2024-10-10T17:24:57+08:002023-08-02|
Contact Information
Title
Research Assistant Professor
Office
(Office) N22-2027
Phone
(Office) +853 8822 4217
Email
changhuoxu@um.edu.mo
Consultation Hours

Tue, Thu 15:00–16:00

Teaching
Education
PhD The Hong Kong University of Science and Technology (Chemistry), China, 2019
MEng Zhejiang University (Chemical Engineering and Technology), China, 2016
BEng Tianjin University (Chemical Engineering and Technology), China, 2013
BEc Nankai University (Finance), China, 2013
Position
03/2023 – Present Research Assistant Professor, Faculty of Health Sciences, University of Macau
08/2021 – 01/2023 Postdoctoral Fellow, Department of Chemistry, The Hong Kong University of Science and Technology
09/2019 – 07/2021 Postdoctoral Fellow, Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology
Research Interests
  1. Tumor-microenvironment-responsive fluorescent probes with aggregation-induced emission (AIE) characteristics
  2. AIE luminogens for multiphoton bioimaging
Representative Publications
  1. Zhang, T.; Yang, X.; Ou, X.; Lee, M. M. S.; Zhang, J.; Xu, C.; Yu, X.; Gong, P.*; Lam, J. W. Y.; Zhang, P.*; Tang, B.Z.* “Tailoring the Amphiphilic Structure of Zwitterionic AIE Photosensitizers to Boost Antitumor Immunity” Advanced Materials 2023, 2303186.
  2. Shen, H.; Xu, C.*; Ye, R.; Liu, T.-M.; Zhang, J.; Kwok, R. T. K.; Lam, J. W. Y.; Guo, Z.; Sun, J.*; Tang, B. Z.* “Water-Soluble Aggregation-Induced Emission Luminogens with Near-Infrared Emission for Advanced Phototheranostics” Small Science 2023, 2300052.
  3. Yang, X.#; Xu, C.#; Zhang, X.; Li, P.; Sun, F.; Liu, X.; Wang, X.; Kwok, R. T. K.; Yang, J.*; Lam, J. W. Y.*; Liang, Y.; Tang, B. Z.* “Development of Sulfonamide‐Functionalized Charge‐Reversal AIE Photosensitizers for Precise Photodynamic Therapy in the Acidic Tumor Microenvironment” Advanced Functional Materials 2023, 2300746.
  4. Xu, C.#; Shen, H.#; Liu, T.-M.; Kwok, R. T. K.; Lam, J. W. Y.*; Tang, B. Z.* “Restriction of Molecular Motion to a Higher Level: Towards Bright AIE Dots for Biomedical Applications” iScience 2023, 26, 106568.
  5. He, X.; Xie, H.; Hu, L.; Liu, P.; Xu, C.; He, W.; Zhang, S.; Xing, H.; Liu, X.; Cheung, T. S.; Li, M. -H.; Kwok, R. T. K.; Lam, J. W. Y.; Lu, J.*; Tang, B. Z.* “A Versatile AIE Fluorogen with Selective Reactivity to Primary Amines for Monitoring Amination, Protein Labeling and Mitochondrial Staining” Aggregate, 2023,4, e239.
  6. Xu, C.#; Zou, H.#; Hu, L.; Shen, H.; Sung, H. H.; Feng, H.; Kwok, R. T. K.; Lam, J. W. Y.*; Zheng, L.*; Tang, B. Z.* “A Photoactivatable AIEgen for Selective Imaging and Killing of Estrogen Receptor-Positive Cells” ACS Materials Letters, 2022, 4,1831-1839.
  7. Xu, C.; Ye, R.; Shen, H.; Zhao, Z.*; Tang, B. Z.* “Molecular Motion and Nonradiative Decay: towards Efficient Photothermal and Photoacoustic Systems” Angewandte Chemie International Edition, 2022, 134, e202204604. (ESI Highly Cited Paper)
  8. Xu, C.; Peng, C.*; Yang, X.; Zhang, R.; Zhao, Z.*; Yan, B.; Zhang, J.; Gong, J.; He, X.; Kwok, R. T. K.; Lam, J. W. Y.; Tang, B. Z.* “One-Pot Synthesis of Customized Metal-Phenolic-Network-Coated AIE Dots for In Vivo Bioimaging” Advanced Science, 2022, 9, 2104997.
