2020-04-23T16:41:50+08:002018-11-09|News and events, Seminars and Workshops|
Talk title Evans blue-based theranostics
Speaker Prof. Xiaoyuan CHEN
Senior Investigator
National Institute of Health (NIH)
Date & Time 8 November 2018 (Thurs)
Venue Room G004, E12 Building (University of Macau)
Abstract Theranostics (Rx/Dx) aims to develop molecular diagnostic tests and targeted therapeutics with the goals of individualizing treatment by targeting therapy to an individual’s specific disease subtype and genetic profile. It can be diagnosis followed by therapy to stratify patients who will likely respond to a given treatment; it can also be therapy followed by diagnosis to monitor early response to treatment and predict treatment efficacy; it is also possible that diagnostics and therapeutics are co-developed (nanotheranostics). This talk will use Evans blue as an example to illustrate how this reversible albumin binder can be suitably for vasculature and lymphatic system imaging, as an enhancer to prolong circulation half-life of drugs for diabetes treatment, radioligand cancer therapy, cancer vaccine and cancer nano prodrug development.