抑制和治療, ZL202010094660.6

Awards
2023	National Excellent Youth Scholar, National (國家自然科學基金優秀青年科學基金)
2022	Excellent Doctor and Mentor, SYSU (中山大學附屬第五醫院名醫名師)
2021	Outstanding Doctoral Supervisor, SYSU (中山大學優秀博士生導師)
2019	2019 Outstanding Young Medical Talents in Guangdong Province (廣東省傑出青年醫學人才)
2017	Hundred Talents Program, SYSU (中山大學“百人計畫”中青年傑出人才)
2017	ATVB Best Cover Award
2013	CTSI (Clinical and Translational Science Institute) Publication Award, UCLA, USA
2012	Philip Whitcome Pre-doctoral Training Program, UCLA, USA
2009	Dr Ursula Mandel Fellowship Award, UCLA, USA

Professional Activities
2013 – Present	Association for Women in Science (AWIS)
2014 – Present	Member, American Association for Cancer Research (AACR)
2016 – Present	Member, American Heart Association (AHA)
2019 – 2023	廣東省醫學會醫學遺傳分會 (第八屆委員會委員) 委員
2020 – 2024	廣東省精準醫學應用學會老年慢病分會副主委
2021 – Present	廣東歐美同學會理事會理事
2021 – Present	Editorial Board Member, BMC Public Health
2024 – Present	廣東省中醫藥學會中醫藥大數據與人工智能專業委員會常務委員