Total publications: 54
Total SCI paper: 53
Publication in journal ranking at Q1 and Q2: 53 (98.1%)

Published papers
* Co-first author publication  # Corresponding author publication

  1. R Ke, SIS Lok, K Singh, BKC Chow, H Janovjak and LTO Lee# 2021 Formation of Kiss1R/GPER heterocomplexes negatively regulates Kiss1R-mediated signalling through limiting receptor cell surface expression J Mol Biol 443(7) 166843
  1. R Lu, N Liu, X Feng, Y Feng, S Zhang, Y Wu, T Jia, X Yang, LTO Lee, Sun L 2020 An association study between MiR-146a and INSR gene polymorphisms and hypertensive disorders of pregnancy in Northeastern Han Chinese population Placenta 104:94-101
  1. QY Zhang, W Zhou, S Yu, Y Ju, SKY To, AST Wong, Y Jiao, TCW Poon, KY Tam, LTO Lee# 2021 Metabolic reprogramming of ovarian cancer involves ACSL1-mediated metastasis stimulation through upregulated protein myristoylation Oncogene 440(1) 97-111
  1. R Ke, SIS Lok, K Singh, BKC Chow, LTO Lee# 2020 GIP receptor suppresses PAC1 receptor-mediated neuronal differentiation via formation of a receptor heterocomplex J Neurochem [Epub ahead of print] doi: 10.1111/jnc.15220
  1. W Zhang, R Xie, XD Zhang, LTO Lee, H Zhang, M Yang, B Peng, J Zheng 2020 Organism Dual RNA-seq Reveals the Importance of BarA/UvrY in Vibrio Parahaemolyticus Virulence. FASEB J doi: 10.1096/fj.201902630R
  1. X Yang, F Hu, JA Liu, S Yu, MPL Cheung, X Liu, IO Ng, XY Guan, KKW Wong, R Sharma, HL Lung, Y Jiao, LTO Lee, M Cheung 2020 Nuclear DLC1 exerts oncogenic function through association with FOXK1 for cooperative activation of MMP9 expression in melanoma. Oncogene 39(20) 4061-4076
  1. S Xu, S Yu, D Dong, LTO Lee# 2019 G Protein-Coupled Estrogen Receptor: A Potential Therapeutic Target in Cancer Front Endocrinol 10:725
  1. S Zhang, S Yu, W Hou, X Li, C Ning, Y Wu, F Zhang, YF Jiao, LTO Lee, L Sun 2019 Diagnostic extended usefulness of RMI: comparison of four risk of malignancy index in preoperative differentiation of borderline ovarian tumors and benign ovarian tumors J Ovarian Res 12(1):87
  1. SS Li, CKM Ip, MYH Tang, Y Tong, J Zhang, AA Hassan, ASC Mak, S Yung, TM Chan, PP Ip, CL Lee, PCN Chiu, LTO Lee, HC Lai, HZ Zeng, HC Shum, AST Wong 2019 Sialyl Lewisx-P-selectin cascade mediates tumor-mesothelial adhesion in ascitic fluid shear flow Nat Commun 10(1):2406
  1. QY Zhang, S Yu, SIS Lok, AST Wong, Y Jiao, LTO Lee# 2019 FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer J Cell Mol Med, 23(7): 4569-4581
  1. QY Zhang, S Yu, MMT Lam, TCW Poon, LT Sun, Y Jiao, AST Wong, LTO Lee# 2019 Angiotensin II promotes ovarian cancer spheroid formation and metastasis by upregulation of lipid desaturation and suppression of endoplasmic reticulum stress. J Exp Clin Canc Res, 38(1):116.
  1. R Ke, X Ma, LTO Lee# 2018 Understanding the functions of kisspeptin and kisspeptin receptor (Kiss1R) from clinical case studies. Peptides, S0196-9781(18)30176-1
  1. X Ma, YF Xiong, LTO Lee# 2018 Application of Nanoparticles for Targeting G Protein-Coupled Receptors. International Journal of Molecular Sciences, 19(7), E2006
  1. S Yu, L Sun, Y Jiao, LTO Lee# 2018 The Role of G Protein-coupled Receptor Kinases in Cancer. International Journal of Biological Sciences 14, 189-203
  1. Q Zhang, NE Madden, AST Wong, BKC Chow, LTO Lee# 2017 The role of endocrine G protein-coupled receptors in ovarian cancer progression. Front Endocrinol doi: 10.3389/fendo.2017.00066
  1. KG Harikumar, ML Augustine, LTO Lee, BKC Chow, LJ Miller 2016 Structure and function of cross-class complexes of G protein-coupled secretin and angiotensin 1a receptors. J Biol Chem 291(33):17332-17344
  1. OWH Chua, KKL Wong, BC Ko, SK Chung, BKC Chow, LTO Lee# 2016 Role of nuclear factor of activated T-cells 5 in regulating hypertonic-mediated secretin receptor expression in kidney collecting duct cells. BBA – Gene Regulatory Mechanisms, 1859 (7): 922-932.
  1. JSW On, C Duan, BKC Chow, LTO Lee# 2015 Functional pairing of class B1 ligand-GPCR in cephalochordate provides evidence of the origin of PTH and PACAP/glucagon receptor family Biol. Evo. 32(8):2048-59.
