2024-10-10T17:23:03+08:002018-01-20|
Contact Information
Title
Associate Dean (Teaching), Chair Professor
Office
(Office) E12-4037 / (Lab) E12-3078
Phone
(Office) +853 8822 4984 / (Lab) +853 8822 9132
Fax
+853 8822 2314
Email
hmshen@um.edu.mo
Consultation Hours

Mon, Wed 10:00 – 11:00

Teaching

HSCI8003 Research Ethics
HSCI8006 Advanced Molecular Cell Biology

Research Team
Name Position Office Phone Email
Leng Kuan CHEONGResearch Assistant (Lab Representative)E12-3038+853 8822 2079charliecheong@um.edu.mo
Zhiwei XUUM Macao Post-doctoral FellowE12-3038+853 8822 2079zhiweixu@um.edu.mo
Mingzhu TANGPhD StudentE12-3038+853 8822 2079
Dade RONGPhD StudentE12-3038+853 8822 2079
Yiguan CHENPhD StudentE12-3038+853 8822 2079
Xiangzheng GAOPhD StudentE12-3038+853 8822 2079
Liangliang GAOPhD StudentE12-3038+853 8822 2079
Yuan GAOPhD Student
Haimei TANGPhD Student
Yichi ZHANGPhD Student
Liming XIEPhD Student
He ZHANGPhD Student
Hanyi HEPhD Student
Zhenqi YUPhD Student
Yuheng QINPhD Student
Xiaoli SUNPhD Student
Education
PhD National University of Singapore (1996)
MMed Zhejiang Medical University, China (1988)
BMed Zhejiang Medical University, China (1985)
Positions
07/2023 – Present Associate Dean (Teaching), Faculty of Health Sciences, University of Macau
01/2020 – Present Chair Professor, Faculty of Health Sciences, University of Macau
07/2016 – 12/2019 Professor (tenured), Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore
07/2007 – 06/2016 Associate Professor (tenured), Department of Physiology/EPH, Yong Loo Lin School of Medicine, National University of Singapore
12/2002 – 06/2007 Assist Professor, Dept. of COFM, Yong Loo Lin School of Medicine, National University of Singapore
04/2002 – 07/2003 Exchange Scientist, National Cancer Institute (NCI), NIH, USA
02/2001 – 11/2002 Research Fellow, Dept. of COFM, Faculty of Medicine, National University of Singapore
01/1996 – 01/2001 Postdoc Research Fellow, Dept. of COFM, Faculty of Medicine, National University of Singapore
Research Interests
  1. Autophagy and lysosome in cancer cell biology
  2. Mitophagy: novel mechanisms and biological importance in health and disease
  3. Cancer metabolism and targeted therapy
Representative Publications
Recent representative publications (all as corresponding author):

