2021-08-25T15:34:43+08:002020-02-13|
聯絡信息
研究團隊
名稱 職稱 辦公室 電話 電郵
Benjamin TAM澳大濠江博士後研究員E12-3058benjamintam@um.edu.mo
Siddharth Sinha博士後研究員E12-3058siddharths@um.edu.mo
吳曉冰博士生E12-3058
郭毛妮博士生E12-3058
秦梓欣博士生E12-3058
詹家勝博士生E12-3058
張利博士生E12-3059
王小雨博士生E12-3059
李嘉恒博士生E12-3059
趙博今博士生E12-3059
Philip Naderev Panuringan LAGNITON博士生N22-2003+853 8822 2908
Education
1996 – 1998 Postdoctoral fellow, Laboratory of Dr. Janet Rowley, Department of Medicine, University of Chicago
1994 – 1996 Postdoctoral fellow, laboratory of Dr. Richard Morimoto, Department of Molecular Sciences, Northwestern University
1989 — 1994 Doctor of Medicine, Swiss Institute for Experimental Cancer Research (ISREC), University of Lausanne, Switzerland
1986 – 1989 Assistant Researcher, Department of Immunology, Institute for Basic Research, China Academy of Traditional Chinese Medicine, Beijing, China
1983 — 1986 Master of Medicine, Shandong Medical University, China
1978 — 1983 Bachelor of Medicine, Jiangxi Medical College, China
Positions
2017 – present Professor, Faculty of Health Sciences, University of Macau
2010 – 2016 Associate Professor, Department of Genetics, Cell Biology & Anatomy,
University of Nebraska Medical Center, Nebraska, USA
2008 – 2010 Adjunct Professor, McCormick School of Engineering and Applied Science, Northwestern University, Illinois, USA
2004 – 2009 Assistant Professor, Northwestern University;
Director, Center for Functional Genomics, ENH Research Institute, Illinois, USA
1998 – 2003 Research Assistant Professor, Department of Medicine, University of Chicago, USA
Research Interests
  • Cancer genomics and genetics
  • Hereditary breast cancer
  • Next-generation DNA sequencing
  • Bioinformatics
  • Whole genome sequencing
  • Exome sequencing
  • Transcriptome
Representative Publications
  1. SM Wang, JD Rowley. A Strategy for Gene Identification: Integrated Procedure for Gene Identification. Proc. Natl. Acad. Sci. USA 95: 11909-11914, 1998
  2. SM Wang, SC Fears, L Zhang, J-J Chen, JD Rowley. Screening poly dA/dT(-) cDNAs for gene identification. Proc. Natl. Acad. Sci. USA 97:4162-4167, 2000. (Commentary by KJ Martin and AB Pardee. Identifying expressed genes. Proc. Natl. Acad. Sci. USA 97: 3789-3791, 2000)
  3. D Nam, S Lee, G Zhou, X Cao, C Wang, J Chen, T Clark, JD Rowley, SM Wang. Oligo dT primer generates a high frequency of truncated cDNAs through internal poly A priming during reverse transcription. Proc. Natl. Acad. Sci. USA. 99: 6152-6156, 2002
  4. J Chen, M Sun, S Lee, G Zhou, JD Rowley, SM Wang. Identifying novel transcripts and novel genes in the human genome by using novel SAGE tags. Proc. Natl. Acad. Sci. USA 99: 12257-12262, 2002
  5. S Lee, J Bao, G Zhou, J Shapino, J Xu, RZ Shi, X Lu, T Clark, D Johnson, YC Kim, C Wing, C Tseng, M Sun, W Lin, J Wang, W Du, CI Wu, X Zhang, SM Wang. Detecting novel low-abundant transcripts in Drosophila. RNA 11: 939-946, 2005
  6. S Lee, J Chen, G Zhou, RZ Shi, G Bouffard, M Kocherginsky, X Ge, M Sun, N Jayathilaka, YC Kim, N Emmanuel, S Bohlander, M Minden, J Kline, O Ozer, R Larson, M LeBeau, E Green, J Trent, T Karrison, P Liu, SM Wang, JD Rowley. Gene Expression Profiles in Acute Myeloid Leukemia with Common Translocations using SAGE, Proc. Natl. Acad. Sci. USA 103: 1030-1035, 2006
  7. X Ge, Q Wu, YC Jung, J Chen, SM Wang. A large quantity of novel human antisense transcripts detected by LongSAGE. Bioinformatics. 22: 2475-2479, 2006. (“the Hot Paper in Computer Science” in 2008 by Essential Science Indicators of Thompson Scientific)
  8. S Lee, J Hwang, J Ulaszek, YC Kim, H Dong, HS Kim, JW Seok, BK Suh, SJ Yim, D Johnson, NH Choe, KT Chang, ZY Ryoo, CC Tseng, A Wickrema, SM Wang. Stable transcriptional status in the apoptotic erythroid genome. Biochem Biophys Res Commun. 359: 556-562, 2007
  9. SM Wang. Understanding SAGE data. Trends in Genetics 23: 42-50, 2007
  10. J Lu, Y Shen, Q Wu, S Kumar, B He, RW Carthew, SM Wang, CI Wu. The birth and death of microRNA genes in Drosophila. Nature Genetics 40: 351-355, 2008.
  11. J Chen, YC. Kim, Y-C Jung, Z Xuan, G Dworkin, Y Zhang, MQ Zhang, SM Wang. Scanning the human genome at kilobase resolution. Genome Research 18: 751-762, 2008
  12. Q Wu, YC Kim, J Lu, Z Xuan, J Chen, YL Zheng, T Zhou, MQ Zhang, CI Wu, SM Wang. Poly A- transcripts expressed in HeLa cells. PLoS ONE 3: e2803, 2008
