Contact Information
Research Team
Name Position Office Phone Email
Yuzhao FENGPhD Student (Lab Representative)E12-1023+853 8822 4222yc27608@um.edu.mo
Dr. Bei LIResearch Assistant ProfessorE12-1023beili@um.edu.mo
Wei SANGResearch AssistantE12-1023+853 8822 4222weisang@um.edu.mo
Hao TIANPhD StudentE12-1023+853 8822 4222
Wenxi LIPhD StudentE12-1023+853 8822 4222
Guohao WANGPhD StudentE12-1023+853 8822 4222
Jie YANPhD StudentE12-1023+853 8822 4222
Ye TIANPhD StudentE12-1023+853 8822 4222
Songtao ZHOUPhD Student
Xinying YUPhD StudentE12-1023+853 8822 4222
Chao JIANGPhD Student
Ziliang YANPhD StudentE12-1023+853 8822 4222
Fengfeng XIAOPhD Student
DSc Inorganic Chemistry, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), China (2014)
BEng Chemical Engineering and Technology, Harbin Engineering University, China (2009)
08/2022 – Present Associate Professor, Faculty of Health Sciences, University of Macau
08/2018 – 08/2022 Assistant Professor, Faculty of Health Sciences, University of Macau
09/2016 – 07/2018 Postdoc Fellow, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), USA
10/2014 – 09/2016 Research Fellow, The University of Melbourne, Australia
06/2014 – 10/2014 Lecturer, Harbin Engineering University, China
Research Interests
Our group research interest mainly focuses on the nanomaterials for targeted delivery of anticancer therapeutics and multimodal biological imaging (X-ray computed tomography, optical imaging, magnetic resonance imaging and photoacoustic imaging, etc). We aim to develop inorganic nanomaterials and nanoscale coordination materials for gene and drug delivery, immunotherapy and biological imaging. In particular, we are working on designing and preparing multi-functional nanomaterials for enhanced anticancer therapy by exploiting the tumor microenvironment. We are also developing promising nanodrugs for clinical translation.


Representative Publications
Google Scholar: https://scholar.google.com/citations?user=g0XS-6QAAAAJ

H-index: 61, a total citation of over 11,200 times based on Google Scholar


From University of Macau

  • Chang Lu, Ye Tian, Hao Tian, Bei Li, Bo Peng, Jun Zheng*, Yunlu Dai*(corresponding author). An ultrasound activable metal-phenolic network nano-antibiotics for in vivo on-site infection therapy, Sci. China Mater., 2022, DOI: 10.1007/s40843-022-2125-1.
  • Zhan Zhang, Rinkoo Dalan, Zhenyu Hu, Jiong-Wei Wang, Nicholas WS Chew, Kian-Keong Poh, Ru-San Tan, Tuck Wah Soong, Yunlu Dai*(corresponding author), Lei Ye*, Xiaoyuan Chen*, Reactive Oxygen Species Scavenging Nanomedicine for The Treatment of Ischemic Heart Disease, Adv. Mater., 2022, DOI: 10.1002/adma.202202169.
  • Ye Tian, Wei Sang, Hao Tian, Lisi Xie, Guohao Wang, Zhan Zhang, Wenxi Li, Yunlu Dai*(Corresponding author). A Two-Step Flexible Ultrasound Strategy to Enhance the Tumor Radiotherapy via Metal-Phenolic Network Nanoplatform, Adv. Funct. Mater., 2022, 32, 2205690.
  • Chang Lu, Nian Zhang, Sihoi Kou, Liangliang Gao, Bo Peng, Yunlu Dai*(Corresponding author), Jun Zheng*, Sanguinarine synergistically potentiates aminoglycoside-mediated bacterial killing, Microb. Biotechnol., 2022, 15, 2055.
  • Jie Li, Lisi Xie, Wei Sang, Wenxi Li, Guohao Wang, Jie Yan, Zhan Zhang, Hao Tian, Quli Fan, Yunlu Dai*(Corresponding author). A Metal-Phenolic Nanosensitizer Performs Hydrogen Sulfide-Reprogrammed Oxygen Metabolism for Cancer Radiotherapy Intensification and Immunogenicity, Angew. Chem. Int. Ed., 2022, 61, e202200830.
  • Wei Sang, Zhan Zhang, Guohao Wang, Lisi Xie, Jie Li, Wenxi Li, Hao Tian,, and Yunlu Dai*(corresponding author), A triple-kill strategy for tumor eradication reinforced by metal-phenolic network nanopumps, Adv. Funct. Mater., 2022, 32, 2113168.
