2024-10-09T18:18:39+08:002020-02-13|
聯絡信息
職稱
澳門大學認知與腦科學研究中心主任, 教授
辦公室
(辦公室) E12-1047 /(實驗室) E12-1073a/3078/3080/4030
電話
(辦公室) +853 8822 4989 / (實驗室) +853 8822 9184
傳真
+853 8822 2314
電郵
zhenyuan@um.edu.mo
諮詢時間

星期一、三、四 10:00 – 12:00, 星期四、五 17:00 – 18:00

教學

HSCI3000 Neuroscience and Neurodegenerative Diseases
HSCI8119 Advanced Biomedical and Chemical Engineering

研究團隊
名稱 職稱 辦公室 電話 電郵
陳宇浩博士生 (實驗室代表)E12-1032+853 8822 2736yc27645@um.edu.mo
范榮愛研究助理E12-1032+853 8822 2736rongaifan@um.edu.mo
陳昕研究助理E12-1032+853 8822 2736xxinchen@um.edu.mo
李祺琦研究助理N21-G004keikeilei@um.edu.mo
華林博士生N21-G004
劉靜博士生
喬羊博士生
耿曉瑞博士生E12-3017+853 8822 2736
黃昱靜博士生E12-1034
韋憲圓博士生E12-1032+853 8822 2736
梁笑博士生
何毓文博士生
郭錦桐博士生E12-1034+853 8822 2948
王新新博士生E12-1032+853 8822 2736
張譽競博士生
藍思逸博士生E12-1032+853 8822 2736
梁嘉琪博士生
梁振達博士生
楊思嘉博士生
陳永童博士生
錢凡博士生
郭騏瑋博士生
游科博士生
張勝男博士生
Education
DEng Mechanical Engineering (Biomedical Direction), University of Science and Technology of China, Hefei, China (2002)
MEng Chinese Academic of Mechanical Sciences
BEng Henan University of Science and Technology
Positions
08/2021 – Present Professor, Faculty of Health Sciences, University of Macau
08/2017 – 08/2021 Associate Professor, Faculty of Health Sciences, University of Macau
08/2013 – 08/2017 Assistant Professor, Faculty of Health Sciences, University of Macau
Research Field: Molecular Imaging and Neuroimaging.
10/2012 – 06/2013 Clinical Assistant Professor, Department of Psychology/School of Communication, Arizona State University
Research Field: EEG-fMRI fusion
09/2007 – 10/2012 Research Assistant Professor, Biomedical Engineering Department, University of Florida.
Research Field: Biomedical Imaging and Biomedical Optics
01/2005 – 09/2007 Postdoctoral Research Associate, Biomedical Engineering Department, University of Florida, Gainesville, FL32611. Research Field: Biomedical Imaging and Signal Processing
03/2004 – 01/2005 Postdoctoral Research Fellow, Department of Physics, Clemson University, SC29634
Research Field: Biomedical Optical Imaging
03/2002 – 03/2004 Postdoctoral Research Scientist, Institute of High performance Computing, National University of Singapore, Singapore 117523. Research Field: BioMEMS and Biomaterials
Research Interests
Neurosciences and Neuroimaging

  • Neuroimaging
  • Brain Disorders and Brain Cognition
  • Hyperscanning
  • Optogenetics, Brain Intervention and Brain Modulation

Biomedical Optics and Optical Molecular Imaging

  • Diffuse Optical Tomography(DOT);
  • Functional Near Infrared Spectroscopy (fNIRS);
  • Photoacoustic Tomography/Photoacoustic Microscopy (PAT and PAM);
  • Optical Coherence Tomography(OCT);
  • Photothermal and Photodynamic Therapy;
  • Molecular Imaging and Cancer Nanomedicine;
Representative Publications
Neurophotonics and Neuroscience