  1. Wang L, Qi H, Tang YC, Shen HM*. Post-Translational Modifications of Key Machinery in Control of Mitophagy. Trend in Biochem Sci 2019 Oct 9. pii: S0968-0004(19)30178-1.
  2. Lu G, Yi J, Gubas A, Wang YT, Wu Y, Ren Y, Wu M, Shi Y, Ouyang C, Tan HWS, Wang T, Wang L, Yang N, Deng S, Xia D, Chen RY, Tooze SA, Shen HM*. Suppression of autophagy during mitosis via CRL4s-mediated WIPI2 polyubiquitination and proteasomal degradation. Autophagy 2019 Mar 22:1-18.
  3. Zhang J, Wang J, Zhou Z, Park JE, Wang L, Wu S, Sun X, Lu L, Wang T, Lin Q, Sze SK, Huang D, Shen HM*. Importance of TFEB acetylation in control of its transcriptional activity and lysosomal function in response to histone deacetylase inhibitors. Autophagy. 2018;14(6):1043-1059.
  4. Wang L, Cho YL, Tang Y, Wang J, Park JE, Wu Y, Wang C, Tong Y, Chawla R, Zhang J, Shi Y, Deng S, Lu G, Wu Y, Tan HW, Pawijit P, Lim GG, Chan HY, Zhang J, Fang L, Yu H, Liou YC, Karthik M, Bay BH, Lim KL, Sze SK, Yap CT, Shen HM*. PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy. Cell Res. 2018 Aug;28(8):787-802. doi: 10.1038/s41422-018-0056-0 (cover story)
  5. Wang JG#*, Zhang JB#, Shi Y#, Xu CC#, Zhang CJ, Wong YK, Lee YM, Krishna S, He YK, Lim TK, Liu B, Hua ZC, Shen HM*, Lin QS*. Mechanistic Investigation of the Specific Anticancer Property of Artemisinin and Its Combination with Aminolevulinic Acid for Enhanced Anti-colorectal Cancer Activity. ACS Central Sciences (cover story), 2017, Jul 26;3(7):743-750.
  6. Wong YK, Zhang JB, Hua ZC, Lin QS, Shen HM*, Wang JG*. Recent Advances in Quantitative and Chemical Protoemics for Autophagy Studies (review). Autophagy. 2017, Sep 2;13(9):1472-1486
  7. Wang J, Zhang J, Lee YM, Ng S, Shi Y, Hua ZC, Lin Q, Shen HM*. Nonradioactive quantification of autophagic protein degradation with L-azidohomoalanine labeling. Nat Protoc. 2017; 12(2):279-288.
  8. Wang J, Zhang J, Lee YM, Koh PL, Ng S, Bao F, Lin Q, Shen HM*. Quantitative chemical proteomics profiling of de novo protein synthesis during starvation-mediated autophagy. Autophagy. 2016 Oct 2;12(10):1931-1944.
  9. Shi Y, Tan SH, Ng S, Zhou J, Yang ND, McMahon KA, del Pozo MA, Hill MA, Parton RG, Kim YS, Shen HM*. Caveolin-1 and lipid rafts play a critical role in determining cell stress responses in human breast cancer cells via modulation of autophagy and lysosomal function. Autophagy 2015;11(5):769-784.
  10. Zhang J, Ng S, Wang J, Tan SH, Zhou J, Yang N, Lin Q, Xia D, Shen HM*. Histone deacetylase inhibitors induce autophagy through FoxO1-dependent pathways. Autophagy 2015 Apr 3;11(4):629-42
  11. Yang ND, Tan SH, Ng S, Shi Y, Zhou J, Tan KS, Wong WS, Shen HM*. Artesunate induces cell death in human cancer cells via enhancing lysosomal function and lysosomal degradation of ferritin. J Biol Chem. 2014 Oct 10. pii:jbc.M114.564567. [Epub ahead of print] PubMed PMID: 25305013.
  12. Zhang J, Wang J, Ng S, Lin Q, Shen HM*. Development of a novel method for quantification of autophagic protein degradation by AHA labeling. Autophagy. 2014 May;10(5):901-12. PubMed PMID: 24675368
  13. Tan SH, Shui G, Zhou J, Shi Y, Huang J, Xia D, Wenk MR, Shen HM*. Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway. Autophagy. 2014 Feb;10(2):226-42
  14. Shen HM*, Mizushima N. At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy. Trends Biochem Sci. 2014 Feb;39(2):61-71.
  15. Zhou J, Tan SH, Codogno P, Shen HM*. Dual suppressive effect of MTORC1 on autophagy: tame the dragon by shackling both the head and the tail. Autophagy. 2013 May;9(5):803-5.
  16. Zhou J, Tan SH, Nicolas V, Bauvy C, Yang ND, Zhang J, Xue Y, Codogno P, Shen HM*. Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion. Cell Res. 2013 Apr;23(4):508-23.
  17. Shen HM*, Codogno P. Cross talks between autophagy and necrotic cell death. Exp Cell Res (invited review), 2012, 318 (11): 1304-1308.