  • Hao Tian, Guohao Wang, Wei Sang, Lisi Xie, Zhan Zhang, Wenxi Li, Jie Yan, Ye Tian, Jie Li, Bei Li, Yunlu Dai*(Corresponding author). Manganese-phenolic nanoadjuvant combines sonodynamic therapy with cGAS-STING activation for enhanced cancer immunotherapy, Nano Today, 2022, 43, 101405.
  • Lisi Xie, Jie Li, Guohao Wang, Wei Sang, Mengze Xu, Wenxi Li, Jie Yan, Bei Li, Zhan Zhang, Qi Zhao, Zhen Yuan, Quli Fan, and Yunlu Dai*(corresponding author), Phototheranostic Metal-Phenolic Networks with Antiexosomal PD-L1 Enhanced Ferroptosis for Synergistic Immunotherapy, J. Am. Chem. Soc., 2022, 144, 787.
  • Jie Yan, Guohao Wang, Lisi Xie, Hao Tian, Jie Li, Bei Li, Wei Sang, Wenxi Li, Zhan Zhang, Yunlu Dai*(corresponding author), Engineering radiosensitizer-based metal-phenolic networks potentiate STING pathway activation for advanced radiotherapy, Adv. Mater., 2022, 34, 2105783.
  • Wenxi Li, Lisi Xie, Yi Ju, Zhan Zhang, Bei Li, Jie Li, Wei Sang, Guohao Wang, Hao Tian, Yunlu Dai*(corresponding author), A “three musketeers” tactic for inclining interferon-γ as a comrade-in-arm to reinforce the synergistic-tumoricidal therapy, Nano Res., 2022, 15, 3458.
  • Jie Li, Lisi Xie, Wei Sang, Guohao Wang, Hao Tian, Zhan, Zhang, Jianhua Liu, Quli Fan, Yunlu Dai*(corresponding author), NIR-II-absorbing conjugated polymer-based theranostic agent for NIR-II fluorescence imaging-guided photothermal therapy acting synergistically with tumor microenvironment-responsive nitric oxide therapy, ChemPhysMater, 2022, 1, 51.
  • Guohao Wang, Lisi Xie, Bei Li, Wei Sang, Jie Yan, Jie Li, Hao Tian, Wenxi Li, Zhan Zhang, Ye Tian, Yunlu Dai*(corresponding author), A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis, Nat. Commun., 2021, 12, 5733.
  • Zhan Zhang, Bei Li, Lisi Xie, Wei Sang, Hao Tian, Jie Li, Guohao Wang, Yunlu Dai*(corresponding author), Metal-Phenolic Network-Enabled Lactic Acid Consumption Reverses Immunosuppressive Tumor Microenvironment for Sonodynamic Therapy, ACS Nano., 2021, 15, 16934.
  • Jie Li, Wenxi Li, Lisi Xie, Wei Sang, Guohao Wang, Zhan Zhang, Bei Li, Hao Tian, Jie Yan, Ye Tian, Zhenhua Li, Quli Fan, Lin Yu, Yunlu Dai*(corresponding author), A metal–polyphenolic nanosystem with NIR-II fluorescence-guided combined photothermal therapy and radiotherapy, Chem. Commun., 2021, 57, 11473.
  • Jie Yan, Bei Li, Piaoping Yang*, Jun Lin*, Yunlu Dai*(corresponding author), Progress in Light-Responsive Lanthanide Nanoparticles towards Deep Tumor Theranostics, Adv. Funct. Mater., 2021, 31, 2104325.
  • Boshi Tian, Shikai Liu, Lili Feng, Shaohua Liu, Shili Gai, Yunlu Dai*(corresponding author), Lisi Xie, Bin Liu, Piaoping Yang*, Yanli Zhao*, Renal‐Clearable Nickel‐Doped Carbon Dots with Boosted Photothermal Conversion Efficiency for Multimodal Imaging‐Guided Cancer Therapy in the Second Near‐Infrared Biowindow, Adv. Funct. Mater., 2021, 31, 2100549.
  • Jie Li, Lisi Xie, Bei Li†, Chao Yin, Guohao Wang, Wei Sang, Wenxi Li, Hao Tian, Zhan Zhang, Xuanjun Zhang, Quli Fan*, Yunlu Dai*(corresponding author), Engineering a Hydrogen Sulfide-based Nanomodulator to Normalize Hyperactive Photothermal Immunogenicity for Combination Cancer Therapy, Adv. Mater., 2021, 33, 2008481.
  • Zhan Zhang, Lisi Xie, Yi Ju, Yunlu Dai*(corresponding author), Recent Advances in Metal-Phenolic Networks for Cancer Theranostics. Small, 2021, 17, 2100314.
