王麗博士

• Adipocyte and muscle Metabolism
• Obesity; Diabetes
• Metabolism syndrome

1. Wang L*, Wang Y, Zhang C, Li J, Meng Y, Dou M, Noguchi CT, Di L. Inhibiting Glycogen Synthase Kinase 3 Reverses Obesity-Induced White Adipose Tissue Inflammation by Regulating Apoptosis Inhibitor of Macrophage/CD5L-Mediated Macrophage Migration. Arterioscler Thromb Vasc Biol. 2018 Jul 19. 38:2103-2116 [Epub ahead of print]
2. Wang L*, Wang Y, Meng Y, Zhang C, Di L. Gsk3-activated stat5 regulates expression of sfrps to modulate adipogenesis. FASEB J. 2018 Mar 26
3. Wang L, Li J, Guo L, Li P, Zhao Z, Zhou H, Di L. Molecular link between glucose and glutamine consumption in cancer cells mediated by CtBP and SIRT4. Oncogenesis. 2018 Mar 13. 7(3):26
4. Hao D, Liu J, Chen M, Li J, Wang L, Li X, Zhao Q, Di L*. Immunogenomic analyses of advanced serous ovarian cancer reveal immune score is a strong prognostic factor and an indicator of chemo-sensitivity. Clin Cancer Res. 2018 Aug 1. 24(15):3560-3571.
5. Hao D, Li J, Jia S, Meng Y, Zhang C, Wang L, Di L. Integrated Analysis Reveals Tubal- and Ovarian-Originated Serous Ovarian Cancer and Predicts Differential Therapeutic Responses. Clin Cancer Res. 2017 Dec 1. 23(23):7400-7411
6. Li J, Hao D, Wang L, Wang H, Wang Y, Zhao Z, Li P, Deng C, Di L. Epigenetic targeting drugs potentiate chemotherapeutic effects in solid tumor therapy. Sci Rep. 2017 Jun 22. 7(1):4035
7. Wang Y, Hao D, Li J, Wang L, Di L. Genome-wide methylome and chromatin interactome identify abnormal enhancer to be risk factor of breast cancer Oncotarget. 2017 Jun 2 [Epub ahead of print]
8. Li P, Li J, Wang L, Di L. Proximity labeling of interacting proteins: Application of BioID as a discovery tool. 2017 Mar 8. 17(20) [Epub ahead of print]
9. Wang L, Chan JY, Zhou X, Cui G, Yan Z, Wang L, Yan R, Di L, Wang Y, Hoi MP, Shan L, Lee SM. A Novel Agent Enhances the Chemotherapeutic Efficacy of Doxorubicin in MCF-7 Breast Cancer Cells. Front. Pharmacol. 2016 August 10. 7:249
10. Zhao ZQ, Wang L, Di L. Compartmentation of metabolites in regulating epigenome of cancer. Molecular Medicine. 2016 (accepted for publication)
11. Hao D, Wang L, Di L. Distinct mutation accumulation rates among tissues determine the variation in cancer risk. Scientific Reports. 2016. 6:19458
12. Wang L, Zhang X, Cui G, Chan JY, Wang L, Li C, Shan L, Xu C, Zhang Q, Wang Y, Di L, Lee SM. A novel agent exerts antitumor activity in breast cancer cells by targeting mitochondrial complex II. Oncotarget. 2016 Mar 27 [Epub ahead of print]
13. Wang L, Di L. Wnt/β-catenin mediates AICAR effect in increasing GATA3 expression and inhibiting adipogenesis. J Biol Chem. 2015. 290:19458-19468
14. Wang L, Zhou H, Wang Y, Cui, G, Di L. CtBP maintains cancer cell growth and metabolic homeostasis via regulating SIRT4. Cell Death Dis. 2015 Jan 29. 6:e1620
15. Wang L*, Di L, Noguchi CT. AMPK is involved in mediation of erythropoietin influence on metabolic activity and reactive oxygen species production in white adipocytes. Int J Biochem Cell Biol. 2014 Sep. 54:1-9
16. Wang L*, Li-Jun Di. BRCA1 And Estrogen/Estrogen Receptor In Breast Cancer: Where They Interact? International Journal of biological Sciences. 2014. 10(5):566-575
17. Zhang Y, Wang L, Dey S, Alnaeeli M, Suresh S, Rogers H, Teng R, Noguchi CT. Erythropoietin action in stress response, tissue maintenance and metabolism. J. Mol. Sci. 2014. 15(6):10296-10333
18. Wang L, Di L, Noguchi CT. Erythropoietin, a novel versatile player regulating energy metabolism beyond the erythroid system. International Journal of Biological Sciences. 2014 Aug 23. 10(8):921-39
19. Wang L, Teng R, Di L, Rogers H, Wu H, Kopp JB, Noguchi CT. PPARα and Sirt1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders. Diabetes. 2013 Dec. 62(12):4122-31
20. Wang L, Jia Y, Rogers H, Suzuki N, Gassmann M, Wang Q, McPheron A, Kopp J, Yamamoto M, Noguchi CT. Erythropoietin contributes to slow oxidative muscle fiber specification via PGC-1a and AMPK. The International Journal of Biochemistry & Cell Biology. 2013 July. 45(7):1155-1164
21. Wang L, Jia Y, Rogers H, Huang S, Noguchi CT. GATA-4 and TAL1 regulate myogenic differentiation and erythropoietin response via cross talk with Sirt1. J Biol Chem. 2012 Aug 31. 287(36):30157-69
22. Rogers H#, Wang L# (#co-first author), Yu X, Alnaeeli M, Cui K, Zhao K, Bieker JJ, Prchal J, Huang S, Weksler B, Noguchi CT. T-cell Acute Leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis. J Biol Chem. 2012 Oct 26. 287(44):36720-31
23. Alnaeeli M, Wang L, Piknova B, Rogers H, Li X, Noguchi CT. Erythropoietin in Brain Development and Beyond. Anatomy Research International. 2012. 2012:953264
24. Beleslin-Čokić BB, Cokić VP, Wang L, Piknova B, Teng R, Schechter AN, Noguchi CT. Erythropoietin and hypoxia increase erythropoietin receptor and nitric oxide levels in lung microvascular endothelial cells. 2011 May. 54(2):129-35
25. Foskett A, Alnaeeli M, Wang L, Teng, R, Noguchi CT. The effects of Erythropoietin Dose Titration During High Fat Diet-induced Journal of Biomedicine & Biotechnology. 2011. 2011:373781
26. Chen ZY, Wang L, Asavaritkrai P, Noguchi CT. Up-Regulation of Erythropoietin Receptor by Nitric Oxide Mediates Hypoxia Preconditioning. Journal of Neuroscience Research. 2010 Nov 1. 88(14):3180-8
27. Wang L, Di LJ, Lv X, Zheng W, Xue Z, Guo ZC, Liu DP, Liang CC. Inter-MAR Association Contributes to Transcriptionally Active Looping Events in Human b-globin Gene Cluster.  PLoS ONE. 2009. 4(2):e4629
28. Gong H, Wang Z, Zhao GW, Lv X, Wei GH, Wang L, Liu DP, Liang CC. SATB1 regulates beta-like globin genes through matrix related nuclear relocation of the cluster. Biochem Biophys Res Commun. 2009 May 22. 383(1):11-5
29. Di LJ*, Wang L*(Co-first author), Zhou GL, Wu XS, Guo ZC, Ke XS, Liu DP, Liang CC, Identification of Long Range Regulatory Elements of Mouse a-Globin Gene Cluster by Quantitative Associated Chromatin Trap (QACT). J Cell Biochem. 2008 Sep 1. 105(1):301-12
30. Noguchi CT, Wang L, Rogers HM, Teng R, and Jia Y. Survival and proliferative roles of erythropoietin beyond the erythroid lineage. Expert Rev Mol Med. 2008 Jan. 10:e36.

