| Talk title | From TRP to TMC, the Molecular Mechanisms Underlying Mechanosensation in C. elegans |
| Speaker | Prof. Lijun KANG Professor Department of Neurobiology, Institute of Neuroscience, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang University School of Medicine |
| Date & Time | 08 Nov 2019 (Fri) 16:30-17:30 |
| Venue | Room G002, N22 Building (University of Macau) |
| Abstract | Animals have many modes of sensation such as hearing, touch and proprioception medicated by the mechanosensitive channels. Neurons transduce mechanical stimuli into electrical impulses through mechanosensitive channels within the molecular conformation of their plasma membranes, and then they pass the signal of the sensory system to the downstream. In metazoan, there are few mechnosensitive channel confirmed, so finding the new mechnosensitive channel is an important question. Using combinatorial techniques including molecular genetics, electrophysiology, functional imaging, opto-genetics and behavioral tracking, Prof. KANG’s team are addressing how putative mechanosensitive channels such as TRP and TMC channels process sensory cues to encode behavioral outputs. Their work may provide valuable insights regarding the molecular mechanisms of mechnotransdcution, and has the potential to develop possible diagnostic tools and treatments for the degradation of mechanosensation. |