Contact Information

Course Outlines

HSCI3000 Neuroscience and Neurodegenerative Diseases

Advanced Biomedical and Chemical Engineering

Research Team
Mengze XUPhD Student (Lab Representative)
Cheng-Hang LIUVisiting FellowE12-3017+853 8822
Yubin LIUUM Macao Post-doctoral FellowE12-3017+853 8822
Bin XUEResearch AssistantE12-3017+853 8822
Dan WANGResearch AssistantE12-3017+853 8822
Chenggang WUResearch AssistantE12-3017+853 8822
Hanran LIResearch
Jing LIUPhD StudentE12-3017+853 8822 2736
Shiyang XUPhD StudentE12-3017+853 8822 2736
TANIA ALEXANDRA PINHO COUTOPhD StudentE12-3017+853 8822 2736
Xiaoju MENPhD StudentE12-3017+853 8822 2736
Miriam AKIOMAPhD StudentE12-3017+853 8822 2736
Yang QIAOPhD StudentE12-3017+853 8822 2736
PhDMechanical Engineering (Biomedical Direction), University of Sciences and Technology of China, Hefei, China (2002)
08/2017-presentAssociate Professor, Faculty of Health Sciences, University of Macau
08/2013-08/2017Assistant Professor, Faculty of Health Sciences, University of Macau
Research Field: Molecular Imaging and Neuroimaging.
10/2012-06/2013Clinical Assistant Professor, Department of Psychology/School of Communication, Arizona State University
Research Field: EEG-fMRI fusion
09/2007-10/2012Research Assistant Professor, Biomedical Engineering Department, University of Florida.
Research Field: Biomedical Imaging and Biomedical Optics
01/2005-09/2007Postdoctoral Research Associate, Biomedical Engineering Department, University of Florida, Gainesville, FL32611. Research Field: Biomedical Imaging and Signal Processing
03/2004-01/2005Postdoctoral Research Fellow, Department of Physics, Clemson University, SC29634
Research Field: Biomedical Optical Imaging
03/2002-03/2004Postdoctoral Research Scientist, Institute of High performance Computing, National University of Singapore, Singapore 117523. Research Field: BioMEMS and Biomaterials
Research Interests
Neurosciences and Neuroimaging

  • Neuroimaging
  • Brain Disorders and Brain Cognition
  • Hyperscanning
  • Optogenetics, Brain Intervention and Brain Modulation

Biomedical Optics and Optical Molecular Imaging

  • Diffuse Optical Tomography(DOT);
  • Functional Near Infrared Spectroscopy (fNIRS);
  • Photoacoustic Tomography/Photoacoustic Microscopy (PAT and PAM);
  • Optical Coherence Tomography(OCT);
  • Photothermal and Photodynamic Therapy;
  • Molecular Imaging and Cancer Nanomedicine;
Representative Publications
Neurophotonics and Neuroscience

