劉蔚蔚博士

Education
PharmD	School of Pharmacy, University of Wisconsin (2011)
PhD	Biochemistry and Molecular Biology, Baylor College of Medicine (2005)
BSc	Biochemistry and Molecular Biology, Peking University (1999)

Position
2017 – Present	Operation Manager, Bioimaging and Stem Cell Core Facility, Faculty of Health Sciences, University of Macau
2014 – Present	Senior Instructor, Faculty of Health Sciences, University of Macau
2011 – 2014	Clinical pharmacist, Doctors Community Hospital, Lanham, MD, USA
2005 – 2006	Research associate, Department of Biochemistry and Molecular Biology, Baylor College of Medicine

Research Interests
The stem cell niche and impact of individual cultural factors on stem cell survival and differentiation; Interplay between metabolism and cell signaling in cell fate determination; Optimization of cell culture environment for research and production.

Representative Publications
Ren, Z. L., Zhong, H., Song, C. C., Deng, C. H., Hsieh, H. T., Liu, W., and Chen, G. (2020) Insulin Promotes Mitochondrial Respiration and Survival through PI3K/AKT/GSK3 Pathway in Human Embryonic Stem Cells. Stem Cell Rep 15 (6), 1362-1376 Zhong, H., Ren, Z. L., Wang, X. Y., Miao, K., Ni, W. J., Meng, Y., Lu, L. G., Wang, C. M., Liu, W., Deng, C. X., Xu, R. H., and Chen, G. K. (2020) Stagewise Keratinocyte Differentiation from Human Embryonic Stem Cells by Defined Signal Transduction Modulators. Int J Biol Sci 16, 1450-1462 Yang, Y., Ren, Z. L., Xu, F. X., Meng, Y., Zhang, Y. M., Ai, N., Long, Y., Fok, H. I., Deng, C. H., Zhao, X. Y., Huang, L. C., Zhao, Q., Wang, J. X., Liu, W., Ge, W., and Chen, G. K. (2019) Endogenous IGF Signaling Directs Heterogeneous Mesoderm Differentiation in Human Embryonic Stem Cells. Cell Rep 29, 3374-3384 e3375 Song, C. C., Xu, F. X., Ren, Z. L., Zhang, Y. M., Meng, Y., Yang, Y. Q., Lingadahalli, S., Cheung, E., Li, G., Liu, W., Wan, J. B., Zhao, Y., and Chen, G. K. (2019) Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and Ampk/mTOR Pathway in Human Embryonic Stem Cells. Stem Cell Rep 13, 338-351 Ma, B. H., Luo, M. Y., Yang, H., Li, T. J., Liu, W., Xu, F. X., Shu, C., Chen, G. K., and Zhou, Z. (2019) Generation of a Human Induced Pluripotent Stem Cell Line (NCCDFWi001-A) from a Marfan Syndrome Patient Carrying Two FBN1 Variants (C.2613a > C and C.684_736 + 4del). Stem Cell Res 42, 101690 Liu, W., Deng, C. H., Godoy-Parejo, C., Zhang, Y. M., and Chen, G. K. (2019) Developments in Cell Culture Systems for Human Pluripotent Stem Cells. World J Stem Cells 11, 968-981 Godoy-Parejo, C., Deng, C. H., Zhang, Y. M., Liu, W., and Chen, G. K. (2019) Roles of Vitamins in Stem Cells. Cell Mol Life Sci Godoy-Parejo, C., Deng, C. H., Liu, W., and Chen, G. K. (2019) Insulin Stimulates PI3K/AKT and Cell Adhesion to Promote the Survival of Individualized Human Embryonic Stem Cells. Stem Cells 37, 1030-1041 Meng, Y., Ren, Z. L., Xu, F. X., Zhou, X. X., Song, C. C., Wang, V. Y. F., Liu, W., Lu, L. G., Thomson, J. A., and Chen, G. K. (2018) Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells. Stem Cell Rep 11, 1347-1356 Liu, W., Ren, Z. L., Lu, K., Song, C. C., Cheung, E. C. W., Zhou, Z., and Chen, G. K. (2018) The Suppression of Medium Acidosis Improves the Maintenance and Differentiation of Human Pluripotent Stem Cells at High Density in Defined Cell Culture Medium. Int J Biol Sci 14, 485-496 Liu, W., and Chen, G. K. (2014) Cryopreservation of Human Pluripotent Stem Cells in Defined Medium. Curr Protoc Stem Cell Biol 31, 1C.17.11-11C.17.13 Martin, B., Moroney, S. M., Vanderheyden, B., and Liu, W. (2011) Hormone Replacement Therapy – What Have We Learned since the Women’s Health Initiative? JPSW, 8-14 Morgans, C. W., Liu, W., Wensel, T. G., Brown, R. L., Perez-Leon, J. A., Bearnot, B., and Duvoisin, R. M. (2007) Gbeta5-RGS Complexes Co-Localize with mGluR6 in Retinal ON-bipolar Cells. Eur J Neurosci 26, 2899-2905 Liu, W., Wang, Q., and Wensel, T. G. (2004) Regulation of Neuronal G Protein GAP RGS7 by Interplay among Calcium, Calmodulin, Neurogranin, PKC, and Membrane Lipids. Gulf Coast Consortium for Membrane Biology Fall Symposium Liu, W., and Wensel, T. G. (2003) Interactions of Calmodulin with RGS7 and RGS9. Society for Neuroscience 33rd Annual Meeting
Full publications list

Awards
08/2008	Pharmacists Mutual Companies Scholarship and Award, University of Wisconsin, School of Pharmacy
08/2007	Mern Keir Scholarship, University of Wisconsin, School of Pharmacy
08/2004	V.C. Joshi Memorial Award, Department of Biochemistry and Molecular Biology, Baylor College of Medicine
2003 – 2004	Robert A. Welch pre-doctoral fellowship

Professional Activities
Supervisory Board Member, Macau Society for Stem Cell Research (MSSCR) Registered Pharmacist, State of Maryland Maryland vaccination registration Health Care Provider CPR/AED certificate, International CPR Institute American Pharmacists Association (APhA) American Society of Health-System Pharmacists (ASHP)