郭珩輝教授 - Faculty of Health Sciences (FHS)

lornachau Chau Long Lei2024-10-09T18:18:20+08:002020-02-13|

聯絡信息

職稱

系主任, 教授

辦公室

(辦公室) E12-2063 /(實驗室) E12-3071

電話

(辦公室) +853 8822 4991 / (實驗室) +853 8822 9120

傳真

+853 8822 2314

電郵

hfkwok@um.edu.mo

諮詢時間

星期二、三 10:00 – 11:00

教學

HSCI1003 General and Clinical Biochemistry
HSCI4009 Toxicology
HSCI7005 Toxicology and Environmental Health

研究團隊

名稱	職稱	辦公室	電話	電郵
林子琦	博士生 (實驗室代表)	E12-3051	+853 8822 4219	yc17669@um.edu.mo
秦海心	研究助理	E12-3051	+853 8822 9104	haixinqin@um.edu.mo
左偉敏	博士生	E12-3051	+853 8822 4219
李靜	博士生	E12-3051	+853 8822 4219
黃倩華	博士生	E12-3051
李忠亮	博士生
羅思源	博士生	E12-3050
張家盛	博士生	E12-3050
張詩玲	博士生
何丹桂	博士生
朱燕	博士生
彭靜旋	博士生

Education
Knowledge Transfer Partnership (KTP) Postdoctoral Fellow	Queen’s University Belfast, UK (2004-2007)
PhD in Biomedical Sciences	University of Ulster, UK (2003)
BSc (1st Class Hons) in Biotechnology	University of Ulster, UK (2000)
NVQ Level 4 (Higher National Diploma) in Management	Chartered Management Institute, UK (2007)

Positions
2024 – Present	Professor, Faculty of Health Sciences, University of Macau
2022 – Present	Fellow of the Royal Society of Chemistry (FRSC), UK
2022 – Present	Fellow of the Royal Society of Biology (FRSB), UK
2018 – 2024	Associate Professor, Faculty of Health Sciences, University of Macau
2013 – Present	Visiting Scientist/Mentor, Cancer Research UK Cambridge Institute, University of Cambridge, UK
2014 – 2018	Assistant Professor, Faculty of Health Sciences, University of Macau
2007 – 2017	Visiting Research Fellow, School of Pharmacy, Queen’s University Belfast, UK
2011 – 2014	Senior Research Associate / Fellow, Department of Oncology / Cancer Research UK Cambridge Institute, University of Cambridge, UK
2007 – 2011	Senior Scientist, Fusion Antibodies Ltd., UK

Research Interests
Prof. Kwok’s research interests mainly focus on developing novel monoclonal antibodies and natural biomolecules (including venom-based peptides, plant-derived molecules etc.) as prototype drugs for anticancer and anti-inflammatory therapies. In addition, Prof. Kwok’s research group also expands their research and scientific knowledge in the areas of existing and novel cancer biomarkers such as matricellular protein — OPN, metalloproteinase — ADAM17, ADAMTS5 and ADAMTS8, DNA replication licensing factor — MCM proteins, small GTP binding protein — RAN and RCC1, immunotherapy markers (e.g. PD-1/PD-L1), as well as markers for photoelectrochemical immunoassay (e.g. sulfide- / Zn0.5Cd0.5S- PSA) in order to identify and validate their prognostic and therapeutic values according to the roles in hallmarks of cancer and chronic diseases. For more details, please kindly further visit the Faculty of Health Sciences (FHS) Newsletter link — Principle Investigator (PI) Introduction Series and Prof. Kwok’s research group website as below: https://mp.weixin.qq.com/s/jNol5GBHnYXzl6h2s6LL7Q http://www.henrykwoklab.com

Research Interests

Prof. Kwok’s research interests mainly focus on developing novel monoclonal antibodies and natural biomolecules (including venom-based peptides, plant-derived molecules etc.) as prototype drugs for anticancer and anti-inflammatory therapies. In addition, Prof. Kwok’s research group also expands their research and scientific knowledge in the areas of existing and novel cancer biomarkers such as

matricellular protein — OPN,
metalloproteinase — ADAM17, ADAMTS5 and ADAMTS8,
DNA replication licensing factor — MCM proteins,
small GTP binding protein — RAN and RCC1,
immunotherapy markers (e.g. PD-1/PD-L1), as well as markers for photoelectrochemical immunoassay (e.g. sulfide- / Zn0.5Cd0.5S- PSA)

in order to identify and validate their prognostic and therapeutic values according to the roles in hallmarks of cancer and chronic diseases.

For more details, please kindly further visit the Faculty of Health Sciences (FHS) Newsletter link — Principle Investigator (PI) Introduction Series and Prof. Kwok’s research group website as below:

Representative Publications
Journal Articles: Guo L., Li B., Wong S. W., Chen M., Xu Q, Ge L and Kwok H. F. (2023) Enzyme-catalyzed high-performing reaction with in-situ amplified photocurrent on carbon-functionalized inorganic photoanode for immunosensing. Biosensors and Bioelectronics 236, 115404 Wu Q., Chen P., Li J., Lin Z., Zhang Q. and Kwok H. F. (2023) Inhibition of bladder cancer growth with Homoharringtonine by inactivating integrin α5/β1-FAK/Src axis: A novel strategy for drug application. Pharmacological Research 188, 106654 Li J., Zhu L. and Kwok H. F. (2023) Nanotechnology-based approaches overcome lung cancer drug resistance through diagnosis and treatment. Drug Resistance Updates 66, 100904 Li B., Guo L., Ge L., and Kwok H. F. (2023) Pearson’s principle-inspired hollow metal sulfide for amplified photoelectrochemical immunoassay for disease-related protein. Biosensors and Bioelectronics 221, 114210 Li J., Chen P., Wu Q., Guo L., Leong K. W., Chan K. I., and Kwok H. F. (2022) A novel combination treatment of antiADAM17 antibody and erlotinib to overcome acquired drug resistance in non-small cell lung cancer through the FOXO3a/FOXM1 axis. Cellular and Molecular Life Sciences 79, 614 Li J., Zhu L., and Kwok H. F. (2022) Nanotechnology-based approaches overcome lung cancer drug resistance through diagnosis and treatment. Drug Resistance Updates (In Press) Mughal M. J., Chan K. I., Mahadevappa R., Wong S. W., Wai, K. C., and Kwok H. F. (2022) Over-activation of Minichromosome Maintenance Protein 10 promotes genomic instability in early stages of breast cancer progression. International Journal of Biological Sciences 18(9), 3827-3844 Li B., Guo L., Chen M., Guo Y., Ge L., and Kwok H. F. (2022) Single-atom Pt-anchored Zn0.5Cd0.5S boosted photoelectrochemical immunoassay of prostate-specific antigen. Biosensors and Bioelectronics 202, 114006 Mughal, M. J. and Kwok, H. F. (2021) Multidimensional role of bacteria in cancer: mechanisms insight, diagnostic, preventive and therapeutic potential. Seminars in Cancer Biology 21, 00181-001814 Wei, R., Wu, Q., Ai, N., Wang, L., Zhou, M., Shaw, C., Chen, T., Ye, R. D., Ge, W., Siu, S. W. I. and Kwok, H. F. (2021) A novel bioengineered fragment peptide of Vasostatin-1 exerts smooth muscle pharmacological activities and anti-angiogenic effects via blocking VEGFR signalling pathway. Computational and Structural Biotechnology Journal 19, 2664-2675 Li, B., Ge, L. L., Lyu, P., Chen, M. J., Zhang, X. F., Xie, S., Wu, Q. and Kwok, H. F. (2021) Handheld pH Meter-Assisted Immunoassay for C-Reactive Protein Using Glucose Oxidase-Conjugated Dendrimer Loaded with Platinum Nanozymes. Microchim Acta 188 (1), 14 Xie, J., Chen, P., Xie, X, Sun, Y., Huang, Z., Wei, R., Maio, Z., Wang, Q., Zhang, S. D., Wong, K. H., Lin, Y., Huang, C. and Kwok, H. F. (2020) Exploration of Gastric Neuroendocrine Carcinoma (GNEC) specific signaling pathways involved in chemoresistance via transcriptome and in vitro analysis. Computational and Structural Biotechnology Journal 18, 2610-2620 Ma, R. and Kwok, H. F. (2020) New opportunities and challenges of venom-based and bacteria-derived molecules for anticancer therapy. Seminars in Cancer Biology 20, 30182-30186 Guo, L., Wei, R., Lin, Y. and Kwok, H. F. (2020) Clinical and Recent Patents Applications of PD-1/PD-L1 Targeting Immunotherapy in Cancer Treatment — Current Progress, Strategy and Future Perspective. Frontiers in Immunology 11, 1508 Li, J. and Kwok, H. F. (2020) Current Strategies for Treating NSCLC: From Biological Mechanisms to Clinical Treatment. Cancers (Basel) 12 (6), E1587 Ma, R., Ren, Z. L., Li, B., Siu, S. W. I., Chen, G. K. and Kwok, H. F. (2020) Novel Venom-Based Peptides (P13 and its Derivative-M6) to Maintain Self-Renewal of Human Embryonic Stem Cells by Activating FGF and TGFbeta Signaling Pathways. Stem Cell Res Ther 11 (1), 243 Ma, R., Wong, S. W., Ge, L., Shaw, C., Siu, S. W. I. and Kwok, H. F. (2020) In Vitro and MD Simulation Study to Explore Physicochemical Parameters for Antibacterial Peptide to Become Potent Anticancer Peptide. Mol Ther Oncolytics 16, 7-19 Yang, Z., Chan, K. I., Kwok, H. F. and Tam, K. Y. (2019) Novel Therapeutic Anti-ADAM17 Antibody A9(B8) Enhances EGFR-Tki-Mediated Anticancer Activity in NSCLC. Transl Oncol 12 (11), 1516-1524 Ge, L. L., Li, B., Xu, H. X., Pu, W. Y. and Kwok, H. F. (2019) Backfilling Rolling Cycle Amplification with Enzyme-DNA Conjugates on Antibody for Portable Electrochemical Immunoassay with Glucometer Readout. Biosensors and Bioelectronics 132, 210-216 Chen, P. C., Wang, Q. S., Xie, J. W. and Kwok, H. F. (2019) Signaling Networks and the Feasibility of Computational Analysis in Gastroenteropancreatic Neuroendocrine Tumors. Semin Cancer Biol 58, 80-89 Wei, R., Wong, J. P. C., Lyu, P., Xi, X. P., Tong, O., Zhang, S. D., Yuen, H. F., Shirasawa, S. and Kwok, H. F. (2018) In Vitro and Clinical Data