  13. YC. Kim, Q Wu, J Chen, Z Xuan, Y-C Jung, MQ Zhang, JD Rowley, SM Wang. The transcriptome of human CD34+ hematopoietic stem-progenitor cells. Proc. Natl. Acad. Sci. USA 106: 8278-8283, 2009
  14. X Huang, H Guo, S Tammana, YC Jung, E Mellgren, P Bassi, L Ma, ZJ Tu, SC Ekker, X Wu, SM Wang, XZ Zhou. Gene Transfer Efficiency and Genome-Wide Integration Profiling of Sleeping Beauty, Tol2 and PiggyBac Transposons in Human Primary T Cells. Molecular Therapy. 18(10):1803-13, 2010
  15. Wen H, Li Y, Malek SN, Kim YC, Xu J, Chen P, Xiao F, Huang X, Zhou X, Xuan Z, Mankala S, Hou G, Rowley JD, Zhang MQ, SM Wang. New fusion transcripts identified in normal karyotype acute myeloid leukemia. PLoS One 7:e51203, 2012
  16. Lynch H, Wen H, Kim YC, Snyder C, Kinarsky Y, Chen PX, Xiao F, Goldgar D, Cowan KH, SM Wang. Can unknown predisposition in familial breast cancer be family-specific? The Breast Journal, 19:520-528, 2013
  17. Wen H, Kim Y, Snyder C, Xiao F, Fleissner EA, Becirovic D, Luo J, Downs B, Sherman S, Cowan KH, Lynch HT, SM Wang. Family-specific, novel, deleterious germline variants provide a rich source to identify genetic predispositions for BRCAx familial breast cancer. BMC Cancer, 14:470, 2014.
  18. Lynch H, Synder C, SM Wang. Considerations for comprehensive assessment of genetic predisposition in familial breast cancer. Breast J. 21(1):67-75, 2015.
  19. Angulo-Ibáñez M, Rovira-Clavé X, Downs B, Kim YC, SM Wang, Tournier C, Reina M, Espel E. Erk5 contributes to balance cellular nucleotide levels and avoid replicative stress, Cell Cycle, 14(24):3864-76, 2015.
  20. Kim KC, Zhao L, Zhang H, Huang Y, Cui J, Xiao F, Downs F, SM Wang. Prevalence and spectrum of BRCA germline variants in mainland Chinese familial breast and ovarian cancer patients. Oncotarget 7(8):9600-12, 2016.
  21. Cui J, Luo L, KimYC, Synder C, Becirovic D, Downs B, Lynch H, SM Wang. Differences of variable number tandem repeats in XRCC5 promoter are associated with increased or decreased risk of familial breast cancer. Frontiers in Oncology, 6:00092, 2016.
  22. Kim YC, Cui J, Luo J, Xiao F, Downs B, Wang SM. Exome-based Variant Detection in Core Promoters. Sci Rep. 6:30716, 2016.
  23. B Downs, S Sherman, J Cui, Y C Kim, C Snyder, M Christensen, J Luo, H Lynch, and SM Wang. Common genetic variants contribute to incomplete penetrance: evidence from cancer-free BRCA1 mutation carriers. Eur J Cancer. 107: 68-78, 2018.
  24. S P Bhaskaran, K Chandratre, H Gupta, L Zhang, X Y Wang, J Cui, Y C Kim, S Sinha, L H Jiang, B Y Lu, X B Wu, Z X Qin, T Huang, and SM Wang. Germline variation in BRCA1/2 is highly ethnic-specific: evidence from over 30,000 Chinese hereditary breast and ovarian cancer patients. Int J Cancer. 145 (4): 962-973, 2019.
  25. M N Guo, S Sinha, and SM Wang. Coupled Genome-Wide DNA Methylation and Transcription Analysis Identified Rich Biomarkers and Drug Targets in Triple-Negative Breast Cancer. Cancers (Basel). 11 (11): E1724, 2019.
  26. L Zhang, S P Bhaskaran, T Huang, H Dong, K Chandratre, X B Wu, Z X Qin, X Y Wang, W M Cao, T H Chen, H Lynch, and SM Wang. Variants of DNA mismatch repair genes derived from 33,998 Chinese individuals with and without cancer reveal their highly ethnic-specific nature. Eur J Cancer. 125: 12-21, 2020.
  27. S Sinha, and SM Wang. Classification of VUS and unclassified variants in BRCA1 BRCT repeats by molecular dynamics simulation. Comput Struct Biotechnol J. 18: 723-736, 2020.
  28. H Dong, K Chandratre, Y Qin, J Zhang, X Q Tian, C Rong, N Wang, M N Guo, G P Zhao, and SM Wang. Prevalence of BRCA1/BRCA2 pathogenic variation in Chinese Han population. J Med Genet. 106970, 2020.
  29. Z Qin, C N Kuok, H Dong, L Jiang, L Zhang, M Guo, H K Leong, L Wang, G Meng, and SM Wang. Can population BRCA screening be applied in non-Ashkenazi Jewish populations? Experience in Macau population. J Med Genet. 107181, 2020.
  30. S P Bhaskaran, T Huang, B K Rajendran, M N Guo, J T Luo, Z X Qin, B J Zhao, J S Chian, S C Li, and SM Wang. Ethnic-specific BRCA1/2 variation within Asia population: evidence from over 78 000 cancer and 40 000 non-cancer cases of Indian, Chinese, Korean and Japanese populations. J Med Genet. 2020.
Full Publications List
Research Grants
Macau Science and Technology Development