  1. Hu, Z. S., Lam, K. F., and Yuan, Z. (2019) Effective connectivity of the fronto-parietal network during the tangram task in a natural environment. Neuroscience 422202-211
  2. Hu, Z. S., Zhang, J., Zhang, L. Y., Xiang, Y. T., and Yuan, Z. (2019) Linking brain activation to topological organization in the frontal lobe as a synergistic indicator to characterize the difference between various cognitive processes of executive functions. Neurophotonics 6(2), 025008
  3. Hu, Z. S., Lam, K. F., Xiang, Y. T., and Yuan, Z. (2019) Causal Cortical Network for Arithmetic Problem-Solving Represents Brain’s Planning Rather than Reasoning. International Journal Of Biological Sciences 15(6), 1148-1160
  4. Couto, T. A., Xu, S. Y., da Silva, P. A., Wu, C. G., Neergaard, K., Wang, M. Y., Zhang, J., Xiang, Y. T., and Yuan, Z. (2020) Effective Connectivity Study Guiding the Neuromodulation Intervention in Figurative Language Comprehension Using Optical Neuroimaging. Neural Plasticity 20208882207
  5. Xu, S. Y., Lu, F. M., Wang, M. Y., Hu, Z. S., Zhang, J., Chen, Z. Y., Armada-da-Silva, P. A. S., and Yuan, Z. (2020) Altered Functional Connectivity in the Motor and Prefrontal Cortex for Children With Down’s Syndrome: An fNIRS Study. Frontiers In Human Neuroscience 146
  6. Zhang, J., Meng, Y. X., Wu, C. G., Xiang, Y. T., and Yuan, Z. (2019) Non-speech and Speech Pitch Perception among Cantonese-speaking Children with Autism Spectrum Disorder: an ERP Study. Neuroscience Letters 703205-212
  7. Hu, Z. S., Zhang, J., Couto, T. A., Xu, S. Y., Luan, P., and Yuan, Z. (2018) Optical Mapping of Brain Activation and Connectivity in Occipitotemporal Cortex During Chinese Character Recognition. Brain Topography 31(6), 1014-1028
  8. Lin, X. H., Sai, L. Y., and Yuan, Z. (2018) Detecting Concealed Information with Fused Electroencephalography and Functional Near-infrared Spectroscopy. Neuroscience 386284-294
  9. Ieong, H. F. H., and Yuan, Z. (2018) Emotion recognition and its relation to prefrontal function and network in heroin plus nicotine dependence: a pilot study. Neurophotonics 5(2), 025011
  10. Wang, M. Y., Lu, F. M., Hu, Z. S., Zhang, J., and Yuan, Z. (2018) Optical mapping of prefrontal brain connectivity and activation during emotion anticipation. Behavioural Brain Research 350122-128
  11. Ieong, H. F. h., and Yuan, Z. (2018) Emotion Recognition and its Relation to Prefrontal Function and Network in Heroin Plus Nicotine Dependence: A Pilot and Translational Study. Biological Psychiatry 83(9), S449-S450
  12. Wang, M. Y., Zhang, J., Lu, F. M., Xiang, Y. T., and Yuan, Z. (2018) Neuroticism and conscientiousness respectively positively and negatively correlated with the network characteristic path length in dorsal lateral prefrontal cortex: A resting-state fNIRS study. Brain And Behavior 8(9), e01074
