2021-02-03T17:48:14+08:002020-02-13|
聯絡信息
教學

課程與科目

GEGA1007 Nutrition in Health and Disease

Advanced Biomedical and Chemical Engineering

研究團隊
名稱 職稱 辦公室 電話 電郵
張展博士生 (實驗室代表)E12-1023+853 8822 4222
謝麗斯澳大濠江博士後研究員E12-1023+853 8822 4222lisixie@um.edu.mo
李蓓澳大濠江博士後研究員E12-1023+853 8822 4222beili@um.edu.mo
李杰博士後研究員E12-1023+853 8822 4222jieli@um.edu.mo
桑瑋博士生E12-1023+853 8822 4222
田浩博士生E12-1023+853 8822 4222
李文曦博士生E12-1023+853 8822 4222
王國浩博士生E12-1023+853 8822 4222
顏潔博士生E12-1023+853 8822 4222
田野博士生E12-1023+853 8822 4222
Education
PhD Inorganic Chemistry, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), China (2014)
BSc Chemical Engineering and Technology, Harbin Engineering University, China (2009)
Positions
08/2018-present Assistant Professor, Faculty of Health Sciences, University of Macau
09/2016-07/2018 Postdoc Fellow, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), USA
10/2014-09/2016 Research Fellow, The University of Melbourne, Australia
06/2014-10/2014 Lecturer, Harbin Engineering University, China
Research Interests
Our group research interest mainly focuses on the nanomaterials for targeted delivery of anticancer therapeutics and multimodal biological imaging (X-ray computed tomography, optical imaging, magnetic resonance imaging and photoacoustic imaging, etc). We aim to develop inorganic nanomaterials and nanoscale coordination materials for gene and drug delivery, immunotherapy and biological imaging. In particular, we are working on designing and preparing multi-functional nanomaterials for enhanced anticancer therapy by exploiting the tumor microenvironment. We are also developing promising nanodrugs for clinical translation.
Representative Publications
Full publication in Google Scholar: https://scholar.google.com/citations?user=g0XS-6QAAAAJ&hl=en#opennewwindow