  • Yuxin Guo, Qing Sun, Fu-Gen Wu*, Yunlu Dai*(corresponding author), Xiaoyuan Chen*, Polyphenol-Containing Nanomaterials: Synthesis, Properties, and Biomedical Applications. Adv. Mater., 2021, 33, 2007356.
  • Lisi Xie, Guohao Wang, Wei Sang, Jie Li, Zhan Zhang, Wenxi Li, Jie Yan, Qi Zhao, Yunlu Dai*(corresponding author), Phenolic immunogenic cell death nanoinducer for sensitizing tumor to PD-1 checkpoint blockade immunotherapy. Biomaterials, 2021, 269, 120638.
  • Zhan Zhang†, Wei Sang†, Lisi Xie†, Wenxi Li, Bei Li, Jie Li, Hao Tian, Zhen Yuan, Qi Zhao, and Yunlu Dai*(corresponding author), Polyphenol-based Nanomedicine Evokes Immune Activation for Combination Cancer Treatment. Angew. Chem. Int. Ed., 2021, 60, 1967.
  • Wei Sang, Lisi Xie, Guohao Wang, Jie Li, Zhan Zhang, Bei Li, Sen Guo, Chu-Xia Deng, Yunlu Dai*(corresponding author), Oxygen Enriched Metal-Phenolic X-Ray Nanoprocessor for Cancer Radio-Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy. Adv. Sci., 2021, 8, 2003338.
  • Liwen Zhang, Lisi Xie, Sihao Xu, Rhiannon P Kuchel, Yunlu Dai*(corresponding author), Kenward Jung*, Cyrille Boyer* Dual Role of Doxorubicin for Photopolymerization and Therapy. Biomacromolecules, 2020, 21, 3887.
  • Jingjing Wang, Wei Sang, Zhen Yang, Zheyu Shen, Zhantong Wang, Orit Jacobson, Yundai Chen, Yong Wang, Mingyan Shao, Gang Niu, Yunlu Dai*(corresponding author), and Xiaoyuan Chen* Polyphenol-based nanoplatform for MRI/PET dual-modality imaging guided effective combination chemotherapy. J. Mater. Chem. B, 2019, 7, 5688.
  • Zhan Zhang, Wei Sang, Lisi Xie, Yunlu Dai*(corresponding author), Metal-organic frameworks for multimodal bioimaging and synergistic cancer chemotherapy. Coordin. Chem. Rev. 2019, 399, 213022.
  • Wei Sang, Zhan Zhang, Yunlu Dai*(corresponding author), Xiaoyuan Chen* Recent Advances in Nanomaterials-based Synergistic Combination Cancer Immunotherapy. Chem. Soc. Rev., 2019, 48, 3771. (Back Cover Paper)
  • Zhimei He, Xiaolin Huang, Chen Wang, Xiangli Li, Yijing Liu, Zijian Zhou, Sheng Wang, Fuwu Zhang, Zhantong Wang, Orit Jacobson, Jun-Jie Zhu,* Guocan Yu,* Yunlu Dai*(corresponding author), Xiaoyuan Chen* A Catalase-Like Metal-Organic Framework Nanohybrid for O2-Evolving Synergistic Chemoradiotherapy, Angew. Chem. Int. Ed. 2019, 58, 8752.
  • Lingling Shan, Guizhen Gao, Weiwei Wang, Wei Tang, Zhantong Wang, Zhen Yang, Wenpei Fan, Guizhi Zhu, Kefeng Zhai, Orit Jacobson, Yunlu Dai*(corresponding author), Xiaoyuan Chen,* Self-assembled Green Tea Polyphenol-based Coordination Nanomaterials to Improve Chemotherapy Efficacy by Inhibition of Carbonyl Reductase 1. Biomaterials, 2019, 210, 62.
  • Yuan Liu, Christina S. Gong, Lisen Lin, Zijian Zhou, Yijing Liu, Zhen Yang, Zheyu Shen, Guocan Yu, Zhantong Wang, Sheng Wang, Ying Ma, Wenpei Fan, Liangcan He, Gang Niu, Yunlu Dai*(corresponding author), Xiaoyuan Chen* Core-shell metal-organic frameworks with fluorescence switch to trigger an enhanced photodynamic therapy. Theranostics 2019, 9, 2791.
  • Zhimei He†, Yunlu Dai†(co-first author), Xiangli Li, Dan Guo, Yijing Liu, Xiaolin Huang, Jingjing Jiang, Sheng Wang, Guizhi Zhu, Fuwu Zhang, Lisen Lin, Jun-Jie Zhu,* Guocan Yu,* Xiaoyuan Chen* Hybrid Nanomedicine Fabricated from Photosensitizer-Terminated Metal-Organic Framework Nanoparticles for Photodynamic Therapy and Hypoxia-Activated Cascade Chemotherapy. Small, 2019, 15, 1804131.