  13. Lin, X. H., Lei, V. L. C., Li, D. F., and Yuan, Z. (2018) Which is more costly in Chinese to English simultaneous interpreting, “pairing” or “transphrasing”? Evidence from an fNIRS neuroimaging study. Neurophotonics 5(2), 025010
  14. Zhang, J., Meng, Y. X., McBride, C., Fan, X. T., and Yuan, Z. (2018) Combining Behavioral and ERP Methodologies to Investigate the Differences Between McGurk Effects Demonstrated by Cantonese and Mandarin Speakers. Frontiers In Human Neuroscience 12181
  15. He, Y., Wang, M. Y., Li, D. F., and Yuan, Z. (2017) Optical mapping of brain activation during the English to Chinese and Chinese to English sight translation. Biomedical Optics Express 8(12), 5399-5411
  16. Zhang, Z. M., Wang, M. Y., Guo, X. W., Miao, X. C., Zhang, T., Gao, D., and Yuan, Z. (2017) Attentional avoidance of threats in obsessive compulsive disorder: An event related potential study. Behaviour Research and Therapy 9796-104
  17. Lu, F. M., Zhou, J. S., Wang, X. P., Xiang, Y. T., and Yuan, Z. (2017) Short-and long-range functional connectivity density alterations in adolescents with pure conduct disorder at resting-state. Neuroscience 35196-107
  18. Ieong, H., and Yuan, Z. (2017) Abnormal resting-state functional connectivity in the orbitofrontal cortex of heroin users and its relationship with anxiety: a pilot fNIRS study. Scientific Reports 7, 46522
  19. Liu, C. H. M., Xin, Yuan, Z., Song, L. P., Jing, B., Lu, H. Y., Tang, L. R., Fan, J. F., Walter, M., Liu, C. Z., Wang, L. H., and Wang, C. Y. (2017) Decreased Resting-State Activity in the Precuneus Is Associated With Depressive Episodes in Recurrent Depression. The Journal of clinical psychiatry 78(4), e372-e382
  20. Lu, F. M., Liu, C. H., Lu, S. L., Tang, L. R., Tie, C. L., Zhang, J., and Yuan, Z. (2017) Disrupted topology of frontostriatal circuits is linked to the severity of insomnia. Frontiers In Neuroscience 11, 214
  21. Zhang, Z. M., Wang, M., Miao, X. C., Li, Y. J., Hitchman, G., and Yuan, Z. (2017) Individuals with high obsessive-compulsive tendencies or undermined confidence rely more on external proxies to access their internal states. Journal of Behavior Therapy and Experimental Psychiatry 54, 263-269
  22. Zhang, J., Lin, X. H., Fu, G. Y., Sai, L. Y., Chen, H. F., Yang, J. B., Wang, M. W., Liu, Q., Yang, G., Zhang, J. R., and Yuan, Z. (2016) Mapping the small-world properties of brain networks in deception with functional near-infrared spectroscopy. Scientific Reports 6, 26730
  23. Yuan, Z. (2013) Fusion of fNIRS and fMRI data: identifying when and where hemodynamic signals are changing in human brains. Frontiers In Human Neuroscience 7, 676
  24. Yuan, Z. (2013) Spatiotemporal and time-frequency analysis of functional near infrared spectroscopy brain signals using independent component analysis. Journal Of Biomedical Optics 18 (10), 106011
  25. Yuan, Z. (2013) Combining independent component analysis and Granger causality to investigate brain network dynamics with fNIRS measurements. Biomedical Optics Express 4(11), 2629-2643

