2021-07-15T17:25:19+08:002020-02-13|
聯絡信息
研究團隊
名稱 職稱 辦公室 電話 電郵
Marta Alves da Silva澳大濠江博士後研究員N22-3040+853 8822 2731martas@um.edu.mo
黎帥博士後研究員N22-3001+853 8822 4219shuaili@um.edu.mo
林若紅博士後研究員N22-3040+853 8822 2731ruohonglin@um.edu.mo
劉琳琳博士生N22-3040+853 8822 2731
MOHD FARHAN博士生N22-3040+853 8822 2731
趙霞博士生N22-3040+853 8822 2731
江一舟博士生N22-3040+853 8822 2731
幸新幹博士生N22-3040+853 8822 2731
王歡博士生N22-3040+853 8822 2731
彭湯明博士生N22-3040+853 8822 2731
周文樹博士生N22-3040+853 8822 2731
周志威博士生N22-3040+853 8822 2731
楊超博士生N22-3040+853 8822 2731
陳義天博士生N22-3040+853 8822 2731
Education
PhD McGill University, Canada
MSc Sun Yat-Sen University of Medical Sciences, China
BSc Sun Yat-Sen University of Medical Sciences, China
Position
2017.8-present Professor, Faculty of Health Sciences, University of Macau
2015-2017.8 Associate Professor, Faculty of Health Sciences, University of Macau
2006-2015 Head of Neuro/ocular Pharmacology lab, Sun Yat-Sen University
2002-2005 Research Associate, Douglas Hospital, McGill University
1993-1995 Visiting Follow, NIH
1992 Visiting Scientist, University of Rochester
Research Interests
Neuro pharmacology; aging, neuronal degenerative disorders including Alzheimer’s disease and degenerative retinal diseases; molecular mechanisms of neuronal death and survival; new drug developments.
Specific current research interests:

  1. the alteration of signaling pathways (new biomarkers) in aging and degenerative disorders such as Alzheimer’s Disease and degenerative retinal diseases and identification of new biomarkers
  2. the role of PI3K/Akt signaling pathway and FoxO transcription factors in aging and degenerative disorders and the identification of new functions and downstream targets of FoxO.
  3. interactions of glutamate and growth factors and their significance in the treatment of neuronal disorders and eye disorders
  4. new drug developments.
  5. IPSC/ESC and their applications in the treatment neuronal degenerative disease and drug screen. The role of FoxO in IPSC/ESC growth, differentiation and death.
Representative Publications
Representative Publications (Total >120 papers, were cited > 5000 times. 15 papers were cited >100 times, New IF this year, *corresponding author)

  1. Shuai Li, Tangming Peng, Xia Zhao, Marta Silva, Linlin Liu, Wenshu Zhou, Ligang Chen and Wenhua Zheng*. (2021) Artemether Confers Neuroprotection on Cerebral Ischemic Injury through Stimulation of the Erk1/2-P90rsk-CREB Signaling Pathway. Redox biology . (Accepted) IF=11.8
  2. Silva M, Peng T, Zhao X, Li S, Farhan M, Zheng W*. Recent trends in drug-delivery systems for the treatment of diabetic retinopathy and associated fibrosis. Adv Drug Deliv Rev. 2021 Jun;173:439-460. IF=15.43
  3. Shuai Li, Yizhou Jiang, Xingan Xing, Ruohong Lin, Qin Li,Wenshu Zhou, Wei Qiu and Wenhua Zheng*. Protective mechanism of berberine on human retinal pigment epithelial cells against apoptosis induced by hydrogen peroxide via the stimulation of autophagy. oxidative medicine and cellular longevity. (Accepted) IF=6.54
  4. Chaojun Han, Pengju Yan, Tao He, Junjie Cheng, Wenhua Zheng, Long-Tai Zheng*, Xuechu Zhen*. (2020) PHLDA1 promotes microglia-mediated neuroinflammation via regulating K63-linked ubiquitination of TRAF6.Brain Behav Immun 88:640-653 IF=7.21
  5. Farhan, M., Silva, M, Li, S., Yan, F. X., Fang, J. K., Peng, T. M., Hu, J., Tsao, M. S., Little, P., and Zheng, W*. (2021) The Role of FOXOs and Autophagy in Cancer and Metastasis-Implications in Therapeutic Development. Med Res Rev 40(6), 2089-2113, Cover page,  IF=12.94
  6. Wenshu Zhou , Marta Silva , Chun Feng , Shumei Zhao, Linlin Liu , Shuai Li , Jingmei Zhong , Wenhua Zheng* .Exosomes derived from human placental mesenchymal stem cells enhanced the recovery of spinal cord injury by activating endogenous neurogenesis Stem Cell Res Ther 2021 Mar 12;12(1):174. IF=6.83
  7. Zhou, YiFan ; Wang, Jingqi ; Chang, Yanyu ; Li, Rui ; Sun, Xiaobo ; Peng, Lisheng ; Zheng, WenHua* ; Qiu, Wei* . (2020) Caffeic Acid Phenethyl Ester Protects against Experimental Autoimmune Encephalomyelitis by Regulating T Cell Activities. Oxid Med Cell Longev, IF=6.54
  8. Zeng, Z. W., Xu, J. Y., and Zheng, W. H*. Artemisinin Protects PC12 Cells against β-Amyloid-Induced Apoptosis through Activation of the Erk1/2 Signaling Pathway. Redox Biol 12, 625-633 IF=11.8
  9. Wang, H.; Zhang. Q; Wen, Q.; Lazarovici, P.; Jiang, H and Zheng, W*,  Proline-rich Akt substrate of 40 kDa (PRAS40): A novel downstream target of PI3k/Akt signaling pathway. Cell signal 2012, 24:17-24  (“The 100 Most Influential International Academic Paper in China in 2012” by “Institute of Scientific and Technical information of China”.
