聯絡信息
職稱
教授
辦公室
(辦公室)E12-3005
/(實驗室)E12-3069
電話
(辦公室) +853 8822 4979
/ (實驗室) +853 8822 9106
傳真
+853 8822 2314
諮詢時間
星期二、五 11:00 – 12:00
Education | |
Post-doctoral Fellow | National Institutes of Health, Bethesda, Maryland (1990-1993) |
PhD | North Carolina State University (1987-1990) |
MSc | North Carolina State University (1984-1987) |
BSc | University of California, Davis (1980-1984) |
Positions | |
2014 – Present | Full Professor, Faculty of Health Sciences, University of Macau |
2010 – 2013 | Professor, Faculty of Health Sciences, University of Eastern Finland |
2005 – 2010 | Professor, Faculty of Nature and Environmental Sciences, Kuopio University, Finland |
2000 – 2005 | Senior Research Fellow, Academy of Finland |
1997 – 2000 | Junior Research Fellow, Academy of Finland |
1993 – 1996 | Visiting Researcher, ALKO Ltd, Helsinki, Finland |
Research Interests |
My laboratory investigates the fundamental biochemical and genetic mechanisms by which dopaminergic neurons undergo degenerative processes observed during Parkinson’s disease, aging, and environmental stress. We use the nematode Caenorhabditis elegans as a model organism for our studies and create transgenic animal models, identify genetic interactors, profile changes at the transcript level using next generation sequencing approaches, and develop bioinformatics tools for the study of gene and small noncoding RNA function. |
Representative Publications |
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Small noncoding RNAs:
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Bioinformatic Tools:
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Research Grants | |
09/2017 – 12/2020 | Multi-Year Research Grant MYRG2017-00123-FHS, “Transgenerational inheritance of epigenetic marks after environmental toxicant exposure in Caenorhabditis elegans.” (Principal Investigator) (1.31M MOP) |
01/2017 – 12/2019 | Multi-Year Research Grant MYRG2016-00101-FHS, “Database Building, Expression Analysis, and Biomarker Mining of Noncanonical Noncoding miRNAs.” (Principal Investigator) (1.45M MOP) |
04/2015 – 03/2018 | Multi-Year Research Grant MYRG2015-00231-FHS, “Single Cell Dopaminergic and GABAergic Neuron Sequencing in Caenorhabditis elegans: A Foundation for Neuronal Conversion.” (Principal Investigator) (1.8M MOP) |
08/2011 – 12/2015 | Academy of Finland Project Grant, “Caenorhabditis elegans: A model system to investigate the molecular basis of methyl mercury neurotoxicity.” (Principal Investigator) (449,000 EUR) |
08/2010 – 07/2013 | NordForsk Researcher Network Grant, “C. elegans Researcher Network of Shared Technology Platforms.”(Steering Board Member) (900,000 NOK) |
01/2010 – 12/2012 | Biocenter Finland Infrastructure Grant, “Bioinformatics Infrastructure Services.”(Principal Investigator/Node Leader) (210,000 EUR) |
01/2009 – 12/2009 | Finnish Foundation for Alcohol Studies Research Project Grant, “A Binge Drinking Model in the nematode Caenorhabditis elegans.” (Principal Investigator) (25,000 EUR) |
08/2007 – 07/2010 | NordForsk Researcher Network Grant, “Nordic C. elegans Network.”(Coordinator) (900,000 NOK) |
06/2006 – 05/2009 | Sigrid Juselius Foundation Research Project Grant, “Aging in Transgenic C. elegansmodels of human disease.” (Principal Investigator) (77,000 EUR) |
Awards | |
2000 – 2005 | Academy of Finland Senior Researcher Award Fellowship |
1997 – 2000 | Academy of Finland Junior Researcher Award Fellowship |
1993 – 1996 | Academy of Finland Visiting Researcher Award |
1990 – 1993 | National Institutes of Health (NIH) Intramural Research Training Award (IRTA) Fellowship |
Professional Activities | |
2010 – Present | Associate Editor, Frontiers in Predictive Toxicity |
2011 – Present | Associate Editor, Frontiers in Toxicogenomics |
2006 – Present | Grant program reviewer for the following organizations:
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