2026-03-05T16:32:55+08:002026-03-04|
Contact Information
Title
Research Assistant Professor
Office
(Address) E12-3017
Lab
(Address) E12-2069
Email
yenengdai@um.edu.mo
Teaching
Education
PhD Nanjing University of Posts and Telecommunications
BEng Nantong University
Position
10/2024 – Present Research Assistant Professor, Faculty of Health Sciences, University of Macau
10/2022 – 10/2024 UM Macao Postdoctoral Fellowship, Faculty of Health Sciences, University of Macau
07/2022 – 10/2022 Postdoctoral Fellow, Faculty of Health Sciences, University of Macau
Research Interests
  1. Smart responsive delivery system and phototheranostic probes
  2. Antibody-drug conjugates (ADCs) and immune regulation
  3. Antibody-engineered cell immunotherapy
Representative Publications
  1. Dai Y, Wang J, Liu Y, Jiao G, Gu Y, Liu Y, Fu S, Fan X, Li J, Guo Z, Leung K, Zhu L*, Zhao Q*. Universal antibody-engineered lipid nanoparticles potentiate chemo-immunotherapy against triple-negative breast cancer by reprogramming tumor cell metabolism. Advanced Science, 2026, e18468.
  2. Dai Y, Guo Z, Leng D, Jiao G, Chen K, Fu M, Liu Y, Shen Q, Wang Q*, Zhu L*, Zhao Q*. Metal-Coordinated NIR-II Nanoadjuvants with Nanobody Conjugation for Potentiating Immunotherapy by Tumor Metabolism Reprogramming. Advanced Science, 2024, 11, 2404886.
  3. Dai Y, Zhu L, Li X, Zhang F, Chen K, Jiao G, Liu Y, Yang Z, Guo Z, Zhang B*, Shen Q*, Zhao Q*. A Biomimetic Cuproptosis Amplifier for Targeted NIR-II Fluorescence/Photoacoustic Imaging-guided Synergistic NIR-II Photothermal Immunotherapy. Biomaterials, 2024, 305, 122455.
  4. Dai Y, Leng D, Guo Z, Wang J, Gu Y, Peng Y, Zhu L*, Zhao Q*. NIR-II Excitation Self-assembly Nanomedicine for Targeted NIR-IIa Fluorescence Imaging-guided Cuproptosis-promoted Synergistic Therapy against Triple-negative Breast Cancer. Chemical Engineering Journal, 2024, 479, 147704.
  5. Dai Y, Li X, Xue Y, Chen K, Jiao G, Zhu L, Li M, Fan Q, Dai Y, Zhao Q*, Shen Q*. Self-delivery of Metal-coordinated NIR-II Nanoadjuvants for Multimodal Imaging-guided Photothermal-chemodynamic Amplified Immunotherapy. Acta Biomaterialia, 2023, 166, 496-511.
  6. Dai Y, Zhang F, Chen K, Sun Z, Wang Z, Xue Y, Li M, Fan Q, Shen Q*, Zhao Q*. An Activatable Phototheranostic Nanoplatform for Tumor Specific NIR-II Fluorescence Imaging and Synergistic NIR-II Photothermal-Chemodynamic Therapy. Small, 2023, 19, 2206053.
  7. Dai Y, Sun Z, Zhao H, Qi D, Li X, Gao D, Li M, Fan Q, Shen Q*, Huang W*. NIR-II Fluorescence Imaging Guided Tumor-specific NIR-II Photothermal Therapy Enhanced by Starvation Mediated Thermal Sensitization Strategy. Biomaterials, 2021, 275, 120935.
  8. Dai Y, Zhao H, He K, Du W, Kong Y, Wang Z, Li M, Shen Q*, Sun P*, Fan Q*. NIR-II Excitation Phototheranostic Nanomedicine for Fluorescence/Photoacoustic Tumor Imaging and Targeted Photothermal-Photonic Thermodynamic Therapy. Small, 2021, 17(42), 2102527.
  9. Dai Y, Du W, Gao D, Zhu H, Zhang F, Chen K, Ni H, Li M, Fan Q, Shen Q*. Near-infrared-II Light Excitation Thermosensitive Liposomes for Photoacoustic Imaging Guided and Enhanced Photothermal-Chemo Synergistic Tumor Therapy. Biomaterials Science, 2022, 10(2), 435-443.