H-index: 48, a total citation of over 8,000 times based on Google Scholar

From University of Macau

  • Lisi Xie†, Guohao Wang†, Wei Sang, Jie Li, Zhan Zhang, Wenxi Li, Jie Yan, Qi Zhao, Yunlu Dai*(corresponding author), Phenolic immunogenic cell death nanoinducer for sensitizing tumor to PD-1 checkpoint blockade immunotherapy. Biomaterials, 2021, 269, 120638. (IF 10.317)
  • Yuxin Guo†, Qing Sun,† Fu-Gen Wu*, Yunlu Dai*(corresponding author), Xiaoyuan Chen*, Polyphenol-Containing Nanomaterials: Synthesis, Properties, and Biomedical Applications. Adv. Mater., 2021, DOI: 10.1002/adma.202007356. (IF 27.398)
  • Zhan Zhang†, Wei Sang†, Lisi Xie†, Wenxi Li, Bei Li, Jie Li, Hao Tian, Zhen Yuan, Qi Zhao, and Yunlu Dai*(corresponding author), Polyphenol-based Nanomedicine Evokes Immune Activation for Combination Cancer Treatment. Angew. Chem. Int. Ed., 2020, DOI: 10.1002/anie.202013406 (IF 12.257)
  • Wei Sang†, Lisi Xie†, Guohao Wang, Jie Li, Zhan Zhang, Bei Li, Sen Guo, Chu-Xia Deng, Yunlu Dai*(corresponding author), Oxygen Enriched Metal-Phenolic X-Ray Nanoprocessor for Cancer Radio-Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy. Adv. Sci., 2020, DOI: 10.1002/advs.202003338 (IF 15.840)
  • Liwen Zhang, Lisi Xie, Sihao Xu, Rhiannon P. Kuchel, Yunlu Dai*(corresponding author), Kenward Jung*, and Cyrille Boyer*, Dual Role of Doxorubicin for Photopolymerization and Therapy. Biomacromolecules 2020, 21, 3887. (IF 6.092)
  • Jingjing Wang†, Wei Sang†, Zhen Yang, Zheyu Shen, Zhantong Wang, Orit Jacobson, Yundai Chen, Yong Wang, Mingyan Shao, Gang Niu, Yunlu Dai*(corresponding author), and Xiaoyuan Chen* Polyphenol-based nanoplatform for MRI/PET dual-modality imaging guided effective combination chemotherapy. J. Mater. Chem. B, 2019, 7, 5688. (IF 5.047)
  • Zhan Zhang†, Wei Sang†, Lisi Xie, Yunlu Dai*(corresponding author), Metal-organic frameworks for multimodal bioimaging and synergistic cancer chemotherapy. Coordin. Chem. Rev. 2019, 399, 213022. (IF 13.550)
  • Wei Sang†, Zhan Zhang†, Yunlu Dai*(corresponding author), Xiaoyuan Chen* Recent Advances in Nanomaterials-based Synergistic Combination Cancer Immunotherapy. Chem. Soc. Rev., 2019, 48, 3771. (Back Cover Paper) (IF 42.846)
  • Zhimei He, Xiaolin Huang, Chen Wang, Xiangli Li, Yijing Liu, Zijian Zhou, Sheng Wang, Fuwu Zhang, Zhantong Wang, Orit Jacobson, Jun-Jie Zhu,* Guocan Yu,* Yunlu Dai*(corresponding author), Xiaoyuan Chen* A Catalase-Like Metal-Organic Framework Nanohybrid for O2-Evolving Synergistic Chemoradiotherapy, Angew. Chem. Int. Ed. 2019, 58, 8752. (IF 12.257)
  • Lingling Shan, Guizhen Gao, Weiwei Wang, Wei Tang, Zhantong Wang, Zhen Yang, Wenpei Fan, Guizhi Zhu, Kefeng Zhai, Orit Jacobson, Yunlu Dai*(corresponding author), Xiaoyuan Chen,* Self-assembled Green Tea Polyphenol-based Coordination Nanomaterials to Improve Chemotherapy Efficacy by Inhibition of Carbonyl Reductase 1. Biomaterials, 2019, 210, 62. (IF 10.317)
  • Yuan Liu, Christina S. Gong, Lisen Lin, Zijian Zhou, Yijing Liu, Zhen Yang, Zheyu Shen, Guocan Yu, Zhantong Wang, Sheng Wang, Ying Ma, Wenpei Fan, Liangcan He, Gang Niu, Yunlu Dai*(corresponding author), Xiaoyuan Chen* Core-shell metal-organic frameworks with fluorescence switch to trigger an enhanced photodynamic therapy. Theranostics 2019, 9, 2791. (IF 8.579)
  • Zhimei He†, Yunlu Dai†(co-first author), Xiangli Li, Dan Guo, Yijing Liu, Xiaolin Huang, Jingjing Jiang, Sheng Wang, Guizhi Zhu, Fuwu Zhang, Lisen Lin, Jun-Jie Zhu,* Guocan Yu,* Xiaoyuan Chen* Hybrid Nanomedicine Fabricated from Photosensitizer-Terminated Metal-Organic Framework Nanoparticles for Photodynamic Therapy and Hypoxia-Activated Cascade Chemotherapy. Small, 2019, 15, 1804131. (IF 11.459)
  • Zhen Yang, Yunlu Dai*(corresponding author), Lingling Shan, Zheyu Shen, Zhantong Wang, Bryant C Yung, Orit Jacobson, Yijing Liu, Wei Tang, Sheng Wang, Lisen Lin, Gang Niu, Pintong Huang*, Xiaoyuan Chen* Tumour microenvironment-responsive semiconducting polymer-based self-assembling nanotheranostics, Nanoscale Horiz., 2019, 4, 426. (IF 9.927)