  • Zhen Yang, Yunlu Dai*(corresponding author), Lingling Shan, Zheyu Shen, Zhantong Wang, Bryant C Yung, Orit Jacobson, Yijing Liu, Wei Tang, Sheng Wang, Lisen Lin, Gang Niu, Pintong Huang*, Xiaoyuan Chen* Tumour microenvironment-responsive semiconducting polymer-based self-assembling nanotheranostics, Nanoscale Horiz., 2019, 4, 426.

Prior to University of Macau

  • Yunlu Dai, Zhen Yang, Siyuan Cheng, Zhongliang Wang,* Ruili Zhang, Guizhi Zhu, Zhantong Wang, Bryant C. Yung, Rui Tian, Orit Jacobson, Can Xu, Qianqian Ni, Jibin Song, Xiaolian Sun, Gang Niu, Xiaoyuan Chen,*. Toxic Reactive Oxygen Species Enhanced Synergistic Combination Therapy by Self-Assembled Metal-Phenolic Network Nanoparticles. Adv. Mater., 2018, 30, 1704877. (IF 27.398)
  • Yunlu Dai, Siyuan Cheng, Zhongliang Wang,* Ruili Zhang, Zhen Yang, Jingjing Wang, Bryant C. Yung, Zhantong Wang, Orit Jacobson, Can Xu, Qianqian Ni, Guocan Yu, Zijian Zhou, and Xiaoyuan Chen,* Hypochlorous Acid Promoted Platinum Drug Chemotherapy by Myeloperoxidase Encapsulated Therapeutic Metal Phenolic Nanoparticles. ACS Nano, 2018, 12, 455. (IF 14.588)
  • Zhen Yang,† Yunlu Dai†(co-first author), Chao Yin, Quli Fan,* Wansu Zhang, Guocan Yu, Wei Tang, Wenpei Fan, Jie Li, Xiang Li, Yufu Tang, Xiangchun Li, Jibin Song,* Wei Huang, Xiaoyuan Chen* Activatable Semiconducting Theranostics: Simultaneous Generation and Ratiometric Photoacoustic Imaging of Reactive Oxygen Species In Vivo Adv. Mater., 2018, 30, 1707509. (IF 27.398)
  • Yunlu Dai, Can Xu, Xiaolian Sun* and Xiaoyuan Chen*. Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment. Chem. Soc. Rev., 2017, 46, 3830-3852. (IF 42.846)
  • Yunlu Dai, Haihua Xiao, Jianhua Liu, Qinghai Yuan, Ping’an Ma, Dongmei Yang Chunxia Li, Zhiyao Hou, Ziyong Cheng, Piaoping Yang* and Jun Lin*. In Vivo Multimodal Imaging and Cancer Therapy by Near-Infrared Light Triggered Trans-platinum Pro-drug Conjugated Upconverison Nanoparticle. J. Am. Chem. Soc. 2013, 135, 18920-18929. (IF 14.612) (Hot paper)
  • Yunlu Dai, Ping’an Ma, Ziyong Cheng*, Xiaojiao Kang, Xiao Zhang, Zhiyao Hou, Chunxia Li, Dongmei Yang, Xuefeng Zhai, Jun Lin*. Up-Conversion Cell Imaging and pH-Induced Thermally Controlled Drug Release from NaYF4:Yb3+/Er3+@Hydrogel Core-Shell Hybrid Microspheres. ACS Nano 2012, 6, 3327-3338. (IF 14.588)
  • Huiting Bi†, Yunlu Dai†(co-first author), Piaoping Yang*, Jiating Xu, Dan Yang, Shili Gai, Fei He, Bin Liu, Chongna Zhong, and Jun Lin*. Glutathione Mediated Size-Tunable UCNPs-Pt(IV)-ZnFe2O4 Nanocomposite for Multiple Bioimaging Guided Synergetic Therapy. Small, 2018, 14, 1703809. (IF 11.459)
  • Zhantong Wang†, Yunlu Dai†(co-first author), Zhe Wang*, Orit Jacobson, Fuwu Zhang, Bryant C. Yung, Pengfei Zhang, Haiyan Gao, Gang Niu, Gang Liu,*, Xiaoyuan Chen,* Metal Ion Assisted Interface Re-engineering of Ferritin Protein Nanocage for Enhanced Biofunctions and Cancer Therapy. Nanoscale, 2018, 10, 1135. (IF 6.895)
  • Yunlu Dai, Cuimiao Zhang, Ziyong Cheng*, Ping’an Ma, Chunxia Li, Xiaojiao Kang, Dongmei Yang, Jun Lin*. pH-Responsive Drug Delivery System Based on Luminescent CaF2:Ce3+/Tb3+-Poly(acrylic acid) Hybrid Microspheres. Biomaterials 2012, 33, 2583-2592. (IF 10.317)
