Contact Information
Research Team
NamePositionOfficePhoneEmail
Xiaowei ZHOUUM Macao Post-doctoral FellowN22-3001+853 8822 4219xiaoweizhou@um.edu.mo
Ran WEIPost-doctoral FellowN22-3001+853 8822 4219ranwei@um.edu.mo
Pengchen CHENPhD StudentN22-3001+853 8822 4219
Libin GUOPhD StudentN22-3001+853 8822 4219
Qiushuang WUPhD StudentN22-3001+853 8822 4219
Junnan LIPhD StudentN22-3001+853 8822 4219
Muhammad Jameel MUGHALPhD StudentN22-3001+853 8822 4219
Education
Knowledge Transfer Partnership (KTP)  Postdoctoral FellowQueen’s University Belfast, UK (2004-2007)
PhD in Biomedical SciencesUniversity of Ulster, UK (2003)
BSc (1st Class Hons) in BiotechnologyUniversity of Ulster, UK (2000)
NVQ Level 4 (Higher National Diploma) in ManagementChartered Management Institute, UK (2007)
Positions
2018-PresentAssociate Professor, Faculty of Health Sciences, University of Macau
2013-presentVisiting Scientist, Cancer Research UK Cambridge Institute, University of Cambridge, UK
2014-2018Assistant Professor, Faculty of Health Sciences, University of Macau
2007-2017Visiting Research Fellow, School of Pharmacy, Queen’s University Belfast, UK
2011-2014Senior Research Associate / Fellow, Department of Oncology / Cancer Research UK Cambridge Institute, University of Cambridge, UK
2007-2011Senior Scientist, Fusion Antibodies Ltd., UK
Research Interests
Prof. Kwok’s research interests mainly focus on the development of novel monoclonal antibodies and natural biomolecules (including venom-based peptides, plant-derived molecules etc.) as prototype drugs for anticancer and anti-inflammatory therapies. In addition, Prof. Kwok’s research group also expands their research and scientific knowledge in the areas of existing and novel cancer biomarkers such as 1) matricellular protein — OPN, 2) metalloproteinase — ADAM17, ADAMTS5 and ADAMTS8, 3) DNA replication licensing factor — MCM proteins, 4) small GTP binding protein — RAN and RCC1, as well as immunotherapy markers (e.g. PD-1/PD-L1) in order to identify and validate their prognostic and therapeutic values according to the roles in hallmarks of cancer and chronic diseases. For more details, please kindly further visit the Faculty of Health Sciences (FHS) Newsletter link — Principle Investigator (PI) Introduction Series and/or Prof. Kwok’s research group website as below:
https://mp.weixin.qq.com/s/jNol5GBHnYXzl6h2s6LL7Q
http://www.henrykwoklab.com
Representative Publications
Journal Articles:

 