Analysis of Osteopontin as a Prognostic Indicator in Colorectal Cancer. J Cell Mol Med 22 (9), 4097-4105 Mughal, M. J., Mahadevappa, R. and Kwok, H. F. (2018) DNA Replication Licensing Proteins: Saints and Sinners in Cancer. Semin Cancer Biol 58, 11-21 Mahadevappa, R., Neves, H., Yuen, S. M., Jameel, M., Bai, Y. C., Yuen, H. F., Zhang, S. D., Zhu, Y. Z., Lin, Y. and Kwok, H. F. (2018) DNA Replication Licensing Protein MCM10 Promotes Tumor Progression and Is a Novel Prognostic Biomarker and Potential Therapeutic Target in Breast Cancer. Cancers (Basel) 10 (9), E282 Li, B., Lyu, P., Xi, X. P., Ge, L. L., Mahadevappa, R., Shaw, C. and Kwok, H. F. (2018) Triggering of Cancer Cell Cycle Arrest by a Novel Scorpion Venom-Derived Peptide – Gonearrestide. J Cell Mol Med 22 (9), 4460-4473 Ye, J., Yuen, S. M., Murphy, G., Xie, R. Y. and Kwok, H. F. (2017) Anti-Tumor Effects of a ‘Human & Mouse Cross-Reactive’ Anti-ADAM17 Antibody in a Pancreatic Cancer Model in Vivo. Eur J Pharm Sci 110, 62-69 Wong, J., Wei, R., Lyu, P., Tong, O., Zhang, S. D., Wen, Q., Yuen, H. F., El-Tanani, M. and Kwok, H. F. (2017) Clinical and in Vitro Analysis of Osteopontin as a Prognostic Indicator and Unveil Its Potential Downstream Targets in Bladder Cancer. Int J Biol Sci 13 (11), 1373 Neves, H. and Kwok, H. F. (2017) In Sickness and in Health: The Many Roles of the Minichromosome Maintenance Proteins. Biochim Biophys Acta (BBA) — Reviews on Cancer 1868 (1), 295-308 Mahadevappa, R., Ma, R. and Kwok, H. F. (2017) Venom Peptides: Improving Specificity in Cancer Therapy. Trends Cancer 3 (9), 611-614 Takayanagi, T., Forrester, S., Kawai, T., Obama, T., Tsuji, T., Elliott, K., Nuti, E., Rossello, A., Kwok, H. F., Scalia, R., Rizzo, V. and Eguchi, S. (2016) Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin Iinovelty and Significance. Hypertension 68 (4), 949-955 Kwok, H. F., Zhang, S. D., McCrudden, C., Yuen, H. F., Ting, K. P., Wen, Q., Khoo, U. S. and Chan, K. Y. K. (2015) Prognostic Significance of Minichromosome Maintenance Proteins in Breast Cancer. Am J Cancer Res 5 (1), 52-71 Kwok, H. F., Botkjaer, K., Tape, C., Huang, Y. C., McCafferty, J. and Murphy, G. (2014) Development of a ‘Mouse and Human Cross-Reactive’affinity-Matured Exosite Inhibitory Human Antibody Specific to TACE (ADAM17) for Cancer Immunotherapy. Protein Eng Des Sel 27 (6), 179-190 Kwok, H. F., Buick, R. J., Kuehn, D., Gormley, J. A., Doherty, D., Jaquin, T. J., McClurg, A., Ward, C., Byrne, T., Jaworski, J., Leung, K. L., Snoddy, P., McAnally, C., Burden, R. E., Gray, B., Lowry, J., Sermadiras, I., Gruszka, N., Courtenay-Luck, N., Kissenpfennig, A., Scott, C. J., Johnston, J. A. and Olwill, S. A. (2011) Antibody Targeting of Cathepsin S Induces Antibody-Dependent Cellular Cytotoxicity. Mol Cancer 10, 147 Fry, B. G., Roelants, K., Winter, K., Hodgson, W. C., Griesman, L., Kwok, H. F., Scanlon, D., Karas, J., Shaw, C., Wong, L. and Norman, J. A. (2010) Novel Venom Proteins Produced by Differential Domain-Expression Strategies in Beaded Lizards and Gila Monsters (Genus Heloderma). Mol Biol Evol 27 (2), 395-407 Fry, B. G., Wroe, S., Teeuwisse, W., van Osch, M. J., Moreno, K., Ingle, J., McHenry, C., Ferrara, T., Clausen, P., Scheib, H., Winter, K. L., Greisman, L., Roelants, K., van der Weerd, L., Clemente, C. J., Giannakis, E., Hodgson, W. C., Luz, S., Martelli, P., Krishnasamy, K., Kochva, E., Kwok, H. F., Scanlon, D., Karas, J., Citron, D. M., Goldstein, E. J., McNaughtan, J. E. and Norman, J. A. (2009) A Central Role for Venom in Predation by Varanus Komodoensis (Komodo Dragon) and the Extinct Giant Varanus (Megalania) Priscus. Proc Natl Acad Sci U S A 106 (22), 8969-8974 Kwok, H. F., Chen, T., O’Rourke, M., Ivanyi, C., Hirst, D. and Shaw, C. (2008) Helokinestatin: A New Bradykinin B2 Receptor Antagonist Decapeptide from Lizard Venom. Peptides 29 (1), 65-72 Books / Book Chapters: Kwok H. F., Shaw C. and Walker B. (Ed.) (2021) Proteases — From Basic Structure to Function to Drug Design as Targeted Therapy (pp. 1-93). Basel, Switzerland: Multidisciplinary Digital Publishing Institute (MDPI) Kwok H. F. (Ed.) (2021) Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases (pp. 1-180). Basel, Switzerland: Multidisciplinary Digital Publishing Institute (MDPI) Kwok, H. F. (Ed.) (2019) Venom Toxins as Potential Targeted Therapy (pp. 1-167). Basel, Switzerland: Multidisciplinary Digital Publishing Institute (MDPI) Fry, B. G., Roelants, K., Jackson, T. N. W., Takacs, Z., Reeks, T. and Kwok, H. F. (2015) Chapter 18 B-Type natriuretic peptides. In Bryan Fry (Ed.), Venomous Reptiles and Their Toxins (pp. 312-317). Oxford, UK: Oxford University Press Fry, B. G., Roelants, K., Jackson, T. N. W., Takacs, Z., Reeks, T. and Kwok, H. F. (2015) Chapter 11 Exendin peptides. In Bryan Fry (Ed.), Venomous Reptiles and Their Toxins (pp. 247-254). Oxford, UK: Oxford University Press Full publications list