  • Xu, S. Y., Lu, F. M., Wang, M. Y., Hu, Z. S., Zhang, J., Chen, Z. Y., Armada-da-Silva, P. A. S., and Yuan, Z. (2020) Altered Functional Connectivity in the Motor and Prefrontal Cortex for Children with Down’s Syndrome: An fNIRS Study. Front Hum Neurosci 14, 6
  • Wang, M. Y., Zhang, Z. M., Miao, X. C., Lin, X. H., and Yuan, Z. (2020) Electrophysiological Evidence of Attentional Avoidance in Sub-Clinical Individuals with Obsessive-Compulsive Symptoms. IEEE Access 8, 91020-91027
  • Ieong, H. F.-h., and Yuan, Z. (2019) Desynchronized Lower Alpha Rhythms Were Associated with Functional Ischemia in the Prefrontal Cortex in Heroin Patients after Protracted Abstinence: A Concurrent EEG-fNIRS Study. Biol Psychiat 85, S295-S296
  • Ieong, H. F. H., Gao, F., and Yuan, Z. (2019) Machine Learning: Assessing Neurovascular Signals in the Prefrontal Cortex with Non-Invasive Bimodal Electro-Optical Neuroimaging in Opiate Addiction. Sci Rep 9, 18262
  • Hu, Z. S., Zhang, J., Zhang, L. Y., Xiang, Y. T., and Yuan, Z. (2019) Linking Brain Activation to Topological Organization in the Frontal Lobe as a Synergistic Indicator to Characterize the Difference between Various Cognitive Processes of Executive Functions. Neurophotonics 6, 025008
  • Hu, Z. S., Lam, K. F., and Yuan, Z. (2019) Effective Connectivity of the Fronto-Parietal Network During the Tangram Task in a Natural Environment. Neuroscience 422, 202-211
  • Hu, Z. S., Lam, K. F., Xiang, Y. T., and Yuan, Z. (2019) Causal Cortical Network for Arithmetic Problem-Solving Represents Brain’s Planning Rather Than Reasoning. Int J Biol Sci 15, 1148-1160
  • Wang, M. Y., Zhang, J., Lu, F. M., Xiang, Y. T., and Yuan, Z. (2018) Neuroticism and Conscientiousness Respectively Positively and Negatively Correlated with the Network Characteristic Path Length in Dorsal Lateral Prefrontal Cortex: A Resting-State fNIRS Study. Brain Behav, e01074
  • Wang, M. Y., Lu, F. M., Hu, Z. S., Zhang, J., and Yuan, Z. (2018) Optical Mapping of Prefrontal Brain Connectivity and Activation During Emotion Anticipation. Behav Brain Res 350, 122-128
  • Ren, H. H., Wang, M. Y., He, Y., Du, Z. C., Zhang, J., and Yuan, Z. (2018) A Novel Phase Analysis Method for Examining fNIRS Neuroimaging Data Associated with Chinese/English Sight Translation. Behav Brain Res 361, 151-158
  • Lin, X. H., Sai, L. Y., and Yuan, Z. (2018) Detecting Concealed Information with Fused Electroencephalography and Functional near-Infrared Spectroscopy. Neuroscience 386, 284-294
  • Lin, X. H., Lei, V. L. C., Li, D. F., and Yuan, Z. (2018) Which Is More Costly in Chinese to English Simultaneous Interpreting, “Pairing” or “Transphrasing”? Evidence from an fNIRS Neuroimaging Study. Neurophotonics 5, 025010
  • Ieong, H. F. H., and Yuan, Z. (2018) Emotion Recognition and Its Relation to Prefrontal Function and Network in Heroin Plus Nicotine Dependence: A Pilot Study. Neurophotonics 5, 025011
  • Hu, Z. S., Zhang, J., Couto, T. A., Xu, S. Y., Luan, P., and Yuan, Z. (2018) Optical Mapping of Brain Activation and Connectivity in Occipitotemporal Cortex During Chinese Character Recognition. Brain Topogr 31, 1014-1028
  • Zhang, Z. M., Wang, M. Y., Guo, X. W., Miao, X. C., Zhang, T., Gao, D., and Yuan, Z. (2017) Attentional Avoidance of Threats in Obsessive Compulsive Disorder: An Event Related Potential Study. Behaviour Research and Therapy 97, 96-104
  • Zhang, Z. M., Wang, M., Miao, X. C., Li, Y. J., Hitchman, G., and Yuan, Z. (2017) Individuals with High Obsessive-Compulsive Tendencies or Undermined Confidence Rely More on External Proxies to Access Their Internal States. Journal of Behavior Therapy and Experimental Psychiatry 54, 263-269
  • Lu, F. M., Zhou, J. S., Wang, X. P., Xiang, Y. T., and Yuan, Z. (2017) Short-and Long-Range Functional Connectivity Density Alterations in Adolescents with Pure Conduct Disorder at Resting-State. Neuroscience 351, 96-107
  • Liu, C. H. M., Xin, Yuan, Z., Song, L. P., Jing, B., Lu, H. Y., Tang, L. R., Fan, J. F., Walter, M., Liu, C. Z., Wang, L. H., and Wang, C. Y. (2017) Decreased Resting-State Activity in the Precuneus Is Associated with Depressive Episodes in Recurrent Depression. The Journal of clinical psychiatry 78, E372-+
  • He, Y., Wang, M. Y., Li, D. F., and Yuan, Z. (2017) Optical Mapping of Brain Activation During the English to Chinese and Chinese to English Sight Translation. Biomed Opt Express 8, 5399-5411
  • Zhang, J., Li, Y. Y., Chen, H. F., Ding, J. R., and Yuan, Z. (2016) An Investigation of the Differences and Similarities between Generated Small-World Networks for Right-and Left-Hand Motor Imageries. Sci Rep-Uk 6, 36562
  • Liu, C. H., Liu, C. Z., Zhang, J. H., Yuan, Z., Tang, L. R., Tie, C. L., Fan, J., and Liu, Q. Q. (2016) Reduced Spontaneous Neuronal Activity in the Insular Cortex and Thalamus in Healthy Adults with Insomnia Symptoms. Brain Res 1648, 317-324
  • Yuan, Z. (2013) Combining Independent Component Analysis and Granger Causality to Investigate Brain Network Dynamics with fNIRS Measurements. Biomed Opt Express 4, 2629-2643
  • Yuan, Z. (2013) Fusion of fNIRS and fMRI Data: Identifying When and Where Hemodynamic Signals Are Changing in Human Brains. Front Hum Neurosci 7, 676

