Prof. Henry Hang Fai KWOK - Faculty of Health Sciences (FHS)

belindalong Long Leng Leng, Belinda2021-01-19T10:13:15+08:002019-11-29|

Contact Information

Title

Associate Professor

Office

(Office) E12-4006 / (Lab) E12-3071

Phone

(Office) +853 8822 4991 / (Lab) +853 8822 4219

Fax

+853 8822 2314

Email

hfkwok@um.edu.mo

Consultation Hours

Tue 10:00 – 11:00, Wed 16:00 – 17:00

Teaching

Course Outlines

HSCI1003 General and Clinical Biochemistry HSCI4009 Toxicology

Research Team

Name	Position	Office	Phone
Pengchen CHEN	PhD Student	E12-3051	+853 8822 4219
Libin GUO	PhD Student	E12-3051	+853 8822 4219
Qiushuang WU	PhD Student	E12-3051	+853 8822 4219
Junnan LI	PhD Student	E12-3051	+853 8822 4219
Muhammad Jameel MUGHAL	PhD Student	E12-3051	+853 8822 4219
Weimin ZUO	PhD Student	E12-3051	+853 8822 4219
Jing LI	PhD Student	E12-3051	+853 8822 4219

Education
Knowledge Transfer Partnership (KTP) Postdoctoral Fellow	Queen’s University Belfast, UK (2004-2007)
PhD in Biomedical Sciences	University of Ulster, UK (2003)
BSc (1st Class Hons) in Biotechnology	University of Ulster, UK (2000)
NVQ Level 4 (Higher National Diploma) in Management	Chartered Management Institute, UK (2007)

Positions
2018-Present	Associate Professor, Faculty of Health Sciences, University of Macau
2013-present	Visiting Scientist, Cancer Research UK Cambridge Institute, University of Cambridge, UK
2014-2018	Assistant Professor, Faculty of Health Sciences, University of Macau
2007-2017	Visiting Research Fellow, School of Pharmacy, Queen’s University Belfast, UK
2011-2014	Senior Research Associate / Fellow, Department of Oncology / Cancer Research UK Cambridge Institute, University of Cambridge, UK
2007-2011	Senior Scientist, Fusion Antibodies Ltd., UK

Research Interests
Prof. Kwok’s research interests mainly focus on the development of novel monoclonal antibodies and natural biomolecules (including venom-based peptides, plant-derived molecules etc.) as prototype drugs for anticancer and anti-inflammatory therapies. In addition, Prof. Kwok’s research group also expands their research and scientific knowledge in the areas of existing and novel cancer biomarkers such as 1) matricellular protein — OPN, 2) metalloproteinase — ADAM17, ADAMTS5 and ADAMTS8, 3) DNA replication licensing factor — MCM proteins, 4) small GTP binding protein — RAN and RCC1, as well as immunotherapy markers (e.g. PD-1/PD-L1) in order to identify and validate their prognostic and therapeutic values according to the roles in hallmarks of cancer and chronic diseases. For more details, please kindly further visit the Faculty of Health Sciences (FHS) Newsletter link — Principle Investigator (PI) Introduction Series and/or Prof. Kwok’s research group website as below: https://mp.weixin.qq.com/s/jNol5GBHnYXzl6h2s6LL7Q http://www.henrykwoklab.com

Research Interests

Prof. Kwok’s research interests mainly focus on the development of novel monoclonal antibodies and natural biomolecules (including venom-based peptides, plant-derived molecules etc.) as prototype drugs for anticancer and anti-inflammatory therapies. In addition, Prof. Kwok’s research group also expands their research and scientific knowledge in the areas of existing and novel cancer biomarkers such as 1) matricellular protein — OPN, 2) metalloproteinase — ADAM17, ADAMTS5 and ADAMTS8, 3) DNA replication licensing factor — MCM proteins, 4) small GTP binding protein — RAN and RCC1, as well as immunotherapy markers (e.g. PD-1/PD-L1) in order to identify and validate their prognostic and therapeutic values according to the roles in hallmarks of cancer and chronic diseases. For more details, please kindly further visit the Faculty of Health Sciences (FHS) Newsletter link — Principle Investigator (PI) Introduction Series and/or Prof. Kwok’s research group website as below:
https://mp.weixin.qq.com/s/jNol5GBHnYXzl6h2s6LL7Q
http://www.henrykwoklab.com

