| Talk title | Toxicological evaluation of nanopolystyrene particles at predictive environmental concentrations in Caenorhabditis elegans |
| Speaker | Prof. Dayong WANG Professor Southeast University Nanjing, China |
| Date & Time | 24 September 2018 (Monday) 10:00-11:00 |
| Venue | Room G004, E12 Building (University of Macau) |
| Abstract | The potential toxicity of nanoplastics to environmental organisms has gradually received great attention recently. An in vivo assay system of Caenorhabditis elegans to investigate the possible transgenerational toxicity of nanopolystyrene particles and the underlying cellular mechanisms will be presented. After prolonged exposure, we observed the toxicity of nanopolystyrene particles at concentrations higher than 10 µg L-1. The transgenerational toxicity was further detected in nematodes exposed to nanopolystyrene particles at concentrations higher than 100 µg L-1. This observed transgenerational toxicity of nanopolystyrene particles might be mainly due to the translocation of nanopolystyrene particles into reproductive organs such as the gonad, which potentially in turn led to the transfer of nanopolystyrene particles to the next generation. expression and functional correction in cultured cells following successful gene integration. |
