| Talk title | Novel Immunomodulators for Treating Solid Tumors |
| Speaker | Prof. Rihe LIU Associate Professor The University of North Carolina at Chapel Hill, USA |
| Date & Time | 20 Sep 2019 (Fri) 10:00-11:00 |
| Venue | Room G004, E12 Building (University of Macau) |
| Abstract | Prof Rihe Liu is currently an associate professor at Eshelman School of Pharmacy, the University of North Carolina at Chapel Hill. He focuses on the sophisticated directed evolution technologies for the development of the next generation trapping or affinity molecules. Hepioneered the application of mRNA-display technology for in vitro selection of proteins with desired functions from various natural proteome libraries and synthetic protein domain/polypeptide libraries. He successfully developed a series of trap molecules that can bind to chemo/cytokines (i.e. CXCL12, CXCL13, CCL2, CCL5, IL-6), immune checkpoints (i.e. PD-1, PD-L1, PD-L2), cell surface receptors (i.e. HER3), and PAMP-mediated innate immune targets (i.e. LPS and STING). They are developing the next-generation biologics using various formats, including the protein, the mRNA as well as the engineered T cells (CAR-T), for both mechanistic studies of the TME immunosuppression and translational combination immunotherapies for major solid tumors
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