Optical Molecular Imaging

  • Wang, D., Xue, B., Ohulchanskyy, T. Y., Liu, Y., Yakovliev, A., Ziniuk, R., Xu, M. Z., Song, J., Qu, J. L., and Yuan, Z. (2020) Inhibiting Tumor Oxygen Metabolism and Simultaneously Generating Oxygen by Intelligent Upconversion Nanotherapeutics for Enhanced Photodynamic Therapy. Biomaterials 251, 120088
  • Men, X. J., Wang, F., Chen, H. B., Liu, Y. B., Men, X. X., Yuan, Y., Zhang, Z., Gao, D. Y., Wu, C. F., and Yuan, Z. (2020) Ultrasmall Semiconducting Polymer Dots with Rapid Clearance for Second near‐Infrared Photoacoustic Imaging and Photothermal Cancer Therapy. Adv Funct Mater, 1909673
  • Fan, X. x., Xu, M. z., Leung, E. L. H., Jun, C., Yuan, Z., and Liu, L. (2020) ROS-Responsive Berberine Polymeric Micelles Effectively Suppressed the Inflammation of Rheumatoid Arthritis by Targeting Mitochondria. Nano-Micro Lett 12, 76
  • Zhang, B. Y., Wang, F., Zhou, H., Gao, D. Y., Yuan, Z., Wu, C. F., and Zhang, X. J. (2019) Polymer Dots Compartmentalized in Liposomes as Photocatalyst for in Situ Hydrogen Therapy. Angew Chem Int Edit 58, 2744-2748
  • Xu, H., Ohulchanskyy, T. Y., Yakovliev, A., Zinyuk, R., Song, J., Liu, L. W., Qu, J. L., and Yuan, Z. (2019) Nanoliposomes Co-Encapsulating CT Imaging Contrast Agent and Photosensitizer for Enhanced, Imaging Guided Photodynamic Therapy of Cancer. Theranostics 9, 1323-1335
  • Wang, S. C., Sheng, Z. H., Yang, Z. G., Hu, D. H., Long, X. J., Feng, G., Liu, Y. B., Yuan, Z., Zhang, J. J., Zheng, H. R., and Zhang, X. J. (2019) Activatable Small-Molecule Photoacoustic Probes That Cross the Blood-Brain Barrier for Visualization of Copper(II) in Mice with Alzheimer’s Disease. Angew Chem Int Ed Engl 58, 12415-12419
  • Gao, D. Y., Zhang, B. Y., Liu, Y. B., Hu, D. H., Sheng, Z. H., Zhang, X. J., and Yuan, Z. (2019) Molecular Engineering of near-Infrared Light-Responsive BODIPY-Based Nanoparticles with Enhanced Photothermal and Photoacoustic Efficiencies for Cancer Theranostics. Theranostics 9, 5315-5331
  • Chang, K. W., Gao, D. Y., Qi, Q. F., Liu, Y. B., and Yuan, Z. (2019) Engineering Biocompatible Benzodithiophene-Based Polymer Dots with Tunable Absorptions as High-Efficiency Theranostic Agents for Multiscale Photoacoustic Imaging-Guided Photothermal Therapy. Biomater Sci-Uk 7, 1486-1492
  • Zhang, D., Xu, H., Zhang, X. L., Liu, Y. B., Wu, M., Li, J., Yang, H. H., Liu, G., Liu, X. L., Liu, J. F., and Yuan, Z. (2018) Self-Quenched Metal-Organic Particles as Dual-Mode Therapeutic Agents for Photoacoustic Imaging-Guided Second near-Infrared Window Photochemotherapy. Acs Appl Mater Inter 10, 25203-25212