Prior to University of Macau

  • Yunlu Dai, Zhen Yang, Siyuan Cheng, Zhongliang Wang,* Ruili Zhang, Guizhi Zhu, Zhantong Wang, Bryant C. Yung, Rui Tian, Orit Jacobson, Can Xu, Qianqian Ni, Jibin Song, Xiaolian Sun, Gang Niu, Xiaoyuan Chen,*. Toxic Reactive Oxygen Species Enhanced Synergistic Combination Therapy by Self-Assembled Metal-Phenolic Network Nanoparticles. Adv. Mater., 2018, 30, 1704877. (IF 27.398)
  • Yunlu Dai, Siyuan Cheng, Zhongliang Wang,* Ruili Zhang, Zhen Yang, Jingjing Wang, Bryant C. Yung, Zhantong Wang, Orit Jacobson, Can Xu, Qianqian Ni, Guocan Yu, Zijian Zhou, and Xiaoyuan Chen,* Hypochlorous Acid Promoted Platinum Drug Chemotherapy by Myeloperoxidase Encapsulated Therapeutic Metal Phenolic Nanoparticles. ACS Nano, 2018, 12, 455. (IF 14.588)
  • Zhen Yang,† Yunlu Dai†(co-first author), Chao Yin, Quli Fan,* Wansu Zhang, Guocan Yu, Wei Tang, Wenpei Fan, Jie Li, Xiang Li, Yufu Tang, Xiangchun Li, Jibin Song,* Wei Huang, Xiaoyuan Chen* Activatable Semiconducting Theranostics: Simultaneous Generation and Ratiometric Photoacoustic Imaging of Reactive Oxygen Species In Vivo Adv. Mater., 2018, 30, 1707509. (IF 27.398)
  • Yunlu Dai, Can Xu, Xiaolian Sun* and Xiaoyuan Chen*. Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment. Chem. Soc. Rev., 2017, 46, 3830-3852. (IF 42.846)
  • Yunlu Dai, Haihua Xiao, Jianhua Liu, Qinghai Yuan, Ping’an Ma, Dongmei Yang Chunxia Li, Zhiyao Hou, Ziyong Cheng, Piaoping Yang* and Jun Lin*. In Vivo Multimodal Imaging and Cancer Therapy by Near-Infrared Light Triggered Trans-platinum Pro-drug Conjugated Upconverison J. Am. Chem. Soc. 2013, 135, 18920-18929. (IF 14.612) (Hot paper)
  • Yunlu Dai, Ping’an Ma, Ziyong Cheng*, Xiaojiao Kang, Xiao Zhang, Zhiyao Hou, Chunxia Li, Dongmei Yang, Xuefeng Zhai, Jun Lin*. Up-Conversion Cell Imaging and pH-Induced Thermally Controlled Drug Release from NaYF4:Yb3+/Er3+@Hydrogel Core-Shell Hybrid. ACS Nano 2012, 6, 3327-3338. (IF 14.588)
  • Huiting Bi†, Yunlu Dai†(co-first author), Piaoping Yang*, Jiating Xu, Dan Yang, Shili Gai, Fei He, Bin Liu, Chongna Zhong, and Jun Lin*. Glutathione Mediated Size-Tunable UCNPs-Pt(IV)-ZnFe2O4 Nanocomposite for Multiple Bioimaging Guided Synergetic Therapy. Small, 2018, 14, 1703809. (IF 11.459)
  • Zhantong Wang†, Yunlu Dai†(co-first author), Zhe Wang*, Orit Jacobson, Fuwu Zhang, Bryant C. Yung, Pengfei Zhang, Haiyan Gao, Gang Niu, Gang Liu,*, Xiaoyuan Chen,* Metal Ion Assisted Interface Re-engineering of Ferritin Protein Nanocage for Enhanced Biofunctions and Cancer Therapy. Nanoscale, 2018, 10, 1135. (IF 6.895)
  • Yunlu Dai, Cuimiao Zhang, Ziyong Cheng*, Ping’an Ma, Chunxia Li, Xiaojiao Kang, Dongmei Yang, Jun Lin*. pH-Responsive Drug Delivery System Based on Luminescent CaF2:Ce3+/Tb3+-Poly(acrylic acid) Hybrid Biomaterials 2012, 33, 2583-2592. (IF 10.317)
  • Yunlu Dai, Dongmei Yang, Ping’an Ma, Xiaojiao Kang, Xiao Zhang, Chunxia Li, Zhiyao Hou, Ziyong Cheng,* Jun Lin*. Doxorubicin Conjugated NaYF4:Yb3+/Tm3+Nanoparticles for Therapy and Sensing of Drug Delivery by Luminescence Resonance Energy Biomaterials 2012, 33, 8704-8713. (IF 10.317)