Representative Publications
Journal Articles: Xie J., Chen P., Xie. X, Sun Y., Huang Z., Wei R., Maio Z., Wang Q., Zhang S. D., Wong K. H., Lin Y., Huang C., Kwok, H. F.* (2020) Exploration of Gastric Neuroendocrine Carcinoma (GNEC) specific signaling pathways involved in chemoresistance via transcriptome and in vitro analysis. Computational and Structural Biotechnology Journal 18, 2610-2620 Ma R., Kwok, H. F. (2020) New opportunities and challenges of venom-based and bacteria-derived molecules for anticancer therapy. Semin Cancer Biol (In Press) https://doi.org/10.1016/j.semcancer.2020.08.010 Guo, L., Wei, R., Lin, Y., Kwok, H. F. (2020) Clinical and Recent Patents Applications of PD-1/PD-L1 Targeting Immunotherapy in Cancer Treatment — Current Progress, Strategy and Future Perspective. Frontiers in Immunology 11, 1508 Li, J. N., and Kwok, H. F. (2020) Current Strategies for Treating NSCLC: From Biological Mechanisms to Clinical Treatment. Cancers (Basel) 12 (6), E1587 Ma, R., Ren, Z. L., Li, B., Siu, S. W. I., Chen, G. K., and Kwok, H. F. (2020) Novel Venom-Based Peptides (P13 and its Derivative-M6) to Maintain Self-Renewal of Human Embryonic Stem Cells by Activating FGF and TGFbeta Signaling Pathways. Stem Cell Res Ther 11 (1), 243 Yeung, L., Anderson, J. M. L., Wee, J. L., Demaria, M. C., Finsterbusch, M., Liu, Y. S., Hall, P., Smith, B. C., Dankers, W., Elgass, K. D., Wicks, I. P., Kwok, H. F., Wright, M. D., and Hickey, M. J. (2020) Leukocyte Tetraspanin CD53 Restrains Alpha3 Integrin Mobilization and Facilitates Cytoskeletal Remodeling and Transmigration in Mice. J Immunol 205: 10.4049/jimmunol.1901054 Ma, R., Wong, S. W., Ge, L., Shaw, C., Siu, S. W. I., and Kwok, H. F. (2020) In Vitro and MD Simulation Study to Explore Physicochemical Parameters for Antibacterial Peptide to Become Potent Anticancer Peptide. Mol Ther Oncolytics 16, 7-19 Yang, Z., Chan, K. I., Kwok, H. F., and Tam, K. Y. (2019) Novel Therapeutic Anti-ADAM17 Antibody A9(B8) Enhances EGFR-Tki-Mediated Anticancer Activity in NSCLC. Transl Oncol 12 (11), 1516-1524 Li, B., Lyu, P., Xie, S. P., Qin, H. X., Pu, W. Y., Xu, H. X., Chen, T., Shaw, C., Ge, L. L., and Kwok, H. F. (2019) Lfb: A Novel Antimicrobial Brevinin-Like Peptide from the Skin Secretion of the Fujian Large Headed Frog, Limnonectes Fujianensi. Biomolecules 9 (6), E242 Ge, L. L., Li, B., Xu, H. X., Pu, W. Y., and Kwok, H. F. (2019) Backfilling Rolling Cycle Amplification with Enzyme-DNA Conjugates on Antibody for Portable Electrochemical Immunoassay with Glucometer Readout. Biosensors and Bioelectronics 132, 210-216 Chen, P. C., Wang, Q. S., Xie, J. W., and Kwok, H. F. (2019) Signaling Networks and the Feasibility of Computational Analysis in Gastroenteropancreatic Neuroendocrine Tumors. Semin Cancer Biol 58, 80-89 Wei, R., Wong, J. P. C., Lyu, P., Xi, X. P., Tong, O., Zhang, S. D., Yuen, H. F., Shirasawa, S., and Kwok, H. F. (2018) In Vitro and Clinical Data Analysis of Osteopontin as a Prognostic Indicator in Colorectal Cancer. J Cell Mol Med 22 (9), 4097-4105 Rajendran, B. K., Xavier Suresh, M., Bhaskaran, S. P., Harshitha, Y., Gaur, U., and Kwok, H. F. (2018) Pharmacoinformatic Approach to Explore the Antidote Potential of Phytochemicals on Bungarotoxin from Indian Krait, Bungarus Caeruleus. Computational and Structural Biotechnology Journal 16, 450-461 Mughal, M. J., Mahadevappa, R., and Kwok, H. F. (2018) DNA Replication Licensing Proteins: Saints and Sinners in Cancer. Semin Cancer Biol 58, 11-21 Mahadevappa, R., Neves, H., Yuen, S. M., Jameel, M., Bai, Y. C., Yuen, H. F., Zhang, S. D., Zhu, Y. Z., Lin, Y., and Kwok, H. F. (2018) DNA Replication Licensing Protein MCM10 Promotes Tumor Progression and Is a Novel Prognostic Biomarker and Potential Therapeutic Target in Breast Cancer. Cancers (Basel) 10 (9), E282 Li, B., Lyu, P., Xi, X. P., Ge, L. L., Mahadevappa, R., Shaw, C., and Kwok, H. F. (2018) Triggering of Cancer Cell Cycle Arrest by a Novel Scorpion Venom-Derived Peptide-Gonearrestide. J Cell Mol Med 22 (9), 4460-4473 Huang, Y. D., Zhang, Y. F., Ge, L. L., Lin, Y., and Kwok, H. F. (2018) The Roles of Protein Tyrosine Phosphatases in Hepatocellular Carcinoma. Cancers (Basel) 10 (3), E82 Ye, J., Yuen, S. M., Murphy, G., Xie, R. Y., and Kwok, H. F. (2017) Anti-Tumor Effects of a ‘Human & Mouse Cross-Reactive’ Anti-ADAM17 Antibody in a Pancreatic Cancer Model in Vivo. Eur J Pharm Sci 110, 62-69 Wong, J., Wei, R., Lyu, P., Tong, O., Zhang, S. D., Wen, Q., Yuen, H. F., El-Tanani, M., and Kwok, H. F. (2017) Clinical