| Talk title | Developing New Technologies for studying Gene Regulation from 1D to 3D |
| Speaker | Prof. Michael Qiwei ZHANG Chair Professor, Tsinghua University |
| Date & Time | 29 June 2017 (Thursday) 10:00-11:00 |
| Venue | Room G004, E12 Building (University of Macau) |
| Abstract | Cell fate determination and transformation is intimately related to chromatin interaction and 3D genome structure. Many 1D cancer or other developmental regulatory disease markers, such as GWAS SNPs/CNVs, heritable or somatic mutations, gene fusions, viral insertion hotspots, epi-mutations, etc., are often linked to dis-regulation of cis-regulatory elements to their target genes through altered 3D DNA loops. I will review the history of computational genome regulation and then introduce some new biochemical (BL-Hi-C), biophysical (Super-resolution imaging) and Bioinformatics (MICC, 3CPET, FIND) technology developments that may be used for studying 3D genomes and disease markers in the near future. |