  • Sun, K., Yang, Y. K., Zhou, H., Yin, S. Y., Qin, W. P., Yu, J. B., Chiu, D., Yuan, Z., Zhang, X. J., and Wu, C. F. (2018) Ultrabright Polymer-Dot Transducer Enabled Wireless Glucose Monitoring Via a Smartphone. Acs Nano 12, 5176-5184
  • Gao, D. Y., Zhang, P. F., Liu, Y. B., Sheng, Z. H., Chen, H. J., and Yuan, Z. (2018) Protein-Modified Conjugated Polymer Nanoparticles with Strong near-Infrared Absorption: A Novel Nanoplatform to Design Multifunctional Nanoprobes for Dual-Modal Photoacoustic and Fluorescence Imaging. Nanoscale 10, 19742-19748
  • Gao, D. Y., Ji, X., Wang, J. L., Wang, Y. T., Li, D. L., Liu, Y. B., Chang, K. W., Qu, J. L., Zheng, J., and Yuan, Z. (2018) Engineering a Protein-Based Nanoplatform as an Antibacterial Agent for Light Activated Dual-Modal Photothermal and Photodynamic Therapy of Infection in Both the NIR I and II Windows. J Mater Chem B 6, 732-739
  • Chang, K. W., Liu, Y. B., Hu, D. H., Qi, Q. F., Gao, D. Y., Wang, Y. T., Li, D. L., Zhang, X. J., Zheng, H. R., Sheng, Z. H., and Yuan, Z. (2018) Highly Stable Conjugated Polymer Dots as Multifunctional Agents for Photoacoustic Imaging-Guided Photothermal Therapy. Acs Appl Mater Inter 10, 7012-7021
  • Zhang, J., Chen, H. B., Zhou, T., Wang, L. M., Gao, D. Y., Zhang, X. J., Liu, Y. B., Wu, C. F., and Yuan, Z. (2017) A PIID-DTBT Based Semi-Conducting Polymer Dots with Broad and Strong Optical Absorption in the Visible-Light Region: Highly Effective Contrast Agents for Multiscale and Multi-Spectral Photoacoustic Imaging. Nano Res 10, 64-76
  • Gao, D. Y., Sheng, Z. H., Liu, Y. B., Hu, D. H., Zhang, J., Zhang, X. J., Zheng, H. R., and Yuan, Z. (2017) Protein-Modified CuS Nanotriangles: A Potential Multimodal Nanoplatform for in Vivo Tumor Photoacoustic/Magnetic Resonance Dual-Modal Imaging. Adv Healthc Mater 6
  • Chen, H. B., Zhang, J., Chang, K. W., Men, X. J., Fang, X. F., Zhou, L. B., Li, D. L., Gao, D. Y., Yin, S. Y., Zhang, X. J., Yuan, Z., and Wu, C. F. (2017) Highly Absorbing Multispectral near-Infrared Polymer Nanoparticles from One Conjugated Backbone for Photoacoustic Imaging and Photothermal Therapy. Biomaterials 144, 42-52
  • Chang, K. W., Liu, Z. H., Fang, X. F., Chen, H. B., Men, X. J., Yuan, Y., Sun, K., Zhang, X. J., Yuan, Z., and Wu, C. F. (2017) Enhanced Phototherapy by Nanoparticle-Enzyme Via Generation and Photolysis of Hydrogen Peroxide. Nano Lett 17, 4323-4329