  10. Zhu L, Leng D, Guo Z, Zhao Y, Leung K, Dai Y*, Li J*, Zhao Q*. Self-catalyzed nitric oxide nanocomplexes induce ferroptosis for cancer immunotherapy. Journal of Controlled Release, 2025, 377, 524-539.
  11. Yang Y, Dai Y*, Zhao Q*. Recent trends and applications of nanoparticle-based lateral flow immunoassays in infectious diseases detection. Microchemical Journal, 2025, 216, 114797.
  12. Li Y#, Dai Y#, Wang B#, Zhang N, Yan K, Chen H, Shi H, Chen H, Wang Q, Yan J, Wang X, Gao P, Ma G*, Hou Y*, Ding Q*, Zhao Q*. NIR imaging-guided carbon monoxide nanomedicine: Design strategies, stimuli-responsive release, and multimodal synergistic therapies for precision disease treatment. Materials Today Bio, 2026, 36, 102700.
  13. Wang Q#, Dai Y#, Xu J, Cai J, Niu X, Zhang L, Chen R, Shen Q*, Huang W, Fan Q*. All-in-One Phototheranostics: Single Laser Triggers NIR-II Fluorescence/Photoacoustic Imaging Guided Photothermal/Photodynamic/Chemo Combination Therapy. Advanced Functional Materials, 2019, 29(31), 1901480.
  14. Wang B#, Dai Y#, Kong Y, Du W, Ni H, Zhao H, Sun Z, Shen Q*, Li M*, Fan Q*. Tumor Microenvironment-Responsive Fe(III)-Porphyrin Nanotheranostics for Tumor Imaging and Targeted Chemodynamic-Photodynamic Therapy. ACS Applied Materials & Interfaces, 2020, 12(48), 53634-53645.
  15. Kong Y, Dai Y, Qi D, Du W, Ni H, Zhang F, Zhao H, Shen Q*, Li M*, Fan Q*. Injectable and Thermosensitive Liposomal Hydrogels for NIR-II Light-Triggered Photothermal-Chemo Therapy of Pancreatic Cancer. ACS Applied Bio Materials, 20214(10), 7595-7604.
  16. Huang S, Xing F, Dai Y, Zhang Z, Zhou G, Yang S, Liu Y, Yuan Z, Luo K, Ying T, Chu D*, Liu T*, Deng C*, Zhao Q*. Navigating Chimeric Antigen Receptor-engineered Natural Killer Cells as Drug Carriers via Three-dimensional Mapping of the Tumor Microenvironment. Journal of Controlled Release, 2023, 362, 524-535.
  17. Liu Y, Xiang C, Dai Y, Li C, Okeke M, Jiang T, Yang X, Assaraf Y, Miao K, Wang Y, Zhang Z, Zhang D*, Li Y*, Gong P*, Zhao Q*. Engineered apoptotic vesicle mimetics with tunable “Eat-Me” signaling precisely regulate tumor-associated macrophages for potentiating cancer immunotherapy. Acta Pharmaceutica Sinica B, 2025, https://doi.org/10.1016/j.apsb.2025.11.032.
Research Grants
Macau Science and Technology Development Fund (0065/2025/ITP1)
Patents
Awards
06/2023 Best Poster Award for 9th Macau Symposium on Biomedical Sciences 2023 (MSBS2023)
04/2023 The Second Prize for oral presentation of 7th Symposium on Biomedical Sciences for Students, Postdoctoral Fellows and Research Assistants 2023
12/2019 National scholarship for graduate students, China
Professional Activities
  • Young Editorial Board Member of VIEWJournal (IF: 8.5)
  • Youth Committee Member of Guangdong Society for Immunology
  • 11th Asian Biological Inorganic Chemistry Conference (AsBIC11), Guilin, 2024, China, Oral Lecture
  • Chinese Biomaterials Congress, Basic Research and Application Transformation, Shanghai, 2021, China, Invited Speaker
  • Reviewer for Journal of Nanobiotechnology, Biomaterials, Chemical Engineering Journal, Microchimica Acta