  • Guo, L., Wei, R., Lin, Y., Kwok, H. F. (2020) Clinical and Recent Patents Applications of PD-1/PD-L1 Targeting Immunotherapy in Cancer Treatment — Current Progress, Strategy and Future Perspective. Frontiers in Immunology (In Press)
  • Li, J. N., and Kwok, H. F. (2020) Current Strategies for Treating NSCLC: From Biological Mechanisms to Clinical Treatment. Cancers (Basel) 12 (6), E1587
  • Ma, R., Ren, Z. L., Li, B., Siu, S. W. I., Chen, G. K., and Kwok, H. F. (2020) Novel Venom-Based Peptides (P13 and its Derivative-M6) to Maintain Self-Renewal of Human Embryonic Stem Cells by Activating FGF and TGFbeta Signaling Pathways. Stem Cell Res Ther 11 (1), 243
  • Yeung, L., Anderson, J. M. L., Wee, J. L., Demaria, M. C., Finsterbusch, M., Liu, Y. S., Hall, P., Smith, B. C., Dankers, W., Elgass, K. D., Wicks, I. P., Kwok, H. F., Wright, M. D., and Hickey, M. J. (2020) Leukocyte Tetraspanin CD53 Restrains Alpha3 Integrin Mobilization and Facilitates Cytoskeletal Remodeling and Transmigration in Mice. J Immunol 205
  • Ma, R., Wong, S. W., Ge, L., Shaw, C., Siu, S. W. I., and Kwok, H. F. (2020) In Vitro and MD Simulation Study to Explore Physicochemical Parameters for Antibacterial Peptide to Become Potent Anticancer Peptide. Mol Ther Oncolytics 16, 7-19
  • Yang, Z., Chan, K. I., Kwok, H. F., and Tam, K. Y. (2019) Novel Therapeutic Anti-ADAM17 Antibody A9(B8) Enhances EGFR-Tki-Mediated Anticancer Activity in NSCLC. Transl Oncol 12 (11), 1516-1524
  • Li, B., Lyu, P., Xie, S. P., Qin, H. X., Pu, W. Y., Xu, H. X., Chen, T., Shaw, C., Ge, L. L., and Kwok, H. F. (2019) Lfb: A Novel Antimicrobial Brevinin-Like Peptide from the Skin Secretion of the Fujian Large Headed Frog, Limnonectes Fujianensi. Biomolecules 9 (6), E242
  • Ge, L. L., Li, B., Xu, H. X., Pu, W. Y., and Kwok, H. F. (2019) Backfilling Rolling Cycle Amplification with Enzyme-DNA Conjugates on Antibody for Portable Electrochemical Immunoassay with Glucometer Readout. Biosensors and Bioelectronics 132, 210-216
  • Chen, P. C., Wang, Q. S., Xie, J. W., and Kwok, H. F. (2019) Signaling Networks and the Feasibility of Computational Analysis in Gastroenteropancreatic Neuroendocrine Tumors. Semin Cancer Biol 58, 80-89
  • Wei, R., Wong, J. P. C., Lyu, P., Xi, X. P., Tong, O., Zhang, S. D., Yuen, H. F., Shirasawa, S., and Kwok, H. F. (2018) In Vitro and Clinical Data Analysis of Osteopontin as a Prognostic Indicator in Colorectal Cancer. J Cell Mol Med 22 (9), 4097-4105
  • Rajendran, B. K., Xavier Suresh, M., Bhaskaran, S. P., Harshitha, Y., Gaur, U., and Kwok, H. F. (2018) Pharmacoinformatic Approach to Explore the Antidote Potential of Phytochemicals on Bungarotoxin from Indian Krait, Bungarus Caeruleus. Computational and Structural Biotechnology Journal 16, 450-461
  • Mughal, M. J., Mahadevappa, R., and Kwok, H. F. (2018) DNA Replication Licensing Proteins: Saints and Sinners in Cancer. Semin Cancer Biol 58, 11-21
  • Mahadevappa, R., Neves, H., Yuen, S. M., Jameel, M., Bai, Y. C., Yuen, H. F., Zhang, S. D., Zhu, Y. Z., Lin, Y., and Kwok, H. F. (2018) DNA Replication Licensing Protein MCM10 Promotes Tumor Progression and Is a Novel Prognostic Biomarker and Potential Therapeutic Target in Breast Cancer. Cancers (Basel) 10 (9), E282
  • Li, B., Lyu, P., Xi, X. P., Ge, L. L., Mahadevappa, R., Shaw, C., and Kwok, H. F. (2018) Triggering of Cancer Cell Cycle Arrest by a Novel Scorpion Venom-Derived Peptide-Gonearrestide. J Cell Mol Med 22 (9), 4460-4473
  • Huang, Y. D., Zhang, Y. F., Ge, L. L., Lin, Y., and Kwok, H. F. (2018) The Roles of Protein Tyrosine Phosphatases in Hepatocellular Carcinoma. Cancers (Basel) 10 (3), E82
  • Ye, J., Yuen, S. M., Murphy, G., Xie, R. Y., and Kwok, H. F. (2017) Anti-Tumor Effects of a ‘Human & Mouse Cross-Reactive’ Anti-ADAM17 Antibody in a Pancreatic Cancer Model in Vivo. Eur J Pharm Sci 110, 62-69
