2024-10-09T17:35:54+08:002021-01-27|
聯絡信息
職稱
研究助理教授, 動物研究核心實驗中心, 營運經理
辦公室
(辦公室) N22-3067, 4031 /(實驗室) N22-4033
電話
(辦公室) +853 8822 8803
電郵
hengsun@um.edu.mo
諮詢時間

星期一、四 09:00-13:00, 14:30-17:45
星期五 09:00-13:00, 14:30-17:30

教學

HSCI2001 Cell and Molecular Biology Lab

研究團隊
名稱 職稱 辦公室 電話 電郵
葉家宇研究助理N22-4034+853 8822 2903clementip@um.edu.mo
Education
PhD University of Chinese Academy of Sciences (2014)
BS Shandong Normal University (2007)
Position
2021 – Present Research Assistant Professor, Faculty of Health Sciences, University of Macau
2015 – 2020 Postdoctoral Fellow, Faculty of Health Sciences, University of Macau
2014 – 2015 Visiting Fellow, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US
2013 – 2014 Research Assistant, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Research Interests
Inter- and intra-tumor heterogeneity in breast cancers and mechanisms of breast cancer initiation, development, metastasis and anti-cancer drug resistance.
Representative Publications
  1. Sun, H., Zeng, J., Miao, Z., Lei, J. K. C., Huang, C., Hu, L., Su, S. M., Chan, U. I., Miao, K., Zhang, X., Zhang, A., Guo, S., Meng, Y., Wong, K. H., Zhang, X. D., Xu, X., and Deng, C.-X. Dissecting the heterogeneity and tumorigenesis of BRCA1 deficient mammary tumors via single cell RNA sequencing. (in submission)
  2. Sun, H., Zhang, X., Chan, U., Su, S., Guo, S., Xu, X. L., and Deng, C. X. In vivo Mouse Mammary Gland Formation. Bio-Protocol, 2020, 10 (13), e3667
  3. Sun, H., Xu, X. L., and Deng, C. Preparation of Single Epithelial Cells Suspension from Mouse Mammary Glands. Bio-Protocol, 2020, 10 (4), e3530
  4. Liu, J. L., Adhav, R., Miao, K., Su, S. M., Mo, L. H., Chan, U. I., Zhang, X., Xu, J., Li, J. J., Shu, X. D., Zeng, J. M., Zhang, X., Lyu, X., Pardeshi, L., Tan, K. L., Sun, H., Wong, K. H., Deng, C., and Xu, X. L. Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor. Nature Communications, 2020, 11 (1), 4875
  5. Miao, K., Lei, J. H. P., Valecha, M. V., Zhang, A. P., Xu, J., Wang, L. J., Lyu, X. Y., Chen, S., Miao, Z. Q., Zhang, X., Su, S. M., Shao, F. Y., Rajendran, B. K., Bao, J. L., Zeng, J. M., Sun, H., Chen, P., Tan, K. L., Chen, Q., Wong, K. H., Xu, X. L., and Deng, C. X. NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation. Nature Communications, 2020, 11 (1), 3256
  6. Sun, H., Miao, Z. Q., Zhang, X., Chan, U. I., Su, S. M., Guo, S., Wong, C. K. H., Xu, X. L., and Deng, C. X. Single-cell RNA-Seq reveals cell heterogeneity and hierarchy within mouse mammary epithelia. The Journal of Biological Chemistry, 2018, 293 (22), 8315-8329
  7. Shao, F. Y., Sun, H., and Deng, C. X. Potential therapeutic targets of triple-negative breast cancer based on its intrinsic subtype. Oncotarget, 2017, 8 (42), 73329-73344
  8. Wong, A. H. H., Li, H. R., Jia, Y. W., Mak, P. I., Martins, R. P. d. S., Liu, Y., Vong, C. M., Wong, H. C., Wong, P. K., Wang, H. T., Sun, H., and Deng, C. X. Drug screening of cancer cell lines and human primary tumors using droplet microfluidics. Scientific Reports, 2017, 7 (1), 9109
  9. Chen, S.*, Sun, H.*, Miao, K.*, and Deng, C. X. CRISPR-Cas9: from Genome Editing to Cancer Research. International Journal Of Biological Sciences, 2016 12 (12), 1427-1436 (*, equal contribution)
  10. Sun, H., Li, X., Fan, L., Wu, G., Li, M., and Fang, J. TRAF6 is upregulated in colon cancer and promotes proliferation of colon cancer cells. The International Journal of Biochemistry & Cell Biology, 2014, 53, 195-201
  11. Sun, H., Li, X. B., Meng, Y., Fan, L., Li, M., and Fang, J. TRAF6 upregulates expression of HIF-1alpha and promotes tumor angiogenesis. Cancer Res, 2013, 73 (15), 4950-4959
  12. Sun, H., Li, X., and Fang, J. Hypoxia and tumors. Chinese Bulletin of Life Sciences, 2013, 25 (2), 206-217
  13. Chen, Y., Zhang, H. S., Fong, G. H., Xi, Q. L., Wu, G. H., Bai, C. G., Ling, Z. Q., Fan, L., Xu, Y. M., Qin, Y. Q., Yuan, T. L., Sun, H., and Fang, J. PHD3 Stabilizes the Tight Junction Protein Occludin and Protects Intestinal Epithelial Barrier Function. Journal Of Biological Chemistry, 2015, 290 (33), 20580-20589
  14. Liu, Q., Hu, T., He, L., Huang, X., Tian, X., Zhang, H., He, L., Pu, W., Zhang, L., Sun, H., Fang, J., Yu, Y., Duan, S., Hu, C., Hui, L., Zhang, H., Quertermous, T., Xu, Q., Red-Horse, K., Wythe, J. D., and Zhou, B. Genetic targeting of sprouting angiogenesis using Apln-CreER. Nature Communications, 2015, 6, 6020
  15. Zhou, C. F., Li, X. B., Sun, H., Zhang, B., Han, Y. S., Jiang, Y., Zhuang, Q. L., Fang, J., and Wu, G. H. Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells. IUBMB Life, 2012, 64 (9), 775-782
  16. Xue, J., Lv, D. D., Jiao, S., Zhao, W., Li, X., Sun, H., Yan, B., Fan, L., Hu, R. G., and Fang, J. pVHL mediates K63-linked ubiquitination of nCLU. PLoS One, 2012, 7 (4), e35848
  17. Li, X. B., Jiao, S., Sun, H., Xue, J., Zhao, W. T., Fan, L., Wu, G. H., and Fang, J. The orphan nuclear receptor EAR2 is overexpressed in colorectal cancer and it regulates survivability of colon cancer cells. Cancer Letters, 2011, 309 (2), 137-144
  18. Meng, D., Lv, D. D., Zhuang, X., Sun, H., Fan, L., Shi, X. L., and Fang, J. Benzo[a]pyrene induces expression of matrix metalloproteinases and cell migration and invasion of vascular smooth muscle cells. Toxicology Letters, 2009, 184 (1), 44-49
Full publications list
Research Grants
01/2017 – 12/2019 National Natural Science Funding of China, 81602587