Representative Publications

Journal Articles:

Guo L., Li B., Wong S. W., Chen M., Xu Q, Ge L and Kwok H. F. (2023) Enzyme-catalyzed high-performing reaction with in-situ amplified photocurrent on carbon-functionalized inorganic photoanode for immunosensing. Biosensors and Bioelectronics 236, 115404
Wu Q., Chen P., Li J., Lin Z., Zhang Q. and Kwok H. F. (2023) Inhibition of bladder cancer growth with Homoharringtonine by inactivating integrin α5/β1-FAK/Src axis: A novel strategy for drug application. Pharmacological Research 188, 106654
Li J., Zhu L. and Kwok H. F. (2023) Nanotechnology-based approaches overcome lung cancer drug resistance through diagnosis and treatment. Drug Resistance Updates 66, 100904
Li B., Guo L., Ge L., and Kwok H. F. (2023) Pearson’s principle-inspired hollow metal sulfide for amplified photoelectrochemical immunoassay for disease-related protein. Biosensors and Bioelectronics 221, 114210
Li J., Chen P., Wu Q., Guo L., Leong K. W., Chan K. I., and Kwok H. F. (2022) A novel combination treatment of antiADAM17 antibody and erlotinib to overcome acquired drug resistance in non-small cell lung cancer through the FOXO3a/FOXM1 axis. Cellular and Molecular Life Sciences 79, 614
Li J., Zhu L., and Kwok H. F. (2022) Nanotechnology-based approaches overcome lung cancer drug resistance through diagnosis and treatment. Drug Resistance Updates (In Press)
Mughal M. J., Chan K. I., Mahadevappa R., Wong S. W., Wai, K. C., and Kwok H. F. (2022) Over-activation of Minichromosome Maintenance Protein 10 promotes genomic instability in early stages of breast cancer progression. International Journal of Biological Sciences 18(9), 3827-3844
Li B., Guo L., Chen M., Guo Y., Ge L., and Kwok H. F. (2022) Single-atom Pt-anchored Zn0.5Cd0.5S boosted photoelectrochemical immunoassay of prostate-specific antigen. Biosensors and Bioelectronics 202, 114006
Mughal, M. J. and Kwok, H. F. (2021) Multidimensional role of bacteria in cancer: mechanisms insight, diagnostic, preventive and therapeutic potential. Seminars in Cancer Biology 21, 00181-001814
Wei, R., Wu, Q., Ai, N., Wang, L., Zhou, M., Shaw, C., Chen, T., Ye, R. D., Ge, W., Siu, S. W. I. and Kwok, H. F. (2021) A novel bioengineered fragment peptide of Vasostatin-1 exerts smooth muscle pharmacological activities and anti-angiogenic effects via blocking VEGFR signalling pathway. Computational and Structural Biotechnology Journal 19, 2664-2675
Li, B., Ge, L. L., Lyu, P., Chen, M. J., Zhang, X. F., Xie, S., Wu, Q. and Kwok, H. F. (2021) Handheld pH Meter-Assisted Immunoassay for C-Reactive Protein Using Glucose Oxidase-Conjugated Dendrimer Loaded with Platinum Nanozymes. Microchim Acta 188 (1), 14
Xie, J., Chen, P., Xie, X, Sun, Y., Huang, Z., Wei, R., Maio, Z., Wang, Q., Zhang, S. D., Wong, K. H., Lin, Y., Huang, C. and Kwok, H. F. (2020) Exploration of Gastric Neuroendocrine Carcinoma (GNEC) specific signaling pathways involved in chemoresistance via transcriptome and in vitro analysis. Computational and Structural Biotechnology Journal 18, 2610-2620
Ma, R. and Kwok, H. F. (2020) New opportunities and challenges of venom-based and bacteria-derived molecules for anticancer therapy. Seminars in Cancer Biology 20, 30182-30186
Guo, L., Wei, R., Lin, Y. and Kwok, H. F. (2020) Clinical and Recent Patents Applications of PD-1/PD-L1 Targeting Immunotherapy in Cancer Treatment — Current Progress, Strategy and Future Perspective. Frontiers in Immunology 11, 1508
Li, J. and Kwok, H. F. (2020) Current Strategies for Treating NSCLC: From Biological Mechanisms to Clinical Treatment. Cancers (Basel) 12 (6), E1587
Ma, R., Ren, Z. L., Li, B., Siu, S. W. I., Chen, G. K. and Kwok, H. F. (2020) Novel Venom-Based Peptides (P13 and its Derivative-M6) to Maintain Self-Renewal of Human Embryonic Stem Cells by Activating FGF and TGFbeta Signaling Pathways. Stem Cell Res Ther 11 (1), 243
Ma, R., Wong, S. W., Ge, L., Shaw, C., Siu, S. W. I. and Kwok, H. F. (2020) In Vitro and MD Simulation Study to Explore Physicochemical Parameters for Antibacterial Peptide to Become Potent Anticancer Peptide. Mol Ther Oncolytics 16, 7-19
Yang, Z., Chan, K. I., Kwok, H. F. and Tam, K. Y. (2019) Novel Therapeutic Anti-ADAM17 Antibody A9(B8) Enhances EGFR-Tki-Mediated Anticancer Activity in NSCLC. Transl Oncol 12 (11), 1516-1524
Ge, L. L., Li, B., Xu, H. X., Pu, W. Y. and Kwok, H. F. (2019) Backfilling Rolling Cycle Amplification with Enzyme-DNA Conjugates on Antibody for Portable Electrochemical Immunoassay with Glucometer Readout. Biosensors and Bioelectronics 132, 210-216
Chen, P. C., Wang, Q. S., Xie, J. W. and Kwok, H. F. (2019) Signaling Networks and the Feasibility of Computational Analysis in Gastroenteropancreatic Neuroendocrine Tumors. Semin Cancer Biol 58, 80-89
Wei, R., Wong, J. P. C., Lyu, P., Xi, X. P., Tong, O., Zhang, S. D., Yuen, H. F., Shirasawa, S. and Kwok, H. F. (2018) In Vitro and Clinical Data Analysis of Osteopontin as a Prognostic Indicator in Colorectal Cancer. J Cell Mol Med 22 (9), 4097-4105
Mughal, M. J., Mahadevappa, R. and Kwok, H. F. (2018) DNA Replication Licensing Proteins: Saints and Sinners in Cancer. Semin Cancer Biol 58, 11-21
Mahadevappa, R., Neves, H., Yuen, S. M., Jameel, M., Bai, Y. C., Yuen, H. F., Zhang, S. D., Zhu, Y. Z., Lin, Y. and Kwok, H. F. (2018) DNA Replication Licensing Protein MCM10 Promotes Tumor Progression and Is a Novel Prognostic Biomarker and Potential Therapeutic Target in Breast Cancer. Cancers (Basel) 10 (9), E282
Li, B., Lyu, P., Xi, X. P., Ge, L. L., Mahadevappa, R., Shaw, C. and Kwok, H. F. (2018) Triggering of Cancer Cell Cycle Arrest by a Novel Scorpion Venom-Derived Peptide – Gonearrestide. J Cell Mol Med 22 (9), 4460-4473
Ye, J., Yuen, S. M., Murphy, G., Xie, R. Y. and Kwok, H. F. (2017) Anti-Tumor Effects of a ‘Human & Mouse Cross-Reactive’ Anti-ADAM17 Antibody in a Pancreatic Cancer Model in Vivo. Eur J Pharm Sci 110, 62-69
Wong, J., Wei, R., Lyu, P., Tong, O., Zhang, S. D., Wen, Q., Yuen, H. F., El-Tanani, M. and Kwok, H. F. (2017) Clinical and in Vitro Analysis of Osteopontin as a Prognostic Indicator and Unveil Its Potential Downstream Targets in Bladder Cancer. Int J Biol Sci 13 (11), 1373
Neves, H. and Kwok, H. F. (2017) In Sickness and in Health: The Many Roles of the Minichromosome Maintenance Proteins. Biochim Biophys Acta (BBA) — Reviews on Cancer 1868 (1), 295-308
Mahadevappa, R., Ma, R. and Kwok, H. F. (2017) Venom Peptides: Improving Specificity in Cancer Therapy. Trends Cancer 3 (9), 611-614
Takayanagi, T., Forrester, S., Kawai, T., Obama, T., Tsuji, T., Elliott, K., Nuti, E., Rossello, A., Kwok, H. F., Scalia, R., Rizzo, V. and Eguchi, S. (2016) Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin Iinovelty and Significance. Hypertension 68 (4), 949-955
Kwok, H. F., Zhang, S. D., McCrudden, C., Yuen, H. F., Ting, K. P., Wen, Q., Khoo, U. S. and Chan, K. Y. K. (2015) Prognostic Significance of Minichromosome Maintenance Proteins in Breast Cancer. Am J Cancer Res 5 (1), 52-71
Kwok, H. F., Botkjaer, K., Tape, C., Huang, Y. C., McCafferty, J. and Murphy, G. (2014) Development of a ‘Mouse and Human Cross-Reactive’affinity-Matured Exosite Inhibitory Human Antibody Specific to TACE (ADAM17) for Cancer Immunotherapy. Protein Eng Des Sel 27 (6), 179-190
Kwok, H. F., Buick, R. J., Kuehn, D., Gormley, J. A., Doherty, D., Jaquin, T. J., McClurg, A., Ward, C., Byrne, T., Jaworski, J., Leung, K. L., Snoddy, P., McAnally, C., Burden, R. E., Gray, B., Lowry, J., Sermadiras, I., Gruszka, N., Courtenay-Luck, N., Kissenpfennig, A., Scott, C. J., Johnston, J. A. and Olwill, S. A. (2011) Antibody Targeting of Cathepsin S Induces Antibody-Dependent Cellular Cytotoxicity. Mol Cancer 10, 147
Fry, B. G., Roelants, K., Winter, K., Hodgson, W. C., Griesman, L., Kwok, H. F., Scanlon, D., Karas, J., Shaw, C., Wong, L. and Norman, J. A. (2010) Novel Venom Proteins Produced by Differential Domain-Expression Strategies in Beaded Lizards and Gila Monsters (Genus Heloderma). Mol Biol Evol 27 (2), 395-407
Fry, B. G., Wroe, S., Teeuwisse, W., van Osch, M. J., Moreno, K., Ingle, J., McHenry, C., Ferrara, T., Clausen, P., Scheib, H., Winter, K. L., Greisman, L., Roelants, K., van der Weerd, L., Clemente, C. J., Giannakis, E., Hodgson, W. C., Luz, S., Martelli, P., Krishnasamy, K., Kochva, E., Kwok, H. F., Scanlon, D., Karas, J., Citron, D. M., Goldstein, E. J., McNaughtan, J. E. and Norman, J. A. (2009) A Central Role for Venom in Predation by Varanus Komodoensis (Komodo Dragon) and the Extinct Giant Varanus (Megalania) Priscus. Proc Natl Acad Sci U S A 106 (22), 8969-8974
Kwok, H. F., Chen, T., O’Rourke, M., Ivanyi, C., Hirst, D. and Shaw, C. (2008) Helokinestatin: A New Bradykinin B2 Receptor Antagonist Decapeptide from Lizard Venom. Peptides 29 (1), 65-72