  • Wong, J., Wei, R., Lyu, P., Tong, O., Zhang, S. D., Wen, Q., Yuen, H. F., El-Tanani, M., and Kwok, H. F. (2017) Clinical and in Vitro Analysis of Osteopontin as a Prognostic Indicator and Unveil Its Potential Downstream Targets in Bladder Cancer. Int J Biol Sci 13 (11), 1373
  • Wei, R., Wong, J. P. C., and Kwok, H. F. (2017) Osteopontin — a Promising Biomarker for Cancer Therapy. J Cancer 8 (12), 2173-2183
  • Wang, Q. S., Lin, W., Tang, X. Q., Li, S. H., Guo, L. B., Lin, Y., and Kwok, H. F. (2017) The Roles of Micrornas in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint. Int J Mol Sci 18 (12), 2540
  • Neves, H., and Kwok, H. F. (2017) In Sickness and in Health: The Many Roles of the Minichromosome Maintenance Proteins. Biochim Biophys Acta 1868 (1), 295-308
  • Mahadevappa, R., Ma, R., and Kwok, H. F. (2017) Venom Peptides: Improving Specificity in Cancer Therapy. Trends Cancer 3 (9), 611-614
  • Kawai, T., Takayanagi, T., Forrester, S., Preston, K., Obama, T., Tsuji, T., Kobayashi, T., Boyer, M., Cooper, H., Kwok, H. F., Hashimoto, T., Scalia, R., Rizzo, V., and Eguchi, S. (2017) Vascular ADAM17 (a Disintegrin and Metalloproteinase Domain 17) Is Required for Angiotensin II/Β-Aminopropionitrile–Induced Abdominal Aortic Aneurysm. Hypertension, HYPERTENSIONAHA. 117.09822
  • Takayanagi, T., Forrester, S., Kawai, T., Obama, T., Tsuji, T., Elliott, K., Nuti, E., Rossello, A., Kwok, H. F., Scalia, R., Rizzo, V., and Eguchi, S. (2016) Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin Iinovelty and Significance. Hypertension 68 (4), 949-955
  • Kwok, H. F., Zhang, S. D., McCrudden, C., Yuen, H. F., Ting, K. P., Wen, Q., Khoo, U. S., and Chan, K. Y. K. (2015) Prognostic Significance of Minichromosome Maintenance Proteins in Breast Cancer. Am J Cancer Res 5 (1), 52-71
  • Kwok, H. F., Botkjaer, K., Tape, C., Huang, Y. C., McCafferty, J., and Murphy, G. (2014) Development of a ‘Mouse and Human Cross-Reactive’affinity-Matured Exosite Inhibitory Human Antibody Specific to TACE (ADAM17) for Cancer Immunotherapy. Protein Eng Des Sel 27 (6), 179-190
  • Kwok, H. F., Buick, R. J., Kuehn, D., Gormley, J. A., Doherty, D., Jaquin, T. J., McClurg, A., Ward, C., Byrne, T., Jaworski, J., Leung, K. L., Snoddy, P., McAnally, C., Burden, R. E., Gray, B., Lowry, J., Sermadiras, I., Gruszka, N., Courtenay-Luck, N., Kissenpfennig, A., Scott, C. J., Johnston, J. A., and Olwill, S. A. (2011) Antibody Targeting of Cathepsin S Induces Antibody-Dependent Cellular Cytotoxicity. Mol Cancer 10, 147
  • Fry, B. G., Winter, K., Norman, J. A., Roelants, K., Nabuurs, R. J., van Osch, M. J., Teeuwisse, W. M., van der Weerd, L., McNaughtan, J. E., Kwok, H. F., Scheib, H., Greisman, L., Kochva, E., Miller, L. J., Gao, F., Karas, J., Scanlon, D., Lin, F., Kuruppu, S., Shaw, C., Wong, L., and Hodgson, W. C. (2010) Functional and Structural Diversification of the Anguimorpha Lizard Venom System. Mol Cell Proteomics 9 (11), 2369-2390
  • Fry, B. G., Roelants, K., Winter, K., Hodgson, W. C., Griesman, L., Kwok, H. F., Scanlon, D., Karas, J., Shaw, C., Wong, L., and Norman, J. A. (2010) Novel Venom Proteins Produced by Differential Domain-Expression Strategies in Beaded Lizards and Gila Monsters (Genus Heloderma). Mol Biol Evol 27 (2), 395-407
  • Fry, B. G., Wroe, S., Teeuwisse, W., van Osch, M. J., Moreno, K., Ingle, J., McHenry, C., Ferrara, T., Clausen, P., Scheib, H., Winter, K. L., Greisman, L., Roelants, K., van der Weerd, L., Clemente, C. J., Giannakis, E., Hodgson, W. C., Luz, S., Martelli, P., Krishnasamy, K., Kochva, E., Kwok, H. F., Scanlon, D., Karas, J., Citron, D. M., Goldstein, E. J., McNaughtan, J. E., and Norman, J. A. (2009) A Central Role for Venom in Predation by Varanus Komodoensis (Komodo Dragon) and the Extinct Giant Varanus (Megalania) Priscus. Proc Natl Acad Sci U S A 106 (22), 8969-8974
  • Kwok, H. F., Chen, T., O’Rourke, M., Ivanyi, C., Hirst, D., and Shaw, C. (2008) Helokinestatin: A New Bradykinin B2 Receptor Antagonist Decapeptide from Lizard Venom. Peptides 29 (1), 65-72