Book Chapter

Wang L. The author of the fifth chapter: The Molecular Mechanism of Magnesium Absorption in Plants, Nutrition Molecular Mechanism and Signal Transduction in Plants(book) 2nd edition(in Chinese), Science Press- Scientific Pubishing Center, Beijing,P.R. China.ISBN:7030166957. 2006

Li PP, Meng Y, Wang L, and Di LJ, BioID: A Proximity-Dependent Labeling Approach 2 in Proteomics Study Functional Proteomics : Functions and methods, Springer, ISBN 9781588299710. 2018

Invited Conference Oral Presentation

Wang L. GSK3 inhibitors reverse fat inflammation during diet-induced obesity. 2017, Inflammation – Basic Mechanisms & Related Diseases conference, 2017

Wang L. GSK3β activity that can be regulated by AICAR via stimulated AKT in preadipocytes is involved in the regulation of adipogenesis, glucose metabolism and insulin action in adipocytes, Chinese Society of Biochemistry and Molecular Biology meeting, 2016

Wang L. AICAR increases GATA3 expression and regulates Wnt/ß-catenin pathway to inhibit adipogenesis. Lipid Metabolism and Human Metabolic Disorders, 2015

Role in the Project: Principal Investigator

Funding Period: 01/01/2015-01/01/2018 – 31/12/2019

Senior instructor; Director of Metabolomics core, Faculty of Health Sciences, University of Macau