Talk title The Hippo Pathway in Cell Growth, Organ Size, and Cancer
SpeakerProf. Kun-Liang GUAN
Distinguished Professor
Date & Time21 March 2019 (Thu)
VenueRoom G002, N22 Building (University of Macau)
AbstractThe Hippo pathway is crucial in organ size control and its dysregulation contributes to tumorigenesis.  Core components of the Hippo pathway include the protein kinases of MST1/2, MAP4Ks, LATS1/2, the transcription co-activators YAP/TAZ and their DNA binding partners TEADs. LATS phosphorylates YAP/TAZ to promote cytoplasmic localization and degradation, thereby inhibiting YAP/TAZ and cell growth. The TEAD transcription factors also shuttle between nuclear and cytoplasm in a Hippo independent manner. The Hippo pathway is regulated by a wide range of signals, including cell density, GPCR, cellular energy levels, and mechanical cues. The emerging role of the Hippo pathway in tumorigenesis suggests potential therapeutic value of targeting this pathway for cancer treatment.