Books / Book Chapters:

  • Kwok, H. F. (Ed.)* (2019) Venom Toxins as Potential Targeted Therapy (pp. 1-167). Basel, Switzerland: Multidisciplinary Digital Publishing Institute (MDPI).
  • Fry, B. G., Roelants, K., Jackson, T. N. W., Takacs, Z., Reeks, T. and Kwok, H. F. (2015) Chapter 18 B-Type natriuretic peptides. In Bryan Fry (Ed.), Venomous Reptiles and Their Toxins (pp. 312-317). Oxford, UK: Oxford University Press.
  • Fry, B. G., Roelants, K., Jackson, T. N. W., Takacs, Z., Reeks, T. and Kwok, H. F. (2015) Chapter 11 Exendin peptides. In Bryan Fry (Ed.), Venomous Reptiles and Their Toxins (pp. 247-254). Oxford, UK: Oxford University Press.

Full publications list

 
Grants 
2019-2022The Science and Technology Development Fund (FDCT), Novel combination treatment strategy with “Anti-ADAM17 Antibody + EGFR-TKi” for tackling the drug resistance issue in EGFR-mutant lung cancer
2017-2020The Science and Technology Development Fund (FDCT), Discover & investigate the role of novel venom-based peptide(s) in cancer progression to unlock its mechanism as a therapeutic drug development to fight against cancer
2017-2020The Science and Technology Development Fund (FDCT) — Minister of Science and Technology of China (MOST), Investigation of the correlation between PD-L1 expression and KRAS signaling pathway and its potential clinical application
2015-2018The Science and Technology Development Fund (FDCT), Investigate the role of MCM10 in breast cancer progression & its potential as a therapeutic target
2015-2018University of Macau Multi-Year Research Grant, A model system for structural and functional convergence of venom peptides: unlock a new era in drug development
2015–2018University of Macau Multi-Year Research Grant, Osteopontin (OPN) expression as a prognostic indicator in colorectal cancer & its potential as a therapeutic target
2014-2016University of Macau Start-Up Research Grant, Investigate novel regulator(s) for ADAM17 ectodomain shedding by cellular & proteomics approaches: Evaluation in biology and medicine
2011-2016Cancer Research UK Research Grant (with Prof Gillian Murphy), Development of human TACE (mouse & human cross-reactive) therapeutic antibody against cancer
2007-2011Invest Northern Ireland (NI) European Development Research Fund, Discovery, development & evaluation of the therapeutic efficacy of APO-1 antibody and human Cathepsin S antibody for the treatment of cancer
2006-2009InterTrade Ireland Innova Grant, TB diagnostic kit/assay development
2004-2007UK Technology Strategy Board KTP Funding, Define the shortfalls in current protein production techniques, and to develop novel techniques to permit more efficient and scaled protein engineering, protein expression and protein purification
Patents