  9. Zhang, T; Zhang, J.; Wang, F.-B; Cao, H.; Zhu, D.; Chen, X.; Xu, C.; Yang, X.; Huang, W.; Wang, Z.; Wang, J.; He, Z.; Zheng, Z.*; Lam, J. W. Y.*; Tang, B. Z.* “Mitochondria-Targeting Phototheranostics by Aggregation-Induced NIR-II Emission Luminogens: Modulating Intramolecular Motion by Electron Acceptor Engineering for Multi-Modal Synergistic Therapy” Advanced Functional Materials, 2022, 2110526.
  10. Shen, H.; Xu, C.; Sun, F.; Zhao, M.; Wu, Q.; Zhang, J.; Li, S.; Zhang, J.*; Lam, J. W. Y.*; Tang, B. Z.* “Metal-Based Aggregation-Induced Emission Theranostic Systems” ChemMedChem, 2022, e202100578.
  11. Shen, H.; Sun, F.; Zhu, X.; Zhang, J.; Ou, X.; Zhang, J.; Xu, C.; Sung, H. H. Y.; Williams, I. D.; Chen, S.; Kwok, R. T. K.; Lam, J. W. Y.; Sun, J.; Zhang, F.*; Tang, B. Z.* “Rational Design of NIR-II AIEgens with Ultrahigh Quantum Yields for Photo- and Chemiluminescence Imaging” Journal of The American Chemical Society, 2022, 144, 15391. (ESI Hot Paper and Highly Cited Paper)
  12. Sun, F.; Zhao, W.; Shen, H.; Fan, N.; Zhang, J.; Liu, Q.; Xu, C.; Luo, J.; Zhao, M.; Chen, Y.; Lam, K. W. K.; Yang, X.; Kwok, R. T. K.; Lam, J. W. Y.; Zhang, H.*; Tang, B. Z.* “Design of Smart Aggregates: towards Rapid Clinical Diagnosis of Hyperlipidemia in Human Blood” Advanced Materials, 2022, 2207671.
  13. Zhou, Q.; Huang, J.; Hao, L.; Geng, Y.; Xu, C.; Zhou, Z.; Tang, J.; Zhou, R.*; Shen, Y.* “Hydrophobicity Effects of γ-Glutamyl Transpeptidase Responsive Polymers on the Catalytic Activity and Transcytosis Efficacy” Bioconjugate Chemistry, 2022, 33, 2132-2142.
  14. Xu, C.#; Zou, H.#; Zhao, Z.; Zheng, Z.*; Kwok, R. T. K.; Lam, J. W. Y.; Sung, H. H. Y.; Williams, I. D.; Chen, S.; Zheng, L.*; Tang, B. Z.* “Turning on Light Emission of a Dark Pro‐Aggregation‐Induced Emission Luminogen in Aqueous Media Through Reductase‐Modulated Derotation” Advanced NanoBiomed Research 2021, 1, 2000080. (Top Cited Article 2021-2022, Wiley)
  15. Xu, C.#; Zou, H.#; Zhao, Z.; Zhang, P.; Kwok, R. T. K.; Lam, J. W. Y.; Sung, H. H. Y.; Williams, I. D.; Tang, B. Z.* “A New Strategy toward “Simple” Water-Soluble AIE Probes for Hypoxia Detection” Advanced Functional Materials 2019, 29, 1903278.  (Top Downloaded Paper 2018-2019, Wiley)
  16. Zhou, Q.; Shao, S.; Wang, J.; Xu, C.; Xiang, J.; Piao, Y.; Zhou, Z.; Yu, Q.; Tang, J.; Liu, X.; Gan, Z.; Mo, R.; Gu, Z. *; Shen, Y.* “Enzyme-Activatable Polymer-Drug Conjugate Augments Tumour Penetration and Treatment Efficacy” Nature Nanotechnology 2019, 14, 799. (ESI Highly Cited Paper)
  17. Xu, C.; Zhou, Q.; Zhu, D.; Qiu, N.; Shao, S.; Liu, X.; Shen, Y.* “Esterase-activated Self-Immolative Polymeric Vector Based on Menschutkin Reaction for Gene Delivery” Acta Polymerica Sinica 2017, 6, 937.
Patents
  1. Shen, Y.; Zhou, Q.; Xu, C.; Xiang, J. “Polymer with catalytically hydrolyzed gamma-glutamyltranspeptidase to induce overturning of charges and application thereof in drug delivery field” Chinese Patent CN109593158B, 2021-02-26. (The patent has been assigned to Hainan Poly Pharm. Co., Ltd. to jointly apply for FDA approval of clinical trial)
  2. Tang, B. Z.; Xu, C.; Zou, H. “Biological probe and applications thereof” Chinese Patent CN111443066B, 2023-02-10.