and in Vitro Analysis of Osteopontin as a Prognostic Indicator and Unveil Its Potential Downstream Targets in Bladder Cancer. Int J Biol Sci 13 (11), 1373 Wei, R., Wong, J. P. C., and Kwok, H. F. (2017) Osteopontin — a Promising Biomarker for Cancer Therapy. J Cancer 8 (12), 2173-2183 Wang, Q. S., Lin, W., Tang, X. Q., Li, S. H., Guo, L. B., Lin, Y., and Kwok, H. F. (2017) The Roles of Micrornas in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint. Int J Mol Sci 18 (12), 2540 Neves, H., and Kwok, H. F. (2017) In Sickness and in Health: The Many Roles of the Minichromosome Maintenance Proteins. Biochim Biophys Acta 1868 (1), 295-308 Mahadevappa, R., Ma, R., and Kwok, H. F. (2017) Venom Peptides: Improving Specificity in Cancer Therapy. Trends Cancer 3 (9), 611-614 Kawai, T., Takayanagi, T., Forrester, S., Preston, K., Obama, T., Tsuji, T., Kobayashi, T., Boyer, M., Cooper, H., Kwok, H. F., Hashimoto, T., Scalia, R., Rizzo, V., and Eguchi, S. (2017) Vascular ADAM17 (a Disintegrin and Metalloproteinase Domain 17) Is Required for Angiotensin II/Β-Aminopropionitrile–Induced Abdominal Aortic Aneurysm. Hypertension, HYPERTENSIONAHA. 117.09822 Takayanagi, T., Forrester, S., Kawai, T., Obama, T., Tsuji, T., Elliott, K., Nuti, E., Rossello, A., Kwok, H. F., Scalia, R., Rizzo, V., and Eguchi, S. (2016) Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin Iinovelty and Significance. Hypertension 68 (4), 949-955 Kwok, H. F., Zhang, S. D., McCrudden, C., Yuen, H. F., Ting, K. P., Wen, Q., Khoo, U. S., and Chan, K. Y. K. (2015) Prognostic Significance of Minichromosome Maintenance Proteins in Breast Cancer. Am J Cancer Res 5 (1), 52-71 Kwok, H. F., Botkjaer, K., Tape, C., Huang, Y. C., McCafferty, J., and Murphy, G. (2014) Development of a ‘Mouse and Human Cross-Reactive’affinity-Matured Exosite Inhibitory Human Antibody Specific to TACE (ADAM17) for Cancer Immunotherapy. Protein Eng Des Sel 27 (6), 179-190 Kwok, H. F., Buick, R. J., Kuehn, D., Gormley, J. A., Doherty, D., Jaquin, T. J., McClurg, A., Ward, C., Byrne, T., Jaworski, J., Leung, K. L., Snoddy, P., McAnally, C., Burden, R. E., Gray, B., Lowry, J., Sermadiras, I., Gruszka, N., Courtenay-Luck, N., Kissenpfennig, A., Scott, C. J., Johnston, J. A., and Olwill, S. A. (2011) Antibody Targeting of Cathepsin S Induces Antibody-Dependent Cellular Cytotoxicity. Mol Cancer 10, 147 Fry, B. G., Winter, K., Norman, J. A., Roelants, K., Nabuurs, R. J., van Osch, M. J., Teeuwisse, W. M., van der Weerd, L., McNaughtan, J. E., Kwok, H. F., Scheib, H., Greisman, L., Kochva, E., Miller, L. J., Gao, F., Karas, J., Scanlon, D., Lin, F., Kuruppu, S., Shaw, C., Wong, L., and Hodgson, W. C. (2010) Functional and Structural Diversification of the Anguimorpha Lizard Venom System. Mol Cell Proteomics 9 (11), 2369-2390 Fry, B. G., Roelants, K., Winter, K., Hodgson, W. C., Griesman, L., Kwok, H. F., Scanlon, D., Karas, J., Shaw, C., Wong, L., and Norman, J. A. (2010) Novel Venom Proteins Produced by Differential Domain-Expression Strategies in Beaded Lizards and Gila Monsters (Genus Heloderma). Mol Biol Evol 27 (2), 395-407 Fry, B. G., Wroe, S., Teeuwisse, W., van Osch, M. J., Moreno, K., Ingle, J., McHenry, C., Ferrara, T., Clausen, P., Scheib, H., Winter, K. L., Greisman, L., Roelants, K., van der Weerd, L., Clemente, C. J., Giannakis, E., Hodgson, W. C., Luz, S., Martelli, P., Krishnasamy, K., Kochva, E., Kwok, H. F., Scanlon, D., Karas, J., Citron, D. M., Goldstein, E. J., McNaughtan, J. E., and Norman, J. A. (2009) A Central Role for Venom in Predation by Varanus Komodoensis (Komodo Dragon) and the Extinct Giant Varanus (Megalania) Priscus. Proc Natl Acad Sci U S A 106 (22), 8969-8974 Kwok, H. F., Chen, T., O’Rourke, M., Ivanyi, C., Hirst, D., and Shaw, C. (2008) Helokinestatin: A New Bradykinin B2 Receptor Antagonist Decapeptide from Lizard Venom. Peptides 29 (1), 65-72 Books / Book Chapters: Kwok, H. F. (Ed.)* (2019) Venom Toxins as Potential Targeted Therapy (pp. 1-167). Basel, Switzerland: Multidisciplinary Digital Publishing Institute (MDPI). Fry, B. G., Roelants, K., Jackson, T. N. W., Takacs, Z., Reeks, T. and Kwok, H. F. (2015) Chapter 18 B-Type natriuretic peptides. In Bryan Fry (Ed.), Venomous Reptiles and Their Toxins (pp. 312-317). Oxford, UK: Oxford University Press. Fry, B. G., Roelants, K., Jackson, T. N. W., Takacs, Z., Reeks, T. and Kwok, H. F. (2015) Chapter 11 Exendin peptides. In Bryan Fry (Ed.), Venomous Reptiles and Their Toxins (pp. 247-254). Oxford, UK: Oxford University Press. Full publications list