Books / Book Chapters:

Kwok H. F., Shaw C. and Walker B. (Ed.) (2021) Proteases — From Basic Structure to Function to Drug Design as Targeted Therapy (pp. 1-93). Basel, Switzerland: Multidisciplinary Digital Publishing Institute (MDPI)
Kwok H. F. (Ed.) (2021) Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases (pp. 1-180). Basel, Switzerland: Multidisciplinary Digital Publishing Institute (MDPI)
Kwok, H. F. (Ed.) (2019) Venom Toxins as Potential Targeted Therapy (pp. 1-167). Basel, Switzerland: Multidisciplinary Digital Publishing Institute (MDPI)
Fry, B. G., Roelants, K., Jackson, T. N. W., Takacs, Z., Reeks, T. and Kwok, H. F. (2015) Chapter 18 B-Type natriuretic peptides. In Bryan Fry (Ed.), Venomous Reptiles and Their Toxins (pp. 312-317). Oxford, UK: Oxford University Press
Fry, B. G., Roelants, K., Jackson, T. N. W., Takacs, Z., Reeks, T. and Kwok, H. F. (2015) Chapter 11 Exendin peptides. In Bryan Fry (Ed.), Venomous Reptiles and Their Toxins (pp. 247-254). Oxford, UK: Oxford University Press

Full publications list

Research Grants
2024	Dr. Stanley Ho Medical Development Foundation “Set Sail for New Horizons, Create the Future” Grant: Visiting Scholar Exchange Program
2022 – Present	The Science and Technology Development Fund (FDCT), To investigate the molecular mechanisms of Osteopontin (OPN) and KRAS mutant/wild-type in colon cancer development and prognosis as an early diagnosis and therapeutic target
2021 – Present	The Science and Technology Development Fund (FDCT) — National Natural Science Foundation of China (NSFC), Role and mechanism of animal venom peptide family BmKDfsin3/4 against HBV/HCV and the related-hepatocellular carcinoma mediated by p38 MAPK signal pathway
2019 – 2022	The Science and Technology Development Fund (FDCT), Novel combination treatment strategy with “Anti-ADAM17 Antibody + EGFR-TKi” for tackling the drug resistance issue in EGFR-mutant lung cancer
2017 – 2020	The Science and Technology Development Fund (FDCT), Discover & investigate the role of novel venom-based peptide(s) in cancer progression to unlock its mechanism as a therapeutic drug development to fight against cancer
2017 – 2020	The Science and Technology Development Fund (FDCT) — Minister of Science and Technology of China (MOST), Investigation of the correlation between PD-L1 expression and KRAS signaling pathway and its potential clinical application
2015 – 2018	The Science and Technology Development Fund (FDCT), Investigate the role of MCM10 in breast cancer progression & its potential as a therapeutic target
2015 – 2018	University of Macau Multi-Year Research Grant, A model system for structural and functional convergence of venom peptides: unlock a new era in drug development
2015 – 2018	University of Macau Multi-Year Research Grant, Osteopontin (OPN) expression as a prognostic indicator in colorectal cancer & its potential as a therapeutic target
2014 – 2016	University of Macau Start-Up Research Grant, Investigate novel regulator(s) for ADAM17 ectodomain shedding by cellular & proteomics approaches: Evaluation in biology and medicine
2011 – 2016	Cancer Research UK Research Grant (with Prof Gillian Murphy), Development of human TACE (mouse & human cross-reactive) therapeutic antibody against cancer
2007 – 2011	Invest Northern Ireland (NI) European Development Research Fund, Discovery, development & evaluation of the therapeutic efficacy of APO-1 antibody and human Cathepsin S antibody for the treatment of cancer
2006 – 2009	InterTrade Ireland Innova Grant, TB diagnostic kit/assay development
2004 – 2007	UK Technology Strategy Board KTP Funding, Define the shortfalls in current protein production techniques, and to develop novel techniques to permit more efficient and scaled protein engineering, protein expression and protein purification

Patents
Kwok H. F., Ma R., Chen G. (2022) Venom-based peptide and application thereof. Patent CN 111574593 B and WO2021237904A1 Kwok H. F., Xie R. (2020) Use of anti-tumour effects of a ‘human & mouse cross-reactive’anti-adam17 antibody in treating pancreatic cancer. Patent US 16/033,654 Kwok H. F. (2019) Method of Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II. Patent US 16/032,482 Olwill S. A., Kwok H. F., Johnston J. A., Whelan C., Clarke J., Shuralev E. (2010) Diagnostic methods and kits – The identification of tuberculosis infection in animals such as badgers, cervids and wild boar. Patent WO 2010097625 Olwill S. A., Buick R., Kwok H. F., Scott C., Ward C. (2010) Antibody Therapy – Described are methods of inhibiting angiogenesis, the methods comprising the simultaneous, sequential or separate administration of (i) an anti- Cathepsin S antibody molecule, and (ii) an anti-VEGF antibody molecule. Also described are anti-Cathepsin S humanized antibodies, pharmaceutical compositions and methods of treatment using such antibodies. Patent WO 2010094981 Olwill S. A., Johnston J. A., Kwok H. F., Whelan C, Clarke J. (2009) Diagnostic method and kit – The invention relates to methods for diagnosis of tuberculosis comprising determining the presence or absence of, or an immune response to a group of antigens. Patent WO2009024822 Olwill S. A., Buick R. J., Kwok H. F., Johnston J. A. (2006) Assays for diagnosis of tuberculosis and uses thereof – The identification of mycobacterial antigens which are highly immunogenic and which may be used in assays and methods for the diagnosis of tuberculosis. Patent WO2006117538