Optical Molecular Imaging

  1. Men, X. J., Wang, F., Chen, H. B., Liu, Y. B., Men, X. X., Yuan, Y., Zhang, Z., Gao, D. Y., Wu, C. F., and Yuan, Z. (2020) Ultrasmall Semiconducting Polymer Dots with Rapid Clearance for Second Near‐Infrared Photoacoustic Imaging and Photothermal Cancer Therapy. Advanced Functional Materials 1909673
  2. Wang, D., Xue, B., Ohulchanskyy, T. Y., Liu, Y., Yakovliev, A., Ziniuk, R., Xu, M. Z., Song, J., Qu, J. L., and Yuan, Z. (2020) Inhibiting tumor oxygen metabolism and simultaneously generating oxygen by intelligent upconversion nanotherapeutics for enhanced photodynamic therapy. Biomaterials 251, 120088
  3. Fan, X. x., Xu, M. z., Leung, E. L. H., Jun, C., Yuan, Z., and Liu, L. (2020) ROS-Responsive Berberine Polymeric Micelles Effectively Suppressed the Inflammation of Rheumatoid Arthritis by Targeting Mitochondria. Nano-Micro Letters 12 (1), 76
  4. Men, X. J., Chen, H. B., Sun, C., Liu, Y. B., Wang, R. B., Zhang, X. J., Wu, C. F., and Yuan, Z. (2020) Thermosensitive Polymer Dot Nanocomposites for Trimodal Computed Tomography/Photoacoustic/Fluorescence Imaging-Guided Synergistic Chemo-Photothermal Therapy. ACS Applied Materials & Interfaces 12 (46), 51174-51184
  5. Liu, Y. B., Xu, M. Z., Dai, Y. L., Zhao, Q., Zhu, L. P., Guan, X. W., Li, G., Yang, S. H., and Yuan, Z. (2020) NIR-II Dual-Modal Optical Coherence Tomography and Photoacoustic Imaging-Guided Dose-Control Cancer Chemotherapy. ACS Applied Polymer Materials 2 (5), 1964-1973
  6. Gao, D. Y., Zhang, B. Y., Liu, Y. B., Hu, D. H., Sheng, Z. H., Zhang, X. J., and Yuan, Z. (2019) Molecular Engineering of Near-Infrared Light-Responsive BODIPY-Based Nanoparticles with Enhanced Photothermal and Photoacoustic Efficiencies for Cancer Theranostics. Theranostics 9 (18), 5315-5331
  7. Wang, S. C., Sheng, Z. H., Yang, Z. G., Hu, D. H., Long, X. J., Feng, G., Liu, Y. B., Yuan, Z., Zhang, J. J., Zheng, H. R., and Zhang, X. J. (2019) Activatable Small-Molecule Photoacoustic Probes that Cross the Blood-Brain Barrier for Visualization of Copper(II) in Mice with Alzheimer’s Disease. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58 (36), 12415-12419
  8. Xu, H., Ohulchanskyy, T. Y., Yakovliev, A., Zinyuk, R., Song, J., Liu, L. W., Qu, J. L., and Yuan, Z. (2019) Nanoliposomes Co-Encapsulating CT Imaging Contrast Agent and Photosensitizer for Enhanced, Imaging Guided Photodynamic Therapy of Cancer. Theranostics 9 (5), 1323-1335
  9. Chang, K. W., Gao, D. Y., Qi, Q. F., Liu, Y. B., and Yuan, Z. (2019) Engineering biocompatible benzodithiophene-based polymer dots with tunable absorptions as high-efficiency theranostic agents for multiscale photoacoustic imaging-guided photothermal therapy. Biomaterials Science 7 (4), 1486-1492
  10. Chang, K. W., Liu, Y. B., Hu, D. H., Qi, Q. F., Gao, D. Y., Wang, Y. T., Li, D. L., Zhang, X. J., Zheng, H. R., Sheng, Z. H., and Yuan, Z. (2018) Highly Stable Conjugated Polymer Dots as Multifunctional Agents for Photoacoustic Imaging-Guided Photothermal Therapy. Acs Applied Materials & Interfaces 10 (8), 7012-7021
