名稱 職稱 辦公室 電話 電郵
李彧思博士生 (實驗室代表)E12-3044
DSc Chinese Academy of Sciences (2006 – 2011)
BMed Nanjing Medical University (1997 – 2002)
2019 – Present Assistant Professor, Faculty of Health Sciences, University of Macau
2018 – 2019 Instructor, Stanford University
2014 – 2018 Postdoctoral fellow, Stanford University
2012 – 2014 Postdoctoral fellow, Icahn School of Medicine at Mount Sinai, New York
2011 – 2012 Research assistant, CAS-MPG Partner Institute for Computational Biology
2002 – 2006 Resident, Nanjing DrumTower Hospital affiliated to Nanjing University School of Medicine
Research Interests
My research interests focus on the translational equivalency of model animals to human development and diseases, and the multi-omics integration analysis of human development and diseases. Heart disease is the top adult killer in the Western world and bringing a considerable health burden to the society and individuals. Understanding how the heart works from the building blocks to the whole building has clear importance not only for defining of the etiology of heart but also for discovering novel regeneration strategies to treat heart disease. Recently with the application of next generation sequencing (NGS), the bottleneck of the biomedical studies transferred from data generation to data analysis. Effectively integrating large-scale data analysis with “wet” biology is the essential way to investigate the whole system from the building bricks. I am working on the integration of genome, transcriptome, and epigenome of human and mouse to investigate the development and related diseases in human.
Representative Publications
  1. Lee, J.#, Shao, N.-Y.# et al. Essential Roles of SETD7 as Transcriptional Activator and Co-regulator of H3K36me in Cardiac Lineage Commitment. Cell Stem Cell(2018), http://dx.doi.org/10.1016/j.stem. 2018.02.005.
  2. Gu, M.#, Shao, N.-Y.# et al. iPSCs Reveal Protective Modifiers of the BMPR2 mutation in Pulmonary Arterial Hypertension. Cell Stem Cell (2016), http://dx.doi.org/10.1016/j.stem.2016.08.019.
  3. Zhao, M.#, Shao, N.-Y.# et al. Cell Type-Specific Chromatin Signatures Underline Regulatory DNA Elements in Human Induced Pluripotent Stem Cells and Somatic Cells. Circulation Research (2017), http://dx.doi.org/10.1161/CIRCRESAHA.117.311367.
  4. Shao, N.-Y. et al. Comprehensive survey of human brain microRNA by deep sequencing. BMC Genomics 11, 409 (2010).
  5. Shen, L.#, Shao, N.-Y.#, et al. ngs.plot: Quick mining and visualization of next-generation sequencing data by integrating genomic databases. BMC Genomics 15, 284 (2014).
  6. Shen, L., Shao, N.-Y., et al. diffReps: detecting differential chromatin modification sites from ChIP-seq data with biological replicates. PLoS ONE (2013).
  7. Feng, J., Shao, N.-Y., et al. Role of Tet1 and 5-hydroxymethylcytosine in cocaine action. Nat. Neurosci. 18, 536–544 (2015).
  8. Ferguson, D., Shao, N.-Y., et al. SIRT1-FOXO3a Regulate Cocaine Actions in the Nucleus Accumbens. J. Neurosci. 35, 3100–3111 (2015).
  9. Yuan, K., Shao, N.-Y., et al. Increased Pyruvate Dehydrogenase Kinase 4 Expression in Lung Pericytes Is Associated with Reduced Endothelial-Pericyte Interactions and Small Vessel Loss in Pulmonary Arterial Hypertension. Am. J. Pathol. 0, (2016).
  10. Dias, C., Feng, J., Sun, H., Shao, N.-Y., et al. β-catenin mediates stress resilience through Dicer1/microRNA regulation. Nature (2014). doi:10.1038/nature13976.
2018 Career Development Award: American Heart Association