Patents

Kwok H. F., Ma R., Chen G. (2022) Venom-based peptide and application thereof. Patent CN 111574593 B and WO2021237904A1
Kwok H. F., Xie R. (2020) Use of anti-tumour effects of a ‘human & mouse cross-reactive’anti-adam17 antibody in treating pancreatic cancer. Patent US 16/033,654
Kwok H. F. (2019) Method of Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II. Patent US 16/032,482
Olwill S. A., Kwok H. F., Johnston J. A., Whelan C., Clarke J., Shuralev E. (2010) Diagnostic methods and kits – The identification of tuberculosis infection in animals such as badgers, cervids and wild boar. Patent WO 2010097625
Olwill S. A., Buick R., Kwok H. F., Scott C., Ward C. (2010) Antibody Therapy – Described are methods of inhibiting angiogenesis, the methods comprising the simultaneous, sequential or separate administration of (i) an anti- Cathepsin S antibody molecule, and (ii) an anti-VEGF antibody molecule. Also described are anti-Cathepsin S humanized antibodies, pharmaceutical compositions and methods of treatment using such antibodies. Patent WO 2010094981
Olwill S. A., Johnston J. A., Kwok H. F., Whelan C, Clarke J. (2009) Diagnostic method and kit – The invention relates to methods for diagnosis of tuberculosis comprising determining the presence or absence of, or an immune response to a group of antigens. Patent WO2009024822
Olwill S. A., Buick R. J., Kwok H. F., Johnston J. A. (2006) Assays for diagnosis of tuberculosis and uses thereof – The identification of mycobacterial antigens which are highly immunogenic and which may be used in assays and methods for the diagnosis of tuberculosis. Patent WO2006117538

Awards
2021 – 2022	Faculty of Health Sciences Best Teacher (Overall Performance) Award
2020 – 2021	Cancer Biology & Medicine Outstanding Reviewer Award
2020	Incentive Award Scheme for Outstanding Academic Staff
2019 – 2020	Faculty of Health Sciences Best Teacher (Excellence in Service) Award
2018	Incentive Award Scheme for Outstanding Academic Staff
2017 – 2018	Faculty of Health Sciences Best Teacher (Excellence in Service) Award
2014	Winner of Protein Discovery Summit Poster Presentation: GTC’s 2nd Antibody & Protein Therapeutics Conference
2011 – 2014	CRUK Research Fellowship
2008	Winner of Knowledge Transfer Partnership (KTP) Regional Award
2004 – 2007	Knowledge Transfer Partnerships (KTP) Fellowship
2000 – 2003	Vice-Chancellor Research Scholarship
1999	University of Ulster Overseas student Bursary Award

Professional Activities
Invited Editorial Service Editor-in-Chief (Natural and Bio-inspired Molecules Section) – Biomolecules Executive Editor — Expert Reviews in Molecular Medicine Editor — PeerJ Associate Editor — Frontiers in Molecular Biosciences Associate Editor – Biology Frontiers Section Editor (Antibodies and Peptides in Cancer Therapy) — Recent Patents on Anti-Cancer Drug Discovery Guest Editor — Seminars in Cancer Biology (Thematic Issue: Regulating cell cycle-related activities: the right target for cancer therapy) Guest Editor — Pharmacological Research (Special Issue: Nano-/synthetic-based particles & natural-based biomolecules: Innovative drug design and delivery for potential pharmaceutical applications) Guest Editor — Toxins (Special Issue: Venom and Toxins as Targeted Therapy) Guest Editor — Scientific Reports (Collection: Therapeutic antibodies) Guest Editor — Biomolecules (Special Issue: Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases) Guest Editor — Biology (Special Issue: Proteases — From Basic Structure to Function to Drug Design as Targeted Therapy) Guest Editor — Molecules (Special Issue: Recent Advances in Natural Drug Discovery and Development – Is It a New Wave of Medicine?) Guest Editor — Biology (Special Issue: Recent Prototype Drug Development: Insights in Protein Science and Enzymology for Precision Medicine) Guest Editor — Frontiers in Pharmacology (Special Issue: New Mechanistic Insights into Cancer Precision Medicine) Guest Editor — Frontiers in Molecular Biosciences (Special Issue: Insights in Protein Chemistry and Enzymology: 2021) Guest Editor — Frontiers in Molecular Biosciences (Special Issue: Enzyme Inhibitors from Venoms and Plant Natural Biomolecules as Therapeutics) Guest Editor — Frontiers in Molecular Biosciences (Special Issue: ADAM, ADAMTS and Astacin Proteases: Challenges and Breakthroughs in the -Omics Era I & II) Guest Editor — Frontiers in Molecular Biosciences (Special Issue: Exercise and Cancer: From Clinical Association to Mechanistic Insights) Editorial Board Member of Toxins Editorial Board Member of BMC Medical Genomics Editorial Board Member of Biomolecules Editorial Board Member of Scientific Reports Editorial Board Member of Current Protein & Peptide Science Editorial Board Member of Cancer Biology & Medicine Editorial Board Member of Scientific Reports Ad Hoc Invited Reviewer of Journal / Book / Grant Advanced Science Advanced Composites and Hybrid Materials Applied Biochemistry and Biotechnology Analytical Cellular Pathology Aging ACS Omega Biology Biochemical Journal Biochemical Pharmacology BMC Cancer BMC Medical Genomics BMC Molecular Biology BMC Urology Breast Cancer Targets and Therapy Biochemical Society Transactions Biomedicine & Pharmacotherapy Biofactors Biomarkers in Medicine Bioscience Reports Biosensors and Bioelectronics Cells Cell Death and Disease Cancers Cancer Biomarkers Cancer Biology & Medicine Cancer Management & Research Cancer Medicine Cancer Informatics Cancer Letters Cancer Research Cellular and Molecular Life Sciences Cell Biology International Cellular Physiology and Biochemistry Computational & Structural Biotechnology Journal Communications Biology Current Pharmaceutical Biotechnology Current Drug Targets Current Protein & Peptide Science Current Enzyme Inhibition Current Oncology Cancer Biology & Treatment Drug Design, Development and Therapy Discover Oncology Experimental and Therapeutic Medicine Expert Opinion on Biological Therapy Expert Opinion on Drug Discovery European Journal of Pharmacology Future Oncology Global Challenges Heliyon Immunotherapy Immunology Letters International Immunopharmacology IUBMB Life International Journal of Biological Sciences International Journal of Biochemistry Research & Review International Journal of Nanomedicine International Journal of Oncology International Immunopharmacology Journal of Bone Oncology Journal of Cancer Metastasis and Treatment Journal of Cell Science & Therapy Journal of Cell Communication and Signaling Journal of Cellular and Molecular Medicine Journal of Clinical and Translational Research Journal of Experimental & Clinical Cancer Research Journal of Cancer Journal of Immunology Journal of Molecular Evolution Journal of Ovarian Research Journal of Pain Research Journal of Thoracic Disease Journal of Venom Research Journal of Venomous Animals and Toxins including Tropical Diseases Journal of Zhejiang University-SCIENCE B Langenbeck’s Archives of Surgery Life Sciences mAbs Marine Drugs Microorganisms Microbial Pathogenesis Medical Science Monitor Molecular Biotechnology Molecular Biology Reports Molecular Cancer Therapeutics Molecular Medicine Reports Molecular Therapy – Oncolytics Molecular Pain Molecules Mutation Research Oncogene OncoTargets & Therapy Oncology Reports Oncology Letters Oral Diseases Oxidative Medicine and Cellular Longevity PeerJ PLoS One PNAS Peptides Pharmaceuticals Pharmacology & Therapeutics Regulatory Peptide Research in Veterinary Science Seminars in Cancer Biology Scientific Reports Tissue Engineering Toxicology in Vitro Toxins Toxin Reviews Toxicon Theranostics Vaccines World Journal of Microbiology and Biotechnology World Journal of Surgical Oncology Book — Bioactive Natural Products, Elsevier, Amsterdam Book — Peptides in Molecular Pharmaceutics: Targeted Therapy and Drug Delivery, Nature Springer Book — Bioactive Natural Products, Elsevier, Amsterdam Book — Peptides in Molecular Pharmaceutics: Targeted Therapy and Drug Delivery, Nature Springer Book — Cancer Genomics and Human Health, Nature Springer Grant — Swiss National Science Foundation 2024, Switzerland Grant — Baptist University Initiation Grant for Faculty Niche Research Areas 2022/2023, Hong Kong Grant — Cancer Research UK (CRUK) Biotherapeutics Drug Discovery Programme 2020, UK Grant — Israeli Ministry of Science and Technology 2020, Israel Grant — The Wellcome Trust/DBT India Alliance Fellowship 2019, UK/India Grant — Breast Cancer Now 2017, UK Grant — Tyrolean Science Fund 2014/2015, Austria Ad Hoc Invited External Examiner School of Pharmacy, Queen’s University Belfast, UK — PhD programme and MPhil programme Li Ka Shing Faculty of Medicine, University of Hong Kong — MMedSc programme Faculty of Medicine, Nursing & Health Sciences, Monash University, Australia — PhD programme School of Biomedical Sciences, Chinese University of Hong Kong – PhD programme School of Biological Sciences, University of Queensland, Australia — PhD programme

