2024-11-20T11:38:31+08:002024-10-09|
Contact Information
Title
Assistant Professor
Office
(Office) E12-2012
Phone
(Office) +853 8822 9509
Email
edwinkong@um.edu.mo
Consultation Hours

Tue, Thu 11:00-12:00

Teaching
Research Team
Name Position Office Phone Email
Education
PhD The University of Hong Kong, Hong Kong, China, 2013
BSc The University of Hong Kong, Hong Kong, China, 2009
Position
10/2024 – Present Assistant Professor, Faculty of Health Sciences, University of Macau
08/2019 – 09/2024 Post-doctoral Fellow, Institute of Molecular Biology, Mainz, Germany
08/2015 – 07/2019 Post-doctoral Fellow, School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China
01/2014 – 07/2015 Post-doctoral Fellow, Max Planck Institute of Biochemistry, Munich, Germany
Research Interests
My laboratory uses the combination of high-throughput functional genomics and standard molecular biological approaches to study the following areas:

  1. Roles of dysregulated protein degradation in cancer
  2. Roles of ubiquitin ligase mutations in cancer
  3. Quality control of abnormal and unnecessary proteins
  4. Targeting specificity of different ubiquitin ligases and their potential use in anti-cancer PROTACs
Representative Publications
  1. Wong, C. M., Tang, H. M. V., Kong, K. Y. E., Wong, G. W. O., Qiu, H., Jin, D. Y., Hinnebusch, A. G. (2010). Yeast arginine methyltransferase Hmt1p regulates transcription elongation and termination by methylating Npl3p. Nucleic Acids Research, 38(7), 2217–2228.
  2. Kong, K. Y. E., Tang, H. M. V., Pan, K., Huang, Z., Lee, T. H. J., Hinnebusch, A. G., Jin, D. Y., Wong, C. M. (2014). Cotranscriptional recruitment of yeast TRAMP complex to intronic sequences promotes optimal pre-mRNA splicing. Nucleic Acids Research, 42(1), 643–660.
  3. Tang, H. M. V., Pan, K., Kong, K. Y. E., Hu, L., Chan, L. C., Siu, K. L., Sun, H., Wong, C. M., Jin, D. Y. (2015). Loss of APD1 in Yeast Confers Hydroxyurea Sensitivity Suppressed by Yap1p Transcription Factor. Scientific Reports, 5, 7897.
  4. Deng, J. J., Kong, K. Y. E., Gao, W. W., Tang, H. M. V., Chaudhary, V., Cheng, Y., Zhou, J., Chan, C. P., Wong, D. K. H., Yuen, M. F., Jin, D. Y. (2017). Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription. Biochimica et Biophysica Acta – Gene Regulatory Mechanisms, 1860(4), 491–501.
  5. Kong, K. Y. E.#, Hung, T. N. F., Man, P. H. M., Wong, T. N., Cheng, T., Jin, D. Y.# (2019). Post-transcriptional negative feedback regulation of proteostasis through the Dis3 ribonuclease and its disruption by polyQ-expanded Huntingtin. Nucleic Acids Research, 47(19), 10040–10058. (#: co-corresponding authors)
  6. Kong, K. Y. E., Coelho, J. P. L., Feige, M. J., Khmelinskii, A. (2021). Quality control of mislocalized and orphan proteins. Experimental Cell Research, 403(2), 112617.
  7. Kong, K. Y. E.*, Fischer, B.*, Meurer, M.*, Kats, I., Li, Z., Rühle, F., Barry, J. D., Kirrmaier, D., Chevyreva, V., San Luis, B. J., Costanzo, M., Huber, W., Andrews, B. J., Boone, C., Knop, M., Khmelinskii, A. (2021). Timer-based proteomic profiling of the ubiquitin-proteasome system reveals a substrate receptor of the GID ubiquitin ligase. Molecular Cell, 81(11), 2460–2476. (*: co-first authors)
  8. Kong, K. Y. E., Reinbold, C., Knop, M., Khmelinskii, A. (2023). Building yeast libraries to dissect terminal degrons with fluorescent timers. Methods in Enzymology, 686:297-319.
  9. Reinbold, C., Kong, K. Y. E., Kats, I., Khmelinskii, A., Knop, M. (2023). Multiplexed protein stability (MPS) profiling of terminal degrons using fluorescent timer libraries in Saccharomyces cerevisiae. Methods in Enzymology, 686:321-344.
  10. Kong, K. Y. E.*,#, Shankar, S.*, Rühle, F., Khmelinskii, A.# (2023). Orphan quality control by an SCF ubiquitin ligase directed to pervasive C-degrons. Nature Communications, 14(1):8363.  (*: co-first authors; #: co‑corresponding authors)
Awards
2012 Graduate Student Travel Scholarship, Tech Dragon Limited
2011 Ming K. Jeang Scholarship, The Society of Chinese Bioscientists in America
2009 University Postgraduate Fellowship, The University of Hong Kong
Research Grants
07/2017 – 12/2019 Principal Investigator for the project “Roles of the chromatin architectural protein CTCF in hepatitis B virus transcription” funded by Health and Medical Research Fund (HMRF), The Food and Health Bureau, Hong Kong, China.
Professional Activities
Journal reviewer:
Science Advances; Scientific Reports; PLOS ONE