2021-09-03T16:23:21+08:002020-02-13|
聯絡信息
Education
PhD State Key Laboratory of Cellular Stress Biology, Xiamen University (2009)
MSc School of Fishery, Ocean University of China (2006)
BSc School of Fishery, Jimei University (2003)
Positions
2021-present Assistant Professor, Faculty of Health Sciences, University of Macau
2015-2021 Senior Instructor, Faculty of Health Sciences, University of Macau
2012-2015 Visiting Fellow, NIDDK, National Institutes of Health
2009-2012 Postdoctoral Fellow, The First Affiliated Hospital of Xiamen University
Research Interests
  • Molecular mechanisms of cancer development
  • Regulation of metabolic homeostasis
  • Mechanisms of drug resistance in cancer
Representative Publications
  1. Li L, Bao J, Wang H, Lei JH, Peng C, Zeng J, Hao W, Zhang X, Xu X, Yu C, Deng CX*, Chen Q*. Upregulation of amplified in breast cancer 1 contributes to pancreatic ductal adenocarcinoma progression and vulnerability to blockage of hedgehog activation. Theranostics. 2021, 11(4):1672-1689. (* Corresponding author)
  2. Li L, Deng CX, Chen Q*. SRC-3, a Steroid Receptor Coactivator: Implication in Cancer. Int J Mol Sci. 2021, 22(9):4760. (* Corresponding author)
  3. Ding RB, Chen P, Rajendran K, Lyu X, Wang H, Bao J, Zeng J, Hao W, Sun H, Wong A, Valecha M, Yang E, Su S, Choi T, Liu S, Chan K, Yang L, Wu J, Miao K, Chen Q, Shim J, Xu X, Deng CX. Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics. Nat Commun. 2021, 12(1):3046.
  4. Chen Q*, Lei H, Bao J, Wang H, Hao W, Li L, Peng C, Masuda T, Miao K, Xu J, Xu X, Deng CX*. BRCA1 deficiency impairs mitophagy and promotes inflammasome activation and mammary tumor metastasis. Advanced Science. 2020, 7(6):1903616. (* Corresponding author)
  5. Hou W#, Chen Q#, Wang H, Qiu P, Lyu X, Chen W, Chua MLK, Chinn YE, Deng CX, Wang R. The metabolic footprint during adipocyte commitment highlights ceramide modulation as an adequate approach for obesity treatment. EBioMedicine. 2020, 51: 102605. (# They contributed equally to this work)
  6. Shao F, Lyu X, Miao K, Xie L, Wang H, Xiao H, Li J, Chen Q, Ding R, Chen P, Xing F, Zhang X, Luo GH, Zhu W, Cheng G, Lon NW, Martin SE, Wang G, Chen G, Dai Y, Deng CX. Enhanced Protein Damage Clearance Induces Broad Drug Resistance in Multitype of Cancers Revealed by an Evolution Drug-Resistant Model and Genome-Wide siRNA Screening. Advanced Science. 2020, 7(23):2001914.
  7. Miao K, Lei H, Valecha M, Zhang A., Xu J, Wang L, Lyu X, Chen S, Miao Z, Zhang X, Su  S, Shao F, Rajendran B, Bao  J, Zeng J, Sun H, Chen P, Tan K, Chen Q, Wong K, Xu X, Deng CX. NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation. Nat Commun. 2020, 11(1):3256.
  8. Zhang B, Lyu J, Yang EJ, Liu Y, Wu C, Pardeshi L, Tan K, Chen Q, Xu X, Deng CX, Shim JS. Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells. Acta Pharm Sin B. 2020, 10(4): 615-627.
  9. Xu X, Chen E, Mo L, Zhang L, Shao F, Miao K, Liu J, Su SM, Valecha M, In Chan U, Zheng H, Chen M, Chen W, Chen Q, Fu H, Aladjem MI, He Y, Deng CX. BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1-MCM2 signaling during pregnancy. Hum Mol Genet. 2019, 28(5): 842-857.