Professional Activities

Invited Editorial Service

Editor-in-Chief (Natural and Bio-inspired Molecules Section) – Biomolecules
Executive Editor — Expert Reviews in Molecular Medicine
Editor — PeerJ
Associate Editor — Frontiers in Molecular Biosciences
Associate Editor – Biology
Frontiers Section Editor (Antibodies and Peptides in Cancer Therapy) — Recent Patents on Anti-Cancer Drug Discovery
Guest Editor — Seminars in Cancer Biology (Thematic Issue: Regulating cell cycle-related activities: the right target for cancer therapy)
Guest Editor — Pharmacological Research (Special Issue: Nano-/synthetic-based particles & natural-based biomolecules: Innovative drug design and delivery for potential pharmaceutical applications)
Guest Editor — Toxins (Special Issue: Venom and Toxins as Targeted Therapy)
Guest Editor — Scientific Reports (Collection: Therapeutic antibodies)
Guest Editor — Biomolecules (Special Issue: Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases)
Guest Editor — Biology (Special Issue: Proteases — From Basic Structure to Function to Drug Design as Targeted Therapy)
Guest Editor — Molecules (Special Issue: Recent Advances in Natural Drug Discovery and Development – Is It a New Wave of Medicine?)
Guest Editor — Biology (Special Issue: Recent Prototype Drug Development: Insights in Protein Science and Enzymology for Precision Medicine)
Guest Editor — Frontiers in Pharmacology (Special Issue: New Mechanistic Insights into Cancer Precision Medicine)
Guest Editor — Frontiers in Molecular Biosciences (Special Issue: Insights in Protein Chemistry and Enzymology: 2021)
Guest Editor — Frontiers in Molecular Biosciences (Special Issue: Enzyme Inhibitors from Venoms and Plant Natural Biomolecules as Therapeutics)
Guest Editor — Frontiers in Molecular Biosciences (Special Issue: ADAM, ADAMTS and Astacin Proteases: Challenges and Breakthroughs in the -Omics Era I & II)
Guest Editor — Frontiers in Molecular Biosciences (Special Issue: Exercise and Cancer: From Clinical Association to Mechanistic Insights)
Editorial Board Member of Toxins
Editorial Board Member of BMC Medical Genomics
Editorial Board Member of Biomolecules
Editorial Board Member of Scientific Reports
Editorial Board Member of Current Protein & Peptide Science
Editorial Board Member of Cancer Biology & Medicine
Editorial Board Member of Scientific Reports