  18. Tan SH, Shui GH, Zhou J, Wenk MR*, Shen HM*. Induction of autophagy by palmitic acid via protein kinase C-mediated signaling pathway independent of mTOR (mammalian target of rapamycin). J Biol Chem 2012, 287 (18):14364-14376.
  19. Zhou J, Hu SE, Tan SH, Cao R, Chen Y, Xia DJ, Zhu XQ, Yang XF, Ong CN, Shen HM*. Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells. Autophagy 2012, 8:338-349.
  20. Ng SK, Chen B, Wu YT, Zhou J, Shen HM*. Constitutive mTOR activation suppresses autophagy and sensitizes TSC2-null cells to cell death. Autophagy 2011, Oct 1; 7(10):1173-86.
  21. Wu YT, Ouyang W, Lazorchak AS, Liu D, Shen HM*, Su B. mTOR Complex 2 Targets Akt for Proteasomal Degradation via Phosphorylation at the Hydrophobic Motif. J Biol Chem. 2011, 286:14190-14198.
  22. Wu YT, Tan HL, Huang Q, Ong CN, Shen HM*. ZVAD-induced necroptosis in L929 cells depends on autocrine production of TNF? mediated by the PKC-MAPKs-AP-1 pathway. Cell Death and Differentiation 2011, 18:26-37.
  23. Shen HM*, P Codogno. Autophagic cell death: Loch Ness monster or endangered species? (review) Autophagy, 2011, 7:457-465.
  24. Wu YT, Tan HL, Shi GH, Bauvy C, Huang Q, Wenk MR, Ong CN, Codogno P, Shen HM*. Dual role of 3-methyladenine on modulation of autophagy via different temporal patterns on Class I and III PI3K. J Biol Chem 2010,  285:10850-10861, (this article was featured in Faulty of 1000 Biology (http://f1000biology.com/article/id/3091959/evaluation)
  25. Wu YT, Tan HL, Huang Q, Kim YS, Pan N, Ong WY, Liu ZG, Ong CN, Shen HM*. Autophagy plays a protective role during zVAD-induced necrotic cell death. Autophagy 2008, 4:457-466. This article was accompanied by a Commentary from the Associate Editor published together in the same issue White E. Autophagic cell death unraveled: Pharmacological inhibition of apoptosis and autophagy enables necrosis. Autophagy. 2008 May 16;4(4):399-401. Epub 2008 Mar 13.
  26. Wu YT, Zhang SY, Kim YS, Tan HL, Whiteman M, Ong CN, Liu ZG, Ichijo H, Shen HM*. Signaling Pathways from Membrane Lipid Rafts to JNK1 Activation in Reactive Nitrogen Species-Induced Non-Apoptotic Cell Death. Cell Death Differ 2008, 15:386-397.
  27. Zhang, S.Y.; Lin Y; Kim, Y.,S.; Liu, Z.,G.; Ong, C.N.; Shen, HM*. c-Jun N-terminal Kinase Mediates Hydrogen Peroxide-Induced Cell Death via Sustained Poly(ADP-ribose) Activation. Cell Death Differ 2007, 14:1001-1010.
  28. Shen, HM*; Liu, Z.G. JNK Signaling Pathway is a Key Modulator in Cell Death Mediated by Reactive Oxygen and Nitrogen Species (review). Free Radic. Biol. Med. 2006, 40:928-939.
  29. Shi, R. X.; Ong, C. N.; Shen, HM*. Protein kinase C inhibition and x-linked inhibitor of apoptosis protein degradation contribute to the sensitization effect of luteolin on tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cancer cells. Cancer Res. 2005, 65:7815-7823;.
  30. Shi, R. X.; Ong, C. N.; Shen, HM* Luteolin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells. Oncogene. 2004, 23:7712-7721.
Full publications list
Awards
2019 Yong Loo Lin School of Medicine Researcher of the Year Award-AY2017/2018
2019 NUSMedicine Graduate Mentor of The Year (GRAMAY) Award 2019
2019 Swee Liew-Wadsworth Research Award-Gold, Department of Physiology, NUS
2018 Swee Liew-Wadsworth Research Award-Gold, Department of Physiology, NUS
2015 Faculty Research Excellence Award, Yong Loo Lin School of Medicine, NUS
2014 Swee Liew-Wadsworth Research Award-Silver, Department of Physiology, NUS
2013 Swee Liew-Wadsworth Research Award-Gold, Department of Physiology, NUS
2011 Free Radical Biology and Medicine most cited paper 2006-2011 Award
2011 Japan Society for the Promotion of Science (JSPS)-NUS Fellowship
2007 Research Excellence Award, Yong Loo Lin School of Medicine, NUS
2002 – 2003 Oncology Fellowship, National Cancer Institute (NCI), NIH, USA
Professional Activities
Editorial Board:

  1. Associate Editor, Autophagy
  2. Executive Editor, Journal of Cellular Physiology
  3. Supervising Editor, Aging Cell
  4. Academic Editor, PloS One 
  5. Member of the Editorial Board, Frontiers Cell and Developmental Biology

External Grant Review:

As panel member:

  1. National Medical Research Council (NMRC), Singapore
  2. University Research Committee (URC) Expert Panel, NUS
  3. Natural Science Foundation of China (NSFC) (panel member for Phase II review)

As ad-hoc member

  1. Research Grants Council, Hong Kong, since 2008
  2. (ii)National Health and Medical Research Council (NHMRC), Australia, since 2008
  3. Cancer Research UK, since 2011
  4. CARIPARO Foundation, Italy, since 2012
  5. Israel Science Foundation, since 2010
  6. Austrian Science Fund (FWF), since 2013
  7. Health Research Board (HRB) of Ireland, since 2014
  8. Research Foundation Flanders # FWO, Belgium, since 2014
  9. National Science Centre-Poland, since 2015
  10. Hong Kong City University, since 2014
  11. CARIPARO Foundation, Italy, since 2012
  12. Netherlands Organisation for Scientific Research (NWO), since 2013
Others
Prof Shen obtained his Bachelor of Medicine and Master of Medicine from Zhejiang Medical University, China in 1985 and 1988, respectively. He obtained his PhD from National University of Singapore (NUS) in 1996 and then received his postdoctoral training in NUS and in the National Cancer Institute (NCI), NIH, USA. He developed his academic career in NUS, from Assistant Professor (2003-2007) and Associate Professor with tenure (2007-2016) and full professor (from 2016). His main research interests include (i) Autophagy and lysosome in cancer cell biology, (ii) Mitophagy: novel mechanisms and biological importance in health and disease, and (iii) Cancer metabolism and targeted therapy. So far he has published more than 190 research papers and co-edited the book “Necrotic Cell Death” (Humana Press, 2014; with Peter Vandenabeele). (full publication list is available at ORCID: http://orcid.org/0000-0001-7369-5227. His work is also highly cited, with more than 23,000 total citation and H-Index at 76 (Google Scholar, Oct 2019). He currently serves as the Associate Editor for Autophagy, and Academic Editor for PLOS ONE and Supervising Editor for Aging Cell. He received NUS-School of Medicine Research Excellence Award (2007 and 2015), as well as the Researcher of the Year Award -2019, and the NUS Medicine Graduate Mentor of The Year (GRAMAY) Award-2019.沈漢明教授于1985年，1988年在浙江醫科大學取得學士、碩士學位，於1996年在新加坡國立大學獲得博士學位。主要研究領域為細胞自噬、線粒體自噬和腫瘤代謝學。迄今為止，他已在國際期刊發表SCI收錄論文190餘篇，被引用次數超過23,000次，H指數為76 （Google Scholar, 2019年10月）。目前擔任國際權威雜誌Autophagy副主編， Aging Cell和 PLOS ONE編委會委員。編輯出版了細胞壞死專著《Necrotic Cell Death》(Springer, 2014)，並應邀在50餘次國際學術會議及50餘家國內外學術機構上做學術報告。其科研成果獲得新加坡國立大學醫學院Research Excellence Award (2007年和2015年）和Researcher of the Year Award (2019年)。此外，沈漢明教授多年來一直從事一線教學，具備豐富的教學經驗，為新加坡國立大學醫學院和理學院的本科生和研究生主講多門課程。已經訓練培養碩士、博士和博士後研究人員40餘人, 獲得新加坡國立大學醫學院最佳導師獎（NUS Medicine Graduate Mentor of The Year (GRAMAY) Award-2019）。