Representative Publications

Journal Articles:

Xie J., Chen P., Xie. X, Sun Y., Huang Z., Wei R., Maio Z., Wang Q., Zhang S. D., Wong K. H., Lin Y.*, Huang C., Kwok, H. F. (2020) Exploration of Gastric Neuroendocrine Carcinoma (GNEC) specific signaling pathways involved in chemoresistance via transcriptome and in vitro analysis. Computational and Structural Biotechnology Journal 18, 2610-2620
Ma R., Kwok, H. F. (2020) New opportunities and challenges of venom-based and bacteria-derived molecules for anticancer therapy. Semin Cancer Biol (In Press) https://doi.org/10.1016/j.semcancer.2020.08.010
Guo, L., Wei, R., Lin, Y., Kwok, H. F. (2020) Clinical and Recent Patents Applications of PD-1/PD-L1 Targeting Immunotherapy in Cancer Treatment — Current Progress, Strategy and Future Perspective. Frontiers in Immunology 11, 1508
Li, J. N., and Kwok, H. F. (2020) Current Strategies for Treating NSCLC: From Biological Mechanisms to Clinical Treatment. Cancers (Basel) 12 (6), E1587
Ma, R., Ren, Z. L., Li, B., Siu, S. W. I., Chen, G. K., and Kwok, H. F. (2020) Novel Venom-Based Peptides (P13 and its Derivative-M6) to Maintain Self-Renewal of Human Embryonic Stem Cells by Activating FGF and TGFbeta Signaling Pathways. Stem Cell Res Ther 11 (1), 243
Yeung, L., Anderson, J. M. L., Wee, J. L., Demaria, M. C., Finsterbusch, M., Liu, Y. S., Hall, P., Smith, B. C., Dankers, W., Elgass, K. D., Wicks, I. P., Kwok, H. F., Wright, M. D., and Hickey, M. J. (2020) Leukocyte Tetraspanin CD53 Restrains Alpha3 Integrin Mobilization and Facilitates Cytoskeletal Remodeling and Transmigration in Mice. J Immunol 205: 10.4049/jimmunol.1901054
Ma, R., Wong, S. W., Ge, L., Shaw, C., Siu, S. W. I., and Kwok, H. F. (2020) In Vitro and MD Simulation Study to Explore Physicochemical Parameters for Antibacterial Peptide to Become Potent Anticancer Peptide. Mol Ther Oncolytics 16, 7-19
Yang, Z., Chan, K. I., Kwok, H. F., and Tam, K. Y. (2019) Novel Therapeutic Anti-ADAM17 Antibody A9(B8) Enhances EGFR-Tki-Mediated Anticancer Activity in NSCLC. Transl Oncol 12 (11), 1516-1524
Li, B., Lyu, P., Xie, S. P., Qin, H. X., Pu, W. Y., Xu, H. X., Chen, T., Shaw, C., Ge, L. L., and Kwok, H. F. (2019) Lfb: A Novel Antimicrobial Brevinin-Like Peptide from the Skin Secretion of the Fujian Large Headed Frog, Limnonectes Fujianensi. Biomolecules 9 (6), E242
Ge, L. L., Li, B., Xu, H. X., Pu, W. Y., and Kwok, H. F. (2019) Backfilling Rolling Cycle Amplification with Enzyme-DNA Conjugates on Antibody for Portable Electrochemical Immunoassay with Glucometer Readout. Biosensors and Bioelectronics 132, 210-216
Chen, P. C., Wang, Q. S., Xie, J. W., and Kwok, H. F. (2019) Signaling Networks and the Feasibility of Computational Analysis in Gastroenteropancreatic Neuroendocrine Tumors. Semin Cancer Biol 58, 80-89
Wei, R., Wong, J. P. C., Lyu, P., Xi, X. P., Tong, O., Zhang, S. D., Yuen, H. F., Shirasawa, S., and Kwok, H. F. (2018) In Vitro and Clinical Data Analysis of Osteopontin as a Prognostic Indicator in Colorectal Cancer. J Cell Mol Med 22 (9), 4097-4105
Rajendran, B. K., Xavier Suresh, M., Bhaskaran, S. P., Harshitha, Y., Gaur, U., and Kwok, H. F. (2018) Pharmacoinformatic Approach to Explore the Antidote Potential of Phytochemicals on Bungarotoxin from Indian Krait, Bungarus Caeruleus. Computational and Structural Biotechnology Journal 16, 450-461
Mughal, M. J., Mahadevappa, R., and Kwok, H. F. (2018) DNA Replication Licensing Proteins: Saints and Sinners in Cancer. Semin Cancer Biol 58, 11-21
Mahadevappa, R., Neves, H., Yuen, S. M., Jameel, M., Bai, Y. C., Yuen, H. F., Zhang, S. D., Zhu, Y. Z., Lin, Y., and Kwok, H. F. (2018) DNA Replication Licensing Protein MCM10 Promotes Tumor Progression and Is a Novel Prognostic Biomarker and Potential Therapeutic Target in Breast Cancer. Cancers (Basel) 10 (9), E282
Li, B., Lyu, P., Xi, X. P., Ge, L. L., Mahadevappa, R., Shaw, C., and Kwok, H. F. (2018) Triggering of Cancer Cell Cycle Arrest by a Novel Scorpion Venom-Derived Peptide-Gonearrestide. J Cell Mol Med 22 (9), 4460-4473
Huang, Y. D., Zhang, Y. F., Ge, L. L., Lin, Y., and Kwok, H. F. (2018) The Roles of Protein Tyrosine Phosphatases in Hepatocellular Carcinoma. Cancers (Basel) 10 (3), E82