  11. Gao, D. Y., Ji, X., Wang, J. L., Wang, Y. T., Li, D. L., Liu, Y. B., Chang, K. W., Qu, J. L., Zheng, J., and Yuan, Z. (2018) Engineering a protein-based nanoplatform as an antibacterial agent for light activated dual-modal photothermal and photodynamic therapy of infection in both the NIR I and II windows. Journal Of Materials Chemistry B 6 (5), 732-739
  12. Gao, D. Y., Sheng, Z. H., Liu, Y. B., Hu, D. H., Zhang, J., Zhang, X. J., Zheng, H. R., and Yuan, Z. (2017) Protein-Modified CuS Nanotriangles: A Potential Multimodal Nanoplatform for In Vivo Tumor Photoacoustic/Magnetic Resonance Dual-Modal Imaging. Advanced Healthcare Materials 6 (1), 1601094
  13. Gao, D. Y., Zhang, P. F., Liu, Y. B., Sheng, Z. H., Chen, H. J., and Yuan, Z. (2018) Protein-modified conjugated polymer nanoparticles with strong near-infrared absorption: a novel nanoplatform to design multifunctional nanoprobes for dual-modal photoacoustic and fluorescence imaging. Nanoscale 10 (42), 19742-19748
  14. Zhang, J., Chen, H. B., Zhou, T., Wang, L. M., Gao, D. Y., Zhang, X. J., Liu, Y. B., Wu, C. F., and Yuan, Z. (2017) A PIID-DTBT based semi-conducting polymer dots with broad and strong optical absorption in the visible-light region: Highly effective contrast agents for multiscale and multi-spectral photoacoustic imaging. Nano Research 10 (1), 64-76
  15. Zhang, B. Y., Wang, F., Zhou, H., Gao, D. Y., Yuan, Z., Wu, C. F., and Zhang, X. J. (2019) Polymer Dots Compartmentalized in Liposomes as Photocatalyst for In Situ Hydrogen Therapy. Angewandte Chemie-International Edition 58 (9), 2744-2748
  16. Wang, S., Li, Z., Liu, Y., Feng, G., Zheng, J., Yuan, Z., and Zhang, X. (2018) Activatable photoacoustic and fluorescent probe of nitric oxide for cellular and in vivo imaging. SENSORS AND ACTUATORS B-CHEMICAL 267 403-411
  17. Zhang, D., Xu, H., Zhang, X. L., Liu, Y. B., Wu, M., Li, J., Yang, H. H., Liu, G., Liu, X. L., Liu, J. F., and Yuan, Z. (2018) Self-Quenched Metal-Organic Particles as Dual-Mode Therapeutic Agents for Photoacoustic Imaging-Guided Second Near-Infrared Window Photochemotherapy. Acs Applied Materials & Interfaces 10 (30), 25203-25212
  18. Sun, K., Yang, Y. K., Zhou, H., Yin, S. Y., Qin, W. P., Yu, J. B., Chiu, D., Yuan, Z., Zhang, X. J., and Wu, C. F. (2018) Ultrabright Polymer-Dot Transducer Enabled Wireless Glucose Monitoring via a Smartphone. Acs Nano 12 (6), 5176-5184
  19. Chang, K. W., Liu, Z. H., Fang, X. F., Chen, H. B., Men, X. J., Yuan, Y., Sun, K., Zhang, X. J., Yuan, Z., and Wu, C. F. (2017) Enhanced Phototherapy by Nanoparticle-Enzyme via Generation and Photolysis of Hydrogen Peroxide. Nano Letters 17 (7), 4323-4329
  20. Chen, H. B., Zhang, J., Chang, K. W., Men, X. J., Fang, X. F., Zhou, L. B., Li, D. L., Gao, D. Y., Yin, S. Y., Zhang, X. J., Yuan, Z., and Wu, C. F. (2017) Highly absorbing multispectral near-infrared polymer nanoparticles from one conjugated backbone for photoacoustic imaging and photothermal therapy. Biomaterials 144 42-52
  21. Sun, K., Tang, Y., Li, Q., Yin, S. Y., Qin, W. P., Yu, J. B., Chiu, D., Liu, Y. B., Yuan, Z., Zhang, X. J., and Wu, C. F. (2016) In vivo dynamic monitoring of small molecules with implantable polymer-dot transducer. Acs Nano 10 (7), 6769-6781