  • Human genome core-promoter polymorphism and its application in cancer genome mutation studies (085/2017/A2)

Macau Science and Technology Development / Ministry of Science and Technology of People’s Republic of China

  • BRCA mutation Standard Database in Chinese population: construction, characterization, and clinical application (0077/2019/ AMJ)

University of Macau

  • Identification of key functional genes in genome instability caused by BRCA1 germline mutation (SRG2017-00097-FHS)
  • Determine BRCA gene mutation in Macau population (MYRG2019-00018-FHS)
  • Applying structural-based MDS and 3D topology approaches to systematically classify PTEN VUS (MYRG2020-00094-FHS)

University of Macau Faculty of Health Sciences

  • Classifying variants of uncertain significance (VUS) within BRCA2-RAD51 complex using molecular dynamics simulations
  • Searching Evidence for the Presence of RNA World in Modern Life
Professional Activities
Editorial

  • Journal of Genetic Mutation Disorders (Editorial board member, 2015 –)
  • Advances in Modern Oncology Research (Editorial board member, 2015 –)
  • Journal of Medical Genomics & Biomarkers (Editorial board member, 2015 –)
  • Clinics in Oncology (Editorial board member, 2015 –)
  • microRNA (2014 –)
  • Methods in Next-Generation Sequencing (Editor 2013 – 2014)
Advisory board member

  • The Kamie K. Preston Hereditary Cancer Foundation, Board of Directors. (2015 –)
Journal reviewer
Analytical Biochemistry, Biochemistry Research International, Bioinformatics, BioTechniques, BMC Cancer, BMC Developmental Biology, BMC Evolutionary Biology, BMC Genomics, BMC Bioinformatics, BMC Medical Genetics, BMC Medical Genomics, Case Reports in Obstetrics and Gynecology, Cell Cycles, Cell Death and Differentiation, Current Medicinal Chemistry, Cancer Genetics, Cancer Biomarkers, Cancer Medicine, Differentiation, Experimental Hematology, Familial Cancer, The Breast Journal, FEBS Letters, Gene, Genes, Chromosomes & Cancer, Genome Biology, Genetics, Genome Research, Genomics, In Silico Bioinformatics, Insect MicroRNAs, Molecular Biology, Journal of Africa Biotechnology, Journal of Biology, Journal of Biotechnology, Journal of Biomedicine and Biotechnology, Molecular Pharmacology, Nature, Nature Biotechnology, Nature Communication, Nature Methods, Nature Review of Genetics, Nature Protocol, Neurotoxicity Research, Nucleic Acid Research, Oncogene, Oncotarget, Pathology – Research and Practice, Physiological Genomics, PLOS One, PNAS, Proteomics, Science, Stem Cell
Conference organization committee

  • 3rd World Congress and Expo on Oncology & Radiology, San Francisco, 2017
  • 2nd International Conference on Transcriptomics, Orlando, 2016
  • 20th International Conference on Intelligent System for Computational Biology and 11th European Conference on Computational Biology, 2013
  • 19th International Conference on Intelligent System for Computational Biology and 10th European Conference on Computational Biology, 2011
  • The 9th European Conference on Computational Biology 2010, Section of Gene Regulation and Transcriptomics, Ghent, Belgium, 2010
  • The 16th Annual International Conference on Intelligent Systems for Molecular Biology, Toronto, Canada. 2008
  • The 15th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB) & 6th European Conference on Computational Biology (ECCB), Vienna, Austria. 2007
Visiting Professorship

  • Visiting Professor, Shandong University (2004 –)
  • Visiting Professor, Beijing Institute of Genomics, Chinese Academy of Sciences (2002 –)
Postdoctoral fellows trained
8
Graduate students trained
12 (MS), PhD (4)