Ye, J., Yuen, S. M., Murphy, G., Xie, R. Y., and Kwok, H. F. (2017) Anti-Tumor Effects of a ‘Human & Mouse Cross-Reactive’ Anti-ADAM17 Antibody in a Pancreatic Cancer Model in Vivo. Eur J Pharm Sci 110, 62-69
Wong, J., Wei, R., Lyu, P., Tong, O., Zhang, S. D., Wen, Q., Yuen, H. F., El-Tanani, M., and Kwok, H. F. (2017) Clinical and in Vitro Analysis of Osteopontin as a Prognostic Indicator and Unveil Its Potential Downstream Targets in Bladder Cancer. Int J Biol Sci 13 (11), 1373
Wei, R., Wong, J. P. C., and Kwok, H. F. (2017) Osteopontin — a Promising Biomarker for Cancer Therapy. J Cancer 8 (12), 2173-2183
Wang, Q. S., Lin, W., Tang, X. Q., Li, S. H., Guo, L. B., Lin, Y., and Kwok, H. F. (2017) The Roles of Micrornas in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint. Int J Mol Sci 18 (12), 2540
Neves, H., and Kwok, H. F. (2017) In Sickness and in Health: The Many Roles of the Minichromosome Maintenance Proteins. Biochim Biophys Acta 1868 (1), 295-308
Mahadevappa, R., Ma, R., and Kwok, H. F. (2017) Venom Peptides: Improving Specificity in Cancer Therapy. Trends Cancer 3 (9), 611-614
Kawai, T., Takayanagi, T., Forrester, S., Preston, K., Obama, T., Tsuji, T., Kobayashi, T., Boyer, M., Cooper, H., Kwok, H. F., Hashimoto, T., Scalia, R., Rizzo, V., and Eguchi, S. (2017) Vascular ADAM17 (a Disintegrin and Metalloproteinase Domain 17) Is Required for Angiotensin II/Β-Aminopropionitrile–Induced Abdominal Aortic Aneurysm. Hypertension, HYPERTENSIONAHA. 117.09822
Takayanagi, T., Forrester, S., Kawai, T., Obama, T., Tsuji, T., Elliott, K., Nuti, E., Rossello, A., Kwok, H. F., Scalia, R., Rizzo, V., and Eguchi, S. (2016) Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin Iinovelty and Significance. Hypertension 68 (4), 949-955
Kwok, H. F., Zhang, S. D., McCrudden, C., Yuen, H. F., Ting, K. P., Wen, Q., Khoo, U. S., and Chan, K. Y. K. (2015) Prognostic Significance of Minichromosome Maintenance Proteins in Breast Cancer. Am J Cancer Res 5 (1), 52-71
Kwok, H. F., Botkjaer, K., Tape, C., Huang, Y. C., McCafferty, J., and Murphy, G. (2014) Development of a ‘Mouse and Human Cross-Reactive’affinity-Matured Exosite Inhibitory Human Antibody Specific to TACE (ADAM17) for Cancer Immunotherapy. Protein Eng Des Sel 27 (6), 179-190
Kwok, H. F., Buick, R. J., Kuehn, D., Gormley, J. A., Doherty, D., Jaquin, T. J., McClurg, A., Ward, C., Byrne, T., Jaworski, J., Leung, K. L., Snoddy, P., McAnally, C., Burden, R. E., Gray, B., Lowry, J., Sermadiras, I., Gruszka, N., Courtenay-Luck, N., Kissenpfennig, A., Scott, C. J., Johnston, J. A., and Olwill, S. A. (2011) Antibody Targeting of Cathepsin S Induces Antibody-Dependent Cellular Cytotoxicity. Mol Cancer 10, 147
Fry, B. G., Winter, K., Norman, J. A., Roelants, K., Nabuurs, R. J., van Osch, M. J., Teeuwisse, W. M., van der Weerd, L., McNaughtan, J. E., Kwok, H. F., Scheib, H., Greisman, L., Kochva, E., Miller, L. J., Gao, F., Karas, J., Scanlon, D., Lin, F., Kuruppu, S., Shaw, C., Wong, L., and Hodgson, W. C. (2010) Functional and Structural Diversification of the Anguimorpha Lizard Venom System. Mol Cell Proteomics 9 (11), 2369-2390
Fry, B. G., Roelants, K., Winter, K., Hodgson, W. C., Griesman, L., Kwok, H. F., Scanlon, D., Karas, J., Shaw, C., Wong, L., and Norman, J. A. (2010) Novel Venom Proteins Produced by Differential Domain-Expression Strategies in Beaded Lizards and Gila Monsters (Genus Heloderma). Mol Biol Evol 27 (2), 395-407
Fry, B. G., Wroe, S., Teeuwisse, W., van Osch, M. J., Moreno, K., Ingle, J., McHenry, C., Ferrara, T., Clausen, P., Scheib, H., Winter, K. L., Greisman, L., Roelants, K., van der Weerd, L., Clemente, C. J., Giannakis, E., Hodgson, W. C., Luz, S., Martelli, P., Krishnasamy, K., Kochva, E., Kwok, H. F., Scanlon, D., Karas, J., Citron, D. M., Goldstein, E. J., McNaughtan, J. E., and Norman, J. A. (2009) A Central Role for Venom in Predation by Varanus Komodoensis (Komodo Dragon) and the Extinct Giant Varanus (Megalania) Priscus. Proc Natl Acad Sci U S A 106 (22), 8969-8974
Kwok, H. F., Chen, T., O’Rourke, M., Ivanyi, C., Hirst, D., and Shaw, C. (2008) Helokinestatin: A New Bradykinin B2 Receptor Antagonist Decapeptide from Lizard Venom. Peptides 29 (1), 65-72