  • Yunlu Dai, Junling Guo, Ting‐Yi Wang, Yi Ju, Andrew J Mitchell, Thomas Bonnard, Jiwei Cui, Joseph J Richardson, Christoph E Hagemeyer, Karen Alt*, Frank Caruso*. Self‐Assembled Nanoparticles from Phenolic Derivatives for Cancer Therapy. Adv. Healthcare Mater. 2017, 6, 1700467. (IF 6.270)
  • Yunlu Dai, Huiting Bi, Xiaoran Deng, Chunxia Li,* Fei He, Piaoping Yang,* Jun Lin*. 808 nm near-infrared light controlled dual-drug release and cancer therapy in vivo by upconversion mesoporous silica nanostructures J. Mater. Chem. B, 2017, 5, 2086-2095 (IF 5.047) (Hot paper)
  • Huiting Bi, Yunlu Dai*(corresponding author), Jiating Xu, Ruichan Lv, Fei He, Shili Gai, Dan Yang, Piaoping Yang*. CuS–Pt (iv)–PEG–FA nanoparticles for targeted photothermal and chemotherapy. J. Mater. Chem. B, 2016, 4, 5938-5946. (IF 5.047)
  • Huiting Bi, Yunlu Dai*(corresponding author), Ruichan Lv, Chongna Zhong, Fei He, Shili Gai, Arif Gulzar, Guixin Yang, Piaoping Yang*. Doxorubicin-conjugated CuS nanoparticles for efficient synergistic therapy triggered by near-infrared light. Dalton Trans., 2016, 45, 5101-5110. . (IF 4.052)
  • Yunlu Dai, Xiaojiao Kang, Dongmei Yang, Xuejiao Li, Xiao Zhang, Chunxia Li, Zhiyao Hou, Ziyong Cheng, Ping’an Ma* and Jun Lin*. Platinum (IV) Pro-drug Conjugated NaYF4:Yb3+/Er3+Nanoparticles for Targeted Drug Delivery and Up-conversion Cell. Adv. Healthcare Mater. 2013, 2, 562-567. (IF 6.270) (Cover Paper)
  • Junling Guo; Blaise L Tardy; Andrew J Christofferson; Yunlu Dai; Joseph J Richardson; Wei Zhu; Ming Hu; Yi Ju; Jiwei Cui; Raymond R Dagastine, Irene Yarovsky; Frank Caruso*, Modular assembly of superstructures from polyphenol-functionalized building blocks. Nature Nanotechnol. 2016, 11, 1105. (IF 31.538)
  • Lili Feng; Shili Gai; Yunlu Dai; Fei He; Chunqiang Sun; Piaoping Yang*; Ruichan Lv; Na Niu; Guanghui An; Jun Lin*, Controllable Generation of Free Radicals from Multifunctional Heat-Responsive Nanoplatform for Targeted Cancer Therapy. Chem. Mater. 2018, 30, 526-539. (IF 9.567)
Research Grants
Start-up Research Grant (SRG) of University of Macau (SRG2018-00130-FHS).
Science and Technology Development Fund of Macao SAR (FDCT 0109/2018/A3).
Awards
  • “The National Scholarship” Award, 2007
  • “Outstanding Scholarship” Award, Harbin Engineering University, 2006-2009
  • “Merit Student” Award,  Changchun  Institute  of  Applied  Chemistry, Chinese Academy of Sciences, 2012 and 2013
  • “The National Scholarship” Award, 2013
  • “The Zhu Liyuehua Scholarship” Award, 2014
  • “The CASNN rising Star Award, 2019, Chinese American Society of Nanomedicine and Nanobiotechnology, CASNN
Professional Activities
Ad hoc reviewer:
Nature Communications. Advanced Materials, ACS Nano, Biomaterials, Chemistry of Materials, Journal of Controlled Release, Theranostics, ACS Applied Materials & Interfaces, Acta Biomaterialia, European Journal of Medicinal Chemistry, Chemical Engineering Journal, Chinese Chemical Letters
Team members
Dr. Yunlu Dai, Principle InvestigatorDr. Lisi Xie, postdoc fellow
Cheok Kei SI, research assistant
Wei Sang, PhD candidate
Zhan Zhang, PhD candidate
Guohao Wang, PhD candidate
Wenxi Li, PhD candidate
Hao Tian, PhD candidate