1. Li, S., Peng, T., Silva, M., Liu, L., Zhou, W. and Zheng, W. (2020) Artemether Confers Neuroprotection on Cerebral Ischemic Injury through Stimulation of the Erk1/2-P90rsk-CREB Signaling Pathway. Redox biology (Minor revision)
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  19. Kamato D, Burch M, Zhou Y, Mohamed R, Stow JL, Osman N, Zheng W, Little PJ. (2019) Individual Smad2 linker region phosphorylation sites determine the expression of proteoglycan and glycosaminoglycan synthesizing genes. Cell signaling 53, 365-373
  20. Zhao, X., Zeng, Z. W., Gaur, U., Fang, J., Peng, T., Li, S., and Zheng, W. (2019) Metformin Protects PC12 Cells and Hippocampal Neurons from H2O2 -Induced Oxidative Damage through Activation of AMPK Pathway. J Cell Physiol 234(9), 16619-16629
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  23. Wang, B. B., Bao, S. Y., Zhang, Z. G., Zhou, X. Y., Wang, J., Fan, Y. H., Zhang, Y., Li, Y., Chen, L. H., Jia, Y. Z., Li, J., Li, M. X., Zheng, W.,et al. (2018) A Rare Variant in MLKL Confers Susceptibility to ApoE Varepsilon4-Negative Alzheimer’s Disease in Hong Kong Chinese Population. Neurobiol Aging 68, 160.e1-160.e7
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  28. Yan, Fengxia ; Liao, Rifang ; Lin, Shaofen ; Deng, Xianguo ; Little, Peter J. ; Zheng, Wenhua. (2018) Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl-2-like protein 11 and cyclin-dependent kinase inhibitor 1B. Molecular medicine reports 17(2), 3109-3114
  29. Wang, Haitao ; Gaur, Uma ; Xiao, Jiao ; Xu, Bingtian ; Xu, Jiangping ; Zheng, Wenhua. (2018) Targeting phosphodiesterase 4 as a potential therapeutic strategy for enhancing neuroplasticity following ischemic stroke. International journal of biological sciences 14(12), 1745-1754
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  31. Jiajia Chen, Hui Yu, Jiahong Zhong, Hongfang Feng, Haitao Wang, Zhengqiang Zou, Chang Huang, Zhongzhen Zhou, Wenhua Zheng, Jiangping Xu. (2018) The phosphodiesterase-4 inhibitor, FCPR16, attenuates ischemia-reperfusion injury in rats subjected to middle cerebral artery occlusion and reperfusion. Brain research bulletin 137, 98-106
  32. Afroz, R., Cao, Y. N., Rostam, M. A., Ta, H., Xu, S. W., Zheng, W., Osman, N., Kamato, D., and Little, P. (2018) Signalling Pathways Regulating Galactosaminoglycan Synthesis and Structure in Vascular Smooth Muscle: Implications for Lipoprotein Binding and Atherosclerosis. Pharmacol Therapeut 187, 88-97
  33. Liao, R. F., Yan, F. X., Zeng, Z. P., Wang, H. T., Qiu, K. F., Xu, J. Y., and Zheng, W. (2018) Insulin-Like Growth Factor-1 Activates PI3K/Akt Signalling to Protect Human Retinal Pigment Epithelial Cells from Amiodarone-Induced Oxidative Injury. Brit J Pharmacol 175(1), 125-139
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  35. Zheng, W., Meng, Q., Wang, H. T., Yan, F. X., Little, P. J., Deng, X. G., and Lin, S. F. (2017) IGF-1-Mediated Survival from Induced Death of Human Primary Cultured Retinal Pigment Epithelial Cells Is Mediated by an Akt-Dependent Signaling Pathway. Mol Neurobiol 55(3), 1915-1927