Biomedical Optics and Optical Imaging

  1. Liu, Y. B., Gao, D. Y., Xu, M. Z., and Yuan, Z. (2018) Multispectral photoacoustic imaging of cancer with broadband CuS nanoparticles covering both NIR-I and NIR-II biological windows. Journal Of Biophotonics e201800237
  2. Liu, Y. B., Zhang, L. Y., Li, S. S., Han, X. N., and Yuan, Z. (2018) Imaging molecular signatures for clinical detection of scleroderma in the hand by multispectral photoacoustic elastic tomography. Journal Of Biophotonics 11 (6), e201700267
  3. Zhang, J., Liu, J., Wang, L. M., Li, Z. Y., and Yuan, Z. (2017) Retroreflective-type Janus microspheres as a novel contrast agent for enhanced optical coherence tomography. Journal Of Biophotonics 10 (6-7), 878-886
  4. Liu, Y. B., Jiang, H. B., and Yuan, Z. (2016) Two schemes for quantitative photoacoustic tomography based on Monte Carlo simulation. Medical Physics 43 (7), 3987-3997
  5. Liu, Y. B., and Yuan, Z. (2016) Multi-spectral photoacoustic elasticity tomography. Biomedical Optics Express 7 (9), 3323-3334
  6. Zhang, J., Ge, W., and Yuan, Z. (2015) In vivo three-dimensional characterization of the adult zebrafish brain using a 1325 nm spectral-domain optical coherence tomography system with the 27 frame/s video rate. Biomedical Optics Express 6 (10), 3932-3940
  7. Yuan, Z., Zhang, J., Wang, X. D., and Li, C. Q. (2014) A systematic investigation of reflectance diffuse optical tomography using nonlinear reconstruction methods and continuous wave measurements. Biomedical Optics Express 5 (9), 3011-3022
  8. Yuan, Z., Zhang, Q., and Jiang, H. (2006) Simultaneous reconstruction of acoustic and optical properties of heterogeneous media by quantitative photoacoustic tomography. Optics Express 14 (15), 6749-6754
  9. Yuan, Z., and Jiang, H. (2012) A calibration-free, one-step method for quantitative photoacoustic tomography. Medical Physics 39 (11), 6895-6899
  10. Yuan, Z., Zhang, Q., Sobel, E., and Jiang, H. (2007) Three-dimensional diffuse optical tomography of osteoarthritis: initial results in the finger joints. Journal Of Biomedical Optics 12 (3), 034001
  11. Yuan, Z., Wang, Q., and Jiang, H. (2007) Reconstruction of optical absorption coefficient maps of heterogeneous media by photoacoustic tomography coupled with diffusion equation based regularized Newton method. Optics Express 15 (26), 18076-18081
  12. Yuan, Z., Zhang, Q., Sobel, E. S., and Jiang, H. (2008) Tomographic x-ray-guided three-dimensional diffuse optical tomography of osteoarthritis in the finger joints. J Biomed Opt 13 (4), 044006
  13. Yuan, Z., Hu, X. H., and Jiang, H. (2009) A higher order diffusion model for three-dimensional photon migration and image reconstruction in optical tomography. Physics In Medicine And Biology 54 (1), 65-88
  14. Yuan, Z., and Jiang, H. (2007) Three-dimensional finite-element-based photoacoustic tomography: reconstruction algorithm and simulations. Medical Physics 34 (2), 538-546
  15. Yuan, Z., and Jiang, H. (2009) Simultaneous recovery of tissue physiological and acoustic properties and the criteria for wavelength selection in multispectral photoacoustic tomography. Optics Letters 34 (11), 1714-1716
  16. Yuan, Z., and Jiang, H. (2009) Quantitative photoacoustic tomography. Philos Trans A Math Phys Eng Sci 367 (1900), 3043-3054
  17. Yuan, Z., Zhang, Q., Sobel, E., and Jiang, H. (2009) Comparison of diffusion approximation and higher order diffusion equations for optical tomography of osteoarthritis. Journal Of Biomedical Optics 14 (5), 054013
  18. Yuan, Z., Zhang, Q., Sobel, E. S., and Jiang, H. (2010) Image-guided optical spectroscopy in diagnosis of osteoarthritis: a clinical study. Biomedical Optics Express 1 (1), 74-86
  19. Yuan, Z., Zhang, Q., Sobel, E. S., and Jiang, H. (2010) High-resolution x-ray guided three-dimensional diffuse optical tomography of joint tissues in hand osteoarthritis: morphological and functional assessments. Medical Physics 37 (8), 4343-4354
  20. Yuan, Z., Wu, C., Zhao, H., and Jiang, H. (2005) Imaging of small nanoparticle-containing objects by finite-element-based photoacoustic tomography. Optics Letters 30 (22), 3054-3056
  21. Yuan, Z., and Jiang, H. (2006) Quantitative photoacoustic tomography: Recovery of optical absorption coefficient maps of heterogeneous media. Applied Physics Letters 88 (23),