  1. JSW On, BKC Chow, LTO Lee# 2015 Evolution of parathyroid hormone receptor family and their ligands in vertebrate. Front Endocrinol 6: 1-6.
  1. JKV Tam, LTO Lee, J Jin, BKC Chow 2014 Molecular evolution of GPCRs: secretin and secretin receptor. J Endocrinol. 52(3): T1-T14.
  1. LTO Lee*, SYL Ng*, JYS Chu, R Sekar, KG Harikumar, LJ Miller, BKC Chow 2014 Transmembrane peptides as unique tools to show in vivo action on water intake of a GPCR hetero-complex FASEB J 28(6): 2632-2644.
  1. JKV Tam, BKC Chow, LTO Lee# 2013 Structural and functional divergence of growth hormone-releasing hormone receptors in early sarcopterygians: lungfish and Xenopus. PLoS ONE 8(1): e53482.
  1. SYL Ng, LTO Lee, BKC Chow 2012 Receptor oligomerization: from early evidence to current understanding in class B GPCRs Front Endocrinol 3: 175.
  1. Y Yuan, BKC Chow, VHY Lee, LTO Lee# 2012 Neuron-restrictive silencer factor functions to suppress Sp1-mediated transactivation of human secretin receptor gene. BBA-Gene Regul Mech 1829(2):231-238.
  1. SYL Ng, Billy K.C. Chow, J Kasamatsu, M Kasahara, LTO Lee# 2012 Agnathan VIP, PACAP and their receptors: ancestral origins of today’s highly diversified forms. PLoS ONE 7(9)
  1. VHY Lee, IPY Lam, HS Choi, BKC Chow, LTO Lee# 2012 The estrogen-related receptor alpha upregulates secretin expressions in response to hypertonicity and angiotensin II stimulation. PLoS ONE 7(6): e39913.
  1. JKV Tam, LTO Lee, CHK Cheng, BKC Chow 2011 Discovery of a new reproductive hormone in teleosts: Pituitary adenylate cyclase-activating polypeptide-related peptide (PRP). Comp. Endocrinol. 173(3):4-5-410.
  1. JKV Tam*, KW Lau*, LTO Lee*, JYS Chu, KM Ng, A Fournier, H Vaudry, BKC Chow 2011 Origin of secretin receptor precedes the advent of tetrapoda: evidence on the separated origins of secretin and orexin. PLoS ONE 6(4): e19384.
  1. Y Yuan, LTO Lee, SSM Ng, BKC Chow 2011 Extragastrointestinal functions and transcriptional regulation of secretin and secretin receptors. Ann N Y Acad Sci. 1220(1):23-33.
  1. KKY Wong, SYL Ng, LTO Lee, HK Ng, BKC Chow 2011 Orexins and their receptors from fish to mammals: a comparative approach. Comp. Endocrinol. 1171(2):124-130.
  1. VHY Lee*, LTO Lee*, Chu JYS, IPY Lam, FKY Siu, H Vaudry, BKC Chow 2010 An indispensable role of secretin in mediating the osmoregulatory functions of angiotensin II. FASEB J 24(12):5024-5032.
    • Recommended by Faculty 1000 as must read paper: http://f1000.com/10505956
  1. SYL Ng, LTO Lee, BKC Chow 2010 Insights into evolution of proglucagon-derived peptides and receptors in fish and amphibians. Ann N Y Acad Sci. 1200:15-32.
  1. JYS Chu, LTO Lee, CH Lai, H Vaudry, YS Chan, WH Yung, BKC Chow 2009 Secretin as a neurohypophysial factor regulating body fluid homeostasis. Natl. Acad. Sci. U.S.A. 106(37):15961-6.
    • Journal Impact factor: 9.432
    • Awarded Research Output Prize by HKU
  1. VHY Lee, BKC Chow, KW Lo, LS Chow, C Man, SW Tsao, LTO Lee# 2009 Regulation of RASSF1A in nasopharyngeal cells and its response to UV irradiation. Gene 443(1-2):55-63
  1. IPY Lam*, LTO Lee*, Choi HS, Alpini G, Chow BKC 2009 Bile acids inhibit duodenal secretin expression via orphan nuclear receptor small heterodimer partner (SHP). Am J Physiol Gastrointest Liver Physiol. 297(1):G90-97.
  1. LTO Lee, JKV Tam, DW Chan, BKC Chow 2009 Molecular cloning and mRNA distribution of pituitary adenylate cyclase-activating polypeptide (PACAP)/ PACAP-related peptide in the lungfish. Ann N Y Acad Sci. 1163: 204-214.
  1. VHY Lee, LTO Lee, BKC Chow 2008 Gonadotropin-releasing hormone: regulation of the GnRH gene. FEBS J. 275(22):5458-5478.
  1. LTO Lee, IPY Lam, BKC Chow 2008 A functional variable number of tandem repeats is located at the 5’ flanking region of the human secretin gene plays a down regulatory role in expression. J Mol Neurosci. 36(1-3):125-131.
  1. FKY Siu*, LTO Lee*, BKC Chow 2008 Southwestern blotting in investigating transcriptional regulation. Nat Protoc. 3(1): 51-58.