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  40. Farhan, Mohd ; Wang, Haitao ; Gaur, Uma ; Little, Peter J. ; Xu, Jiangping ; Zheng, Wenhua. (2017) FOXO Signaling Pathways as Therapeutic Targets in Cancer. International journal of biological sciences 13(7), 815–827
  41. Zeng, Z. W., Xu, J. Y., and Zheng, W. H. (2017) Artemisinin Protects PC12 Cells against β-Amyloid-Induced Apoptosis through Activation of the Erk1/2 Signaling Pathway. Redox Biol 12, 625-633
  42. Kamato, D., Mitra, P., Davis, F., Osman, N., Chaplin, R., Cabot, P., Afroz, R., Thomas, W., Zheng, W., Kaur, H., Brimble, M., and Little, P. (2017) Gaq Proteins: Molecular Pharmacology and Therapeutic Potential. Cell Mol Life Sci 74 (8), 1379-1390
  43. Zeng, Z. W., Wang, X., Bhardwaj, S., Zhou, X. H., Little, P., Quirion, R., Srivastava, L., and Zheng, W. (2017) The Atypical Antipsychotic Agent, Clozapine, Protects against Corticosterone-Induced Death of PC12 Cells by Regulating the Akt/Foxo3a Signaling Pathway. Mol Neurobiol 54(5), ‏ 3395-3406
  44. Yan, F. X., Wang, H. T., Gao, Y., Xu, J. P., and Zheng, W. (2017) Artemisinin Protects Retinal Neuronal Cells against Oxidative Stress and Restores Rat Retinal Physiological Function from Light Exposed Damage. Acs Chem Neurosci 8(8), 1713-1723
  45. Linlin, L.; Zeng, Z.; Gaur, U.; Yan, F.; Zheng, W., (2017) The p38-MAPK Pathway Is Involved in Neuroprotection of Artemisinin against H2O2-induced Apoptosis in PC12 Cells. Journal of Pharmacy and Pharmacology 7, 416-423
  46. You T, Cheng Y, Zhong J, Bi B, Zeng B, Zheng W, Wang H, Xu J. (2017) Roflupram, a Phosphodiesterase 4 Inhibitior, Suppresses Inflammasome Activation through Autophagy in Microglial Cells. ACS Chem Neurosci 8(11), 2381-2392
  47. Zou, Z.Q.; Chen, J.J.; Feng, H.F.; Cheng, Y.F.; Wang, H.T.; Zhou, Z.Z.; Guo, H.B.; Zheng, W.; Xu, J.P. (2017) Novel Phosphodiesterase 4 Inhibitor FCPR03 Alleviates Lipopolysaccharide-Induced Neuroinflammation by Regulation of the cAMP/PKA/CREB Signaling Pathway and NF-κB Inhibition. Journal of Pharmacology and Experimental Therapeutics 362(1), 67-77
  48. Kamato D, Bhaskarala VV, Mantri N, Oh TG, Ling D, Janke R, Zheng W, Little PJ, Osman N. (2017) RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells. PLoS One12(7)
  49. Liu L, Zeng Z, Gaur U, Fang J, Little PJ and Zheng W. (2017) Berberine protect pc12 cells from H2O2 induced oxidative damage through activation of ERK1/2 pathways. Journal of Clinical and Experimental Pharmacology 7.
  50. Ostrowski PP, Barszczyk A, Forstenpointner J, Zheng W, Feng ZP. (2016) Meta-Analysis of Serum Insulin-Like Growth Factor 1 in Alzheimer’s Disease. PLoS One 11(5)
  51. Al Gwairi O, Osman N, Getachew R, Zheng W, Liang XL, Kamato D, Thach L, Little PJ. (2016) Multiple Growth Factors, But Not VEGF, Stimulate Glycosaminoglycan Hyperelongation in Retinal Choroidal Endothelial Cells. Int J Biol Sci 12(9), 1041-1051
