張海燕博士

Education
PhD & MD	School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 2016
Msc	School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 2013
Bsc	Department of Clinical Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, 2010

Position
03/2023 – Present	Research Assistant Professor, Faculty of Health Sciences, University of Macau
10/2019 – 11/2022	Research Assistant Professor, Sun Yat-sen University Cancer Center, Guangzhou, China
03/2018 – 03/2019	Research Officer (Level 2), Cancer Immunotherapy Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia
08/2016 – 01/2018	Resident, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
03/2014 – 04/2015	Visiting Research Fellow, Liver Unit and Center for Autoimmune Liver Diseases, Humanitas Clinical and Research Center, Rozzano, Milan, Italy

Research Interests
My research primarily focuses on understanding the tumor immune microenvironment using immunogenomics and cellular immunology approaches, with the goal of developing improved strategies for combination immunotherapy for cancer.

Representative Publications

Zhuwan Lyu, Bingyuan Huang, Jun Zhang, Qiwei Qian, Xiting Pu, Nana Cui, Yiyan Ou, Bo Li, Zhengrui You, Min Lian, Ruqi Tang, Weihua Chen, Zhicong Zhao, Jiajie Hou, M Eric Gershwin, Haiyan Zhang#(co-corresponding), Qiang Xia#, Xiong Ma#.Suppression of YTHDF2 attenuates autoimmune hepatitis by expansion of myeloid-derived suppressor cells. Journal of Autoimmunity. 2023 Feb;135:102993. Haiyan Zhang, Min Lian, Jun Zhang, Zhaolian Bian, Ruqi Tang, Qi Miao, Yanshen Peng, Jingyuan Fang, Zhengrui You, Pietro Invernizzi, Qixia Wang, M. Eric Gershwin, Xiong Ma. The functional characteristic CCN1 modulation of myeloid derived suppressor cells in liver inflammation. Hepatology. 2018 Jan;67(1):232-246. Jiajie Hou*, Haiyan Zhang*(co-first author), Beicheng Sun, Michael Karin. The immunobiology of hepatocellular carcinoma in humans and mice: basic concepts and therapeutic implications. Journal of Hepatology. 2020;72(1):167-182. Haiyan Zhang, Yuan Liu, Zhaolian Bian, Shanshan Huang, Xiaofeng Han, Zhengrui You, Qixia Wang, Dekai Qiu, Qi Miao, Yanshen Peng, Xiaoying Li, Pietro Invernizzi, Xiong Ma. The critical role of myeloid-derived suppressor cells and FXR activation in immune-mediated liver injury. Journal of Autoimmunity. 2014,53:55-66 Haiyan Zhang, Dipti Vijayan, Xian-Yang Li, Simon C. Robson, Nishamol Geetha, Michele W. L. Teng, and Mark J. Smyth. The role of NK cells and CD39 in the immunological control of tumor metastases. Oncoimmunology.2019 Apr 2;8(6):e1593809. Haiyan Zhang, Patrick S.C.Leung, M. Eric Gershwin and Xiong Ma. How the biliary tree maintains immune tolerance? BBA Molecular Basis of Disease. 2018 Apr;1864(4 Pt B):1367-1373. Haiyan Zhang, Francesca Bernuzzi, Ana Lleo, Xiong Ma, Pietro Invernizzi. Therapeutic Potential of IL-17-Mediated Signaling Pathway in Autoimmune Liver Diseases. Mediators of Inflammation. 2015;2015:436450 Haiyan Zhang, Marco Carbone, Ana Lleo, Pietro Invernizzi, Geoepidemiology. Genetic and Environmental Risk Factors for PBC. Digestive Diseases. 2015,33:94-101

Patents
Hou J, Zhang H. A new use of Sodium-glucose Cotransporter-2 (SGLT2) inhibitor as a reagent for enhanced cancer immunotherapy. National Invention Patent of China (202211707300)

Awards
2016	Excellent Doctoral Graduate in Shanghai
2015	National Scholarship for Excellent Postgraduates (China)
2015	Excellent Master Thesis in Shanghai

Research Grants
06/2023 – 12/2023	Type I project , Ministry of Education Frontiers Science Centre for Precision Oncology, University of Macau (SP2023-00001-FSCPO)
01/2018 – 12/2020	Youth Program, National Natural Science Foundation of China, 81700498
01/2018 – 12/2020	Chen Guang Project in Shanghai Municipal Education Commission and Shanghai Education Development Foundation, 17CG10