Full publications list
Research Grants
Present Grants as Principal Investigator in UM (Over 15M MOP)
2021 – 2025 多模態腦功能影像引導的經顱磁刺激早期干預小兒唐氏綜合症，RMB 100,000→Science Foundation of Guangdong Province → 廣東省科學基金
2021 – 2023 Dual-modal optical coherence tomography and photoacoustic imaging-guided dose-control cancer chemotherapy in the second near-infrared window, MOP 560,000 →MYRG2020-00067-FHS → 澳門大學多年度研究資助
2020 – 2023 Dual-modal photoacoustic and ultrasound imaging-guided cancer phototherapy with bacteria as the multifunctional theranostics agent, MOP 1,200,000→ FDCT 0020/2019/AMJ→ 澳門科學技術發展基金研究資助
2019 – 2021 NIR-II light-responsive oxygen-independent hybrid nanoplatform for multiscale photoacoustic imaging-guided photothermal/photodynamic synergistic cancer therapy, MOP 750,000→ MYRG2019-00082-FHS → 澳門大學多年度研究資助
2018 – 2021 Photoacoustic Molecular Imaging and Functional Neuroimaging Guided Photodynamic Therapy of Brain Glioma, MOP 1,800,000→ FDCT 0011/2018/A1 → 澳門科學技術發展基金研究資助
2018 – 2021 Development of quantitative multispectral photoacoustic elastic tomography for clinical detection of early-stage scleroderma,  MOP 900,000→ MYRG2018-00081-FHS → 澳門大學多年度研究資助
2016 – 2019 Structural and functional in vivo imaging of the bone-implant systems by multiscale photoacoustic tomography-使用多尺度光聲斷層成像實現骨- 植入物系統的活體結構和功能成像, MOP 1,310,000→ MYRG2016-00110-FHS → 澳門大學多年度研究資助
2016 – 2019 Using fused EEG and fNIRS to Study the Efficacy of Physical Therapy on Cerebral Palsy -使用融合的腦電和近紅外光譜成像研究運動療法治療腦癱的效果 MOP 2,200,000 → FDCT 025/2015/A1 → 澳門科學技術發展基金研究資助
2016 – 2019 Using fused EEG and fNIRS to Study the Efficacy of Physical Therapy on Cerebral Palsy -使用融合的腦電和近紅外光譜成像研究運動療法治療腦癱的效果 MOP 700,000 → UM MRG →澳門大學多年度研究資助
2015 – 2018 Monitoring Responses to Neoadjuvant Chemotherapy in Breast
2014 – 2017 Photoacoustic Imaging of Binding Rate of Nanoparticles in Cancer Nanomedicine – 光聲成像癌症納米探針的結合率, MOP 500,000 →MYRG2014-00093-FHS → 澳門大學多年度研究資助
2015 – 2018 Development of Functional Multimodal Optical Imaging Techniques for Clinical Screening of Breast Cancer -基於乳腺癌臨床篩選的多功能光學成像技術的研究MOP 1,780,000 → FDCT 026/2014/A1→ 澳門科學技術發展基金研究資助
2015 – 2018 Development of Functional Multimodal Optical Imaging Techniques for Clinical Screening of Breast Cancer -基於乳腺癌臨床篩選的多功能光學成像技術的研究MOP 600,000 → UM MRG →澳門大學多年度研究資助
2013 – 2014 Identifying the Cortical Network Dynamics of Gambling Disorders in the Human Brains Using fNIRS Measurements-使用近紅外光譜測量識別人腦賭癮的神經網絡動力MOP 100,000 → UM SRG → 澳門大學新職員啟動研究資助
— Cancer Using Quantitative Photoacoustic Spectroscopy Imaging-使用定量的光聲 譜成像監測乳腺癌對新輔助化療的反應, MOP 2,000,000→MYRG2015-00036-FHS→ 澳門大學多年度研究資助
Patents
  1. Hybrid Photoacoustic Tomography (PAT) and Diffuse Optical Tomography (DOT): Methods and Algorithms, International Application No. PCT/US2008/055894.
  2. METHOD AND APPARATUS FOR TOMOGRAPHIC IMAGING OF ABSOLUTE OPTICAL ABSORPTION COEFFICIENT IN TURBID MEDIA USING COMBINED PHOTOACOUSTIC AND DIFFUSING LIGHT MEASUREMENTS (WO/2009/011934)
  3. 一種融合光聲顯微，螢光顯微和超聲成像於一體的多模態顯微成像系統。中國專利號201820951744.5。
Awards
2017 FHS Best Teacher Award in Research
2016 中國光學重大成果獎
Professional Activities
Editorial Board Members:

  • Associate Editor of BMC Medical Imaging
  • Associate Editor of Frontiers in Human Neuroscience
  • Editorial Member of Quantitative Imaging in Medicine and Surgery
  • Special issue Editor for Biomedical Research International
  • Special issue Editor for Journal of Innovative Optical Health Sciences
  • Special issue Editor for Frontiers in Human Neuroscience
  • Special issue Editor for Biomed Research International
  • Guess Associate Editor of Medical Physics

Society Membership:

  • Senior Member of SPIE
  • Senior Member of OSA
  • Senior Member of China Biomedical Engineering Society
  • Senior Member of China Biomedical Optics Society
  • Committee Members of China Biomedical Engineering Society
Others
Teaching Interests

  • Biomedical Optics
  • Neuroimaging
  • Introduction to Neurosciences
  • Introduction to Molecular Imaging; Optical Molecular Imaging
  • Introduction to Cognitive Neuroscience
  • Cellular and Molecular Neurobiology
  • Computational Neuroscience/Neuroengineering
  • Systems and Integrative Neuroscience
  • Philosophy of Mind
  • Neurohumanities, Arts and Society
  • Clinical Neuroscience
  • Cellular and Molecular Neuroscience