  10. Zhang B, Lyu J, Liu Y, Wu C, Yang EJ, Pardeshi L, Tan K, Wong KH, Chen Q, Xu X, Deng CX, Shim JS. BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition. Oncogene. 2018, 37(49): 6341-6356.
  11. Chen Z, Liu J, Chu D, Shan Y, Ma G, Zhang H, Zhang XD, Wang P, Chen Q, Deng CX, Chen W, Dimitrov DS, Zhao Q. A dual-specific IGFI/II human engineered antibody domain inhibits IGF signaling in breast cancer cells. Int J Biol Sci. 2018, 14(7): 799-806.
  12. Chen Q, Hao WH, Xiao CY, Wang RH, Xu XL, Lu HY, Chen WP, Deng CX. SIRT6 is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion. Cell Reports. 2017, 18: 3155–3166.
  13. Wang RH, Zhao T, Cui K, Hu G, Chen Q, Chen W, Wang XW, Soto-Gutierrez A, Zhao K, Deng CX. Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging. Sci Rep. 2016, 6: 28633.
  14. Li WJ, Li M, Su XH, Qin LP, Miao MM, Yu CD, Shen YM, Luo Q, Chen Q*. Mycoepoxydiene induces apoptosis and inhibits TPA-induced invasion in human cholangiocarcinoma cells via blocking NF-κB pathway. Biochimie. 2014, 101: 183-191. (* Corresponding author)
  15. Su XH#Chen Q#, Chen TH, Li WJ, Li Y, Dou XF, Zhang YF, Shen YM, Wu H, Yu CD. Mycoepoxydiene inhibits activation of BV2 microglia stimulated by lipopolysaccharide through suppressing NF-κB, ERK 1/2 and toll-like receptor pathways. Int Immunopharmacol. 2014, 3: 88-93. (# They contributed equally to this work)
  16. Wang RH, Lahusen TJ, Chen Q, Xu X, Jenkins LM, Leo E, Fu H, Aladjem M, Pommier Y, Appella E, Deng CX. SIRT1 Deacetylates TopBP1 and Modulates Intra-S-Phase Checkpoint and DNA Replication Origin Firing. Int J Biol Sci. 2014, 10: 1193-1202.
  17. Xia XC, Wan W, Chen Q, Liu K, Majaz S, Mo PL, Xu JM, Yu CD. Deficiency in steroid receptor coactivator 3 enhances cytokine production in IgE-stimulated mast cells and passive systemic anaphylaxis in mice. Cell Biosci. 2014, 4:21.
  18. Xia XC, Chen Q, Liu K, Mo PL, Zhu JW, Zhuang MQ, Shen YM, Yu CD. Mycoepoxydiene inhibits antigen-stimulated activation of mast cells and suppresses IgE-mediated anaphylaxis in mice. Int Immunopharmacol. 2013, 17: 336-341.
  19. Zhu JW, Chen Q, Xia XC, Mo PL, Shen YM, Yu CD. Mycoepoxydiene suppresses RANKL-induced osteoclast differentiation and reduces ovariectomy-induced bone loss in mice. Appl Microbiol Biotechnol. 2013, 97:  767-774.
  20. Chen Q, Li WJ, Wan YY, Xia XC, Wu Q, Chen YL, Lai ZD, Yu CD, Li WG. Amplified in Breast Cancer 1 Enhances Human Cholangiocarcinoma Growth and Chemoresistance by Simultaneous Activation of Akt and Nrf2 Pathways. Hepatology. 2012, 55: 1820-1829.
  21. Chen Q, Chen TH, Li WJ, Zhang W, Zhu JW, Li Y, Huang YJ, Shen YM, Yu CD.Mycoepoxydiene inhibits lipopolysaccharide-induced inflammatory responses through suppression of TRAF6 polyubiquitination. PLoS ONE. 2012, 7: e44890.
  22. Chen TH, Chen Q, Xu XY, Zhu JW, Zhang H, Wu Q, Xu JM, Yu CD. SRC-3 is required for CAR-regulated hepatocyte proliferation and drug metabolism. J Hepatol. 2012, 56: 210-217.
