2021-08-20T16:44:04+08:002020-01-15|
聯絡信息
Education
PharmD School of Pharmacy, University of Wisconsin, 2011
PhD Biochemistry and Molecular Biology, Baylor College of Medicine, 2005
BS Biochemistry and Molecular Biology, Peking University, 1999
Position
2017-present Operation Manager, Bioimaging and Stem Cell Core Facility, Faculty of Health Sciences, University of Macau
2014-present Senior Instructor, Faculty of Health Sciences, University of Macau
2011-2014 Clinical pharmacist, Doctors Community Hospital, Lanham, MD, USA
2005-2006 Research associate, Department of Biochemistry and Molecular Biology, Baylor College of Medicine
Research Interests
  • The stem cell niche and impact of individual cultural factors on stem cell survival and differentiation;
  • Interplay between metabolism and cell signaling in cell fate determination;
  • Optimization of cell culture environment for research and production.
Representative Publications
  • Ren, Z. L., Zhong, H., Song, C. C., Deng, C. H., Hsieh, H. T., Liu, W., and Chen, G. (2020) Insulin Promotes Mitochondrial Respiration and Survival through PI3K/AKT/GSK3 Pathway in Human Embryonic Stem Cells. Stem Cell Rep 15 (6), 1362-1376
  • Zhong, H., Ren, Z. L., Wang, X. Y., Miao, K., Ni, W. J., Meng, Y., Lu, L. G., Wang, C. M., Liu, W., Deng, C. X., Xu, R. H., and Chen, G. K. (2020) Stagewise Keratinocyte Differentiation from Human Embryonic Stem Cells by Defined Signal Transduction Modulators. Int J Biol Sci 16, 1450-1462
  • Yang, Y., Ren, Z. L., Xu, F. X., Meng, Y., Zhang, Y. M., Ai, N., Long, Y., Fok, H. I., Deng, C. H., Zhao, X. Y., Huang, L. C., Zhao, Q., Wang, J. X., Liu, W., Ge, W., and Chen, G. K. (2019) Endogenous IGF Signaling Directs Heterogeneous Mesoderm Differentiation in Human Embryonic Stem Cells. Cell Rep 29, 3374-3384 e3375
  • Song, C. C., Xu, F. X., Ren, Z. L., Zhang, Y. M., Meng, Y., Yang, Y. Q., Lingadahalli, S., Cheung, E., Li, G., Liu, W., Wan, J. B., Zhao, Y., and Chen, G. K. (2019) Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and Ampk/mTOR Pathway in Human Embryonic Stem Cells. Stem Cell Rep 13, 338-351
  • Ma, B. H., Luo, M. Y., Yang, H., Li, T. J., Liu, W., Xu, F. X., Shu, C., Chen, G. K., and Zhou, Z. (2019) Generation of a Human Induced Pluripotent Stem Cell Line (NCCDFWi001-A) from a Marfan Syndrome Patient Carrying Two FBN1 Variants (C.2613a > C and C.684_736 + 4del). Stem Cell Res 42, 101690
  • Liu, W., Deng, C. H., Godoy-Parejo, C., Zhang, Y. M., and Chen, G. K. (2019) Developments in Cell Culture Systems for Human Pluripotent Stem Cells. World J Stem Cells 11, 968-981
  • Godoy-Parejo, C., Deng, C. H., Zhang, Y. M., Liu, W., and Chen, G. K. (2019) Roles of Vitamins in Stem Cells. Cell Mol Life Sci
  • Godoy-Parejo, C., Deng, C. H., Liu, W., and Chen, G. K. (2019) Insulin Stimulates PI3K/AKT and Cell Adhesion to Promote the Survival of Individualized Human Embryonic Stem Cells. Stem Cells 37, 1030-1041
  • Meng, Y., Ren, Z. L., Xu, F. X., Zhou, X. X., Song, C. C., Wang, V. Y. F., Liu, W., Lu, L. G., Thomson, J. A., and Chen, G. K. (2018) Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells. Stem Cell Rep 11, 1347-1356
  • Liu, W., Ren, Z. L., Lu, K., Song, C. C., Cheung, E. C. W., Zhou, Z., and Chen, G. K. (2018) The Suppression of Medium Acidosis Improves the Maintenance and Differentiation of Human Pluripotent Stem Cells at High Density in Defined Cell Culture Medium. Int J Biol Sci 14, 485-496
  • Liu, W., and Chen, G. K. (2014) Cryopreservation of Human Pluripotent Stem Cells in Defined Medium. Curr Protoc Stem Cell Biol 31, 1C.17.11-11C.17.13
  • Martin, B., Moroney, S. M., Vanderheyden, B., and Liu, W. (2011) Hormone Replacement Therapy – What Have We Learned since the Women’s Health Initiative? JPSW, 8-14
  • Morgans, C. W., Liu, W., Wensel, T. G., Brown, R. L., Perez-Leon, J. A., Bearnot, B., and Duvoisin, R. M. (2007) Gbeta5-RGS Complexes Co-Localize with mGluR6 in Retinal ON-bipolar Cells. Eur J Neurosci 26, 2899-2905
  • Liu, W., Wang, Q., and Wensel, T. G. (2004) Regulation of Neuronal G Protein GAP RGS7 by Interplay among Calcium, Calmodulin, Neurogranin, PKC, and Membrane Lipids. Gulf Coast Consortium for Membrane Biology Fall Symposium
  • Liu, W., and Wensel, T. G. (2003) Interactions of Calmodulin with RGS7 and RGS9. Society for Neuroscience 33rd Annual Meeting
Full publications list
Awards
  • Pharmacists Mutual Companies Scholarship and Award, University of Wisconsin, School of Pharmacy, August, 2008
  • Mern Keir Scholarship, University of Wisconsin, School of Pharmacy, August, 2007
  • V.C. Joshi Memorial Award, Department of Biochemistry and Molecular Biology, Baylor College of Medicine, August, 2004
  • Robert A. Welch pre-doctoral fellowship, 2003-2004
Professional Activities
  • Supervisory Board Member, Macau Society for Stem Cell Research (MSSCR)
  • Registered Pharmacist, State of Maryland
  • Maryland vaccination registration
  • Health Care Provider CPR/AED certificate, International CPR Institute
  • American Pharmacists Association (APhA)
  • American Society of Health-System Pharmacists (ASHP)