1. Kwok H. F., Rui M., Chen G. (2020) A venom-based peptide and its application. Patent CN 202010469590.8
2. Kwok H. F., Xie R. (2020) Use of anti-tumour effects of a’human & mouse cross-reactive’anti-adam17 antibody in treating pancreatic cancer. Patent US 20190375848A1
3. Kwok H. F. (2019) Method of Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II. Patent US 20190015505A1
4. Olwill S. A., Kwok H. F., Johnston J. A., Whelan C., Clarke J., Shuralev E. (2010) Diagnostic methods and kits – The identification of tuberculosis infection in animals such as badgers, cervids and wild boar. Patent WO 2010097625
5. Olwill S. A., Buick R., Kwok H. F., Scott C., Ward C. (2010) Antibody Therapy – Described are methods of inhibiting angiogenesis, the methods comprising the simultaneous, sequential or separate administration of (i) an anti- Cathepsin S antibody molecule, and (ii) an anti-VEGF antibody molecule. Also described are anti-Cathepsin S humanized antibodies, pharmaceutical compositions and methods of treatment using such antibodies. Patent WO 2010094981
6. Olwill S. A., Johnston J. A., Kwok H. F., Whelan C, Clarke J. (2009) Diagnostic method and kit – The invention relates to methods for diagnosis of tuberculosis comprising determining the presence or absence of, or an immune response to a group of antigens. Patent WO2009024822
7. Olwill S. A., Buick R. J., Kwok H. F., Johnston J. A. (2006) Assays for diagnosis of tuberculosis and uses thereof – The identification of mycobacterial antigens which are highly immunogenic and which may be used in assays and methods for the diagnosis of tuberculosis. Patent WO2006117538

Awards
2019-2020Incentive Award Scheme for Outstanding Academic Staff
2017-2018Incentive Award Scheme for Outstanding Academic Staff
2017-2018Faculty of Health Sciences Best Teacher (Excellence in Service) Award
2014Winner of Protein Discovery Summit Poster Presentation:
GTC’s 2nd Antibody & Protein Therapeutics Conference
2011-2014CRUK Research Fellowship
2008Winner of Knowledge Transfer Partnership (KTP) Regional Award
2004-2007Knowledge Transfer Partnerships (KTP) Fellowship
2000-2003Vice-Chancellor Research Scholarship
1999University of Ulster Overseas student Bursary Award
Professional Activities
Invited Editorial Service:

 

  • Associate Editor in Protein Chemistry and Enzymology of Frontiers in Molecular Biosciences
  • Guest Editor — Toxins (Special Issue: Venom and Toxins as Targeted Therapy)
  • Guest Editor — Biomolecules (Special Issue: Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases)
  • Guest Editor — Biology (Special Issue: Proteases — From Basic Structure to Function to Drug Design as Targeted Therapy)
  • Guest Editor — Frontiers in Molecular Biosciences (Special Issue: Enzyme Inhibitors from Venoms and Plant Natural Biomolecules as Therapeutics)
  • Section Editor — Recent Patents on Anti-Cancer Drug Discovery (Special Issue: New Frontiers in Cancer)
  • Editorial Board Member of Toxins
  • Editorial Board Member of Biomolecules
  • Editorial Board Member of Scientific Reports
  • Editorial Board Member of Recent Patents on Anti-Cancer Drug Discovery
  • Editorial Board Member of Current Protein & Peptide Science
  • Topic Board Member of Biology

Ad Hoc Invited Reviewer of Journals / Book / Grants:

  • Applied Biochemistry and Biotechnology
  • Analytical Cellular Pathology
  • Biology
  • BMC Cancer
  • BMC Urology
  • BMC Molecular Biology
  • Breast Cancer Targets and Therapy
  • Biochemical Pharmacology
  • Biomedicine & Pharmacotherapy
  • Biofactors
  • Biomarkers in Medicine
  • Cells
  • Cell Death and Disease
  • Cancers
  • Cancer Biomarkers
  • Cancer Biology & Medicine
  • Cancer Management & Research
  • Cancer Medicine
  • Cancer Informatics
  • Cellular and Molecular Life Sciences
  • Cell Biology International
  • Cellular Physiology and Biochemistry
  • Computational & Structural Biotechnology Journal
  • Communications Biology
  • Current Pharmaceutical Biotechnology
  • Current Drug Targets
  • Current Protein & Peptide Science
  • Current Enzyme Inhibition
  • Cancer Biology & Treatment
  • Drug Design, Development and Therapy
  • Experimental and Therapeutic Medicine
  • Future Oncology
  • Immunology Letters
  • IUBMB Life
  • International Journal of Biological Sciences
  • International Journal of Biochemistry Research & Review
  • International Journal of Nanomedicine
  • International Journal of Oncology
  • International Immunopharmacology
  • Journal of Cancer Metastasis and Treatment
  • Journal of Cell Science & Therapy
  • Journal of Cellular and Molecular Medicine
  • Journal of Experimental & Clinical Cancer Research
  • Journal of Cancer
  • Journal of Molecular Evolution
  • Journal of Ovarian Research
  • Journal of Pain Research
  • Journal of Thoracic Disease
  • Journal of Venom Research
  • Langenbeck’s Archives of Surgery
  • mAbs
  • Microbial Pathogenesis
  • Medical Science Monitor
  • Molecular Biotechnology
  • Molecular Biology Reports
  • Molecular Medicine Reports
  • Molecular Therapy – Oncolytics
  • Molecular Pain
  • Molecules
  • Mutation Research
  • Oncogene
  • OncoTargets & Therapy
  • Oncology Reports
  • Oncology Letters
  • PeerJ
  • PLoS One
  • PNAS
  • Peptides
  • Pharmacology & Therapeutics
  • Regulatory Peptide
  • Research in Veterinary Science
  • Seminars in Cancer Biology
  • Scientific Reports
  • Toxicology in Vitro
  • Toxins
  • Toxicon
  • Theranostics
  • Book — Bioactive Natural Products – Elsevier, Amsterdam
  • Book — Peptides in Molecular Pharmaceutics: Targeted Therapy and Drug Delivery – Nature Springer
  • Grant — Breast Cancer Now 2017, UK
  • Grant — Tyrolean Science Fund 2014/2015, Austria
  • Grant — The Wellcome Trust/DBT India Alliance Fellowship 2019, UK/India
  • Grant — Cancer Research UK (CRUK) Biotherapeutics Drug Discovery Programme, UK

Ad Hoc Invited External Examiner:

  • School of Pharmacy, Queen’s University Belfast, UK — PhD programme and MPhil programme
  • Li Ka Shing Faculty of Medicine, University of Hong Kong — MMedSc programme
  • Faculty of Medicine, Nursing & Health Sciences, Monash University, Australia — PhD programme
  • School of Biomedical Sciences, Chinese University of Hong Kong – PhD programme
Others
Conference Presentations

 

 

  • Kwok H. F. (2018) 3rd International Conference on Cancer Research & Targeted Therapy, London, UK. “Anti-TACE antibody drug development for the treatment of cancer”.
  • Li B., Lyu P., Ma R., Mahadevappa R., Xi X. and Kwok H. F. (2017) 6th IAPC Meeting — World Conference on Physico Chemical Methods and World Conference on ADMET and DMPK, Zagreb, Croatia. “Venom-based Peptide Drug Discovery: Enhancing Specificity in Cancer Treatment”. (Invited Keynote Speaker)
  • Yuen S.M., Ye J., Murphy G., Xie R. and Kwok H. F. (2016) 5th IAPC Meeting — Emerging Technologies in Drug Discovery and Development, Zhuhai, China. “Anti-Tumour Effects of a Human & Mouse Cross-Reactive’ Anti-TACE Antibody in a Pancreatic Cancer Model In Vivo”. (Invited Keynote Speaker)
  • Lin Y., Meng C., Lin W., Cheng G. and Kwok H. F. (2016) 3rd Macao Symposium on Biomedical Sciences, Macau SAR. “Regulation of PD-L1 by KRAS and p53”.
  • Li B., Xi X, Chen T., Shaw C. and Kwok H. F. (2015) 18th World Congress of the International Society on Toxinology, Oxford, UK. “High-throughput approach for isolation and identification of novel peptides with anticancer activities from scorpion venoms”.
  • Kwok H. F. (2014) 3rd Antibody & Protein Therapeutics Conference, Boston, USA. “Discovery and Development of Therapeutic TACE (ADAM17) Antibodies”.