  23. Liu Y, Tong ZW, Li T, Chen Q, Zhuo LT, Li WG, Wu RC, Yu C. Hepatitis B virus X protein stabilizes amplified in breast cancer 1 protein and cooperates with it to promote human hepatocellular carcinoma cell invasiveness. Hepatology. 2012, 56: 1015-1024.
  24. Xiao CY, Wang RH, Lahusen TJ, Park O, Bertola A, Maruyama T, Reynolds D, Chen Q,Xu XL, Young HA, Chen WJ, Gao B, Deng CX. Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice. J Biol Chem. 2012, 287: 41903-41913.
  25. Chen Q, Jiang Y, An Y, Zhao N, Zhao Y, Yu CD. Soluble FGFR4 extracellular domain inhibits FGF19-induced activation of FGFR4 signaling and prevents nonalcoholic fatty liver disease. Biochem Bioph Res Co. 2011, 409: 651-656.
  26. Chen Q, Chen TH, Xu YX, Zhu JW, Jiang Y, Zhao Y, Xu JM, Yu CD. SRC-3 is required for clearing bacteria and repressing inflammatory response in Escherichia coli-induced septic peritonitis. J Immunol. 2010, 185: 5444-5452.
  27. Xu XY#Chen Q#, Li WG, Su XH, Chen TH, Liu YH, Zhao Y, Yu CD. Overexpression of transcriptional coactivator AIB1 promotes hepatocellular carcinoma progression by enhancing cell proliferation and invasiveness. Oncogene. 2010, 29: 3386-3397. (# They contributed equally to this work)
  28. Chen Q, Zhao Y, Cheng Z, Xu YX, Yu CD. Establishment of a cell-based assay for examining the expression of tumor necrosis factor alpha (TNF-alpha) gene. Appl Microbiol Biotechnol. 2008, 80: 357-363.
  29. Chen Q, Yan QP, Wang KJ, Zhuang ZX, Wang XR. Portal of entry for pathogenic Vibrio alginolyticusinto large yellow croaker Pseudosciaena crocea, and characteristics of bacterial adhesion to mucus. Dis Aquat Organ. 2008, 80: 181-188.
  30. Chen Q, Yan QP, Ma S, Zhuang ZX, Wang XR. Adhesion of pathogenic Vibrio alginolyticus to the gill mucus of Pseudosciaena crocea. ACTA Oceanol Sin. 2007, 26: 101-109.
Research Grants
  • 2021    University of Macau Start-up Research Grant (SRG2021-00008-FHS), PI
  • 2020    FHS Internal Grant (Innovation), PI
  • 2019    FHS Internal Grant (Precision Medicine), PI
  • 2016    National Natural Science Foundation of China (81672603), PI
  • 2014    National Natural Science Foundation of China (81401978), PI
  • 2010    China Postdoctoral Science Foundation (20100480713), PI
  • 2010    Natural Science Foundation of Fujian Province of China (2010D015), PI
  • 2010    Youth Foundation of Health Department of Fujian Province (2010-2-84), PI
Patents
  1. Yu CD, Zhu JW, Chen Q, Zhao Y, Mo PL, Shen YM. Mycoepoxydiene is applied as osteoclast differentiation inhibitor. (ZL 2012 1 0020829.9)
  2. Yu CD, Huang YJ, Zhao Y, Chen Q, Chen TH, Shen YM. Mycoepoxydiene is applied as anti-inflammatory chemical compound. (ZL 2009 1 0112087.0)
Professional Activities
Membership for Professional Societies

  • American Association for Cancer Research
  • American Society of Microbiology
  • Chinese Society of Cell Biology
  • Society of Chinese Bioscientists in America

Journal Reviewer
Cell Research, Molecular Cell, Science Translational Medicine, Diabetes, EBioMedicine, Aging cell, International Journal of Biological Sciences, Frontiers in Physiology, Biochemical Journal, Acta Biochimica et Biophysica Sinica, Clinical Breast Cancer, Oncology Letters, Molecular medicine reports