Biomedical Optics and Optical Imaging

  • Liu, Y. B., Zhang, L. Y., Li, S. S., Han, X. N., and Yuan, Z. (2018) Imaging Molecular Signatures for Clinical Detection of Scleroderma in the Hand by Multispectral Photoacoustic Elastic Tomography. J Biophotonics 11, e201700267
  • Liu, Y. B., Gao, D. Y., Xu, M. Z., and Yuan, Z. (2018) Multispectral Photoacoustic Imaging of Cancer with Broadband CuS Nanoparticles Covering Both NIR-I and NIR-II Biological Windows. J Biophotonics, e201800237
  • Zhang, J., Liu, J., Wang, L. M., Li, Z. Y., and Yuan, Z. (2017) Retroreflective-Type Janus Microspheres as a Novel Contrast Agent for Enhanced Optical Coherence Tomography. J Biophotonics 10, 878-886
  • Liu, Y. B., and Yuan, Z. (2016) Multi-Spectral Photoacoustic Elasticity Tomography. Biomed Opt Express 7, 3323-3334
  • Liu, Y. B., Jiang, H. B., and Yuan, Z. (2016) Two Schemes for Quantitative Photoacoustic Tomography Based on Monte Carlo Simulation. Med Phys 43, 3987-3997
  • Zhang, J., Ge, W., and Yuan, Z. (2015) In Vivo Three-Dimensional Characterization of the Adult Zebrafish Brain Using a 1325 Nm Spectral-Domain Optical Coherence Tomography System with the 27 Frame/S Video Rate. Biomed Opt Express 6, 3932-3940
  • Yuan, Z., Zhang, J., Wang, X. D., and Li, C. Q. (2014) A Systematic Investigation of Reflectance Diffuse Optical Tomography Using Nonlinear Reconstruction Methods and Continuous Wave Measurements. Biomed Opt Express 5, 3011-3022
  • Yuan, Z., and Jiang, H. (2012) A Calibration-Free, One-Step Method for Quantitative Photoacoustic Tomography. Med Phys 39, 6895-6899
  • Yuan, Z., Zhang, Q., Sobel, E. S., and Jiang, H. (2010) High-Resolution X-Ray Guided Three-Dimensional Diffuse Optical Tomography of Joint Tissues in Hand Osteoarthritis: Morphological and Functional Assessments. Med Phys 37, 4343-4354
  • Yuan, Z., Zhang, Q., Sobel, E. S., and Jiang, H. (2010) Image-Guided Optical Spectroscopy in Diagnosis of Osteoarthritis: A Clinical Study. Biomed Opt Express 1, 74-86
  • Yuan, Z., and Jiang, H. (2009) Quantitative Photoacoustic Tomography. Philos Trans A Math Phys Eng Sci 367, 3043-3054
  • Yuan, Z., and Jiang, H. (2009) Simultaneous Recovery of Tissue Physiological and Acoustic Properties and the Criteria for Wavelength Selection in Multispectral Photoacoustic Tomography. Opt Lett 34, 1714-1716
  • Yuan, Z., Hu, X. H., and Jiang, H. (2009) A Higher Order Diffusion Model for Three-Dimensional Photon Migration and Image Reconstruction in Optical Tomography. Phys Med Biol 54, 65-88
  • Yuan, Z., Zhang, Q., Sobel, E. S., and Jiang, H. (2008) Tomographic X-Ray-Guided Three-Dimensional Diffuse Optical Tomography of Osteoarthritis in the Finger Joints. J Biomed Opt 13, 044006
  • Yuan, Z., Zhang, Q., Sobel, E., and Jiang, H. (2007) Three-Dimensional Diffuse Optical Tomography of Osteoarthritis: Initial Results in the Finger Joints. J Biomed Opt 12, 034001
  • Yuan, Z., Wang, Q., and Jiang, H. (2007) Reconstruction of Optical Absorption Coefficient Maps of Heterogeneous Media by Photoacoustic Tomography Coupled with Diffusion Equation Based Regularized Newton Method. Opt Express 15, 18076-18081
  • Yuan, Z., and Jiang, H. (2007) Three-Dimensional Finite-Element-Based Photoacoustic Tomography: Reconstruction Algorithm and Simulations. Med Phys 34, 538-546
  • Yuan, Z., Zhang, Q., and Jiang, H. (2006) Simultaneous Reconstruction of Acoustic and Optical Properties of Heterogeneous Media by Quantitative Photoacoustic Tomography. Opt Express 14, 6749-6754