  10. Zheng, W*., Chong, C. M., Wang, H. T., Zhou, X. H., Zhang, L., Wang, R. K., Meng, Q., Lazarovici, P., and Fang, J. K. (2016) Artemisinin Conferred ERK Mediated Neuroprotection to PC12 Cells and Cortical Neurons Exposed to Sodium Nitroprusside-Induced Oxidative Insult. Free Radical Bio Med 97, 158-167 IF= 7.38
  11. Yan, Fengxia ; Wang, Rikang ; Li, Shuai ; Zhao, Xia ; Jiang, Yizhou ; Liu, Linlin ; Fang, Jiankang ; Zhen, Xuechu ; Lazarovici, Philip ; Zheng, Wenhua*. (2020) FoxO3a suppresses neuropeptide W expression in neuronal cells and in rat hypothalamus and its implication in hypothalamic-pituitary-adrenal (HPA) axis. International journal of biological sciences 16(15), 2775-2787. IF=6.50
  12. Zhao, X., Han, C., Zeng, Z. W., Liu, L. L., Wang, H. T., Xu, J. P., Feng, Z. P., Little, P. J., Quirion, R., and Zheng, W*. (2020) Glutamate Attenuates the Survival Property of IGFR through NR2B Containing N-Methyl-D-Aspartate Receptors in Cortical Neurons. Oxid Med Cell Longev, 5173184 IF=6.54
  13. Zhao, X., Liu, L. L., Jiang, Y. Z., Silva, M., Zhen, X. C., and Zheng, W.* (2020) Protective Effect of Metformin against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial (RPE) Cells by Enhancing Autophagy through Activation of Ampk Pathway. Oxid Med Cell Longev, 2524174 IF=6.54
  14. Liu, L. L., Zhao, X., Silva, M., Li, S., Xing, X. G., and Zheng, W.* (2020) Artemisinin Protects Motoneurons against Axotomy-Induced Apoptosis through Activation of the PKA-Akt Signaling Pathway and Promotes Neural Stem/Progenitor Cells Differentiation into NeuN(+) Neurons. Pharmacol Res 159. IF=7.66
  15. Zhao, X., Li, S., Gaur, U., and Zheng, W.* (2020) Artemisinin Improved Neuronal Functions in Alzheimer’s Disease Animal Model 3xtg Mice and Neuronal Cells via Stimulating the ERK/CREB Signaling Pathway. Aging Dis 11 (4), 801-819. IF=6.74
  16. Chong, C. M., and Zheng, W.* Artemisinin Protects Human Retinal Pigment Epithelial Cells from Hydrogen Peroxide-Induced Oxidative Damage through Activation of ERK/CREB Signaling. Redox Biol 9, 50-56. IF=11.8
  17. Farhan M, Silva M, Xingan X, Huang Y, Zheng W.* (2020) Role of FOXO Transcription Factors in Cancer Metabolism and Angiogenesis. Cells 9(7). IF=6.5
  18. Liao, R. F., Yan, F. X., Zeng, Z. P., Wang, H. T., Qiu, K. F., Xu, J. Y., and Zheng, W*. (2018) Insulin-Like Growth Factor-1 Activates PI3K/Akt Signalling to Protect Human Retinal Pigment Epithelial Cells from Amiodarone-Induced Oxidative Injury. Brit J Pharmacol 175(1), 125-139. IF=8.74
  19. Fang, J. K., Zhao, X., Li, S. A., Xing, X. G., Wang, H. T., Lazarovici, P., and Zheng, W. *(2019) Protective Mechanism of Artemisinin on Rat Bone Marrow-Derived Mesenchymal Stem Cells against Apoptosis Induced by Hydrogen Peroxide via Activation of c-Raf-Erk1/2-p90(rsk)-CREB Pathway. Stem Cell Res Ther 10 (1). IF= 6.83
  20. Jiang, Yizhou ;Yan, Fengxia ; Feng, Zhongping ; Lazarovici, Philip ; Zheng, Wenhua. *(2019) Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction. Cells 9(1). IF=6.5
  21. Afroz, R.; Cao, Y.; Rostam, M. A.; Ta, H.; Xu, S.; Zheng, W.*; Osman, N.; Kamato, D.; Little, P. J., Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: Implications for lipoprotein binding and atherosclerosis. Pharmacology & therapeutics 2018, 187, 88-97. IF= 12.3