  • Yunlu Dai, Dongmei Yang, Ping’an Ma, Xiaojiao Kang, Xiao Zhang, Chunxia Li, Zhiyao Hou, Ziyong Cheng,* Jun Lin*. Doxorubicin Conjugated NaYF4:Yb3+/Tm3+ Nanoparticles for Therapy and Sensing of Drug Delivery by Luminescence Resonance Energy Transfer. Biomaterials 2012, 33, 8704-8713. (IF 10.317)
  • Yunlu Dai, Junling Guo, Ting‐Yi Wang, Yi Ju, Andrew J Mitchell, Thomas Bonnard, Jiwei Cui, Joseph J Richardson, Christoph E Hagemeyer, Karen Alt*, Frank Caruso*. Self‐Assembled Nanoparticles from Phenolic Derivatives for Cancer Therapy. Adv. Healthcare Mater. 2017, 6, 1700467. (IF 6.270)
  • Yunlu Dai, Huiting Bi, Xiaoran Deng, Chunxia Li,* Fei He, Piaoping Yang,* Jun Lin*. 808 nm near-infrared light controlled dual-drug release and cancer therapy in vivo by upconversion mesoporous silica nanostructures J. Mater. Chem. B, 2017, 5, 2086-2095 (IF 5.047) (Hot paper)
  • Huiting Bi, Yunlu Dai*(corresponding author), Jiating Xu, Ruichan Lv, Fei He, Shili Gai, Dan Yang, Piaoping Yang*. CuS–Pt (iv)–PEG–FA nanoparticles for targeted photothermal and chemotherapy. J. Mater. Chem. B, 2016, 4, 5938-5946. (IF 5.047)
  • Huiting Bi, Yunlu Dai*(corresponding author), Ruichan Lv, Chongna Zhong, Fei He, Shili Gai, Arif Gulzar, Guixin Yang, Piaoping Yang*. Doxorubicin-conjugated CuS nanoparticles for efficient synergistic therapy triggered by near-infrared light. Dalton Trans., 2016, 45, 5101. (IF 4.052)
  • Yunlu Dai, Xiaojiao Kang, Dongmei Yang, Xuejiao Li, Xiao Zhang, Chunxia Li, Zhiyao Hou, Ziyong Cheng, Ping’an Ma* and Jun Lin*. Platinum (IV) Pro-drug Conjugated NaYF4:Yb3+/Er3+ Nanoparticles for Targeted Drug Delivery and Up-conversion Cell Imaging. Adv. Healthcare Mater. 2013, 2, 562-567. (IF 6.270) (Cover Paper)
Research Grants
12/2021 – 12/2023 Science and Technology Development Fund of Macao SAR (FDCT 0103/2021/A)
06/2019 – 06/2022 Science and Technology Development Fund of Macao SAR (FDCT 0109/2018/A3)
10/2018 – 10/2021 Start-up Research Grant (SRG) of University of Macau (SRG2018-00130-FHS)
National Natural Science Foundation of China (NSFC 32222090)
National Natural Science Foundation of China (NSFC 32171318)
Shenzhen Science and Technology Innovation Commission, Shenzhen-Hong Kong-Macau
Science and Technology Plan C (No. SGDX20201103093600004)
  • The Excellent Young Scholars Fund, National Natural Science Foundation of China (NSFC) in 2022 (國家自然科學基金-優青)
  • The “Outstanding Academic Staff” awarded by the University of Macau Academic Award Scheme in 2020/2021
  • The “Best Teacher (Excellence in Research)” Award by the Faculty of Health Sciences in 2021
  • The Rising Star award of Chinese American Society of Nanomedicine in 2019
Professional Activities
Ad hoc reviewer:
Nature Communications. Science Advances, Advanced Materials, JACS, Angew. Chem., ACS Nano, Biomaterials, Journal of Controlled Release, Theranostics, Chinese Chemical Letters
Team members
Dr. Yunlu Dai, Principle InvestigatorDr. Lisi Xie, postdoc fellow
Cheok Kei SI, research assistant
Wei Sang, PhD candidate
Zhan Zhang, PhD candidate
Guohao Wang, PhD candidate
Wenxi Li, PhD candidate
Hao Tian, PhD candidate