  • Yuan, Z., and Jiang, H. (2006) Quantitative Photoacoustic Tomography: Recovery of Optical Absorption Coefficient Maps of Heterogeneous Media. Appl Phys Lett 88
  • Yuan, Z., Wu, C., Zhao, H., and Jiang, H. (2005) Imaging of Small Nanoparticle-Containing Objects by Finite-Element-Based Photoacoustic Tomography. Opt Lett 30, 3054-3056
Full publications list
Research Grants
2019-2021NIR-II light-responsive oxygen-independent hybrid nanoplatform for multiscale photoacoustic imaging-guided photothermal/photodynamic synergistic cancer therapy  MOP 900,000→ UM MYRG → 澳門大學多年度研究資助
2018-2021Photoacoustic Molecular Imaging and Functional Neuroimaging Guided Photodynamic Therapy of Brain Glioma MOP 1,800,000→ FDCT → 澳門科學技術發展基金研究資助
2019-2022Development of quantitative multispectral photoacoustic elastic tomography for clinical detection of early-stage scleroderma MOP 900,000→ UM MYRG → 澳門大學多年度研究資助
2016-2019Structural and functional in vivo imaging of the bone-implant systems by multiscale photoacoustic tomography-使用多尺度光聲斷層成像實現骨-植入物系統的活體結構和功能成像 MOP 1,310,000→ UM MYRG → 澳門大學多年度研究資助
2016-2019Using fused EEG and fNIRS to Study the Efficacy of Physical Therapy on Cerebral Palsy-使用融合的腦電和近紅外光譜成像研究運動療法治療腦癱的效果 MOP 2,200,000 → FDCT → 澳門科學技術發展基金研究資助
2015-2018Monitoring Responses to Neoadjuvant Chemotherapy in Breast Cancer Using Quantitative Photoacoustic Spectroscopy Imaging-使用定量的光聲譜成像監測乳腺癌對新輔助化療的反應 MOP 2,000,000→ UM MYRG → 澳門大學多年度研究資助
2015-2018Development of Functional Multimodal Optical Imaging Techniques for Clinical Screening of Breast Cancer-基於乳腺癌臨床篩選的多功能光學成像技術的研究 MOP 1,780,000 → FDCT → 澳門科學技術發展基金研究資助
2014-2017Photoacoustic Imaging of Binding Rate of Nanoparticles in Cancer Nanomedicine-光聲成像癌症納米探針的結合率 MOP 500,000 → UM MYRG → 澳門大學多年度研究資助
2015-2018Development of Functional Multimodal Optical Imaging Techniques for Clinical Screening of Breast Cancer-基於乳腺癌臨床篩選的多功能光學成像技術的研究 MOP 600,000 → UM MRG →澳門大學多年度研究資助
2013-2014Identifying the Cortical Network Dynamics of Gambling Disorders in the Human Brains Using fNIRS Measurements-使用近紅外光譜測量識別人腦賭癮的神經網絡動力 MOP 100,000 → UM SRG → 澳門大學新職員啟動研究資助
  1. Hybrid Photoacoustic Tomography (PAT) and Diffuse Optical Tomography (DOT): Methods and Algorithms, International Application No. PCT/US2008/055894.
  3. 一種融合光聲顯微,螢光顯微和超聲成像於一體的多模態顯微成像系統。中國專利號201820951744.5。
  • 2016年中國光學重大成果獎
  • 2017 FHS Best Teacher Award in Research
Professional Activities
Editorial Board Members:

  • Associate Editor of BMC Medical Imaging
  • Associate Editor of Frontiers in Human Neuroscience
  • Editorial Member of Quantitative Imaging in Medicine and Surgery
  • Special issue Editor for Biomedical Research International
  • Special issue Editor for Journal of Innovative Optical Health Sciences
  • Special issue Editor for Frontiers in Human Neuroscience
  • Special issue Editor for Biomed Research International
  • Guess Associate Editor of Medical Physics

Society Membership:

  • Senior Member of SPIE
  • Senior Member of OSA
  • Senior Member of China Biomedical Engineering Society
  • Senior Member of China Biomedical Optics Society
  • Committee Members of China Biomedical Engineering Society
Teaching Interests

  • Biomedical Optics
  • Neuroimaging
  • Introduction to Neurosciences
  • Introduction to Molecular Imaging; Optical Molecular Imaging
  • Introduction to Cognitive Neuroscience
  • Cellular and Molecular Neurobiology
  • Computational Neuroscience/Neuroengineering
  • Systems and Integrative Neuroscience
  • Philosophy of Mind
  • Neurohumanities, Arts and Society
  • Clinical Neuroscience
  • Cellular and Molecular Neuroscience