  52. Al Gwairi O, Thach L, Zheng W, Osman N, Little PJ. (2016) Cellular and Molecular Pathology of Age-Related Macular Degeneration: Potential Role for Proteoglycans. J Ophthalmol
  53. Muhamad A Rostam, Danielle Kamato, Terence J Piva, Wenhua Zheng, Peter J Little, Narin Osman. (2016) The role of specific Smad linker region phosphorylation in TGF-β mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle. Cell Signal 28(8), 956-966
  54. Danielle Kamato , Lyna Thach , Robel Getachew , Micah Burch , Morley D Hollenberg , Wenhua Zheng , Peter J Little , Narin Osman. (2016) Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes. Cell Signal 28(1), 110-119
  55. Yan Fengxia ; Liao Rifang ; Farhan, Mohd ; Wang Tinghuai ; Chen Jiashu ; Zhong Wang ; Little, Peter J. ; Zheng Wenhua. (2016) Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells. Biomedicine&pharmacotherapy 84, 1538-1550
  56. Zeng, Zhiwen ; Wang, Haitao ; Shang, Fu ; Zhou, Lihua ; Little, Peter J. ; Quirion, Remi ; Zheng, Wenhua. (2016) Lithium ions attenuate serum-deprivation-induced apoptosis in PC12 cells through regulation of the Akt/FoxO1 signaling pathways. Psychopharmacology 233, 785-794
  57. Wang, Rikang ; Zhao, Jiaqiang ; Zhang, Lei ; Peng, Lizhi ; Zhang, Xinyi ; Zheng, Wenhua ; Chen, Heru. (2016) Genipin Derivatives Protect RGC-5 from Sodium Nitroprusside-Induced Nitrosative Stress. International journal of molecular sciences 17(1)
  58. Chong, C. M., and Zheng, W. (2016) Artemisinin Protects Human Retinal Pigment Epithelial Cells from Hydrogen Peroxide-Induced Oxidative Damage through Activation of ERK/CREB Signaling. Redox Biol 9, 50-56
  59. Zheng, W., Chong, C. M., Wang, H. T., Zhou, X. H., Zhang, L., Wang, R. K., Meng, Q., Lazarovici, P., and Fang, J. K. (2016) Artemisinin Conferred ERK Mediated Neuroprotection to PC12 Cells and Cortical Neurons Exposed to Sodium Nitroprusside-Induced Oxidative Insult. Free Radical Bio Med 97, 158-167
  60. Little, P., Hollenberg, M., Kamato, D., Thomas, W., Chen, J., Wang, T., Zheng, W., and Osman, N. (2016) Integrating the GPCR Transactivation‐Dependent and Biased Signalling Paradigms in the Context of Par1 Signalling. Brit J Pharmacol 173 (20), 2992-3000
  61. Rebekah Bernard, Robel Getachew, Danielle Kamato, Lyna Thach, Narin Osman, Vincent Chan, Wenhua Zheng, Peter J Little. (2016) Evaluation of the potential synergism of imatinib-related poly kinase inhibitors using growth factor stimulated proteoglycan synthesis as a model response. J Pharm Pharmacol 68(3), 368-378
  62. Afroz R, Tanvir EM, Zheng W and Little PJ. (2016) Molecular Pharmacology of Honey. Journal of Clinical and Experimental Pharmacology 6(3), 1-13
  63. Al Gwairi O, Thach L, Zheng W, Osman N, Little PJ. (2016) Cellular and MolecularPathology of Age-Related Macular Degeneration: Potential Role for Proteoglycans. J Ophthalmol
  64. Fengxia Yan, Rifang Liao, Peter J. Little and Wenhua Zheng. (2016) FoxO3a suppressed uveal melanoma development via increasing the expression of Bim and p27 Kip1. Molecular Medicine Reports.