  22. Jiang, Yizhou ; Peng, Tangming ; Gaur, Uma ; Silva, Marta ; Little, Peter ; Chen, Zhong ; Qiu, Wei ; Zhang, Yandong ; Zheng, Wenhua.*(2019) Role of Corticotropin Releasing Factor in the Neuroimmune Mechanisms of Depression: Examination of Current Pharmaceutical and Herbal Therapies. Frontiers in cellular neuroscience. IF=5.5
  23. Zhao, Xia ; Fang, Jiankang ; Li, Shuai ; Gaur, Uma ; Xing, Xingan ; Wang, Huan ; Zheng, Wenhua.* (2019) Artemisinin Attenuated Hydrogen Peroxide (H2O2)-Induced Oxidative Injury in SH-SY5Y and Hippocampal Neurons via the Activation of AMPK Pathway. International journal of molecular sciences 20(11), IF=4.653
  24. Peng, Tangming ; Jiang, Yizhou ; Farhan, Mohd ; Lazarovici, Philip ; Chen, Ligang ; Zheng, Wenhua.* (2019) Anti-inflammatory Effects of Traditional Chinese Medicines on Preclinical in vivo Models of Brain Ischemia-Reperfusion-Injury: Prospects for Neuroprotective Drug Discovery and Therapy. Frontiers in pharmacology 10, IF=5.8
  25. Li, Shuai; Chaudhary, Shubhash Chandra; Zhao, Xia; Gaur, Uma; Fang, Jiankang; Yan, Fengxia; Zheng, Wenhua.* (2019) Artemisinin Protects Human Retinal Pigmented Epithelial Cells Against Hydrogen Peroxide-induced Oxidative Damage by Enhancing the Activation of AMP-active Protein Kinase. International journal of biological sciences 15(9), 2016-2028 IF=6.5
  26. Zhao, X., Zeng, Z. W., Gaur, U., Fang, J., Peng, T., Li, S., and Zheng, W.* (2019) Metformin Protects PC12 Cells and Hippocampal Neurons from H2O2 -Induced Oxidative Damage through Activation of AMPK Pathway. J Cell Physiol 234(9), 16619-16629 IF=6.38
  27. Liao, Rifang ; Yan, Fengxia ; Zeng, Zhuanping ; Farhan, Mohd ; Little, Peter ; Quirion, Remi ; Srivastava, Lalit K. ; Zheng, Wenhua.* (2017) Amiodarone-Induced Retinal Neuronal Cell Apoptosis Attenuated by IGF-1 via Counter Regulation of the PI3k/Akt/FoxO3a Pathway. Molecular neurobiology 54(9), 6931-6943 IF=6.15
  28. Li, S., Zhao, X., Lazarovici, P., and Zheng, W.* (2019) Artemether Activation of AMPK/GSK3β(Ser9)/Nrf2 Signaling Confers Neuroprotection Towards Beta-Amyloid-Induced Neurotoxicity in 3xTg Alzheimer’s Mouse Model. Oxid Med Cell Longev, 1-24. IF=6.5
  29. Mohamed R, Janke R, Guo W, Cao Y, Zhou Y, Zheng W*, Babaahmadi-Rezaei H, Xu S, Kamato D, Little PJ. (2019) GPCR transactivation signalling in vascular smooth muscle cells: role of NADPH oxidases and reactive oxygen species. Vasc Biol 1(1), 1-11. IF=6.604
  30. Wang, H.; Lazarovici, P.; Zheng, W*. Forkhead box protein O, a family of transcription factors integrating diverse biological functions. Encyclopedia of Signaling Molecules, 2nd Edition 2018, 1821-1836 (Invited book for WH)
Full publications list
Research Grants
Active grants: (more than 20 grants in total including 6 NSFC grants)
FDCT 0113/2018/A3 (in charge, 2019-2023)
MYRG2018-00134-FHS (in charge, 2019-2022)
National Natural Science Fund of China (NSFC 31771128, in charge, 2018-2022)
FHS competition grant (in charge, 2017- 2019)
FDCT 016/2016/A1 (in charge, 2017-2019)
MYRG2016-00052-FHS (in charge, 2017-2019)
FSH allocation fund (in charge, 2015-2023)
NFSC 31371088 (in charge-2020).
Awards
A paper published in 《Cell Signaling》was chosen as “The 100 Most Influential International Academic Paper in China in 2012” by “Institute of Scientific and Technical information of China” last year
Professional Activities
Member of American Society of Neuroscience, Adjunct Professor at RMIT university, Editor 《Chinese J of Biology》