  1. LTO Lee, FKY Siu, JKV Tam, ITY Lau, H Vaudry, MCM Lin, AOL Wong, BKC Chow 2007 Discovery of growth hormone-releasing hormones and receptors in non-mammalian vertebrates. Natl. Acad. Sci. U.S.A. 104(7):2133-2138.
    • Journal Impact factor: 9.598
    • Communicated by Nobel laureate, R Guillemin
  1. JKV Tam, LTO Lee, BKC Chow 2007 PACAP-related peptide (PRP) – molecular evolution and potential functions. Peptides 28(9): 1920-29.
    • Journal Impact factor: 2.368
  1. RLC Hoo, KYY Chan, FKY Leung, LTO Lee, PCK Leung, BKC Chow 2007 Involvement of NF-kappa B subunit p65 and retinoic acid receptors RAR alpha and RXR alpha in the transcriptional regulation of the human GnRH II gene. FEBS J. 274(11):2695-706
    • Journal Impact factor: 3.396
  1. C Man, J Rosa, LTO Lee, VHY Lee, BKC Chow, KW Lo, S Doxsey, ZG Wu, YL Kwong, DY Jin, ALM Cheung, SW Tsao 2007 Latent membrane protein 1 suppresses RASSF1A expression, disrupts microtubule structures and induces chromosomal aberrations in human epithelial cells. Oncogene. 26(21):3069-3080.
    • Journal Impact factor: 6.440
  1. JY Chu, LTO Lee, FK Siu, BKC Chow 2006 The secretin/pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide superfamily in the central nervous system. Med. Chem.Central Nervous System Agents 6: 27-57.
  1. LTO Lee, Tan-Un KC, BKC Chow 2006 Retinoic acid-induced human secretin gene expression in neuronal cells is mediated by cyclin-dependent kinase 1 N. Y. Acad. Sci. 1070: 393-398.
  1. LTO Lee, VH Lee, PY Yuan, BKC Chow 2006 Identification of repressor element 1 in secretin/PACAP/VIP genes N. Y. Acad. Sci. 1070: 388-392.
  1. IPY Lam, LTO Lee, HS Choi, BKC Chow 2006 Localization of small heterodimer partner (SHP) with the secretin in mouse duodenal cells N. Y. Acad. Sci. 1070: 371-375.
  1. LTO Lee, KC Tan-Un, MCM Lin, BKC Chow 2005 Retinoic acid activates human secretin gene expression by Sp-proteins and Nuclear Factor I in neuronal SH-SY5Y cells. Journal of Neurochemistry 93:339-350.
  1. LTO Lee, TU Tan, RTK Pang, DTW Lam, BKC Chow 2004 Regulation of the human secretin gene is controlled by the combined effects of CpG methylation, Sp1/Sp3 ratio and the E-Box element. Molecular Endocrinology 18(7):1740-1755.
  1. RTK Pang, LTO Lee, SSM Ng, WH Yung, BKC Chow 2004 CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene. Molecular Endocrinology 18(2): 471-483.
  1. LTO Lee, G Nong, YH Chan, DL Tse, CH Cheng 2001 Molecular cloning of a teleost growth hormone receptor and its functional interaction with human growth hormone. Gene 270:121-129.
  1. DL Tse, BKC Chow, CB Chan, LTO Lee, CH Cheng 2000 Molecular cloning and expression studies of a prolactin receptor in goldfish (Carassius auratus). Life Sci. 66:593-605.


  1. Wang, YF, Chen, XQ, Sha, L, Lee, LTO, Kendrick KM, Cheng CHK 2020 Editorial: Neuroendocrine Research in Health and Disease Neuroscience 14: 176
  1. Lee LTO 2019 Satellite symposium of to the 13th international symposium on VIP, PACAP and related peptides in Macau 120: 170070

Published Papers (Chinese Journal)

  1. Y Wu, S Yu, LTO Lee, XY Li, LT Sun 2018 Logistic regression analysis of combining transvaginal conventional ultrasonography and 3D power Doppler ultrasonography 3D-PDUS in differential diagnosis of ovarian tumor. Chin J Ultrasonogr 27(3) 237-242

Edited Book

  1. “Wang, Y.-F., Chen, X. Q., Sha, L., Lee, L. T. O., Kendrick, K. M., Cheng, C. H. K., eds. (2020). Neuroendocrine Research in Health and Disease. Lausanne: Frontiers Media SA. doi: 10.3389/978-2-88963-714-0”