  65. Kamato D, Thach L, Bernard R, Chan V, Zheng W, Kaur H, Brimble M, Osman N, Little PJ. (2015) Structure, Function, Pharmacology, and Therapeutic Potential of the G Protein, Gα/q,11. Front Cardiovasc Med 2
  66. Wang, H. T., Quirion, R., Little, P., Cheng, Y. F., Feng, Z. P., Sun, H. S., Xu, J. P., and Zheng, W. (2015) Forkhead Box O Transcription Factors as Possible Mediators in the Development of Major Depression. Neuropharmacology 99, 527-537
  67. Wang, Rikang ; Peng, Lizhi ; Zhao, Jiaqiang ; Zhang, Laitao ; Guo, Cuiping ; Zheng, Wenhua ; Chen, Heru. (2015) Gardenamide A Protects RGC-5 Cells from H2O2-Induced Oxidative Stress Insults by Activating PI3K/Akt/eNOS Signaling Pathway. International journal of molecular sciences 16(9), ‏ 22350-22367
  68. Zhao, Jiaqiang ; Peng, Lizhi ; Zheng, Wenhua ; Wang, Rikang ; Zhang, Lei ; Yang, Jian ; Chen, Heru. (2015) Chemically Bonding of Amantadine with Gardenamide A Enhances the Neuroprotective Effects against Corticosterone-Induced Insults in PC12 Cells. International journal of molecular sciences 16(9), 22795-22810
  69. Wang R, Yang J, Peng L, Zhao J, Mu N, Huang J, Lazarovici P, Chen H, Zheng W. (2015) Gardenamide A attenuated cell apoptosis induced by serum deprivation insult via the ERK1/2 and PI3K/AKT signaling pathways. Neuroscience 286, 242-250
  70. Kamato D, Rostam MA, Bernard R, Piva TJ, Mantri N, Guidone D, Zheng W, Osman N, Little PJ. (2015) The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signaling frontier. Cell Mol Life Sci 72(4), 799-808
  71. Barszczyk A, Sun HS, Quan Y, Zheng W, Charlton MP, Feng ZP. (2015) Differential Roles of the Mevalonate Pathway in the Development and Survival of Mouse Purkinje Cells in Culture. Mol Neurobiol 51(3), 1116-1129
  72. Rostam MA, Piva TJ, Rezaei HB, Kamato D, Little PJ, Zheng W, Osman N. (2015) Peptidyl-prolyl isomerases: functionality and potential therapeutic targets in cardiovascular disease. Clin Exp Pharmacol Physiol 42(2), 117-124
  73. Chen, Qian ; Wang, Haitao ; Liao, Sufen ; Gao, Yang ; Liao, Rifang ; Little, Peter J. ; Xu, Jiangping ; Feng, Zhong-Ping ; Zheng, Yongxin ; Zheng, Wenhua. (2015) Nerve growth factor protects retinal ganglion cells against injury induced by retinal ischemia-reperfusion in rats. Growth factors 33(2), 149-159
  74. Haitao Wang,Jiangping Xu,Jiashu Chen,Peter J Little,Wenhua Zheng (2015) Role of IGF-1 signaling in the pathology of diabetic retinopathy. Therapeutic Targets for Neurological Diseases.
  75. Kamato D, Rostam MA, Piva TJ, BabaahmadiRezaei H, Getachew R, ThachL,Bernard R, Zheng W, Little PJ, Osman N. (2014) Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells. J Pharm Pharmacol 66(12),1722-33
  76. Wang H, Wang R, Thrimawithana T, Little PJ, Xu J, Feng ZP, Zheng W. (2014) The nerve growth factor signaling and its potential as therapeutic target for glaucoma. Biomed Res Int
  77. Al-aryahi S, Kamato D, Getachew R, Zheng W, Potocnik SJ, Cohen N, Guidone D, Osman N, Little PJ. (2014) Atherogenic, fibrotic and glucose utilising actions of glucokinase activators on vascular endothelium and smooth muscle. Cardiovasc Diabetol 13
  78. Wang R, Yang J, Liao S, Xiao G, Luo J, Zhang L, Little PJ, Chen H, Zheng W. (2014) Stereoselective reduction of 1-o-isopropyloxygenipin enhances its neuroprotective activity in neuronal cells from apoptosis induced by sodium nitroprusside. Chem Med Chem 9(7),1397-401
  79. Osman N, Getachew R, Thach L, Wang H, Su X, Zheng W, Little PJ. (2014) Platelet-derived growth factor-stimulated versican synthesis but not glycosaminoglycan elongation in vascular smooth muscle is mediated via Akt phosphorylation. Cell Signal 26(5), 912-916