Ad Hoc Invited Reviewer of Journal / Book / Grant

Advanced Science
Advanced Composites and Hybrid Materials
Applied Biochemistry and Biotechnology
Analytical Cellular Pathology
Aging
ACS Omega
Biology
Biochemical Journal
Biochemical Pharmacology
BMC Cancer
BMC Medical Genomics
BMC Molecular Biology
BMC Urology
Breast Cancer Targets and Therapy
Biochemical Society Transactions
Biomedicine & Pharmacotherapy
Biofactors
Biomarkers in Medicine
Bioscience Reports
Biosensors and Bioelectronics
Cells
Cell Death and Disease
Cancers
Cancer Biomarkers
Cancer Biology & Medicine
Cancer Management & Research
Cancer Medicine
Cancer Informatics
Cancer Letters
Cancer Research
Cellular and Molecular Life Sciences
Cell Biology International
Cellular Physiology and Biochemistry
Computational & Structural Biotechnology Journal
Communications Biology
Current Pharmaceutical Biotechnology
Current Drug Targets
Current Protein & Peptide Science
Current Enzyme Inhibition
Current Oncology
Cancer Biology & Treatment
Drug Design, Development and Therapy
Discover Oncology
Experimental and Therapeutic Medicine
Expert Opinion on Biological Therapy
Expert Opinion on Drug Discovery
European Journal of Pharmacology
Future Oncology
Global Challenges
Heliyon
Immunotherapy
Immunology Letters
International Immunopharmacology
IUBMB Life
International Journal of Biological Sciences
International Journal of Biochemistry Research & Review
International Journal of Nanomedicine
International Journal of Oncology
International Immunopharmacology
Journal of Bone Oncology
Journal of Cancer Metastasis and Treatment
Journal of Cell Science & Therapy
Journal of Cell Communication and Signaling
Journal of Cellular and Molecular Medicine
Journal of Clinical and Translational Research
Journal of Experimental & Clinical Cancer Research
Journal of Cancer
Journal of Immunology
Journal of Molecular Evolution
Journal of Ovarian Research
Journal of Pain Research
Journal of Thoracic Disease
Journal of Venom Research
Journal of Venomous Animals and Toxins including Tropical Diseases
Journal of Zhejiang University-SCIENCE B
Langenbeck’s Archives of Surgery
Life Sciences
mAbs
Marine Drugs
Microorganisms
Microbial Pathogenesis
Medical Science Monitor
Molecular Biotechnology
Molecular Biology Reports
Molecular Cancer Therapeutics
Molecular Medicine Reports
Molecular Therapy – Oncolytics
Molecular Pain
Molecules
Mutation Research
Oncogene
OncoTargets & Therapy
Oncology Reports
Oncology Letters
Oral Diseases
Oxidative Medicine and Cellular Longevity
PeerJ
PLoS One
PNAS
Peptides
Pharmaceuticals
Pharmacology & Therapeutics
Regulatory Peptide
Research in Veterinary Science
Seminars in Cancer Biology
Scientific Reports
Tissue Engineering
Toxicology in Vitro
Toxins
Toxin Reviews
Toxicon
Theranostics
Vaccines
World Journal of Microbiology and Biotechnology
World Journal of Surgical Oncology
Book — Bioactive Natural Products, Elsevier, Amsterdam
Book — Peptides in Molecular Pharmaceutics: Targeted Therapy and Drug Delivery, Nature Springer
Book — Bioactive Natural Products, Elsevier, Amsterdam
Book — Peptides in Molecular Pharmaceutics: Targeted Therapy and Drug Delivery, Nature Springer
Book — Cancer Genomics and Human Health, Nature Springer
Grant — Swiss National Science Foundation 2024, Switzerland
Grant — Baptist University Initiation Grant for Faculty Niche Research Areas 2022/2023, Hong Kong
Grant — Cancer Research UK (CRUK) Biotherapeutics Drug Discovery Programme 2020, UK
Grant — Israeli Ministry of Science and Technology 2020, Israel
Grant — The Wellcome Trust/DBT India Alliance Fellowship 2019, UK/India
Grant — Breast Cancer Now 2017, UK
Grant — Tyrolean Science Fund 2014/2015, Austria

Ad Hoc Invited External Examiner

School of Pharmacy, Queen’s University Belfast, UK — PhD programme and MPhil programme
Li Ka Shing Faculty of Medicine, University of Hong Kong — MMedSc programme
Faculty of Medicine, Nursing & Health Sciences, Monash University, Australia — PhD programme
School of Biomedical Sciences, Chinese University of Hong Kong – PhD programme
School of Biological Sciences, University of Queensland, Australia — PhD programme

Others
Conference Presentations Kwok H. F. (2018) 3^rd International Conference on Cancer Research & Targeted Therapy, London, UK. “Anti-TACE antibody drug development for the treatment of cancer”. Li B., Lyu P., Ma R., Mahadevappa R., Xi X. and Kwok H. F. (2017) 6^th IAPC Meeting — World Conference on Physico Chemical Methods and World Conference on ADMET and DMPK, Zagreb, Croatia. “Venom-based Peptide Drug Discovery: Enhancing Specificity in Cancer Treatment”. (Invited Keynote Speaker) Yuen S.M., Ye J., Murphy G., Xie R. and Kwok H. F. (2016) 5^th IAPC Meeting — Emerging Technologies in Drug Discovery and Development, Zhuhai, China. “Anti-Tumour Effects of a Human & Mouse Cross-Reactive’ Anti-TACE Antibody in a Pancreatic Cancer Model In Vivo”. (Invited Keynote Speaker) Lin Y., Meng C., Lin W., Cheng G. and Kwok H. F. (2016) 3^rd Macao Symposium on Biomedical Sciences, Macau SAR. “Regulation of PD-L1 by KRAS and p53”. Li B., Xi X, Chen T., Shaw C. and Kwok H. F. (2015) 18^th World Congress of the International Society on Toxinology, Oxford, UK. “High-throughput approach for isolation and identification of novel peptides with anticancer activities from scorpion venoms”. Kwok H. F. (2014) 3^rd Antibody & Protein Therapeutics Conference, Boston, USA. “Discovery and Development of Therapeutic TACE (ADAM17) Antibodies”.

Others

Conference Presentations

Kwok H. F. (2018) 3^rd International Conference on Cancer Research & Targeted Therapy, London, UK. “Anti-TACE antibody drug development for the treatment of cancer”.
Li B., Lyu P., Ma R., Mahadevappa R., Xi X. and Kwok H. F. (2017) 6^th IAPC Meeting — World Conference on Physico Chemical Methods and World Conference on ADMET and DMPK, Zagreb, Croatia. “Venom-based Peptide Drug Discovery: Enhancing Specificity in Cancer Treatment”. (Invited Keynote Speaker)
Yuen S.M., Ye J., Murphy G., Xie R. and Kwok H. F. (2016) 5^th IAPC Meeting — Emerging Technologies in Drug Discovery and Development, Zhuhai, China. “Anti-Tumour Effects of a Human & Mouse Cross-Reactive’ Anti-TACE Antibody in a Pancreatic Cancer Model In Vivo”. (Invited Keynote Speaker)
Lin Y., Meng C., Lin W., Cheng G. and Kwok H. F. (2016) 3^rd Macao Symposium on Biomedical Sciences, Macau SAR. “Regulation of PD-L1 by KRAS and p53”.
Li B., Xi X, Chen T., Shaw C. and Kwok H. F. (2015) 18^th World Congress of the International Society on Toxinology, Oxford, UK. “High-throughput approach for isolation and identification of novel peptides with anticancer activities from scorpion venoms”.
Kwok H. F. (2014) 3^rd Antibody & Protein Therapeutics Conference, Boston, USA. “Discovery and Development of Therapeutic TACE (ADAM17) Antibodies”.