Books / Book Chapters:

Kwok, H. F. (Ed.)* (2019) Venom Toxins as Potential Targeted Therapy (pp. 1-167). Basel, Switzerland: Multidisciplinary Digital Publishing Institute (MDPI).
Fry, B. G., Roelants, K., Jackson, T. N. W., Takacs, Z., Reeks, T. and Kwok, H. F. (2015) Chapter 18 B-Type natriuretic peptides. In Bryan Fry (Ed.), Venomous Reptiles and Their Toxins (pp. 312-317). Oxford, UK: Oxford University Press.
Fry, B. G., Roelants, K., Jackson, T. N. W., Takacs, Z., Reeks, T. and Kwok, H. F. (2015) Chapter 11 Exendin peptides. In Bryan Fry (Ed.), Venomous Reptiles and Their Toxins (pp. 247-254). Oxford, UK: Oxford University Press.

Full publications list

Grants
2019-2022	The Science and Technology Development Fund (FDCT), Novel combination treatment strategy with “Anti-ADAM17 Antibody + EGFR-TKi” for tackling the drug resistance issue in EGFR-mutant lung cancer
2017-2020	The Science and Technology Development Fund (FDCT), Discover & investigate the role of novel venom-based peptide(s) in cancer progression to unlock its mechanism as a therapeutic drug development to fight against cancer
2017-2020	The Science and Technology Development Fund (FDCT) — Minister of Science and Technology of China (MOST), Investigation of the correlation between PD-L1 expression and KRAS signaling pathway and its potential clinical application
2015-2018	The Science and Technology Development Fund (FDCT), Investigate the role of MCM10 in breast cancer progression & its potential as a therapeutic target
2015-2018	University of Macau Multi-Year Research Grant, A model system for structural and functional convergence of venom peptides: unlock a new era in drug development
2015–2018	University of Macau Multi-Year Research Grant, Osteopontin (OPN) expression as a prognostic indicator in colorectal cancer & its potential as a therapeutic target
2014-2016	University of Macau Start-Up Research Grant, Investigate novel regulator(s) for ADAM17 ectodomain shedding by cellular & proteomics approaches: Evaluation in biology and medicine
2011-2016	Cancer Research UK Research Grant (with Prof Gillian Murphy), Development of human TACE (mouse & human cross-reactive) therapeutic antibody against cancer
2007-2011	Invest Northern Ireland (NI) European Development Research Fund, Discovery, development & evaluation of the therapeutic efficacy of APO-1 antibody and human Cathepsin S antibody for the treatment of cancer
2006-2009	InterTrade Ireland Innova Grant, TB diagnostic kit/assay development
2004-2007	UK Technology Strategy Board KTP Funding, Define the shortfalls in current protein production techniques, and to develop novel techniques to permit more efficient and scaled protein engineering, protein expression and protein purification

Patents
1. Kwok H. F., Rui M., Chen G. (2020) A venom-based peptide and its application. Patent CN 202010469590.8 2. Kwok H. F., Xie R. (2020) Use of anti-tumour effects of a’human & mouse cross-reactive’anti-adam17 antibody in treating pancreatic cancer. Patent US 20190375848A1 3. Kwok H. F. (2019) Method of Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II. Patent US 20190015505A1 4. Olwill S. A., Kwok H. F., Johnston J. A., Whelan C., Clarke J., Shuralev E. (2010) Diagnostic methods and kits – The identification of tuberculosis infection in animals such as badgers, cervids and wild boar. Patent WO 2010097625 5. Olwill S. A., Buick R., Kwok H. F., Scott C., Ward C. (2010) Antibody Therapy – Described are methods of inhibiting angiogenesis, the methods comprising the simultaneous, sequential or separate administration of (i) an anti- Cathepsin S antibody molecule, and (ii) an anti-VEGF antibody molecule. Also described are anti-Cathepsin S humanized antibodies, pharmaceutical compositions and methods of treatment using such antibodies. Patent WO 2010094981 6. Olwill S. A., Johnston J. A., Kwok H. F., Whelan C, Clarke J. (2009) Diagnostic method and kit – The invention relates to methods for diagnosis of tuberculosis comprising determining the presence or absence of, or an immune response to a group of antigens. Patent WO2009024822 7. Olwill S. A., Buick R. J., Kwok H. F., Johnston J. A. (2006) Assays for diagnosis of tuberculosis and uses thereof – The identification of mycobacterial antigens which are highly immunogenic and which may be used in assays and methods for the diagnosis of tuberculosis. Patent WO2006117538

Patents

1. Kwok H. F., Rui M., Chen G. (2020) A venom-based peptide and its application. Patent CN 202010469590.8
2. Kwok H. F., Xie R. (2020) Use of anti-tumour effects of a’human & mouse cross-reactive’anti-adam17 antibody in treating pancreatic cancer. Patent US 20190375848A1
3. Kwok H. F. (2019) Method of Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II. Patent US 20190015505A1
4. Olwill S. A., Kwok H. F., Johnston J. A., Whelan C., Clarke J., Shuralev E. (2010) Diagnostic methods and kits – The identification of tuberculosis infection in animals such as badgers, cervids and wild boar. Patent WO 2010097625
5. Olwill S. A., Buick R., Kwok H. F., Scott C., Ward C. (2010) Antibody Therapy – Described are methods of inhibiting angiogenesis, the methods comprising the simultaneous, sequential or separate administration of (i) an anti- Cathepsin S antibody molecule, and (ii) an anti-VEGF antibody molecule. Also described are anti-Cathepsin S humanized antibodies, pharmaceutical compositions and methods of treatment using such antibodies. Patent WO 2010094981
6. Olwill S. A., Johnston J. A., Kwok H. F., Whelan C, Clarke J. (2009) Diagnostic method and kit – The invention relates to methods for diagnosis of tuberculosis comprising determining the presence or absence of, or an immune response to a group of antigens. Patent WO2009024822
7. Olwill S. A., Buick R. J., Kwok H. F., Johnston J. A. (2006) Assays for diagnosis of tuberculosis and uses thereof – The identification of mycobacterial antigens which are highly immunogenic and which may be used in assays and methods for the diagnosis of tuberculosis. Patent WO2006117538

Awards
2019-2020	Incentive Award Scheme for Outstanding Academic Staff
2017-2018	Incentive Award Scheme for Outstanding Academic Staff
2017-2018	Faculty of Health Sciences Best Teacher (Excellence in Service) Award
2014	Winner of Protein Discovery Summit Poster Presentation: GTC’s 2nd Antibody & Protein Therapeutics Conference
2011-2014	CRUK Research Fellowship
2008	Winner of Knowledge Transfer Partnership (KTP) Regional Award
2004-2007	Knowledge Transfer Partnerships (KTP) Fellowship
2000-2003	Vice-Chancellor Research Scholarship
1999	University of Ulster Overseas student Bursary Award

