2021-08-20T16:43:33+08:002019-11-29|
Contact Information
Education
PharmD School of Pharmacy, University of Wisconsin, 2011
PhD Biochemistry and Molecular Biology, Baylor College of Medicine, 2005
BS Biochemistry and Molecular Biology, Peking University, 1999
Position
2017-present Operation Manager, Bioimaging and Stem Cell Core Facility, Faculty of Health Sciences, University of Macau
2014-present Senior Instructor, Faculty of Health Sciences, University of Macau
2011-2014 Clinical pharmacist, Doctors Community Hospital, Lanham, MD, USA
2005-2006 Research associate, Department of Biochemistry and Molecular Biology, Baylor College of Medicine
Research Interests
  • The stem cell niche and impact of individual cultural factors on stem cell survival and differentiation;
  • Interplay between metabolism and cell signaling in cell fate determination;
  • Optimization of cell culture environment for research and production.
Representative Publications
  • Ren, Z. L., Zhong, H., Song, C. C., Deng, C. H., Hsieh, H. T., Liu, W., and Chen, G. (2020) Insulin Promotes Mitochondrial Respiration and Survival through PI3K/AKT/GSK3 Pathway in Human Embryonic Stem Cells. Stem Cell Rep 15 (6), 1362-1376
  • Zhong, H., Ren, Z. L., Wang, X. Y., Miao, K., Ni, W. J., Meng, Y., Lu, L. G., Wang, C. M., Liu, W., Deng, C. X., Xu, R. H., and Chen, G. K. (2020) Stagewise Keratinocyte Differentiation from Human Embryonic Stem Cells by Defined Signal Transduction Modulators. Int J Biol Sci 16, 1450-1462
  • Yang, Y., Ren, Z. L., Xu, F. X., Meng, Y., Zhang, Y. M., Ai, N., Long, Y., Fok, H. I., Deng, C. H., Zhao, X. Y., Huang, L. C., Zhao, Q., Wang, J. X., Liu, W., Ge, W., and Chen, G. K. (2019) Endogenous IGF Signaling Directs Heterogeneous Mesoderm Differentiation in Human Embryonic Stem Cells. Cell Rep 29, 3374-3384 e3375
  • Song, C. C., Xu, F. X., Ren, Z. L., Zhang, Y. M., Meng, Y., Yang, Y. Q., Lingadahalli, S., Cheung, E., Li, G., Liu, W., Wan, J. B., Zhao, Y., and Chen, G. K. (2019) Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and Ampk/mTOR Pathway in Human Embryonic Stem Cells. Stem Cell Rep 13, 338-351
  • Ma, B. H., Luo, M. Y., Yang, H., Li, T. J., Liu, W., Xu, F. X., Shu, C., Chen, G. K., and Zhou, Z. (2019) Generation of a Human Induced Pluripotent Stem Cell Line (NCCDFWi001-A) from a Marfan Syndrome Patient Carrying Two FBN1 Variants (C.2613a > C and C.684_736 + 4del). Stem Cell Res 42, 101690
  • Liu, W., Deng, C. H., Godoy-Parejo, C., Zhang, Y. M., and Chen, G. K. (2019) Developments in Cell Culture Systems for Human Pluripotent Stem Cells. World J Stem Cells 11, 968-981
  • Godoy-Parejo, C., Deng, C. H., Zhang, Y. M., Liu, W., and Chen, G. K. (2019) Roles of Vitamins in Stem Cells. Cell Mol Life Sci
  • Godoy-Parejo, C., Deng, C. H., Liu, W., and Chen, G. K. (2019) Insulin Stimulates PI3K/AKT and Cell Adhesion to Promote the Survival of Individualized Human Embryonic Stem Cells. Stem Cells 37, 1030-1041
  • Meng, Y., Ren, Z. L., Xu, F. X., Zhou, X. X., Song, C. C., Wang, V. Y. F., Liu, W., Lu, L. G., Thomson, J. A., and Chen, G. K. (2018) Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells. Stem Cell Rep 11, 1347-1356
  • Liu, W., Ren, Z. L., Lu, K., Song, C. C., Cheung, E. C. W., Zhou, Z., and Chen, G. K. (2018) The Suppression of Medium Acidosis Improves the Maintenance and Differentiation of Human Pluripotent Stem Cells at High Density in Defined Cell Culture Medium. Int J Biol Sci 14, 485-496
  • Liu, W., and Chen, G. K. (2014) Cryopreservation of Human Pluripotent Stem Cells in Defined Medium. Curr Protoc Stem Cell Biol 31, 1C.17.11-11C.17.13
  • Martin, B., Moroney, S. M., Vanderheyden, B., and Liu, W. (2011) Hormone Replacement Therapy – What Have We Learned since the Women’s Health Initiative? JPSW, 8-14
  • Morgans, C. W., Liu, W., Wensel, T. G., Brown, R. L., Perez-Leon, J. A., Bearnot, B., and Duvoisin, R. M. (2007) Gbeta5-RGS Complexes Co-Localize with mGluR6 in Retinal ON-bipolar Cells. Eur J Neurosci 26, 2899-2905
  • Liu, W., Wang, Q., and Wensel, T. G. (2004) Regulation of Neuronal G Protein GAP RGS7 by Interplay among Calcium, Calmodulin, Neurogranin, PKC, and Membrane Lipids. Gulf Coast Consortium for Membrane Biology Fall Symposium
  • Liu, W., and Wensel, T. G. (2003) Interactions of Calmodulin with RGS7 and RGS9. Society for Neuroscience 33rd Annual Meeting
Full publications list
Awards
  • Pharmacists Mutual Companies Scholarship and Award, University of Wisconsin, School of Pharmacy, August, 2008
  • Mern Keir Scholarship, University of Wisconsin, School of Pharmacy, August, 2007
  • V.C. Joshi Memorial Award, Department of Biochemistry and Molecular Biology, Baylor College of Medicine, August, 2004
  • Robert A. Welch pre-doctoral fellowship, 2003-2004
Professional Activities
  • Supervisory Board Member, Macau Society for Stem Cell Research (MSSCR)
  • Registered Pharmacist, State of Maryland
  • Maryland vaccination registration
  • Health Care Provider CPR/AED certificate, International CPR Institute
  • American Pharmacists Association (APhA)
  • American Society of Health-System Pharmacists (ASHP)