  80. Kamato D, Burch ML, Piva TJ, Rezaei HB, Rostam MA, Xu S, Zheng W, Little PJ, Osman N. (2013) Transforming growth factor-β signalling: role and consequences of Smad linker region phosphorylation. Cell Signal 25(10), 2017-2024
  81. Kamato D, BabaahmadiRezaei H, Getachew R, Thach L, Guidone D, Osman N,Roufogalis B, Duke CC, Tran VH, Zheng W, Little PJ. (2013) (S)-[6]-Gingerol inhibits TGF-β-stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in  human vascular smooth muscle cells. J Pharm Pharmacol 65(7),1026-1036
  82. Wang, Haitao; Zhou, Xuanhe; Huang, Jianchu; Mu, Nan; Guo, Zeli; Wen, Qiang; Wang, Rikang; Chen, Shaorui; Zheng, Wenhua. (2013) The Role of Akt/FoxO3a in the Protective Effect of Venlafaxine against Corticosterone-induced Cell Death in PC12 cells. Psycopharmacology 228(1), 129-141
  83. Zheng W, Zeng Z, Bhardwaj SK, Jamali S, Srivastava LK. (2013) Lithium normalizes amphetamine-induced changes in striatal FoxO1 phosphorylation and behaviors in rats. Neuroreport 24(10), 560-565
  84. Kamato D, Burch ML, Osman N, Zheng W, Little PJ. (2013) Therapeutic implications of endothelin and thrombin G-protein-coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors. J Pharm Pharmacol 65(4):465-473
  85. Haitao Wang, Xiaolu Duan, Yannan Ren, Yizhi Liu, Min Huang, Peiqing Liu, Rikang Wang, Guoquan Gao, Lihua Zhou, Zhongping Feng,Wenhua Zheng. (2013) FoxO3a negatively regulates nerve growth factor-induced neuronal differentiation through inhibiting the expression of neurochondrin in PC12 cells. Mol Neurobiol 47(1), 24-36
  86. Little PJ, Rostam MA, Piva TJ, Getachew R, Kamato D, Guidone D, Ballinger ML, Zheng W, Osman N. (2013) Suramin inhibits PDGF-stimulated receptor phosphorylation, proteoglycan synthesis and glycosaminoglycan hyperelongation in human vascular smooth muscle cells. J Pharm Pharmacol 65(7):1055-1063
  87. WenhuaZheng, Haitao Wang, ZhiwenZeng, Jun Lin, Peter J Little, Lalit K Srivastava, RemiQuirion. (2012) The possible role of the Akt signaling pathway in schizophrenia. Brain Research 1470,145-158
  88. Haitao Wang, Qishan Zhang, Qiang Wen, Lazarovici Philip, Hao Jiang and WenhuaZheng. (2012) Proline-rich Akt substrate of 40 kDa (PRAS40): A novel downstream target of PI3k/Akt signaling pathway. cell signal 24(1),17-24
  89. Sun C, Meng Q, Zhang L, Wang H, Quirion R, Zheng W. (2012) Glutamate attenuates IGF-1 receptor tyrosine phosphorylation in mouse brain: Possible significance in ischemic brain damage. Neurosci Res 74(3-4),290-297
  90. Haitao Wang, Qishan Zhang, Lang Zhang, Peter J Little, XiaochunXie, QianMeng, YannanRen, Lihua Zhou, GuoquanGao, RemiQuirion, WenhuaZheng. (2012) Insulin-like growth factor-1 induces the phosphorylation of PRAS40 via the PI3K/Akt signaling pathway in PC12 cells. Neuroscience Letters 516(1), 105-109
  91. Qiang Wen, Haitao Wang, Peter J. Little, RemiQuirion, WenhuaZheng. (2012) Forkhead Family Transcription Factors FoxO and Neural Differentiation. Neurogenetics 13(2):105-113
  92. Luo J, Wang R, Huang Z, Yang J, Yao X, Chen H, Zheng W. (2012) Synthesis of stable genipin derivatives and studies of their neuroprotective activity in PC12 cells. Chem Med Chem 7(9):1661-1668
  93. Burch ML, Osman N, Getachew R, Al-Aryahi S, Poronnik P, Zheng W, Hill MA, Little PJ. (2012) G protein coupled receptor transactivation: Extending the paradigm to include serine/threonine kinase receptors. Int J Biochem Cell Biol 44(5):722-727
  94. Zhao X, Wang L, Wang Y , Song F ,Li Y, Fu R, Zheng W, Wu T, Zhou L. (2012) Activation of phospholipase-Cγ and protein kinase C signal pathways helps the survival of spinal motoneurons injured by root avulsion. J Neurochem 121(3):362-372
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