Professional Activities
Invited Editorial Service: Associate Editor — Frontiers in Molecular Biosciences Associate Editor — BMC Medical Genomics Guest Editor — Toxins (Special Issue: Venom and Toxins as Targeted Therapy) Guest Editor — Biomolecules (Special Issue: Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases) Guest Editor — Biology (Special Issue: Proteases — From Basic Structure to Function to Drug Design as Targeted Therapy) Guest Editor — Frontiers in Molecular Biosciences (Special Issue: Enzyme Inhibitors from Venoms and Plant Natural Biomolecules as Therapeutics) Guest Editor — Frontiers in Molecular Biosciences (Special Issue: ADAM, ADAMTS and Astacin Proteases: Challenges and Breakthroughs in the -Omics Era) Section Editor — Recent Patents on Anti-Cancer Drug Discovery (Special Issue: New Frontiers in Cancer) Editorial Board Member of Toxins Editorial Board Member of Biomolecules Editorial Board Member of Scientific Reports Editorial Board Member of Recent Patents on Anti-Cancer Drug Discovery Editorial Board Member of Current Protein & Peptide Science Editorial Board Member of Biology (Cancer Biology Section) Ad Hoc Invited Reviewer of Journal / Book / Grant: Applied Biochemistry and Biotechnology Analytical Cellular Pathology Aging Biology Biochemical Society Transactions BMC Cancer BMC Urology BMC Molecular Biology BMC Medical Genomics Breast Cancer Targets and Therapy Biochemical Pharmacology Biomedicine & Pharmacotherapy Biofactors Biomarkers in Medicine Bioscience Reports Cells Cell Death and Disease Cancers Cancer Biomarkers Cancer Biology & Medicine Cancer Management & Research Cancer Medicine Cancer Informatics Cellular and Molecular Life Sciences Cell Biology International Cellular Physiology and Biochemistry Computational & Structural Biotechnology Journal Communications Biology Current Pharmaceutical Biotechnology Current Drug Targets Current Protein & Peptide Science Current Enzyme Inhibition Cancer Biology & Treatment Drug Design, Development and Therapy Experimental and Therapeutic Medicine Frontiers in Cardiovascular Medicine Frontiers Cell and Developmental Biology Future Oncology Immunology Letters IUBMB Life International Journal of Biological Sciences International Journal of Biochemistry Research & Review International Journal of Nanomedicine International Journal of Oncology International Immunopharmacology Journal of Cancer Metastasis and Treatment Journal of Cell Science & Therapy Journal of Cellular and Molecular Medicine Journal of Experimental & Clinical Cancer Research Journal of Cancer Journal of Molecular Evolution Journal of Ovarian Research Journal of Pain Research Journal of Thoracic Disease Journal of Venom Research Langenbeck’s Archives of Surgery mAbs Microorganisms Microbial Pathogenesis Medical Science Monitor Molecular Biotechnology Molecular Biology Reports Molecular Medicine Reports Molecular Therapy – Oncolytics Molecular Pain Molecules Mutation Research Oncogene OncoTargets & Therapy Oncology Reports Oncology Letters Oral Diseases PeerJ PLoS One PNAS Peptides Pharmacology & Therapeutics Regulatory Peptide Research in Veterinary Science Seminars in Cancer Biology Scientific Reports Theranostics Toxicology in Vitro Toxins Toxins Reviews Toxicon Theranostics Book — Bioactive Natural Products – Elsevier, Amsterdam Book — Peptides in Molecular Pharmaceutics: Targeted Therapy and Drug Delivery – Nature Springer Book — Cancer Genomics and Human Health – Nature Springer Grant — Breast Cancer Now 2017, UK Grant — Tyrolean Science Fund 2014/2015, Austria Grant — The Wellcome Trust/DBT India Alliance Fellowship 2019, UK/India Grant — Cancer Research UK (CRUK) Biotherapeutics Drug Discovery Programme, UK Ad Hoc Invited External Examiner: School of Pharmacy, Queen’s University Belfast, UK — PhD programme and MPhil programme Li Ka Shing Faculty of Medicine, University of Hong Kong — MMedSc programme Faculty of Medicine, Nursing & Health Sciences, Monash University, Australia — PhD programme School of Biomedical Sciences, Chinese University of Hong Kong – PhD programme

Professional Activities

Invited Editorial Service:

Associate Editor — Frontiers in Molecular Biosciences
Associate Editor — BMC Medical Genomics
Guest Editor — Toxins (Special Issue: Venom and Toxins as Targeted Therapy)
Guest Editor — Biomolecules (Special Issue: Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases)
Guest Editor — Biology (Special Issue: Proteases — From Basic Structure to Function to Drug Design as Targeted Therapy)
Guest Editor — Frontiers in Molecular Biosciences (Special Issue: Enzyme Inhibitors from Venoms and Plant Natural Biomolecules as Therapeutics)
Guest Editor — Frontiers in Molecular Biosciences (Special Issue: ADAM, ADAMTS and Astacin Proteases: Challenges and Breakthroughs in the -Omics Era)
Section Editor — Recent Patents on Anti-Cancer Drug Discovery (Special Issue: New Frontiers in Cancer)
Editorial Board Member of Toxins
Editorial Board Member of Biomolecules
Editorial Board Member of Scientific Reports
Editorial Board Member of Recent Patents on Anti-Cancer Drug Discovery
Editorial Board Member of Current Protein & Peptide Science
Editorial Board Member of Biology (Cancer Biology Section)

Ad Hoc Invited Reviewer of Journal / Book / Grant:

Applied Biochemistry and Biotechnology
Analytical Cellular Pathology
Aging
Biology
Biochemical Society Transactions
BMC Cancer
BMC Urology
BMC Molecular Biology
BMC Medical Genomics
Breast Cancer Targets and Therapy
Biochemical Pharmacology
Biomedicine & Pharmacotherapy
Biofactors
Biomarkers in Medicine
Bioscience Reports
Cells
Cell Death and Disease
Cancers
Cancer Biomarkers
Cancer Biology & Medicine
Cancer Management & Research
Cancer Medicine
Cancer Informatics
Cellular and Molecular Life Sciences
Cell Biology International
Cellular Physiology and Biochemistry
Computational & Structural Biotechnology Journal
Communications Biology
Current Pharmaceutical Biotechnology
Current Drug Targets
Current Protein & Peptide Science
Current Enzyme Inhibition
Cancer Biology & Treatment
Drug Design, Development and Therapy
Experimental and Therapeutic Medicine
Frontiers in Cardiovascular Medicine
Frontiers Cell and Developmental Biology
Future Oncology
Immunology Letters
IUBMB Life
International Journal of Biological Sciences
International Journal of Biochemistry Research & Review
International Journal of Nanomedicine
International Journal of Oncology
International Immunopharmacology
Journal of Cancer Metastasis and Treatment
Journal of Cell Science & Therapy
Journal of Cellular and Molecular Medicine
Journal of Experimental & Clinical Cancer Research
Journal of Cancer
Journal of Molecular Evolution
Journal of Ovarian Research
Journal of Pain Research
Journal of Thoracic Disease
Journal of Venom Research
Langenbeck’s Archives of Surgery
mAbs
Microorganisms
Microbial Pathogenesis
Medical Science Monitor
Molecular Biotechnology
Molecular Biology Reports
Molecular Medicine Reports
Molecular Therapy – Oncolytics
Molecular Pain
Molecules
Mutation Research
Oncogene
OncoTargets & Therapy
Oncology Reports
Oncology Letters
Oral Diseases
PeerJ
PLoS One
PNAS
Peptides
Pharmacology & Therapeutics
Regulatory Peptide
Research in Veterinary Science
Seminars in Cancer Biology
Scientific Reports
Theranostics
Toxicology in Vitro
Toxins
Toxins Reviews
Toxicon
Theranostics
Book — Bioactive Natural Products – Elsevier, Amsterdam
Book — Peptides in Molecular Pharmaceutics: Targeted Therapy and Drug Delivery – Nature Springer
Book — Cancer Genomics and Human Health – Nature Springer
Grant — Breast Cancer Now 2017, UK
Grant — Tyrolean Science Fund 2014/2015, Austria
Grant — The Wellcome Trust/DBT India Alliance Fellowship 2019, UK/India
Grant — Cancer Research UK (CRUK) Biotherapeutics Drug Discovery Programme, UK

Ad Hoc Invited External Examiner:

School of Pharmacy, Queen’s University Belfast, UK — PhD programme and MPhil programme
Li Ka Shing Faculty of Medicine, University of Hong Kong — MMedSc programme
Faculty of Medicine, Nursing & Health Sciences, Monash University, Australia — PhD programme
School of Biomedical Sciences, Chinese University of Hong Kong – PhD programme

Others
Conference Presentations Kwok H. F. (2018) 3^rd International Conference on Cancer Research & Targeted Therapy, London, UK. “Anti-TACE antibody drug development for the treatment of cancer”. Li B., Lyu P., Ma R., Mahadevappa R., Xi X. and Kwok H. F. (2017) 6^th IAPC Meeting — World Conference on Physico Chemical Methods and World Conference on ADMET and DMPK, Zagreb, Croatia. “Venom-based Peptide Drug Discovery: Enhancing Specificity in Cancer Treatment”. (Invited Keynote Speaker) Yuen S.M., Ye J., Murphy G., Xie R. and Kwok H. F. (2016) 5^th IAPC Meeting — Emerging Technologies in Drug Discovery and Development, Zhuhai, China. “Anti-Tumour Effects of a Human & Mouse Cross-Reactive’ Anti-TACE Antibody in a Pancreatic Cancer Model In Vivo”. (Invited Keynote Speaker) Lin Y., Meng C., Lin W., Cheng G. and Kwok H. F. (2016) 3^rd Macao Symposium on Biomedical Sciences, Macau SAR. “Regulation of PD-L1 by KRAS and p53”. Li B., Xi X, Chen T., Shaw C. and Kwok H. F. (2015) 18^th World Congress of the International Society on Toxinology, Oxford, UK. “High-throughput approach for isolation and identification of novel peptides with anticancer activities from scorpion venoms”. Kwok H. F. (2014) 3^rd Antibody & Protein Therapeutics Conference, Boston, USA. “Discovery and Development of Therapeutic TACE (ADAM17) Antibodies”.

Others

Conference Presentations

Kwok H. F. (2018) 3^rd International Conference on Cancer Research & Targeted Therapy, London, UK. “Anti-TACE antibody drug development for the treatment of cancer”.
Li B., Lyu P., Ma R., Mahadevappa R., Xi X. and Kwok H. F. (2017) 6^th IAPC Meeting — World Conference on Physico Chemical Methods and World Conference on ADMET and DMPK, Zagreb, Croatia. “Venom-based Peptide Drug Discovery: Enhancing Specificity in Cancer Treatment”. (Invited Keynote Speaker)
Yuen S.M., Ye J., Murphy G., Xie R. and Kwok H. F. (2016) 5^th IAPC Meeting — Emerging Technologies in Drug Discovery and Development, Zhuhai, China. “Anti-Tumour Effects of a Human & Mouse Cross-Reactive’ Anti-TACE Antibody in a Pancreatic Cancer Model In Vivo”. (Invited Keynote Speaker)
Lin Y., Meng C., Lin W., Cheng G. and Kwok H. F. (2016) 3^rd Macao Symposium on Biomedical Sciences, Macau SAR. “Regulation of PD-L1 by KRAS and p53”.
Li B., Xi X, Chen T., Shaw C. and Kwok H. F. (2015) 18^th World Congress of the International Society on Toxinology, Oxford, UK. “High-throughput approach for isolation and identification of novel peptides with anticancer activities from scorpion venoms”.
Kwok H. F. (2014) 3^rd Antibody & Protein Therapeutics Conference, Boston, USA. “Discovery and Development of Therapeutic TACE (ADAM17) Antibodies”.